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Volumn 5, Issue OCT, 2014, Pages

The contribution of experimental in vivo models to understanding the mechanisms of adaptation to mechanical loading in bone

Author keywords

Bone; Experimental models; Mechanical loading; Mechanical strain; Mechanostat

Indexed keywords

ESTRADIOL; STAINLESS STEEL; TAMOXIFEN;

EID: 84926618785     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00154     Document Type: Review
Times cited : (102)

References (131)
  • 2
    • 0022672008 scopus 로고
    • Wolff's law of trabecular architecture at remodeling equilibrium
    • Cowin SC. Wolff's law of trabecular architecture at remodeling equilibrium. J Biomech Eng (1986) 108(1):83-8. doi:10.1115/1.3138584
    • (1986) J Biomech Eng , vol.108 , Issue.1 , pp. 83-88
    • Cowin, S.C.1
  • 3
    • 0023511631 scopus 로고
    • The history of some fundamental concepts in bone biomechanics
    • Roesler H. The history of some fundamental concepts in bone biomechanics. J Biomech (1987) 20(11-12):1025-34. doi:10.1016/0021-9290(87)90020-0
    • (1987) J Biomech , vol.20 , Issue.11-12 , pp. 1025-1034
    • Roesler, H.1
  • 5
    • 74249114163 scopus 로고    scopus 로고
    • Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones
    • Sugiyama T, Price JS, Lanyon LE. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone (2010) 46(2):314-21. doi:10.1016/j.bone.2009.08.054
    • (2010) Bone , vol.46 , Issue.2 , pp. 314-321
    • Sugiyama, T.1    Price, J.S.2    Lanyon, L.E.3
  • 6
    • 79957528374 scopus 로고    scopus 로고
    • Regulation of bone mass: local control or systemic influence or both?
    • Lanyon LE, Sugiyama T, Price JS. Regulation of bone mass: local control or systemic influence or both? IBMS Bonekey (2009) 6(6):218-26. doi:10.1138/20090382
    • (2009) IBMS Bonekey , vol.6 , Issue.6 , pp. 218-226
    • Lanyon, L.E.1    Sugiyama, T.2    Price, J.S.3
  • 7
    • 0019457982 scopus 로고
    • The effect of prolonged physical training on the properties of long bone: a study of Wolff's law
    • Woo SL, Kuei SC, Amiel D, Gomez MA, Hayes WC, White FC, et al. The effect of prolonged physical training on the properties of long bone: a study of Wolff's law. J Bone Joint Surg Am (1981) 63(5):780-7.
    • (1981) J Bone Joint Surg Am , vol.63 , Issue.5 , pp. 780-787
    • Woo, S.L.1    Kuei, S.C.2    Amiel, D.3    Gomez, M.A.4    Hayes, W.C.5    White, F.C.6
  • 8
    • 0026918067 scopus 로고
    • Strenuous exercise-induced remodelling of mature bone: relationships between in vivo strains and bone mechanics
    • Loitz BJ, Zernicke RF. Strenuous exercise-induced remodelling of mature bone: relationships between in vivo strains and bone mechanics. J Exp Biol (1992) 170:1-18.
    • (1992) J Exp Biol , vol.170 , pp. 1-18
    • Loitz, B.J.1    Zernicke, R.F.2
  • 9
    • 0027291061 scopus 로고
    • Influence of exercise on cancellous bone of the aged female rat
    • Yeh JK, Aloia JF, Chen MM, Tierney JM, Sprintz S. Influence of exercise on cancellous bone of the aged female rat. J Bone Miner Res (1993) 8(9):1117-25. doi:10.1002/jbmr.5650080913
    • (1993) J Bone Miner Res , vol.8 , Issue.9 , pp. 1117-1125
    • Yeh, J.K.1    Aloia, J.F.2    Chen, M.M.3    Tierney, J.M.4    Sprintz, S.5
  • 11
    • 0026496147 scopus 로고
    • The effects of exercise mode, swimming vs. running, upon bone growth in the rapidly growing female rat
    • Snyder A, Zierath JR, Hawley JA, Sleeper MD, Craig BW. The effects of exercise mode, swimming vs. running, upon bone growth in the rapidly growing female rat. Mech Ageing Dev (1992) 66(1):59-69. doi:10.1016/0047-6374(92)90073-M
    • (1992) Mech Ageing Dev , vol.66 , Issue.1 , pp. 59-69
    • Snyder, A.1    Zierath, J.R.2    Hawley, J.A.3    Sleeper, M.D.4    Craig, B.W.5
  • 12
    • 80053052327 scopus 로고    scopus 로고
    • Sex and age differences in the impact of the forced swimming test on the levels of steroid hormones
    • Martínez-Mota L, Ulloa R-E, Herrera-Pérez J, Chavira R, Fernández-Guasti A. Sex and age differences in the impact of the forced swimming test on the levels of steroid hormones. Physiol Behav (2011) 104(5):900-5. doi:10.1016/j.physbeh.2011.05.027
    • (2011) Physiol Behav , vol.104 , Issue.5 , pp. 900-905
    • Martínez-Mota, L.1    Ulloa, R-E.2    Herrera-Pérez, J.3    Chavira, R.4    Fernández-Guasti, A.5
  • 13
    • 84859624531 scopus 로고    scopus 로고
    • Differential effects of jump versus running exercise on trabecular architecture during remobilization after suspension-induced osteopenia in growing rats
    • Ju Y-I, Sone T, Ohnaru K, Choi H-J, Fukunaga M. Differential effects of jump versus running exercise on trabecular architecture during remobilization after suspension-induced osteopenia in growing rats. J Appl Physiol (2012) 112(5):766-72. doi:10.1152/japplphysiol.01219.2011
    • (2012) J Appl Physiol , vol.112 , Issue.5 , pp. 766-772
    • Ju, Y-I.1    Sone, T.2    Ohnaru, K.3    Choi, H-J.4    Fukunaga, M.5
  • 14
    • 0030853742 scopus 로고    scopus 로고
    • Five jumps per day increase bone mass and breaking force in rats
    • Umemura Y, Ishiko T, Yamauchi T, Kurono M, Mashiko S. Five jumps per day increase bone mass and breaking force in rats. J Bone Miner Res (1997) 12(9):1480-5. doi:10.1359/jbmr.1997.12.9.1480
    • (1997) J Bone Miner Res , vol.12 , Issue.9 , pp. 1480-1485
    • Umemura, Y.1    Ishiko, T.2    Yamauchi, T.3    Kurono, M.4    Mashiko, S.5
  • 16
    • 0029999157 scopus 로고    scopus 로고
    • Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity
    • Schefer V, Talan MI. Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity. Exp Gerontol (1996) 31(3):387-92. doi:10.1016/0531-5565(95)02032-2
    • (1996) Exp Gerontol , vol.31 , Issue.3 , pp. 387-392
    • Schefer, V.1    Talan, M.I.2
  • 17
    • 34848922736 scopus 로고    scopus 로고
    • Cardiopulmonary exercise testing and its application
    • Albouaini K, Egred M, Alahmar A, Wright DJ. Cardiopulmonary exercise testing and its application. Heart (2007) 93(10):1285-92. doi:10.1136/hrt.2007.121558
    • (2007) Heart , vol.93 , Issue.10 , pp. 1285-1292
    • Albouaini, K.1    Egred, M.2    Alahmar, A.3    Wright, D.J.4
  • 18
    • 79957470408 scopus 로고    scopus 로고
    • Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading
    • Price JS, Sugiyama T, Galea GL, Meakin LB, Sunters A, Lanyon LE. Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading. Curr Osteoporos Rep (2011) 9(2):76-82. doi:10.1007/s11914-011-0050-7
    • (2011) Curr Osteoporos Rep , vol.9 , Issue.2 , pp. 76-82
    • Price, J.S.1    Sugiyama, T.2    Galea, G.L.3    Meakin, L.B.4    Sunters, A.5    Lanyon, L.E.6
  • 19
    • 84882675954 scopus 로고    scopus 로고
    • Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop
    • Bonewald LF, Kiel DP, Clemens TL, Esser K, Orwoll ES, O'Keefe RJ, et al. Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop. J Bone Miner Res (2013) 28(9):1857-65. doi:10.1002/jbmr.1980
    • (2013) J Bone Miner Res , vol.28 , Issue.9 , pp. 1857-1865
    • Bonewald, L.F.1    Kiel, D.P.2    Clemens, T.L.3    Esser, K.4    Orwoll, E.S.5    O'Keefe, R.J.6
  • 20
    • 0014449649 scopus 로고
    • Measurements of bone strain in the walking animal
    • Lanyon LE, Smith RN. Measurements of bone strain in the walking animal. Res Vet Sci (1969) 10(1):93-4.
