Insights from Structural Analysis of Protein-Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation

Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions

Volumn , Issue , 2014, Pages 239-250

  Cheng, Zhihong ^a   Xu, Wenqing ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Frizzled (Fzd) cysteine rich domain (CRD); Lipoprotein receptor related proteins 5 and 6 (LRP5 6); Nuclear protein complexes; Protein protein interactions; catenin Axin binding; Wnt signaling pathway; catenin dectyuction complex; catenin turnover

Indexed keywords

EID: 84926471968     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118444122.ch18     Document Type: Chapter

References (56)

1. Ahn, V.E., Chu, M.L., Choi, H.J. et al. (2011) Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6." Developmental Cell, 21 (5), 862-873.
2. Bazan, J.F., Janda, C.Y., and Garcia, K.C. (2012) "Structural architecture and functional evolution of Wnts." Developmental Cell, 23 (2), 227-232.
3. Bilic, J., Huang, Y.L., Davidson, G. et al. (2007) "Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation." Science, 316 (5831), 1619-1622.
4. Bourhis, E., Wang, W., Tam, C. et al. (2011) "Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6." Structure, 19 (10), 1433-1442.
5. Brott, B.K. and Sokol, S.Y. (2002) "Regulation of Wnt/ LRP signaling by distinct domains of Dickkopf proteins." Molecular and Cellular Biology, 22 (17), 6100-6110.
6. Cadigan, K.M. and Waterman, M.L. (2012) "TCF/ LEFs and Wnt signaling in the nucleus." Cold Spring Harbor Perspectives in Biology, 4 (11), a007906.
7. Chen, L., Wang, K., Shao, Y. et al. (2008) "Structural insight into the mechanisms of Wnt signaling antagonism by Dkk." The Journal of Biological Chemistry, 283 (34), 23364-23370.
8. Chen, S., Bubeck, D., MacDonald, B.T. et al. (2011) "Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling." Developmental Cell, 21 (5), 848-861.
9. Cheng, Z., Biechele, T., Wei, Z. et al. (2011) "Crystal structures of the extracellular domain of LRP6 and its complex with DKK1." Nature Structural & Molecular Biology, 18 (11), 1204-1210.
10. Cortese, M.S., Uversky, V.N., and Dunker, A.K. (2008) "Intrinsic disorder in scaffold proteins: getting more from less." Progress in Biophysics and Molecular Biology, 98 (1), 85-106.
11. Dajani, R., Fraser, E., Roe, S.M. et al. (2003) "Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex." The EMBO Journal, 22 (3), 494-501.
12. Dann, C.E., Hsieh, J.C., Rattner, A. et al. (2001) "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains." Nature, 412 (6842), 86-90.
13. Davidson, G., Wu, W., Shen, J. et al. (2005) "Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction." Nature, 438 (7069), 867-872.
14. de la Roche, M., Rutherford, T.J., Gupta, D. et al. (2012) "An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid." Nature Communications, 3, 680.
15. Fiedler, M., Sanchez-Barrena, M.J., Nekrasov, M. et al. (2008) Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Molecular Cell, 30 (4), 507-518.
16. Fiedler, M., Mendoza-Topaz, C., Rutherford, T.J. et al. (2011) "Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating beta-catenin." Proceedings of the National Academy of Sciences of the United States of America, 108 (5), 1937-1942.
17. Firestein, R., Bass, A.J., Kim, S.Y. et al. (2008) "CDK8 is a colorectal cancer oncogene that regulates betacatenin activity." Nature, 455 (7212), 547-551.
18. Graham, T.A., Weaver, C., Mao, F. et al. (2000) "Crystal structure of a beta-catenin/Tcf complex." Cell, 103 (6), 885-896.
19. Graham, T.A., Ferkey, D.M., Mao, F. et al. (2001) Tcf4 can specifically recognize beta-catenin using alternative conformations. Nature Structural Biology, 8 (12), 1048-1052.
20. Grandy, D., Shan, J., Zhang, X. et al. (2009) "Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled." The Journal of Biological Chemistry, 284 (24), 16256-16263.
21. Guettler, S., LaRose, J., Petsalaki, E. et al. (2011) "Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease." Cell, 147 (6), 1340-1354.
22. Ha, N.C., Tonozuka, T., Stamos, J.L. et al. (2004) "Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in betacatenin degradation." Molecular Cell, 15 (4), 511-521.
23. Hao, H.X., Xie, Y., Zhang, Y. et al. (2012) "ZNRF3 promotes Wnt receptor turnover in an R-spondinsensitive manner." Nature, 485 (7397), 195-200.
24. Hart, M.J., de los Santos, R., Albert, I.N. et al. (1998) "Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta." Current Biology, 8 (10), 573-581.
