Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

Bone

Volumn 49, Issue 2, 2011, Pages 184-193

  Saxon, Leanne K ^a   Jackson, Brendan F ^a   Sugiyama, Toshihiro ^a,b   Lanyon, Lance E ^a,b   Price, Joanna S ^a,b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Bone; Disuse; Lrp5; Mechanical loading; MicroCT

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MASS; BONE STRESS; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; FEMALE; GENE FUNCTION; GENOTYPE; HETEROZYGOSITY; LOAD CARRYING CAPACITY; LOSS OF FUNCTION MUTATION; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MUTATIONAL ANALYSIS; NEURECTOMY; NONHUMAN; OSTEOLYSIS; SCIATIC NERVE; SEX DIFFERENCE; TIBIA; TRABECULAR BONE; WILD TYPE;

ANIMALS; BONE AND BONES; FEMALE; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MALE; MICE; MICE, KNOCKOUT; MUTATION; STRESS, MECHANICAL; TIBIA;

EID: 79958772955     PISSN: 87563282     EISSN: 87563282     Source Type: Journal    
DOI: 10.1016/j.bone.2011.03.683     Document Type: Article

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