    • (1969) Res Vet Sci , vol.10 , Issue.1 , pp. 93-94
    • Lanyon, L.E.1    Smith, R.N.2
  • 21
    • 84912624772 scopus 로고
    • Deformation studies of the femur under dynamic vertical loading
    • Evans FG, Lissner HR, Pedersen HH. Deformation studies of the femur under dynamic vertical loading. Anat Rec (1948) 101(2):225-41. doi:10.1002/ar.1091010208
    • (1948) Anat Rec , vol.101 , Issue.2 , pp. 225-241
    • Evans, F.G.1    Lissner, H.R.2    Pedersen, H.H.3
  • 22
    • 0015545246 scopus 로고
    • Analysis of surface bone strain in the calcaneus of sheep during normal locomotion. Strain analysis of the calcaneus
    • Lanyon LE. Analysis of surface bone strain in the calcaneus of sheep during normal locomotion. Strain analysis of the calcaneus. J Biomech (1973) 6(1):41-9. doi:10.1016/0021-9290(73)90036-5
    • (1973) J Biomech , vol.6 , Issue.1 , pp. 41-49
    • Lanyon, L.E.1
  • 23
    • 0016683563 scopus 로고
    • Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft
    • Lanyon LE, Hampson WG, Goodship AE, Shah JS. Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft. Acta Orthop Scand (1975) 46(2):256-68. doi:10.3109/17453677508989216
    • (1975) Acta Orthop Scand , vol.46 , Issue.2 , pp. 256-268
    • Lanyon, L.E.1    Hampson, W.G.2    Goodship, A.E.3    Shah, J.S.4
  • 24
    • 0014900781 scopus 로고
    • Bone strain in the tibia during normal quadrupedal locomotion
    • Lanyon LE, Smith RN. Bone strain in the tibia during normal quadrupedal locomotion. Acta Orthop Scand (1970) 41(3):238-48. doi:10.3109/17453677008991511
    • (1970) Acta Orthop Scand , vol.41 , Issue.3 , pp. 238-248
    • Lanyon, L.E.1    Smith, R.N.2
  • 25
    • 0015331414 scopus 로고
    • In vivo bone strain recorded from thoracic vertebrae of sheep
    • Lanyon LE. In vivo bone strain recorded from thoracic vertebrae of sheep. J Biomech (1972) 5(3):277-81. doi:10.1016/0021-9290(72)90044-9
    • (1972) J Biomech , vol.5 , Issue.3 , pp. 277-281
    • Lanyon, L.E.1
  • 26
    • 0020391814 scopus 로고
    • Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog
    • Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol (1982) 101:187-211.
    • (1982) J Exp Biol , vol.101 , pp. 187-211
    • Rubin, C.T.1    Lanyon, L.E.2
  • 27
    • 0015177447 scopus 로고
    • Strain in sheep lumbar vertebrae recorded during life
    • Lanyon LE. Strain in sheep lumbar vertebrae recorded during life. Acta Orthop Scand (1971) 42(1):102-12. doi:10.3109/17453677108989030
    • (1971) Acta Orthop Scand , vol.42 , Issue.1 , pp. 102-112
    • Lanyon, L.E.1
  • 28
    • 0017352233 scopus 로고
    • Strain related electrical potentials recorded in vitro and in vivo
    • Lanyon LE, Hartman W. Strain related electrical potentials recorded in vitro and in vivo. Calcif Tissue Res (1977) 22(3):315-27. doi:10.1007/BF02010370
    • (1977) Calcif Tissue Res , vol.22 , Issue.3 , pp. 315-327
    • Lanyon, L.E.1    Hartman, W.2
  • 29
    • 0017214686 scopus 로고
    • The measurement of bone strain "in vivo"
    • Lanyon LE. The measurement of bone strain "in vivo". Acta Orthop Belg (1976) 42(Suppl 1):98-108.
    • (1976) Acta Orthop Belg , vol.42 , pp. 98-108
    • Lanyon, L.E.1
  • 30
    • 0016793216 scopus 로고
    • Locomotor bone strain as the stimulus for bone's mechanical adaptability
    • Clark EA, Goodship AE, Lanyon LE. Locomotor bone strain as the stimulus for bone's mechanical adaptability. J Physiol (Lond) (1975) 245(2):57.
    • (1975) J Physiol (Lond) , vol.245 , Issue.2 , pp. 57
    • Clark, E.A.1    Goodship, A.E.2    Lanyon, L.E.3
  • 31
    • 33746978336 scopus 로고    scopus 로고
    • One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture
    • Skerry TM. One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture. J Musculoskelet Neuronal Interact (2006) 6(2):122-7.
    • (2006) J Musculoskelet Neuronal Interact , vol.6 , Issue.2 , pp. 122-127
    • Skerry, T.M.1
  • 32
    • 0002216099 scopus 로고
    • Functional anatomy of feeding in the bluegill sunfish, Lepomis macrochirus: in vivo measurement of bone strain
    • Lauder GV, Lanyon LE. Functional anatomy of feeding in the bluegill sunfish, Lepomis macrochirus: in vivo measurement of bone strain. J Exp Biol (1980) 80:33-55.
