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Volumn 60, Issue , 2014, Pages 68-77

Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice

Author keywords

Bone formation; Estrogen; Estrogen receptor ; Osteocyte; Wnt signaling

Indexed keywords

CATENIN; DENTIN MATRIX PROTEIN 1; ESTROGEN RECEPTOR ALPHA; RNA; STEROID HORMONE; WNT PROTEIN;

EID: 84891126649     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.12.005     Document Type: Article
Times cited : (95)

References (65)
  • 1
    • 39649101096 scopus 로고    scopus 로고
    • Menopause
    • Nelson H.D. Menopause. Lancet 2008, 371:760-770.
    • (2008) Lancet , vol.371 , pp. 760-770
    • Nelson, H.D.1
  • 2
    • 77954608231 scopus 로고    scopus 로고
    • Minireview: osteoprotective action of estrogens is mediated by osteoclastic estrogen receptor-alpha
    • Imai Y., Kondoh S., Kouzmenko A., Kato S. Minireview: osteoprotective action of estrogens is mediated by osteoclastic estrogen receptor-alpha. Mol Endocrinol 2010, 24:877-885.
    • (2010) Mol Endocrinol , vol.24 , pp. 877-885
    • Imai, Y.1    Kondoh, S.2    Kouzmenko, A.3    Kato, S.4
  • 4
    • 48149084609 scopus 로고    scopus 로고
    • Estrogen deficiency, T cells and bone loss
    • Pacifici R. Estrogen deficiency, T cells and bone loss. Cell Immunol 2008, 252:68-80.
    • (2008) Cell Immunol , vol.252 , pp. 68-80
    • Pacifici, R.1
  • 5
    • 0033767836 scopus 로고    scopus 로고
    • Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    • Dupont S., Krust A., Gansmuller A., Dierich A., Chambon P., Mark M. Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 2000, 127:4277-4291.
    • (2000) Development , vol.127 , pp. 4277-4291
    • Dupont, S.1    Krust, A.2    Gansmuller, A.3    Dierich, A.4    Chambon, P.5    Mark, M.6
  • 6
    • 0036632231 scopus 로고    scopus 로고
    • Elucidation of estrogen receptor function in bone with the use of mouse models
    • Windahl S.H., Andersson G., Gustafsson J.A. Elucidation of estrogen receptor function in bone with the use of mouse models. Trends Endocrinol Metab 2002, 13:195-200.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 195-200
    • Windahl, S.H.1    Andersson, G.2    Gustafsson, J.A.3
  • 7
    • 0036139964 scopus 로고    scopus 로고
    • Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    • Sims N.A., Dupont S., Krust A., Clement-Lacroix P., Minet D., Resche-Rigon M., et al. Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone 2002, 30:18-25.
    • (2002) Bone , vol.30 , pp. 18-25
    • Sims, N.A.1    Dupont, S.2    Krust, A.3    Clement-Lacroix, P.4    Minet, D.5    Resche-Rigon, M.6
  • 8
    • 34548274444 scopus 로고    scopus 로고
    • Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
    • Nakamura T., Imai Y., Matsumoto T., Sato S., Takeuchi K., Igarashi K., et al. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 2007, 130:811-823.
    • (2007) Cell , vol.130 , pp. 811-823
    • Nakamura, T.1    Imai, Y.2    Matsumoto, T.3    Sato, S.4    Takeuchi, K.5    Igarashi, K.6
  • 9
    • 75149165271 scopus 로고    scopus 로고
    • The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone
    • Martin-Millan M., Almeida M., Ambrogini E., Han L., Zhao H., Weinstein R.S., et al. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol 2010, 24:323-334.
    • (2010) Mol Endocrinol , vol.24 , pp. 323-334
    • Martin-Millan, M.1    Almeida, M.2    Ambrogini, E.3    Han, L.4    Zhao, H.5    Weinstein, R.S.6
  • 10
    • 0030884639 scopus 로고    scopus 로고
    • The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
    • Tomkinson A., Reeve J., Shaw R.W., Noble B.S. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab 1997, 82:3128-3135.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3128-3135
    • Tomkinson, A.1    Reeve, J.2    Shaw, R.W.3    Noble, B.S.4
  • 11
    • 0042265549 scopus 로고    scopus 로고
    • Endocrinology: bone adaptation requires oestrogen receptor-alpha
    • Lee K., Jessop H., Suswillo R., Zaman G., Lanyon L. Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature 2003, 424:389.
