Xenobiotic efflux pumps in isolated fish brain capillaries

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 282, Issue 1 51-1, 2002, Pages

  Miller, David S ^a,d   Graeff, Claudia ^c,d   Droulle, Lucy ^b,d   Fricker, Stefanie ^c,d   Fricker, Gert ^c,d  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^c Institut fur Pharmazeutische Technologie und Biopharmazie   (Germany)

^d MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN P; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN; VALSPODAR; VERAPAMIL; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CENTRAL NERVOUS SYSTEM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYPRINODONTIFORMES; DOGFISH; DRUG TRANSPORT; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0036084249     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00305.2001     Document Type: Article

References (21)

1. Functional expression of P-glycoprotein in an immortalized cell line of rat brain endothelial cells, RBE 4
2. Blood-brain interfaces in vertebrates: A comparative approach
3. Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells
4. Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium
5. High levels of P-glycoprotein detected in isolated brain capillaries
6. The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs
7. Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy
8. Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule
9. Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC 833
10. Excretory transport of xenobiotics by dogfish shark rectal gland tubules
11. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
12. Ivermectin excretion by isolated functionally intact brain endothelial capillaries
13. Expression of the conjugate export pump encoded by the mrp 2 gene in the apical membrane of kidney proximal tubules
14. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
15. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
16. P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules
17. Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates
18. Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein
19. Energy state of bovine cerebral microvessels: Comparison of isolation methods
20. Functional involvement of P-glycoprotein in blood-brain barrier
21. Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp 2 expressed in insect cells