    • (1980) J Exp Biol , vol.80 , pp. 33-55
    • Lauder, G.V.1    Lanyon, L.E.2
  • 33
    • 0036756329 scopus 로고    scopus 로고
    • Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading
    • Lee KC, Maxwell A, Lanyon LE. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone (2002) 31(3):407-12. doi:10.1016/S8756-3282(02)00842-6
    • (2002) Bone , vol.31 , Issue.3 , pp. 407-412
    • Lee, K.C.1    Maxwell, A.2    Lanyon, L.E.3
  • 34
    • 28844442933 scopus 로고    scopus 로고
    • Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    • De Souza RL, Matsuura M, Eckstein F, Rawlinson SC, Lanyon LE, Pitsillides AA. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone (2005) 37(6):810-8. doi:10.1016/j.bone.2005.07.022
    • (2005) Bone , vol.37 , Issue.6 , pp. 810-818
    • De Souza, R.L.1    Matsuura, M.2    Eckstein, F.3    Rawlinson, S.C.4    Lanyon, L.E.5    Pitsillides, A.A.6
  • 35
    • 77952490622 scopus 로고    scopus 로고
    • Using digital image correlation to determine bone surface strains during loading and after adaptation of the mouse tibia
    • Sztefek P, Vanleene M, Olsson R, Collinson R, Pitsillides AA, Shefelbine S. Using digital image correlation to determine bone surface strains during loading and after adaptation of the mouse tibia. J Biomech (2010) 43(4):599-605. doi:10.1016/j.jbiomech.2009.10.042
    • (2010) J Biomech , vol.43 , Issue.4 , pp. 599-605
    • Sztefek, P.1    Vanleene, M.2    Olsson, R.3    Collinson, R.4    Pitsillides, A.A.5    Shefelbine, S.6
  • 36
    • 84861760073 scopus 로고    scopus 로고
    • Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered
    • Moustafa A, Sugiyama T, Prasad J, Zaman G, Gross TS, Lanyon LE, et al. Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int (2011) 23(4):1225-34. doi:10.1007/s00198-011-1656-4
    • (2011) Osteoporos Int , vol.23 , Issue.4 , pp. 1225-1234
    • Moustafa, A.1    Sugiyama, T.2    Prasad, J.3    Zaman, G.4    Gross, T.S.5    Lanyon, L.E.6
  • 37
    • 0030995311 scopus 로고    scopus 로고
    • Strain gradients correlate with sites of periosteal bone formation
    • Gross TS, Edwards JL, McLeod KJ, Rubin CT. Strain gradients correlate with sites of periosteal bone formation. J Bone Miner Res (1997) 12(6):982-8. doi:10.1359/jbmr.1997.12.6.982
    • (1997) J Bone Miner Res , vol.12 , Issue.6 , pp. 982-988
    • Gross, T.S.1    Edwards, J.L.2    McLeod, K.J.3    Rubin, C.T.4
  • 38
    • 84878168026 scopus 로고    scopus 로고
    • Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load
    • Willie BM, Birkhold AI, Razi H, Thiele T, Aido M, Kruck B, et al. Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load. Bone (2013) 55(2):335-46. doi:10.1016/j.bone.2013.04.023
    • (2013) Bone , vol.55 , Issue.2 , pp. 335-346
    • Willie, B.M.1    Birkhold, A.I.2    Razi, H.3    Thiele, T.4    Aido, M.5    Kruck, B.6
  • 39
    • 84857053721 scopus 로고    scopus 로고
    • Longitudinal assessment of in vivo bone dynamics in a mouse tail model of postmenopausal osteoporosis
    • Lambers FM, Kuhn G, Schulte FA, Koch K, Müller R. Longitudinal assessment of in vivo bone dynamics in a mouse tail model of postmenopausal osteoporosis. Calcif Tissue Int (2012) 90(2):108-19. doi:10.1007/s00223-011-9553-6
    • (2012) Calcif Tissue Int , vol.90 , Issue.2 , pp. 108-119
    • Lambers, F.M.1    Kuhn, G.2    Schulte, F.A.3    Koch, K.4    Müller, R.5
  • 40
    • 84875015001 scopus 로고    scopus 로고
    • Longitudinal in vivo imaging of bone formation and resorption using fluorescence molecular tomography
    • Lambers FM, Stuker F, Weigt C, Kuhn G, Koch K, Schulte FA, et al. Longitudinal in vivo imaging of bone formation and resorption using fluorescence molecular tomography. Bone (2013) 52(2):587-95. doi:10.1016/j.bone.2012.11.001
    • (2013) Bone , vol.52 , Issue.2 , pp. 587-595
    • Lambers, F.M.1    Stuker, F.2    Weigt, C.3    Kuhn, G.4    Koch, K.5    Schulte, F.A.6
  • 41
    • 0018572547 scopus 로고
    • Functional adaptation of bone to increased stress. An experimental study
    • Goodship AE, Lanyon LE, McFie H. Functional adaptation of bone to increased stress. An experimental study. J Bone Joint Surg Am (1979) 61(4):539-46.
    • (1979) J Bone Joint Surg Am , vol.61 , Issue.4 , pp. 539-546
    • Goodship, A.E.1    Lanyon, L.E.2    McFie, H.3
  • 42
    • 0015102499 scopus 로고
    • Reaction of bone to mechanical stimuli. 1. Continuous and intermittent loading of tibia in rabbit
    • Hert J, Lisková M, Landa J. Reaction of bone to mechanical stimuli. 1. Continuous and intermittent loading of tibia in rabbit. Folia Morphol (Praha) (1971) 19(3):290-300.
    • (1971) Folia Morphol (Praha) , vol.19 , Issue.3 , pp. 290-300
    • Hert, J.1    Lisková, M.2    Landa, J.3
  • 43
    • 0015103499 scopus 로고
    • Reaction of bone to mechanical stimuli. 2. Periosteal and endosteal reaction of tibial diaphysis in rabbit to intermittent loading
    • Lisková M, Hert J. Reaction of bone to mechanical stimuli. 2. Periosteal and endosteal reaction of tibial diaphysis in rabbit to intermittent loading. Folia Morphol (Praha) (1971) 19(3):301-17.
    • (1971) Folia Morphol (Praha) , vol.19 , Issue.3 , pp. 301-317
    • Lisková, M.1    Hert, J.2
  • 44
    • 0014995174 scopus 로고
    • Reaction of bone to mechanical stimuli. 5. Effect of intermittent stress on the rabbit tibia after resection of the peripheral nerves
    • Hert J, Sklenská A, Lisková M. Reaction of bone to mechanical stimuli. 5. Effect of intermittent stress on the rabbit tibia after resection of the peripheral nerves. Folia Morphol (Praha) (1971) 19(4):378-87.
    • (1971) Folia Morphol (Praha) , vol.19 , Issue.4 , pp. 378-387
    • Hert, J.1    Sklenská, A.2    Lisková, M.3
  • 45
    • 0020442377 scopus 로고
    • The influence of strain rate on adaptive bone remodelling
    • O'Connor JA, Lanyon LE, MacFie H. The influence of strain rate on adaptive bone remodelling. J Biomech (1982) 15(10):767-81. doi:10.1016/0021-9290(82)90092-6
    • (1982) J Biomech , vol.15 , Issue.10 , pp. 767-781
    • O'Connor, J.A.1    Lanyon, L.E.2    MacFie, H.3
  • 46
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am (1984) 66(3):397-402.