    • (2003) Nature , vol.424 , pp. 389
    • Lee, K.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.5
  • 12
    • 84873459994 scopus 로고    scopus 로고
    • Inactivation of estrogen receptor alpha in bone-forming cells induces bone loss in female mice
    • Maatta J.A., Buki K.G., Gu G., Alanne M.H., Vaaraniemi J., Liljenback H., et al. Inactivation of estrogen receptor alpha in bone-forming cells induces bone loss in female mice. FASEB J 2012, 27:478-488.
    • (2012) FASEB J , vol.27 , pp. 478-488
    • Maatta, J.A.1    Buki, K.G.2    Gu, G.3    Alanne, M.H.4    Vaaraniemi, J.5    Liljenback, H.6
  • 14
    • 84873824098 scopus 로고    scopus 로고
    • Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual
    • Almeida M., Iyer S., Martin-Millan M., Bartell S.M., Han L., Ambrogini E., et al. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest 2013, 123:394-404.
    • (2013) J Clin Invest , vol.123 , pp. 394-404
    • Almeida, M.1    Iyer, S.2    Martin-Millan, M.3    Bartell, S.M.4    Han, L.5    Ambrogini, E.6
  • 15
    • 84892733720 scopus 로고    scopus 로고
    • Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength
    • (in press) (Epub ahead of print)
    • Melville K.M., Kelly N.H., Khan S.A., Schimenti J.C., Ross F.P., Main R.P., et al. Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength. J Bone Miner Res 2013, (in press) (Epub ahead of print).
    • (2013) J Bone Miner Res
    • Melville, K.M.1    Kelly, N.H.2    Khan, S.A.3    Schimenti, J.C.4    Ross, F.P.5    Main, R.P.6
  • 16
    • 0032895922 scopus 로고    scopus 로고
    • Mechanotransduction in bone-role of the lacuno-canalicular network
    • Burger E.H., Klein-Nulend J. Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB J 1999, (13 Suppl.):S101-S112.
    • (1999) FASEB J , Issue.13 SUPPL.
    • Burger, E.H.1    Klein-Nulend, J.2
  • 17
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling A.G., Niziolek P.J., Baldridge L.A., Condon K.W., Allen M.R., Alam I., et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008, 283:5866-5875.
    • (2008) J Biol Chem , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3    Condon, K.W.4    Allen, M.R.5    Alam, I.6
  • 18
    • 0024326174 scopus 로고
    • Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo
    • Skerry T.M., Bitensky L., Chayen J., Lanyon L.E. Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo. J Bone Miner Res 1989, 4:783-788.
    • (1989) J Bone Miner Res , vol.4 , pp. 783-788
    • Skerry, T.M.1    Bitensky, L.2    Chayen, J.3    Lanyon, L.E.4
  • 22
    • 2442675051 scopus 로고    scopus 로고
    • Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone
    • Nampei A., Hashimoto J., Hayashida K., Tsuboi H., Shi K., Tsuji I., et al. Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. J Bone Miner Metab 2004, 22:176-184.
    • (2004) J Bone Miner Metab , vol.22 , pp. 176-184
    • Nampei, A.1    Hashimoto, J.2    Hayashida, K.3    Tsuboi, H.4    Shi, K.5    Tsuji, I.6
  • 24
    • 33750454816 scopus 로고    scopus 로고
    • Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    • Feng J.Q., Ward L.M., Liu S., Lu Y., Xie Y., Yuan B., et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 2006, 38:1310-1315.
