Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells

Journal of Cellular Biochemistry

Volumn 116, Issue 6, 2015, Pages 985-997

  Kumar, Suresh ^a,b   Guru, Santosh Kumar ^b   Pathania, Anup Singh ^a,b   Manda, Sudhakar ^a,b   Kumar, Ajay ^b   Bharate, Sandip B ^a,b   Vishwakarma, Ram A ^a,b   Malik, Fayaz ^a,b   Bhushan, Shashi ^a,b  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Apoptosis; Autophagy; Caspases; Fascaplysin; PI3K AKT pathway

Indexed keywords

AUTOPHAGY RELATED PROTEIN 7; BECLIN 1; CASPASE 3; EVEROLIMUS; FASCAPLYSIN; HISTONE H2AX GAMMA; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE ASSAY; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HL 60 CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; DRUG EFFECTS; HELA CELL LINE; METABOLISM;

APOPTOSIS; AUTOPHAGY; HELA CELLS; HL-60 CELLS; HUMANS; INDOLES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

EID: 84926626086     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.25053     Document Type: Article

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