    • (1984) J Bone Joint Surg Am , vol.66 , Issue.3 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 47
    • 0021131451 scopus 로고
    • Functional strain as a determinant for bone remodeling
    • Lanyon LE. Functional strain as a determinant for bone remodeling. Calcif Tissue Int (1984) 36(Suppl 1):S56-61. doi:10.1007/BF02406134
    • (1984) Calcif Tissue Int , vol.36 , pp. S56-61
    • Lanyon, L.E.1
  • 48
    • 0021676239 scopus 로고
    • Static vs dynamic loads as an influence on bone remodelling
    • Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomech (1984) 17(12):897-905. doi:10.1016/0021-9290(84)90003-4
    • (1984) J Biomech , vol.17 , Issue.12 , pp. 897-905
    • Lanyon, L.E.1    Rubin, C.T.2
  • 49
    • 0027407141 scopus 로고
    • Induction of bone formation in rat tail vertebrae by mechanical loading
    • Chambers TJ, Evans M, Gardner TN, Turner-Smith A, Chow JW. Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner (1993) 20(2):167-78. doi:10.1016/S0169-6009(08)80025-6
    • (1993) Bone Miner , vol.20 , Issue.2 , pp. 167-178
    • Chambers, T.J.1    Evans, M.2    Gardner, T.N.3    Turner-Smith, A.4    Chow, J.W.5
  • 50
    • 61549133522 scopus 로고    scopus 로고
    • A novel in vivo mouse model for mechanically stimulated bone adaptation-a combined experimental and computational validation study
    • Webster DJ, Morley PL, van Lenthe GH, Müller R. A novel in vivo mouse model for mechanically stimulated bone adaptation-a combined experimental and computational validation study. Comput Methods Biomech Biomed Engin (2008) 11(5):435-41. doi:10.1080/10255840802078014
    • (2008) Comput Methods Biomech Biomed Engin , vol.11 , Issue.5 , pp. 435-441
    • Webster, D.J.1    Morley, P.L.2    van Lenthe, G.H.3    Müller, R.4
  • 51
    • 81355127344 scopus 로고    scopus 로고
    • Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry
    • Lambers FM, Schulte FA, Kuhn G, Webster DJ, Müller R. Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry. Bone (2011) 49(6):1340-50. doi:10.1016/j.bone.2011.08.035
    • (2011) Bone , vol.49 , Issue.6 , pp. 1340-1350
    • Lambers, F.M.1    Schulte, F.A.2    Kuhn, G.3    Webster, D.J.4    Müller, R.5
  • 52
    • 84878207741 scopus 로고    scopus 로고
    • Trabecular bone adapts to long-term cyclic loading by increasing stiffness and normalization of dynamic morphometric rates
    • Lambers FM, Koch K, Kuhn G, Ruffoni D, Weigt C, Schulte FA, et al. Trabecular bone adapts to long-term cyclic loading by increasing stiffness and normalization of dynamic morphometric rates. Bone (2013) 55(2):325-34. doi:10.1016/j.bone.2013.04.016
    • (2013) Bone , vol.55 , Issue.2 , pp. 325-334
    • Lambers, F.M.1    Koch, K.2    Kuhn, G.3    Ruffoni, D.4    Weigt, C.5    Schulte, F.A.6
  • 53
    • 0025872871 scopus 로고
    • A noninvasive, in vivo model for studying strain adaptive bone modeling
    • Turner CH, Akhter MP, Raab DM, Kimmel DB, Recker RR. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone (1991) 12(2):73-9. doi:10.1016/8756-3282(91)90003-2
    • (1991) Bone , vol.12 , Issue.2 , pp. 73-79
    • Turner, C.H.1    Akhter, M.P.2    Raab, D.M.3    Kimmel, D.B.4    Recker, R.R.5
  • 54
    • 0028066776 scopus 로고
    • Mechanical loading thresholds for lamellar and woven bone formation
    • Turner CH, Forwood MR, Rho JY, Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res (1994) 9(1):87-97. doi:10.1002/jbmr.5650090113
    • (1994) J Bone Miner Res , vol.9 , Issue.1 , pp. 87-97
    • Turner, C.H.1    Forwood, M.R.2    Rho, J.Y.3    Yoshikawa, T.4
  • 55
    • 0036179760 scopus 로고    scopus 로고
    • Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction
    • Gross TS, Srinivasan S, Liu CC, Clemens TL, Bain SD. Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. J Bone Miner Res (2002) 17(3):493-501. doi:10.1359/jbmr.2002.17.3.493
    • (2002) J Bone Miner Res , vol.17 , Issue.3 , pp. 493-501
    • Gross, T.S.1    Srinivasan, S.2    Liu, C.C.3    Clemens, T.L.4    Bain, S.D.5
  • 56
    • 0028267333 scopus 로고
    • Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure
    • Torrance AG, Mosley JR, Suswillo RF, Lanyon LE. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure. Calcif Tissue Int (1994) 54(3):241-7. doi:10.1007/BF00301686
    • (1994) Calcif Tissue Int , vol.54 , Issue.3 , pp. 241-247
    • Torrance, A.G.1    Mosley, J.R.2    Suswillo, R.F.3    Lanyon, L.E.4
  • 57
    • 63449096161 scopus 로고    scopus 로고
    • The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading
    • Moustafa A, Sugiyama T, Saxon LK, Zaman G, Sunters A, Armstrong VJ, et al. The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading. Bone (2009) 44(5):930-5. doi:10.1016/j.bone.2008.12.026
    • (2009) Bone , vol.44 , Issue.5 , pp. 930-935
    • Moustafa, A.1    Sugiyama, T.2    Saxon, L.K.3    Zaman, G.4    Sunters, A.5    Armstrong, V.J.6
  • 58
    • 79958709460 scopus 로고    scopus 로고
    • Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice
    • Sugiyama T, Meakin LB, Galea GL, Jackson BF, Lanyon LE, Ebetino FH, et al. Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice. Bone (2011) 49(1):133-9. doi:10.1016/j.bone.2011.03.775
    • (2011) Bone , vol.49 , Issue.1 , pp. 133-139
    • Sugiyama, T.1    Meakin, L.B.2    Galea, G.L.3    Jackson, B.F.4    Lanyon, L.E.5    Ebetino, F.H.6
  • 59
    • 81155148568 scopus 로고    scopus 로고
    • Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
    • Tu X, Rhee Y, Condon KW, Bivi N, Allen MR, Dwyer D, et al. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone (2012) 50(1):209-17. doi:10.1016/j.bone.2011.10.025
    • (2012) Bone , vol.50 , Issue.1 , pp. 209-217
    • Tu, X.1    Rhee, Y.2    Condon, K.W.3    Bivi, N.4    Allen, M.R.5    Dwyer, D.6
  • 60
    • 84872477285 scopus 로고    scopus 로고
    • Estrogen receptor-a is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2
    • Windahl S, Saxon L, Börjesson A, Lagerquist M, Frenkel B, Henning P, et al. Estrogen receptor-a is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2. J Bone Miner Res (2012) 28(2):291-301. doi:10.1002/jbmr.1754
    • (2012) J Bone Miner Res , vol.28 , Issue.2 , pp. 291-301
    • Windahl, S.1    Saxon, L.2    Börjesson, A.3    Lagerquist, M.4    Frenkel, B.5    Henning, P.6
  • 61
    • 79958772955 scopus 로고    scopus 로고
    • Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it
    • Saxon LK, Jackson BF, Sugiyama T, Lanyon LE, Price JS. Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone (2011) 49(2):184-93. doi:10.1016/j.bone.2011.03.683
    • (2011) Bone , vol.49 , Issue.2 , pp. 184-193
    • Saxon, L.K.1    Jackson, B.F.2    Sugiyama, T.3    Lanyon, L.E.4    Price, J.S.5
  • 62
    • 84860344187 scopus 로고    scopus 로고
    • Estrogen receptors a and ß have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone
    • Saxon LK, Galea G, Meakin L, Price J, Lanyon LE. Estrogen receptors a and ß have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone. Endocrinology (2012) 153(5):2254-66. doi:10.1210/en.2011-1977
    • (2012) Endocrinology , vol.153 , Issue.5 , pp. 2254-2266
    • Saxon, L.K.1    Galea, G.2    Meakin, L.3    Price, J.4    Lanyon, L.E.5
  • 63
    • 0036139736 scopus 로고    scopus 로고
    • Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain
    • Mosley JR, Lanyon LE. Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain. Bone (2002) 30(1):314-9. doi:10.1016/S8756-3282(01)00626-3
    • (2002) Bone , vol.30 , Issue.1 , pp. 314-319
    • Mosley, J.R.1    Lanyon, L.E.2
  • 64
    • 0036153065 scopus 로고    scopus 로고
    • The effects of dynamic axial loading on the rat growth plate
    • Ohashi N, Robling AG, Burr DB, Turner CH. The effects of dynamic axial loading on the rat growth plate. J Bone Miner Res (2002) 17(2):284-92. doi:10.1359/jbmr.2002.17.2.284
    • (2002) J Bone Miner Res , vol.17 , Issue.2 , pp. 284-292
    • Ohashi, N.1    Robling, A.G.2    Burr, D.B.3    Turner, C.H.4
  • 66
    • 0026003694 scopus 로고
    • Bone histomorphometric comparison of rat tibial metaphysis after 7-day tail suspension vs. 7-day spaceflight
    • Vico L, Novikov VE, Very JM, Alexandre C. Bone histomorphometric comparison of rat tibial metaphysis after 7-day tail suspension vs. 7-day spaceflight. Aviat Space Environ Med (1991) 62(1):26-31.