    • (2006) Nat Genet , vol.38 , pp. 1310-1315
    • Feng, J.Q.1    Ward, L.M.2    Liu, S.3    Lu, Y.4    Xie, Y.5    Yuan, B.6
  • 25
    • 37249057821 scopus 로고    scopus 로고
    • Osteocytes as dynamic multifunctional cells
    • Bonewald L.F. Osteocytes as dynamic multifunctional cells. Ann N Y Acad Sci 2007, 1116:281-290.
    • (2007) Ann N Y Acad Sci , vol.1116 , pp. 281-290
    • Bonewald, L.F.1
  • 27
    • 84865614567 scopus 로고    scopus 로고
    • Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight
    • Lloyd S.A., Bandstra E.R., Willey J.S., Riffle S.E., Tirado-Lee L., Nelson G.A., et al. Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight. Bone 2012, 51:756-764.
    • (2012) Bone , vol.51 , pp. 756-764
    • Lloyd, S.A.1    Bandstra, E.R.2    Willey, J.S.3    Riffle, S.E.4    Tirado-Lee, L.5    Nelson, G.A.6
  • 28
    • 0036756329 scopus 로고    scopus 로고
    • Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading
    • Lee K.C., Maxwell A., Lanyon L.E. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone 2002, 31:407-412.
    • (2002) Bone , vol.31 , pp. 407-412
    • Lee, K.C.1    Maxwell, A.2    Lanyon, L.E.3
  • 29
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald L.F., Johnson M.L. Osteocytes, mechanosensing and Wnt signaling. Bone 2008, 42:606-615.
    • (2008) Bone , vol.42 , pp. 606-615
    • Bonewald, L.F.1    Johnson, M.L.2
  • 30
    • 33846026749 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
    • Robinson J.A., Chatterjee-Kishore M., Yaworsky P.J., Cullen D.M., Zhao W., Li C., et al. Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 2006, 281:31720-31728.
    • (2006) J Biol Chem , vol.281 , pp. 31720-31728
    • Robinson, J.A.1    Chatterjee-Kishore, M.2    Yaworsky, P.J.3    Cullen, D.M.4    Zhao, W.5    Li, C.6
  • 31
    • 84894467000 scopus 로고    scopus 로고
    • Deletion of a single beta-catenin allele in osteocytes abolishes the bone anabolic response to loading
    • (in press) (Epub ahead of print)
    • Javaheri B., Stern A., Lara N., Dallas M., Zhao H., Liu Y., et al. Deletion of a single beta-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res 2013, (in press) (Epub ahead of print).
    • (2013) J Bone Miner Res
    • Javaheri, B.1    Stern, A.2    Lara, N.3    Dallas, M.4    Zhao, H.5    Liu, Y.6
  • 32
    • 34547111836 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
    • Armstrong V.J., Muzylak M., Sunters A., Zaman G., Saxon L.K., Price J.S., et al. Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem 2007, 282:20715-20727.
    • (2007) J Biol Chem , vol.282 , pp. 20715-20727
    • Armstrong, V.J.1    Muzylak, M.2    Sunters, A.3    Zaman, G.4    Saxon, L.K.5    Price, J.S.6
  • 34
    • 2942750269 scopus 로고    scopus 로고
    • Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
    • Kalajzic I., Braut A., Guo D., Jiang X., Kronenberg M.S., Mina M., et al. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone 2004, 35:74-82.
    • (2004) Bone , vol.35 , pp. 74-82
    • Kalajzic, I.1    Braut, A.2    Guo, D.3    Jiang, X.4    Kronenberg, M.S.5    Mina, M.6
  • 37
    • 0023488581 scopus 로고
    • Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
    • (1987) J Bone Miner Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6
  • 38
    • 68849117424 scopus 로고    scopus 로고
    • Identification of differentially expressed genes between osteoblasts and osteocytes
    • Paic F., Igwe J.C., Nori R., Kronenberg M.S., Franceschetti T., Harrington P., et al. Identification of differentially expressed genes between osteoblasts and osteocytes. Bone 2009, 45:682-692.
