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Volumn 51, Issue 4, 2012, Pages 756-764

Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: A model of long-duration spaceflight

Author keywords

Bone; Hindlimb suspension; Radiation; Spaceflight; Unloading

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MASS; BONE STRENGTH; BONE STRUCTURE; CONTROLLED STUDY; CORTICAL BONE; FEMALE; HISTOPATHOLOGY; IMMOBILIZATION; MOUSE; NONHUMAN; PROTON RADIATION; RADIATION RESPONSE; SPACE FLIGHT; TRABECULAR BONE;

EID: 84865614567     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.07.001     Document Type: Article
Times cited : (55)

References (40)
  • 1
    • 12344309568 scopus 로고    scopus 로고
    • Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight
    • Lang T., LeBlanc A., Evans H., Lu Y., Genant H., Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 2004, 19:1006-1012.
    • (2004) J Bone Miner Res , vol.19 , pp. 1006-1012
    • Lang, T.1    LeBlanc, A.2    Evans, H.3    Lu, Y.4    Genant, H.5    Yu, A.6
  • 2
    • 0036092597 scopus 로고    scopus 로고
    • Hindlimb unloading rodent model: technical aspects
    • Morey-Holton E.R., Globus R.K. Hindlimb unloading rodent model: technical aspects. J Appl Physiol 2002, 92:1367-1377.
    • (2002) J Appl Physiol , vol.92 , pp. 1367-1377
    • Morey-Holton, E.R.1    Globus, R.K.2
  • 4
    • 13844309259 scopus 로고    scopus 로고
    • Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading
    • Squire M., Donahue L.R., Rubin C., Judex S. Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading. Bone 2004, 35:1353-1360.
    • (2004) Bone , vol.35 , pp. 1353-1360
    • Squire, M.1    Donahue, L.R.2    Rubin, C.3    Judex, S.4
  • 5
    • 57249115116 scopus 로고    scopus 로고
    • Characteristic of the radiation field in low Earth orbit and in deep space
    • Reitz G. Characteristic of the radiation field in low Earth orbit and in deep space. Z Med Phys 2008, 18:233-243.
    • (2008) Z Med Phys , vol.18 , pp. 233-243
    • Reitz, G.1
  • 7
    • 0035437824 scopus 로고    scopus 로고
    • Space radiation dosimetry in low-Earth orbit and beyond
    • Benton E.R., Benton E.V. Space radiation dosimetry in low-Earth orbit and beyond. Nucl Instrum Methods Phys Res B 2001, 184:255-294.
    • (2001) Nucl Instrum Methods Phys Res B , vol.184 , pp. 255-294
    • Benton, E.R.1    Benton, E.V.2
  • 8
    • 0033792103 scopus 로고    scopus 로고
    • Biological effects of cosmic radiation: deterministic and stochastic
    • Blakely E.A. Biological effects of cosmic radiation: deterministic and stochastic. Health Phys 2000, 79:495-506.
    • (2000) Health Phys , vol.79 , pp. 495-506
    • Blakely, E.A.1
  • 9
    • 30844447654 scopus 로고    scopus 로고
    • Implications of the space radiation environment for human exploration in deep space
    • Townsend L.W. Implications of the space radiation environment for human exploration in deep space. Radiat Prot Dosimetry 2005, 115:44-50.
    • (2005) Radiat Prot Dosimetry , vol.115 , pp. 44-50
    • Townsend, L.W.1
  • 11
    • 16344396125 scopus 로고    scopus 로고
    • Interplanetary crew dose estimates for worst case solar particle events based on historical data for the Carrington flare of 1859
    • Stephens D.L., Townsend L.W., Hoff J.L. Interplanetary crew dose estimates for worst case solar particle events based on historical data for the Carrington flare of 1859. Acta Astronaut 2005, 56:969-974.