    • (1991) Aviat Space Environ Med , vol.62 , Issue.1 , pp. 26-31
    • Vico, L.1    Novikov, V.E.2    Very, J.M.3    Alexandre, C.4
  • 67
    • 0040031529 scopus 로고
    • Rat and monkey bone study in the Biocosmos 2044 space experiment
    • Zérath E, Holy X, Malouvier A, Caissard JC, Noguès C. Rat and monkey bone study in the Biocosmos 2044 space experiment. Physiologist (1991) 34(1 Suppl):S194-5.
    • (1991) Physiologist , vol.34 , Issue.1 SUPPL , pp. S194-S195
    • Zérath, E.1    Holy, X.2    Malouvier, A.3    Caissard, J.C.4    Noguès, C.5
  • 68
    • 0027053270 scopus 로고
    • Microgravity and bone adaptation at the tissue level
    • Vico L, Alexandre C. Microgravity and bone adaptation at the tissue level. J Bone Miner Res (1992) 7(Suppl 2):S445-7. doi:10.1002/jbmr.5650071415
    • (1992) J Bone Miner Res , vol.7 , pp. S445-S447
    • Vico, L.1    Alexandre, C.2
  • 69
    • 0018134332 scopus 로고
    • Bone loss in response to long-term immobilisation
    • Uhthoff HK, Jaworski ZF. Bone loss in response to long-term immobilisation. J Bone Joint Surg Br (1978) 60-B(3):420-9.
    • (1978) J Bone Joint Surg Br , vol.60B , Issue.3 , pp. 420-429
    • Uhthoff, H.K.1    Jaworski, Z.F.2
  • 70
    • 0022788466 scopus 로고
    • The effects of immobilization on bone histomorphometry in rats
    • Turner RT, Bell NH. The effects of immobilization on bone histomorphometry in rats. J Bone Miner Res (1986) 1(5):399-407. doi:10.1002/jbmr.5650010504
    • (1986) J Bone Miner Res , vol.1 , Issue.5 , pp. 399-407
    • Turner, R.T.1    Bell, N.H.2
  • 71
    • 0023875945 scopus 로고
    • Ultrasonic measurement of immobilization-induced osteopenia: an experimental study in sheep
    • Rubin CT, Pratt GW, Porter AL, Lanyon LE, Poss R. Ultrasonic measurement of immobilization-induced osteopenia: an experimental study in sheep. Calcif Tissue Int (1988) 42(5):309-12. doi:10.1007/BF02556365
    • (1988) Calcif Tissue Int , vol.42 , Issue.5 , pp. 309-312
    • Rubin, C.T.1    Pratt, G.W.2    Porter, A.L.3    Lanyon, L.E.4    Poss, R.5
  • 72
    • 0024448705 scopus 로고
    • Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation
    • Weinreb M, Rodan GA, Thompson DD. Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation. Bone (1989) 10(3):187-94. doi:10.1016/8756-3282(89)90052-5
    • (1989) Bone , vol.10 , Issue.3 , pp. 187-194
    • Weinreb, M.1    Rodan, G.A.2    Thompson, D.D.3
  • 73
    • 0025210639 scopus 로고
    • Adaptation of cancellous bone to aging and immobilization in the rat: a single photon absorptiometry and histomorphometry study
    • Li XJ, Jee WS, Chow SY, Woodbury DM. Adaptation of cancellous bone to aging and immobilization in the rat: a single photon absorptiometry and histomorphometry study. Anat Rec (1990) 227(1):12-24. doi:10.1002/ar.1092270103
    • (1990) Anat Rec , vol.227 , Issue.1 , pp. 12-24
    • Li, X.J.1    Jee, W.S.2    Chow, S.Y.3    Woodbury, D.M.4
  • 74
    • 0027193367 scopus 로고
    • Immobilisation induced bone loss in the sheep is not modulated by calcitonin treatment
    • Skerry TM, Lanyon LE. Immobilisation induced bone loss in the sheep is not modulated by calcitonin treatment. Bone (1993) 14(3):511-6. doi:10.1016/8756-3282(93)90188-G
    • (1993) Bone , vol.14 , Issue.3 , pp. 511-516
    • Skerry, T.M.1    Lanyon, L.E.2
  • 75
    • 0030067077 scopus 로고    scopus 로고
    • Architectural modifications and cellular response during disuse-related bone loss in calcaneus of the sheep
    • Thomas T, Vico L, Skerry TM, Caulin F, Lanyon LE, Alexandre C, et al. Architectural modifications and cellular response during disuse-related bone loss in calcaneus of the sheep. J Appl Physiol (1996) 80(1):198-202.
    • (1996) J Appl Physiol , vol.80 , Issue.1 , pp. 198-202
    • Thomas, T.1    Vico, L.2    Skerry, T.M.3    Caulin, F.4    Lanyon, L.E.5    Alexandre, C.6
  • 76
    • 0023236362 scopus 로고
    • Mechanical, morphological and biochemical adaptations of bone and muscle to hindlimb suspension and exercise
    • Shaw SR, Zernicke RF, Vailas AC, DeLuna D, Thomason DB, Baldwin KM. Mechanical, morphological and biochemical adaptations of bone and muscle to hindlimb suspension and exercise. J Biomech (1987) 20(3):225-34. doi:10.1016/0021-9290(87)90289-2
    • (1987) J Biomech , vol.20 , Issue.3 , pp. 225-234
    • Shaw, S.R.1    Zernicke, R.F.2    Vailas, A.C.3    DeLuna, D.4    Thomason, D.B.5    Baldwin, K.M.6
  • 77
    • 0010546273 scopus 로고    scopus 로고
    • Changes in trabecular bone turnover and bone marrow cell development in tail-suspended mice
    • Sakai A, Nakamura T. Changes in trabecular bone turnover and bone marrow cell development in tail-suspended mice. J Musculoskelet Neuronal Interact (2001) 1(4):387-92.