    • (2009) Bone , vol.45 , pp. 682-692
    • Paic, F.1    Igwe, J.C.2    Nori, R.3    Kronenberg, M.S.4    Franceschetti, T.5    Harrington, P.6
  • 39
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4:44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 40
    • 0031003277 scopus 로고    scopus 로고
    • Beta-MHC transgene expression in suspended and mechanically overloaded/suspended soleus muscle of transgenic mice
    • McCarthy J.J., Fox A.M., Tsika G.L., Gao L., Tsika R.W. Beta-MHC transgene expression in suspended and mechanically overloaded/suspended soleus muscle of transgenic mice. Am J Physiol 1997, 272:R1552-R1561.
    • (1997) Am J Physiol , vol.272
    • McCarthy, J.J.1    Fox, A.M.2    Tsika, G.L.3    Gao, L.4    Tsika, R.W.5
  • 41
    • 10044271053 scopus 로고    scopus 로고
    • Sp3 proteins negatively regulate beta myosin heavy chain gene expression during skeletal muscle inactivity
    • Tsika G., Ji J., Tsika R. Sp3 proteins negatively regulate beta myosin heavy chain gene expression during skeletal muscle inactivity. Mol Cell Biol 2004, 24:10777-10791.
    • (2004) Mol Cell Biol , vol.24 , pp. 10777-10791
    • Tsika, G.1    Ji, J.2    Tsika, R.3
  • 45
    • 77956564468 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
    • Ahn Y., Sanderson B.W., Klein O.D., Krumlauf R. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 2010, 137:3221-3231.
    • (2010) Development , vol.137 , pp. 3221-3231
    • Ahn, Y.1    Sanderson, B.W.2    Klein, O.D.3    Krumlauf, R.4
  • 46
    • 83155189105 scopus 로고    scopus 로고
    • Contribution of the sclerostin domain-containing protein 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men
    • He J.W., Yue H., Hu W.W., Hu Y.Q., Zhang Z.L. Contribution of the sclerostin domain-containing protein 1 (SOSTDC1) gene to normal variation of peak bone mineral density in Chinese women and men. J Bone Miner Metab 2011, 29:571-581.
    • (2011) J Bone Miner Metab , vol.29 , pp. 571-581
    • He, J.W.1    Yue, H.2    Hu, W.W.3    Hu, Y.Q.4    Zhang, Z.L.5
  • 47
    • 43249084231 scopus 로고    scopus 로고
    • The effect of ovariectomy combined with hindlimb unloading and reloading on the long bones of mature Sprague-Dawley rats
    • Tou J.C., Foley A., Yuan Y.V., Arnaud S., Wade C.E., Brown M. The effect of ovariectomy combined with hindlimb unloading and reloading on the long bones of mature Sprague-Dawley rats. Menopause 2008, 15:494-502.
    • (2008) Menopause , vol.15 , pp. 494-502
    • Tou, J.C.1    Foley, A.2    Yuan, Y.V.3    Arnaud, S.4    Wade, C.E.5    Brown, M.6
  • 48
    • 77953392432 scopus 로고    scopus 로고
    • Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
    • Almeida M., Martin-Millan M., Ambrogini E., Bradsher R., Han L., Chen X.D., et al. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res 2010, 25:769-781.
    • (2010) J Bone Miner Res , vol.25 , pp. 769-781
    • Almeida, M.1    Martin-Millan, M.2    Ambrogini, E.3    Bradsher, R.4    Han, L.5    Chen, X.D.6
  • 50
    • 38949160556 scopus 로고    scopus 로고
    • Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    • Krum S.A., Miranda-Carboni G.A., Hauschka P.V., Carroll J.S., Lane T.F., Freedman L.P., et al. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J 2008, 27:535-545.
    • (2008) EMBO J , vol.27 , pp. 535-545
    • Krum, S.A.1    Miranda-Carboni, G.A.2    Hauschka, P.V.3    Carroll, J.S.4    Lane, T.F.5    Freedman, L.P.6
  • 52
    • 84869397973 scopus 로고    scopus 로고
    • Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes
    • Sinnesael M., Claessens F., Laurent M., Dubois V., Boonen S., Deboel L., et al. Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes. J Bone Miner Res 2012, 27:2535-2543.
