Roles of transactivating functions 1 and 2 of estrogen receptor-α In bone

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 15, 2011, Pages 6288-6293

  Borjesson A E ^a   Windahl, S H ^a   Lagerquist, M K ^a   Engdahl, C ^a   Frenkel, B ^b   Moverare Skrtic S ^a   Sjogrena K ^a   Kindblom, J M ^a   Stubelius, A ^a   Islander, U ^a   Antal, M C ^c   Krust, A ^c   Chambon, P ^c   Ohlsson, C ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE; CONFERENCE PAPER; CONTROLLED STUDY; CORTICAL BONE; IN VIVO STUDY; LIVER WEIGHT; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; THYMUS; TRABECULAR BONE; TRANSACTIVATION; UTERUS WEIGHT;

MUS;

EID: 79955009428     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100454108     Document Type: Article

References (44)

1. Khosla S, Melton LJ, 3rd, Riggs BL (2011) The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed? J Bone Miner Res 26: 441-451.
2. LeBlanc ES, et al.; Osteoporotic Fractures in Men Study Group (2009) The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab 94:3337-3346.
3. Mellström D, et al. (2008) Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res 23:1552-1560.
4. Smith EP, et al. (1994) Estrogen resistance caused by a mutation in the estrogenreceptor gene in a man. N Engl J Med 331:1056-1061. (Pubitemid 24317698)
5. Vandenput L, Ohlsson C (2009) Estrogens as regulators of bone health in men. Nat Rev Endocrinol 5:437-443.
6. Daly E, et al. (1996) Risk of venous thromboembolism in users of hormone replacement therapy. Lancet 348:977-980. (Pubitemid 26340751)
7. Anonymous; Collaborative Group on Hormonal Factors in Breast Cancer (1997) Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350:1047-1059.
8. Mödder UI, et al. (2008) The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice. Bone 42:414-421.
9. Movérare S, et al. (2003) Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice. Proc Natl Acad Sci USA 100:13573-13578. (Pubitemid 37448563)
10. Sims NA, et al. (2003) A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. J Clin Invest 111:1319-1327. (Pubitemid 36554702)
11. Sims NA, et al. (2002) Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone 30: 18-25. (Pubitemid 34044296)
12. Windahl SH, et al. (2001) Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss. J Bone Miner Res 16:1388-1398. (Pubitemid 32677073)
13. Windahl SH, Vidal O, Andersson G, Gustafsson JA, Ohlsson C (1999) Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. J Clin Invest 104:895-901. (Pubitemid 29536339)
14. Windahl SH, et al. (2009) The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. Am J Physiol Endocrinol Metab 296: E490-E496.
15. Shang Y, Brown M (2002) Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468. (Pubitemid 34270263)
16. Berry M, Metzger D, Chambon P (1990) Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J 9:2811-2818.
17. Metzger D, Losson R, Bornert JM, Lemoine Y, Chambon P (1992) Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast. Nucleic Acids Res 20:2813-2817.
18. Tora L, et al. (1989) The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell 59:477-487. (Pubitemid 19284461)
19. McKenna NJ, Lanz RB, O'Malley BW (1999) Nuclear receptor coregulators: Cellular and molecular biology. Endocr Rev 20:321-344. (Pubitemid 30649811)
20. Kumar R, Thompson EB (1999) The structure of the nuclear hormone receptors. Steroids 64:310-319. (Pubitemid 29284331)
21. Norris JD, Fan D, Kerner SA, McDonnell DP (1997) Identification of a third autonomous activation domain within the human estrogen receptor. Mol Endocrinol 11:747-754. (Pubitemid 27225302)
22. Metzger D, Ali S, Bornert JM, Chambon P (1995) Characterization of the aminoterminal transcriptional activation function of the human estrogen receptor in animal and yeast cells. J Biol Chem 270:9535-9542.
23. Billon-Galés A, et al. (2009) The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci USA 106:2053-2058.
24. Lindberg MK, et al. (2002) Identification of estrogen-regulated genes of potential importance for the regulation of trabecular bone mineral density. J Bone Miner Res 17:2183-2195. (Pubitemid 35422683)
25. Hofbauer LC, et al. (1999) Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 140: 4367-4370. (Pubitemid 30647136)
26. Bord S, Ireland DC, Beavan SR, Compston JE (2003) The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts. Bone 32:136-141. (Pubitemid 36299141)
27. Couse JF, Yates MM, Walker VR, Korach KS (2003) Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Mol Endocrinol 17:1039-1053. (Pubitemid 36683712)
28. Lindberg MK, et al. (2002) Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol 174:167-178. (Pubitemid 34965757)
29. Manolagas SC (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31:266-300.
30. Métivier R, Penot G, Flouriot G, Pakdel F (2001) Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: Requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains. Mol Endocrinol 15:1953-1970. (Pubitemid 33026110)
31. Mödder UI, et al. (2004) Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Endocrinology 145:913-921. (Pubitemid 38183835)
32. Nakamura T, et al. (2007) Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 130:811-823. (Pubitemid 47332572)
33. Martin-MillanM, et al. (2010) The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol 24: 323-334.
34. Almeida M, et al. (2010) ER? deletion in mesenchymal progenitors or mature osteoblasts decreases cortical bone thickness and increases apoptosis, respectively. J Bone Miner Res 25(suppl 1):1113.
35. Métivier R, et al. (2002) A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol Cell 10:1019-1032. (Pubitemid 35453823)
36. Dupont S, et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127:4277-4291.
37. Börjesson AE, et al. (2010) The role of estrogen receptor ? in growth plate cartilage for longitudinal bone growth. J Bone Miner Res 25:2414-2424.
38. Vidal O, et al. (2000) Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci USA 97:5474-5479. (Pubitemid 30313743)
39. Hildebrand T, Rüegsegger P (1997) Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin 1:15-23.
40. Waarsing JH, Day JS, Weinans H (2004) An improved segmentation method for in vivo microCT imaging. J Bone Miner Res 19:1640-1650. (Pubitemid 41094327)
41. Baron RVA, Neff L, Silverglate A, Maira AS (1983) Processing of undecalcified bone specimens for bone histomorphometry. Bone Histomorphometry: Techniques and Interpretation, ed Recker RR (CRC Press, Boca Raton, FL), pp 18-29.
42. Eriksen EFAD, Melsen F (1994) Bone Histomorphometry (Raven Press, New York).
43. Parfitt AM, et al.; Report of the ASBMR Histomorphometry Nomenclature Committee (1987) Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610.
44. Czerkinsky CC, et al. (1984) An immunoenzyme procedure for enumerating fibronectin-secreting cells. J Immunoassay 5:291-302. (Pubitemid 15125838)