    • (2001) J Musculoskelet Neuronal Interact , vol.1 , Issue.4 , pp. 387-392
    • Sakai, A.1    Nakamura, T.2
  • 78
    • 12444304255 scopus 로고    scopus 로고
    • Osteoclast development in immobilized bone is suppressed by parathyroidectomy in mice
    • Sakai A, Mori T, Sakuma-Zenke M, Takeda T, Nakai K, Katae Y, et al. Osteoclast development in immobilized bone is suppressed by parathyroidectomy in mice. J Bone Miner Metab (2005) 23(1):8-14. doi:10.1007/s00774-004-0534-y
    • (2005) J Bone Miner Metab , vol.23 , Issue.1 , pp. 8-14
    • Sakai, A.1    Mori, T.2    Sakuma-Zenke, M.3    Takeda, T.4    Nakai, K.5    Katae, Y.6
  • 79
    • 33645334941 scopus 로고    scopus 로고
    • Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss
    • Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res (2006) 21(4):605-15. doi:10.1359/jbmr.060107
    • (2006) J Bone Miner Res , vol.21 , Issue.4 , pp. 605-615
    • Aguirre, J.I.1    Plotkin, L.I.2    Stewart, S.A.3    Weinstein, R.S.4    Parfitt, A.M.5    Manolagas, S.C.6
  • 80
    • 84875308404 scopus 로고    scopus 로고
    • Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass
    • Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res (2013) 28(4):875-85. doi:10.1002/jbmr.1814
    • (2013) J Bone Miner Res , vol.28 , Issue.4 , pp. 875-885
    • Ellman, R.1    Spatz, J.2    Cloutier, A.3    Palme, R.4    Christiansen, B.A.5    Bouxsein, M.L.6
  • 81
    • 84865614567 scopus 로고    scopus 로고
    • Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight
    • Lloyd SA, Bandstra ER, Willey JS, Riffle SE, Tirado-Lee L, Nelson GA, et al. Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight. Bone (2012) 51(4):756-64. doi:10.1016/j.bone.2012.07.001
    • (2012) Bone , vol.51 , Issue.4 , pp. 756-764
    • Lloyd, S.A.1    Bandstra, E.R.2    Willey, J.S.3    Riffle, S.E.4    Tirado-Lee, L.5    Nelson, G.A.6
  • 84
    • 80053447794 scopus 로고    scopus 로고
    • Cortical bone resorption following muscle paralysis is spatially heterogeneous
    • Ausk BJ, Huber P, Poliachik SL, Bain SD, Srinivasan S, Gross TS. Cortical bone resorption following muscle paralysis is spatially heterogeneous. Bone (2012) 50(1):14-22. doi:10.1016/j.bone.2011.08.028
    • (2012) Bone , vol.50 , Issue.1 , pp. 14-22
    • Ausk, B.J.1    Huber, P.2    Poliachik, S.L.3    Bain, S.D.4    Srinivasan, S.5    Gross, T.S.6
  • 85
    • 27844517983 scopus 로고    scopus 로고
    • Sympathetic nervous system does not mediate the load-induced cortical new bone formation
    • De Souza RL, Pitsillides AA, Lanyon LE, Skerry TM, Chenu C. Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J Bone Miner Res (2005) 20(12):2159-68. doi:10.1359/JBMR.050812
    • (2005) J Bone Miner Res , vol.20 , Issue.12 , pp. 2159-2168
    • De Souza, R.L.1    Pitsillides, A.A.2    Lanyon, L.E.3    Skerry, T.M.4    Chenu, C.5
  • 86
    • 84864139453 scopus 로고    scopus 로고
    • Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition
    • Sugiyama T, Meakin LB, Browne WJ, Galea GL, Price JS, Lanyon LE. Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res (2012) 27(8):1784-93. doi:10.1002/jbmr.1599
    • (2012) J Bone Miner Res , vol.27 , Issue.8 , pp. 1784-1793
    • Sugiyama, T.1    Meakin, L.B.2    Browne, W.J.3    Galea, G.L.4    Price, J.S.5    Lanyon, L.E.6
  • 87
    • 84874385602 scopus 로고    scopus 로고
    • Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone
    • Warden SJ, Galley MR, Richard JS, George LA, Dirks RC, Guildenbecher EA, et al. Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone. Bone (2013) 54(1):98-105. doi:10.1016/j.bone.2013.01.043
    • (2013) Bone , vol.54 , Issue.1 , pp. 98-105
    • Warden, S.J.1    Galley, M.R.2    Richard, J.S.3    George, L.A.4    Dirks, R.C.5    Guildenbecher, E.A.6
  • 88
    • 77956807497 scopus 로고    scopus 로고
    • Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression
    • Brodt MD, Silva MJ. Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression. J Bone Miner Res (2010) 25(9):2006-15. doi:10.1002/jbmr.96
    • (2010) J Bone Miner Res , vol.25 , Issue.9 , pp. 2006-2015
    • Brodt, M.D.1    Silva, M.J.2
  • 89
    • 77649181032 scopus 로고    scopus 로고
    • Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse
    • Zaman G, Saxon LK, Sunters A, Hilton H, Underhill P, Williams D, et al. Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. Bone (2010) 46(3):628-42. doi:10.1016/j.bone.2009.10.021
    • (2010) Bone , vol.46 , Issue.3 , pp. 628-642
    • Zaman, G.1    Saxon, L.K.2    Sunters, A.3    Hilton, H.4    Underhill, P.5    Williams, D.6
  • 90
    • 0042265549 scopus 로고    scopus 로고
    • Endocrinology: bone adaptation requires oestrogen receptor-alpha
    • Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L. Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature (2003) 424(6947):389. doi:10.1038/424389a
    • (2003) Nature , vol.424 , Issue.6947 , pp. 389
    • Lee, K.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.5
  • 91
    • 0021848241 scopus 로고
    • Regulation of bone mass by mechanical strain magnitude
    • Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int (1985) 37(4):411-7. doi:10.1007/BF02553711
    • (1985) Calcif Tissue Int , vol.37 , Issue.4 , pp. 411-417
    • Rubin, C.T.1    Lanyon, L.E.2
  • 92
    • 78651066496 scopus 로고    scopus 로고
    • Comparing histological, vascular and molecular responses associated with woven and lamellar bone formation induced by mechanical loading in the rat ulna
    • McKenzie JA, Silva MJ. Comparing histological, vascular and molecular responses associated with woven and lamellar bone formation induced by mechanical loading in the rat ulna. Bone (2011) 48(2):250-8. doi:10.1016/j.bone.2010.09.005
    • (2011) Bone , vol.48 , Issue.2 , pp. 250-258
    • McKenzie, J.A.1    Silva, M.J.2
  • 93
    • 0030804099 scopus 로고    scopus 로고
    • Strain gradients correlate with sites of exercise-induced bone-forming surfaces in the adult skeleton
    • Judex S, Gross TS, Zernicke RF. Strain gradients correlate with sites of exercise-induced bone-forming surfaces in the adult skeleton. J Bone Miner Res (1997) 12(10):1737-45. doi:10.1359/jbmr.1997.12.10.1737
    • (1997) J Bone Miner Res , vol.12 , Issue.10 , pp. 1737-1745
    • Judex, S.1    Gross, T.S.2    Zernicke, R.F.3
  • 94
    • 1442324440 scopus 로고    scopus 로고
    • Experimental and finite element analysis of the rat ulnar loading model-correlations between strain and bone formation following fatigue loading
    • Kotha SP, Hsieh YF, Strigel RM, Müller R, Silva MJ. Experimental and finite element analysis of the rat ulnar loading model-correlations between strain and bone formation following fatigue loading. J Biomech (2004) 37(4):541-8. doi:10.1016/j.jbiomech.2003.08.009
    • (2004) J Biomech , vol.37 , Issue.4 , pp. 541-548
    • Kotha, S.P.1    Hsieh, Y.F.2    Strigel, R.M.3    Müller, R.4    Silva, M.J.5
  • 96
    • 0029093747 scopus 로고
    • Interruption of disuse by short duration walking exercise does not prevent bone loss in the sheep calcaneus
    • Skerry TM, Lanyon LE. Interruption of disuse by short duration walking exercise does not prevent bone loss in the sheep calcaneus. Bone (1995) 16(2):269-74. doi:10.1016/8756-3282(94)00039-3
    • (1995) Bone , vol.16 , Issue.2 , pp. 269-274
    • Skerry, T.M.1    Lanyon, L.E.2
  • 97
    • 84874395901 scopus 로고    scopus 로고
    • Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight
    • Meakin LB, Sugiyama T, Galea GL, Browne WJ, Lanyon LE, Price JS. Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight. Bone (2013) 54(1):113-7. doi:10.1016/j.bone.2013.01.029
    • (2013) Bone , vol.54 , Issue.1 , pp. 113-117
    • Meakin, L.B.1    Sugiyama, T.2    Galea, G.L.3    Browne, W.J.4    Lanyon, L.E.5    Price, J.S.6
  • 98
    • 0032190413 scopus 로고    scopus 로고
    • Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats
    • Mosley JR, Lanyon LE. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone (1998) 23(4):313-8. doi:10.1016/S8756-3282(98)00113-6
    • (1998) Bone , vol.23 , Issue.4 , pp. 313-318
    • Mosley, J.R.1    Lanyon, L.E.2
  • 99
    • 0029111672 scopus 로고
    • Mechanotransduction in bone: role of strain rate
    • Turner CH, Owan I, Takano Y. Mechanotransduction in bone: role of strain rate. Am J Physiol (1995) 269(3 Pt 1):E438-42.
