The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading

Bone

Volumn 44, Issue 5, 2009, Pages 930-935

  Moustafa, Alaa ^a   Sugiyama, Toshihiro ^a   Saxon, Leanne K ^a   Zaman, Gul ^a   Sunters, Andrew ^a   Armstrong, Victoria J ^a   Javaheri, Behzad ^a   Lanyon, Lance E ^a   Price, Joanna S ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Fibula; Functional adaptation; Mechanical loading; Parathyroid hormone; Sclerostin

Indexed keywords

PARATHYROID HORMONE[1-34]; SCLEROSTIN;

ADAPTATION; ANIMAL EXPERIMENT; ANKLE; ARTICLE; BIOMECHANICS; BONE STRENGTH; CONTROLLED STUDY; DRUG INTERMITTENT THERAPY; FIBULA; KNEE; LOADING TEST; MOUSE; NONHUMAN; OSTEOCYTE; PROTEIN LOCALIZATION; TIBIA;

ANIMALS; BIOMECHANICS; BONE AND BONES; BONE MORPHOGENETIC PROTEINS; FEMALE; FIBULA; GENETIC MARKERS; MICE; OSTEOCYTES; PARATHYROID HORMONE; TIBIA; TOMOGRAPHY, X-RAY COMPUTED;

EID: 63449096161     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.12.026     Document Type: Article

References (30)

1. Ehrlich P.J., and Lanyon L.E. Mechanical strain and bone cell function: a review. Osteoporos. Int. 13 (2002) 688-700
2. O'Connor J.A., Lanyon L.E., and MacFie H. The influence of strain rate on adaptive bone remodelling. J. Biomech. 15 (1982) 767-781
3. Lanyon L.E., and Rubin C.T. Static vs dynamic loads as an influence on bone remodelling. J. Biomech. 17 (1984) 897-905
4. Pead M.J., Suswillo R., Skerry T.M., Vedi S., and Lanyon L.E. Increased 3H-uridine levels in osteocytes following a single short period of dynamic bone loading in vivo. Calcif. Tissue Int. 43 (1988) 92-96
5. Turner C.H., Akhter M.P., Raab D.M., Kimmel D.B., and Recker R.R. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone 12 (1991) 73-79
6. Chow J.W., Jagger C.J., and Chambers T.J. Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. Am. J. Physiol. 265 (1993) E340-347
7. Torrance A.G., Mosley J.R., Suswillo R.F., and Lanyon L.E. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure. Calcif. Tissue Int. 54 (1994) 241-247
8. Akhter M.P., Cullen D.M., Pedersen E.A., Kimmel D.B., and Recker R.R. Bone response to in vivo mechanical loading in two breeds of mice. Calcif. Tissue Int. 63 (1998) 442-449
9. Lee K.C., Maxwell A., and Lanyon L.E. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone 31 (2002) 407-412
10. Gross T.S., Srinivasan S., Liu C.C., Clemens T.L., and Bain S.D. Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. J. Bone Miner. Res. 17 (2002) 493-501
11. De Souza R.L., Matsuura M., Eckstein F., Rawlinson S.C., Lanyon L.E., and Pitsillides A.A. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 37 (2005) 810-818
12. Fritton J.C., Myers E.R., Wright T.M., and van der Meulen M.C. Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia. Bone 36 (2005) 1030-1038
13. Lee K., Jessop H., Suswillo R., Zaman G., and Lanyon L. Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature 424 (2003) 389
14. Lee K.C., Jessop H., Suswillo R., Zaman G., and Lanyon L.E. The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta. J. Endocrinol. 182 (2004) 193-201
15. Sawakami K., Robling A.G., Ai M., Pitner N.D., Liu D., Warden S.J., et al. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J. Biol. Chem. 281 (2006) 23698-23711
16. Robling A.G., Niziolek P.J., Baldridge L.A., Condon K.W., Allen M.R., Alam I., et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J. Biol. Chem. 283 (2008) 5866-5875
17. Sugiyama T., Saxon L.K., Zaman G., Moustafa A., Sunters A., Price J.S., et al. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice. Bone 43 (2008) 238-248
18. de Souza R.L., Pitsillides A.A., Lanyon L.E., Skerry T.M., and Chenu C. Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J. Bone Miner. Res. 20 (2005) 2159-2168
19. Armstrong V.J., Muzylak M., Sunters A., Zaman G., Saxon L.K., Price J.S., et al. Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J. Biol. Chem. 282 (2007) 20715-20727
20. Marenzana M., De Souza R.L., and Chenu C. Blockade of beta-adrenergic signaling does not influence the bone mechano-adaptive response in mice. Bone 41 (2007) 206-215
21. Fritton J.C., Myers E.R., Wright T.M., and van der Meulen M.C. Bone mass is preserved and cancellous architecture altered due to cyclic loading of the mouse tibia after orchidectomy. J. Bone Miner. Res. 23 (2008) 663-671
22. Saxon L.K., and Lanyon L.E. Assessment of the in vivo adaptive response to mechanical loading. Methods Mol. Biol. 455 (2008) 307-322
23. Baron R., Vignery A., Neff L., Silverglate A., and Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. In: Recker R.R. (Ed). Bone histomorphometry: techniques and interpretation (1983), CRC Press, Boca Raton 13-34
24. Zaman G., Jessop H.L., Muzylak M., De Souza R.L., Pitsillides A.A., Price J.S., et al. Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen. J. Bone Miner. Res. 21 (2006) 1297-1306
25. Keller H., and Kneissel M. SOST is a target gene for PTH in bone. Bone 37 (2005) 148-158
26. Vatsa A., Breuls R.G., Semeins C.M., Salmon P.L., Smit T.H., and Klein-Nulend J. Osteocyte morphology in fibula and calvaria - is there a role for mechanosensing?. Bone 43 (2008) 452-458
27. Robinson J.A., Chatterjee-Kishore M., Yaworsky P.J., Cullen D.M., Zhao W., Li C., et al. Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J. Biol. Chem. 281 (2006) 31720-31728
28. Srinivasan S., Weimer D.A., Agans S.C., Bain S.D., and Gross T.S. Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J. Bone Miner. Res. 17 (2002) 1613-1620
29. Hankenson K.D., Ausk B.J., Bain S.D., Bornstein P., Gross T.S., and Srinivasan S. Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading. Bone 38 (2006) 310-316
30. Sample S.J., Behan M., Smith L., Oldenhoff W.E., Markel M.D., Kalscheur V.L., et al. Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. J. Bone Miner. Res. 23 (2008) 1372-1381