    • (2005) Acta Astronaut , vol.56 , pp. 969-974
    • Stephens, D.L.1    Townsend, L.W.2    Hoff, J.L.3
  • 12
    • 35348876350 scopus 로고    scopus 로고
    • Time, dose, and fractionation in radiotherapy
    • Lippincott, Williams & Wilkins, Philadelphia, USA, K. Barrett (Ed.)
    • Hall E.J., Giaccia A.J. Time, dose, and fractionation in radiotherapy. Radiobiology for the radiologist 2006, 378-406. Lippincott, Williams & Wilkins, Philadelphia, USA. 6th edition. K. Barrett (Ed.).
    • (2006) Radiobiology for the radiologist , pp. 378-406
    • Hall, E.J.1    Giaccia, A.J.2
  • 14
    • 0034077889 scopus 로고    scopus 로고
    • Interplanetary crew dose rates for the August 1972 solar particle event
    • Parsons J.L., Townsend L.W. Interplanetary crew dose rates for the August 1972 solar particle event. Radiat Res 2000, 153:729-733.
    • (2000) Radiat Res , vol.153 , pp. 729-733
    • Parsons, J.L.1    Townsend, L.W.2
  • 15
    • 84865615765 scopus 로고    scopus 로고
    • Washington, D.C., NASA
    • NASA 2011 strategic plan 2011, 10. Washington, D.C.
    • (2011) 2011 strategic plan , pp. 10
  • 16
    • 0142120394 scopus 로고    scopus 로고
    • Radiation dosimetry and biophysical models of space radiation effects
    • Cucinotta F.A., Wu H., Shavers M.R., George K. Radiation dosimetry and biophysical models of space radiation effects. Gravit Space Biol Bull 2003, 16:11-18.
    • (2003) Gravit Space Biol Bull , vol.16 , pp. 11-18
    • Cucinotta, F.A.1    Wu, H.2    Shavers, M.R.3    George, K.4
  • 17
    • 20044385122 scopus 로고    scopus 로고
    • The biological effects of space radiation during long stays in space
    • Ohnishi K., Ohnishi T. The biological effects of space radiation during long stays in space. Biol Sci Space 2004, 18:201-205.
    • (2004) Biol Sci Space , vol.18 , pp. 201-205
    • Ohnishi, K.1    Ohnishi, T.2
  • 18
    • 84865655442 scopus 로고    scopus 로고
    • Acute radiation risk and countermeasures for space radiation
    • National Space Biomedical Research Institute, M.E. Vazquez (Ed.)
    • Cucinotta F.A. Acute radiation risk and countermeasures for space radiation. NSBRI Medical Radiation Countermeasures Workshop 2006, National Space Biomedical Research Institute. M.E. Vazquez (Ed.).
    • (2006) NSBRI Medical Radiation Countermeasures Workshop
    • Cucinotta, F.A.1
  • 20
    • 72049103945 scopus 로고    scopus 로고
    • Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations
    • Willey J.S., Livingston E.W., Robbins M.E., Bourland J.D., Tirado-Lee L., Smith-Sielicki H., et al. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone 2010, 46:101-111.
    • (2010) Bone , vol.46 , pp. 101-111
    • Willey, J.S.1    Livingston, E.W.2    Robbins, M.E.3    Bourland, J.D.4    Tirado-Lee, L.5    Smith-Sielicki, H.6
  • 21
    • 77950229377 scopus 로고    scopus 로고
    • Short-term effects of whole-body exposure to (56)Fe ions in combination with musculoskeletal disuse on bone cells
    • Yumoto K., Globus R.K., Mojarrab R., Arakaki J., Wang A., Searby N.D., et al. Short-term effects of whole-body exposure to (56)Fe ions in combination with musculoskeletal disuse on bone cells. Radiat Res 2010, 173:494-504.
    • (2010) Radiat Res , vol.173 , pp. 494-504
    • Yumoto, K.1    Globus, R.K.2    Mojarrab, R.3    Arakaki, J.4    Wang, A.5    Searby, N.D.6
  • 22
    • 77955981611 scopus 로고    scopus 로고
    • Heavy ion irradiation and unloading effects on mouse lumbar vertebral microarchitecture, mechanical properties and tissue stresses