    • (1995) Am J Physiol , vol.269 , Issue.3 , pp. E438-E442
    • Turner, C.H.1    Owan, I.2    Takano, Y.3
  • 100
    • 0031026788 scopus 로고    scopus 로고
    • High-impact exercise promotes bone gain in well-trained female athletes
    • Taaffe DR, Robinson TL, Snow CM, Marcus R. High-impact exercise promotes bone gain in well-trained female athletes. J Bone Miner Res (1997) 12(2):255-60. doi:10.1359/jbmr.1997.12.2.255
    • (1997) J Bone Miner Res , vol.12 , Issue.2 , pp. 255-260
    • Taaffe, D.R.1    Robinson, T.L.2    Snow, C.M.3    Marcus, R.4
  • 102
    • 84865225753 scopus 로고    scopus 로고
    • Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: results from a population-based study of adolescents
    • Deere K, Sayers A, Rittweger J, Tobias JH. Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: results from a population-based study of adolescents. J Bone Miner Res (2012) 27(9):1887-95. doi:10.1002/jbmr.1631
    • (2012) J Bone Miner Res , vol.27 , Issue.9 , pp. 1887-1895
    • Deere, K.1    Sayers, A.2    Rittweger, J.3    Tobias, J.H.4
  • 103
    • 0031005980 scopus 로고    scopus 로고
    • Bone mass and bone turnover in power athletes, endurance athletes, and controls: a 12-month longitudinal study
    • Bennell KL, Malcolm SA, Khan KM, Thomas SA, Reid SJ, Brukner PD, et al. Bone mass and bone turnover in power athletes, endurance athletes, and controls: a 12-month longitudinal study. Bone (1997) 20(5):477-84. doi:10.1016/S8756-3282(97)00026-4
    • (1997) Bone , vol.20 , Issue.5 , pp. 477-484
    • Bennell, K.L.1    Malcolm, S.A.2    Khan, K.M.3    Thomas, S.A.4    Reid, S.J.5    Brukner, P.D.6
  • 104
    • 2342638385 scopus 로고    scopus 로고
    • Rest insertion combined with high-frequency loading enhances osteogenesis
    • LaMothe JM, Zernicke RF. Rest insertion combined with high-frequency loading enhances osteogenesis. J Appl Physiol (2004) 96(5):1788-93. doi:10.1152/japplphysiol.01145.2003
    • (2004) J Appl Physiol , vol.96 , Issue.5 , pp. 1788-1793
    • LaMothe, J.M.1    Zernicke, R.F.2
  • 105
    • 84904696920 scopus 로고    scopus 로고
    • Age-related impairment of bones' adaptive response to loading in mice is associated with gender-related deficiencies in osteoblasts but no change in osteocytes
    • Meakin LB, Galea GL, Sugiyama T, Lanyon LE, Price JS. Age-related impairment of bones' adaptive response to loading in mice is associated with gender-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res (2014) 29(8):1859-71. doi:10.1002/jbmr.2222
    • (2014) J Bone Miner Res , vol.29 , Issue.8 , pp. 1859-1871
    • Meakin, L.B.1    Galea, G.L.2    Sugiyama, T.3    Lanyon, L.E.4    Price, J.S.5
  • 106
    • 84859360993 scopus 로고    scopus 로고
    • Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
    • Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone (2012) 50(5):1115-22. doi:10.1016/j.bone.2012.01.025
    • (2012) Bone , vol.50 , Issue.5 , pp. 1115-1122
    • Kennedy, O.D.1    Herman, B.C.2    Laudier, D.M.3    Majeska, R.J.4    Sun, H.B.5    Schaffler, M.B.6
  • 107
    • 0033915646 scopus 로고    scopus 로고
    • Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading
    • Robling AG, Burr DB, Turner CH. Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading. J Bone Miner Res (2000) 15(8):1596-602. doi:10.1359/jbmr.2000.15.8.1596
    • (2000) J Bone Miner Res , vol.15 , Issue.8 , pp. 1596-1602
    • Robling, A.G.1    Burr, D.B.2    Turner, C.H.3
  • 108
    • 0035745927 scopus 로고    scopus 로고
    • Recovery periods restore mechanosensitivity to dynamically loaded bone
    • Robling AG, Burr DB, Turner CH. Recovery periods restore mechanosensitivity to dynamically loaded bone. J Exp Biol (2001) 204(Pt 19):3389-99.
    • (2001) J Exp Biol , vol.204 , pp. 3389-3399
    • Robling, A.G.1    Burr, D.B.2    Turner, C.H.3
  • 109
    • 34247891505 scopus 로고    scopus 로고
    • Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles
    • Srinivasan S, Ausk BJ, Poliachik SL, Warner SE, Richardson TS, Gross TS. Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles. J Appl Physiol (2007) 102(5):1945-52. doi:10.1152/japplphysiol.00507.2006
    • (2007) J Appl Physiol , vol.102 , Issue.5 , pp. 1945-1952
    • Srinivasan, S.1    Ausk, B.J.2    Poliachik, S.L.3    Warner, S.E.4    Richardson, T.S.5    Gross, T.S.6
  • 110
    • 0347627147 scopus 로고    scopus 로고
    • Enabling bone formation in the aged skeleton via rest-inserted mechanical loading
    • Srinivasan S, Agans SC, King KA, Moy NY, Poliachik SL, Gross TS. Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone (2003) 33(6):946-55. doi:10.1016/j.bone.2003.07.009
    • (2003) Bone , vol.33 , Issue.6 , pp. 946-955
    • Srinivasan, S.1    Agans, S.C.2    King, K.A.3    Moy, N.Y.4    Poliachik, S.L.5    Gross, T.S.6
  • 111
    • 0036708150 scopus 로고    scopus 로고
    • Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    • Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS. Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J Bone Miner Res (2002) 17(9):1613-20. doi:10.1359/jbmr.2002.17.9.1613
    • (2002) J Bone Miner Res , vol.17 , Issue.9 , pp. 1613-1620
    • Srinivasan, S.1    Weimer, D.A.2    Agans, S.C.3    Bain, S.D.4    Gross, T.S.5
  • 112
    • 15544373884 scopus 로고    scopus 로고
    • Mechanosensitivity of the rat skeleton decreases after a long period of loading, but is improved with time off
    • Saxon LK, Robling AG, Alam I, Turner CH. Mechanosensitivity of the rat skeleton decreases after a long period of loading, but is improved with time off. Bone (2005) 36(3):454-64. doi:10.1016/j.bone.2004.12.001
    • (2005) Bone , vol.36 , Issue.3 , pp. 454-464
    • Saxon, L.K.1    Robling, A.G.2    Alam, I.3    Turner, C.H.4
  • 113
    • 84555187783 scopus 로고    scopus 로고
    • In vivo mechanical loading
    • de Souza RL, Saxon L. In vivo mechanical loading. Methods Mol Biol (2012) 816:621-36. doi:10.1007/978-1-61779-415-5_38
    • (2012) Methods Mol Biol , vol.816 , pp. 621-636
    • de Souza, R.L.1    Saxon, L.2
  • 114
  • 115
    • 84865239540 scopus 로고    scopus 로고
    • Differing risk profiles for individual fracture sites: evidence from the global longitudinal study of osteoporosis in women (GLOW)