    • (2012) J Bone Miner Res , vol.27 , pp. 2535-2543
    • Sinnesael, M.1    Claessens, F.2    Laurent, M.3    Dubois, V.4    Boonen, S.5    Deboel, L.6
  • 54
    • 79955411359 scopus 로고    scopus 로고
    • Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth
    • Cho S.W., Kwak S., Woolley T.E., Lee M.J., Kim E.J., Baker R.E., et al. Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development 2011, 138:1807-1816.
    • (2011) Development , vol.138 , pp. 1807-1816
    • Cho, S.W.1    Kwak, S.2    Woolley, T.E.3    Lee, M.J.4    Kim, E.J.5    Baker, R.E.6
  • 56
    • 65249133047 scopus 로고    scopus 로고
    • Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells
    • Liu G., Vijayakumar S., Grumolato L., Arroyave R., Qiao H., Akiri G., et al. Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J Cell Biol 2009, 185:67-75.
    • (2009) J Cell Biol , vol.185 , pp. 67-75
    • Liu, G.1    Vijayakumar, S.2    Grumolato, L.3    Arroyave, R.4    Qiao, H.5    Akiri, G.6
  • 57
    • 73349110430 scopus 로고    scopus 로고
    • Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis
    • Takada I., Kouzmenko A.P., Kato S. Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol 2009, 5:442-447.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 442-447
    • Takada, I.1    Kouzmenko, A.P.2    Kato, S.3
  • 58
    • 77958096064 scopus 로고    scopus 로고
    • The regulation of differentiation in mesenchymal stem cells
    • Augello A., De Bari C. The regulation of differentiation in mesenchymal stem cells. Hum Gene Ther 2010, 21:1226-1238.
    • (2010) Hum Gene Ther , vol.21 , pp. 1226-1238
    • Augello, A.1    De Bari, C.2
  • 59
    • 84873558051 scopus 로고    scopus 로고
    • WNT signaling in bone homeostasis and disease: from human mutations to treatments
    • Baron R., Kneissel M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 2013, 19:179-192.
    • (2013) Nat Med , vol.19 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 60
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf J.J., Kahler R.A., Schroeder T.M. Wnt signaling in osteoblasts and bone diseases. Gene 2004, 341:19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 62
    • 1542344018 scopus 로고    scopus 로고
    • Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta
    • Tee M.K., Rogatsky I., Tzagarakis-Foster C., Cvoro A., An J., Christy R.J., et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell 2004, 15:1262-1272.
    • (2004) Mol Biol Cell , vol.15 , pp. 1262-1272
    • Tee, M.K.1    Rogatsky, I.2    Tzagarakis-Foster, C.3    Cvoro, A.4    An, J.5    Christy, R.J.6
  • 63
    • 6544233884 scopus 로고    scopus 로고
    • Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour
    • Nakamura E., Kadomatsu K., Yuasa S., Muramatsu H., Mamiya T., Nabeshima T., et al. Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells 1998, 3:811-822.
    • (1998) Genes Cells , vol.3 , pp. 811-822
    • Nakamura, E.1    Kadomatsu, K.2    Yuasa, S.3    Muramatsu, H.4    Mamiya, T.5    Nabeshima, T.6
  • 64
    • 79952695464 scopus 로고    scopus 로고
    • Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading
    • Liedert A., Mattausch L., Rontgen V., Blakytny R., Vogele D., Pahl M., et al. Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading. Bone 2011, 48:945-951.
    • (2011) Bone , vol.48 , pp. 945-951
    • Liedert, A.1    Mattausch, L.2    Rontgen, V.3    Blakytny, R.4    Vogele, D.5    Pahl, M.6
  • 65
    • 79953871100 scopus 로고    scopus 로고
    • Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor
    • Surjit M., Ganti K.P., Mukherji A., Ye T., Hua G., Metzger D., et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 2011, 145:224-241.
    • (2011) Cell , vol.145 , pp. 224-241
    • Surjit, M.1    Ganti, K.P.2    Mukherji, A.3    Ye, T.4    Hua, G.5    Metzger, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.