    • Alwood J.S., Yumoto K., Mojarrab R., Limoli C.L., Almeida E.A., Searby N.D., et al. Heavy ion irradiation and unloading effects on mouse lumbar vertebral microarchitecture, mechanical properties and tissue stresses. Bone 2010, 47:248-255.
    • (2010) Bone , vol.47 , pp. 248-255
    • Alwood, J.S.1    Yumoto, K.2    Mojarrab, R.3    Limoli, C.L.4    Almeida, E.A.5    Searby, N.D.6
  • 23
    • 48249092473 scopus 로고    scopus 로고
    • Spaceflight-relevant types of ionizing radiation and cortical bone: potential LET effect?
    • Lloyd S.A., Bandstra E.R., Travis N.D., Nelson G.A., Bourland J.D., Pecaut M.J., et al. Spaceflight-relevant types of ionizing radiation and cortical bone: potential LET effect?. Adv Space Res 2008, 42:1889-1897.
    • (2008) Adv Space Res , vol.42 , pp. 1889-1897
    • Lloyd, S.A.1    Bandstra, E.R.2    Travis, N.D.3    Nelson, G.A.4    Bourland, J.D.5    Pecaut, M.J.6
  • 24
    • 0035189611 scopus 로고    scopus 로고
    • Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: part I
    • Gridley D.S., Pecaut M.J., Dutta-Roy R., Nelson G.A. Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: part I. Immunol Lett 2002, 80:55-66.
    • (2002) Immunol Lett , vol.80 , pp. 55-66
    • Gridley, D.S.1    Pecaut, M.J.2    Dutta-Roy, R.3    Nelson, G.A.4
  • 25
    • 0034924731 scopus 로고    scopus 로고
    • Dose and dose rate effects of whole-body gamma-irradiation: II. Hematological variables and cytokines
    • Gridley D.S., Pecaut M.J., Miller G.M., Moyers M.F., Nelson G.A. Dose and dose rate effects of whole-body gamma-irradiation: II. Hematological variables and cytokines. In Vivo 2001, 15:209-216.
    • (2001) In Vivo , vol.15 , pp. 209-216
    • Gridley, D.S.1    Pecaut, M.J.2    Miller, G.M.3    Moyers, M.F.4    Nelson, G.A.5
  • 26
    • 84865635044 scopus 로고    scopus 로고
    • International Commission on Radiation Units and Measurements, Bethesda, MD, International Commission on Radiation Units and Measurements
    • International Commission on Radiation Units and Measurements Clinical proton dosimetry 1998, International Commission on Radiation Units and Measurements, Bethesda, MD.
    • (1998) Clinical proton dosimetry
  • 27
    • 0027703826 scopus 로고
    • Effects of rehydration state on the flexural properties of whole mouse long bones
    • Broz J.J., Simske S.J., Greenberg A.R., Luttges M.W. Effects of rehydration state on the flexural properties of whole mouse long bones. J Biomech Eng 1993, 115:447-449.
    • (1993) J Biomech Eng , vol.115 , pp. 447-449
    • Broz, J.J.1    Simske, S.J.2    Greenberg, A.R.3    Luttges, M.W.4
  • 28
    • 0023488581 scopus 로고
    • Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
    • (1987) J Bone Miner Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6
  • 29
    • 36148938367 scopus 로고    scopus 로고
    • Recovery of spaceflight-induced bone loss: bone mineral density after long-duration missions as fitted with an exponential function
    • Sibonga J.D., Evans H.J., Sung H.G., Spector E.R., Lang T.F., Oganov V.S., et al. Recovery of spaceflight-induced bone loss: bone mineral density after long-duration missions as fitted with an exponential function. Bone 2007, 41:973-978.
    • (2007) Bone , vol.41 , pp. 973-978
    • Sibonga, J.D.1    Evans, H.J.2    Sung, H.G.3    Spector, E.R.4    Lang, T.F.5    Oganov, V.S.6
  • 30
    • 33746440607 scopus 로고    scopus 로고
    • Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight
    • Lang T.F., Leblanc A.D., Evans H.J., Lu Y. Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res 2006, 21:1224-1230.
    • (2006) J Bone Miner Res , vol.21 , pp. 1224-1230
    • Lang, T.F.1    Leblanc, A.D.2    Evans, H.J.3    Lu, Y.4
  • 33
    • 34548080918 scopus 로고    scopus 로고
    • Age-related changes in trabecular architecture differ in female and male C57BL/6J mice
    • Glatt V., Canalis E., Stadmeyer L., Bouxsein M.L. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res 2007, 22:1197-1207.
    • (2007) J Bone Miner Res , vol.22 , pp. 1197-1207
    • Glatt, V.1    Canalis, E.2    Stadmeyer, L.3    Bouxsein, M.L.4
  • 34
    • 0041762493 scopus 로고    scopus 로고
    • Bone development and age-related bone loss in male C57BL/6J mice
    • Ferguson V.L., Ayers R.A., Bateman T.A., Simske S.J. Bone development and age-related bone loss in male C57BL/6J mice. Bone 2003, 33:387-398.
    • (2003) Bone , vol.33 , pp. 387-398
    • Ferguson, V.L.1    Ayers, R.A.2    Bateman, T.A.3    Simske, S.J.4
  • 36
    • 41549148147 scopus 로고    scopus 로고
    • Development of a low-dose anti-resorptive drug regimen reveals synergistic suppression of bone formation when coupled with disuse
    • Lloyd S.A., Travis N.D., Lu T., Bateman T.A. Development of a low-dose anti-resorptive drug regimen reveals synergistic suppression of bone formation when coupled with disuse. J Appl Physiol 2008, 104:729-738.
    • (2008) J Appl Physiol , vol.104 , pp. 729-738
    • Lloyd, S.A.1    Travis, N.D.2    Lu, T.3    Bateman, T.A.4
  • 37
    • 0031924615 scopus 로고    scopus 로고
    • Hindlimb unloading of growing rats: a model for predicting skeletal changes during space flight
    • Morey-Holton E.R., Globus R.K. Hindlimb unloading of growing rats: a model for predicting skeletal changes during space flight. Bone 1998, 22:83S-88S.
    • (1998) Bone , vol.22
    • Morey-Holton, E.R.1    Globus, R.K.2
  • 38
    • 24044527149 scopus 로고    scopus 로고
    • The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data
    • Morey-Holton E., Globus R.K., Kaplansky A., Durnova G. The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data. Adv Space Biol Med 2005, 10:7-40.
    • (2005) Adv Space Biol Med , vol.10 , pp. 7-40
    • Morey-Holton, E.1    Globus, R.K.2    Kaplansky, A.3    Durnova, G.4
  • 39
    • 0037372350 scopus 로고    scopus 로고
    • Tail suspension induces bone loss in skeletally mature mice in the C57BL/6J strain but not in the C3H/HeJ strain
    • Amblard D., Lafage-Proust M.H., Laib A., Thomas T., Ruegsegger P., Alexandre C., et al. Tail suspension induces bone loss in skeletally mature mice in the C57BL/6J strain but not in the C3H/HeJ strain. J Bone Miner Res 2003, 18:561-569.
    • (2003) J Bone Miner Res , vol.18 , pp. 561-569
    • Amblard, D.1    Lafage-Proust, M.H.2    Laib, A.3    Thomas, T.4    Ruegsegger, P.5    Alexandre, C.6
  • 40
    • 37849036616 scopus 로고    scopus 로고
    • Baseline bone morphometry and cellular activity modulate the degree of bone loss in the appendicular skeleton during disuse
    • Squire M., Brazin A., Keng Y., Judex S. Baseline bone morphometry and cellular activity modulate the degree of bone loss in the appendicular skeleton during disuse. Bone 2008, 42:341-349.
    • (2008) Bone , vol.42 , pp. 341-349
    • Squire, M.1    Brazin, A.2    Keng, Y.3    Judex, S.4


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