    • FitzGerald G, Boonen S, Compston JE, Pfeilschifter J, LaCroix AZ, Hosmer DW, et al. Differing risk profiles for individual fracture sites: evidence from the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res (2012) 27(9):1907-15. doi:10.1002/jbmr.1652
    • (2012) J Bone Miner Res , vol.27 , Issue.9 , pp. 1907-1915
    • FitzGerald, G.1    Boonen, S.2    Compston, J.E.3    Pfeilschifter, J.4    LaCroix, A.Z.5    Hosmer, D.W.6
  • 116
    • 0034782841 scopus 로고    scopus 로고
    • Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis
    • Lanyon L, Skerry T. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J Bone Miner Res (2001) 16(11):1937-47. doi:10.1359/jbmr.2001.16.11.1937
    • (2001) J Bone Miner Res , vol.16 , Issue.11 , pp. 1937-1947
    • Lanyon, L.1    Skerry, T.2
  • 117
    • 0027474550 scopus 로고
    • Effect of ovariectomy on bone response to in vivo external loading
    • Hagino H, Raab DM, Kimmel DB, Akhter MP, Recker RR. Effect of ovariectomy on bone response to in vivo external loading. J Bone Miner Res (1993) 8(3):347-57. doi:10.1002/jbmr.5650080312
    • (1993) J Bone Miner Res , vol.8 , Issue.3 , pp. 347-357
    • Hagino, H.1    Raab, D.M.2    Kimmel, D.B.3    Akhter, M.P.4    Recker, R.R.5
  • 118
    • 0029804794 scopus 로고    scopus 로고
    • Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone
    • Jagger CJ, Chow JW, Chambers TJ. Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone. J Clin Invest (1996) 98(10):2351-7. doi:10.1172/JCI119047
    • (1996) J Clin Invest , vol.98 , Issue.10 , pp. 2351-2357
    • Jagger, C.J.1    Chow, J.W.2    Chambers, T.J.3
  • 119
    • 78649814990 scopus 로고    scopus 로고
    • Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice
    • Sugiyama T, Galea GL, Lanyon LE, Price JS. Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice. Endocrinology (2010) 151(12):5582-90. doi:10.1210/en.2010-0645
    • (2010) Endocrinology , vol.151 , Issue.12 , pp. 5582-5590
    • Sugiyama, T.1    Galea, G.L.2    Lanyon, L.E.3    Price, J.S.4
  • 120
    • 0023930991 scopus 로고
    • Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats
    • Turner RT, Wakley GK, Hannon KS, Bell NH. Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats. Endocrinology (1988) 122(3):1146-50. doi:10.1210/endo-122-3-1146
    • (1988) Endocrinology , vol.122 , Issue.3 , pp. 1146-1150
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3    Bell, N.H.4
  • 121
    • 34547623094 scopus 로고    scopus 로고
    • Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading
    • Saxon LK, Turner CH. Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Bone (2006) 39(6):1261-7. doi:10.1016/j.bone.2006.06.030
    • (2006) Bone , vol.39 , Issue.6 , pp. 1261-1267
    • Saxon, L.K.1    Turner, C.H.2
  • 122
    • 77953383151 scopus 로고    scopus 로고
    • Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice
    • Callewaert F, Bakker A, Schrooten J, Van Meerbeek B, Verhoeven G, Boonen S, et al. Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice. J Bone Miner Res (2010) 25(1):124-31. doi:10.1359/jbmr.091001
    • (2010) J Bone Miner Res , vol.25 , Issue.1 , pp. 124-131
    • Callewaert, F.1    Bakker, A.2    Schrooten, J.3    Van Meerbeek, B.4    Verhoeven, G.5    Boonen, S.6
  • 124
    • 34547620497 scopus 로고    scopus 로고
    • The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    • Saxon LK, Robling AG, Castillo AB, Mohan S, Turner CH. The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta. Am J Physiol Endocrinol Metab (2007) 293(2):E484-91. doi:10.1152/ajpendo.00189.2007
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.2 , pp. E484-E491
    • Saxon, L.K.1    Robling, A.G.2    Castillo, A.B.3    Mohan, S.4    Turner, C.H.5
  • 125
    • 18544375627 scopus 로고    scopus 로고
    • Estrogen receptor specificity for the effects of estrogen in ovariectomized mice
    • Lindberg MK, Weihua Z, Andersson N, Movérare S, Gao H, Vidal O, et al. Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol (2002) 174(2):167-78. doi:10.1677/joe.0.1740167
    • (2002) J Endocrinol , vol.174 , Issue.2 , pp. 167-178
    • Lindberg, M.K.1    Weihua, Z.2    Andersson, N.3    Movérare, S.4    Gao, H.5    Vidal, O.6
  • 126
    • 77950567146 scopus 로고    scopus 로고
    • Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling
    • Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J Biol Chem (2010) 285(12):8743-58. doi:10.1074/jbc.M109.027086
    • (2010) J Biol Chem , vol.285 , Issue.12 , pp. 8743-8758
    • Sunters, A.1    Armstrong, V.J.2    Zaman, G.3    Kypta, R.M.4    Kawano, Y.5    Lanyon, L.E.6
  • 127
    • 84903961526 scopus 로고    scopus 로고
    • Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling
    • Galea GL, Price JS, Lanyon LE. Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling. Bonekey Rep (2013) 2:413. doi:10.1038/bonekey.2013.147
    • (2013) Bonekey Rep , vol.2 , pp. 413
    • Galea, G.L.1    Price, J.S.2    Lanyon, L.E.3
  • 129
    • 84873824098 scopus 로고    scopus 로고
    • Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual
    • Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, et al. Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest (2012) 123(1):394-404. doi:10.1172/JCI65910
    • (2012) J Clin Invest , vol.123 , Issue.1 , pp. 394-404
    • Almeida, M.1    Iyer, S.2    Martin-Millan, M.3    Bartell, S.M.4    Han, L.5    Ambrogini, E.6
  • 130
    • 84891126649 scopus 로고    scopus 로고
    • Estrogen receptor a in osteocytes regulates trabecular bone formation in female mice
    • Kondoh S, Inoue K, Igarashi K, Sugizaki H, Shirode-Fukuda Y, Inoue E, et al. Estrogen receptor a in osteocytes regulates trabecular bone formation in female mice. Bone (2014) 60:68-77. doi:10.1016/j.bone.2013.12.005
    • (2014) Bone , vol.60 , pp. 68-77
    • Kondoh, S.1    Inoue, K.2    Igarashi, K.3    Sugizaki, H.4    Shirode-Fukuda, Y.5    Inoue, E.6
  • 131
    • 0036139964 scopus 로고    scopus 로고
    • Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    • Sims NA, Dupont S, Krust A, Clement-Lacroix P, Minet D, Resche-Rigon M, et al. Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone (2002) 30(1):18-25. doi:10.1016/S8756-3282(01)00643-3
    • (2002) Bone , vol.30 , Issue.1 , pp. 18-25
    • Sims, N.A.1    Dupont, S.2    Krust, A.3    Clement-Lacroix, P.4    Minet, D.5    Resche-Rigon, M.6


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