25. Holdsworth, G., Slocombe, P., Doyle, C. et al. (2012) "Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors." The Journal of Biological Chemistry, 287 (32), 26464 -26477.
26. Huang, S.M., Mishina, Y.M., Liu, S. et al. (2009) "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling." Nature, 461 (7264), 614-620.
27. Huber, A.H., Nelson, W.J., and Weis, W.I. (1997) "Three-dimensional structure of the armadillo repeat region of beta-catenin." Cell, 90 (5), 871-882.
28. Janda, C.Y., Waghray, D., Levin, A.M. et al. (2012) "Structural basis of Wnt recognition by Frizzled." Science, 337 (6090), 59-64.
29. Kim, S.E., Huang, H., Zhao, M. et al. (2013) "Wnt stabilization of beta-catenin reveals principles for morphogen receptor-scaffold assemblies." Science, 340 (6134), 867-870.
30. Kimelman, D. and Xu, W. (2006) "β-Catenin destruction complex: insights and questions from a structural perspective." Oncogene, 25 (57), 7482-7491.
31. Koo, B.K., Spit, M., Jordens, I. et al. (2012) "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors." Nature, 488 (7413), 665-669.
32. Kramps, T., Peter, O., Brunner, E. et al. (2002) "Wnt/ wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear betacatenin-TCF complex." Cell, 109 (1), 47-60.
33. Li, L., Mao, J., Sun, L. et al. (2002) "Second cysteinerich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled." The Journal of Biological Chemistry, 277 (8), 5977-5981.
34. Liepinsh, E., Banyai, L., Patthy, L., and Otting, G. (2006) "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1." The Journal of Molecular Biology, 357 (3), 942-950.
35. Liu, Y.T., Dan, Q.J., Wang, J., et al. (2011) "Molecular basis of Wnt activation via the DIX-domain protein Ccd1." The Journal of Biological Chemistry, 286 (10), 8597-8608.
36. Malinauskas, T., Aricescu, A.R., Lu, W. et al. (2011) "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1." Nature Structural & Molecular Biology, 18 (8), 886-893.
37. Morris, E.J., Ji, J.Y., Yang, F. et al. (2008) "E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8." Nature, 455 (7212), 552-556.
38. Morrone, S., Cheng, Z., Moon, R.T. et al. (2012) "Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment." Proceedings of the National Academy of Sciences of the United States of America, 109 (5), 1500-1505.
39. Poy, F., Lepourcelet, M., Shivdasani, R.A., and Eck, M.J. (2001) "Structure of a human Tcf4-beta-catenin complex." Nature Structural Biology, 8 (12), 1053-1057.
40. Sampietro, J., Dahlberg, C.L., Cho, U.S. et al. (2006) "Crystal structure of a beta-catenin/BCL9/Tcf4 complex." Molecular Cell, 24 (2), 293-300.
41. Spink, K.E., Polakis, P., and Weis, W.I. (2000) "Structural basis of the Axin-adenomatous polyposis coli interaction." The EMBO Journal, 19 (10), 2270-2279.
42. Stamos, J.L. and Weis, W.I. (2012) "The beta-catenin destruction complex." Cold Spring Harbor Perspectives Biology, 5 (1), a007898.
43. Takada, R., Satomi, Y., Kurata, T. et al. (2006) Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Developmental Cell, 11 (6), 791-801.
44. Takada, K., Zhu, D., Bird, G.H. et al. (2012) "Targeted disruption of the BCL9/beta-catenin complex inhibits oncogenic Wnt signaling." Science Translational Medicine, 4 (148), 148ra117.
45. Tauriello, D.V., Jordens, I., Kirchner, K. et al. (2012) "Wnt/beta-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled." Proceedings of the National Academy of Sciences of the United States of America, 109 (14), E812-E820.
46. Veverka, V., Henry, A.J., Slocombe, P.M. et al. (2009) "Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation." The Journal of Biological Chemistry, 284 (16), 10890-10900.
47. Weidauer, S.E., Schmieder, P., Beerbaum, M. et al. (2009) "NMR structure of the Wnt modulator protein Sclerostin." Biochemical and Biophysical Research Communications, 380 (1), 160-165.
48. Wong, H.C., Mao, J., Nguyen, J.T. et al. (2000) Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nature Structural Biology, 7 (12), 1178-1184.
49. Wong, H.C., Bourdelas, A., Krauss, A. et al. (2003) "Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled." Molecular Cell, 12 (5), 1251-1260.
50. Wu, G., Xu, G., Schulman, B.A. et al. (2003) "Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase." Molecular Cell, 11 (6), 1445-1456.
51. Xing, Y., Clements, W.K., Kimelman, D., and Xu, W. (2003) "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex." Genes & Development, 17 (22), 2753-2764.
52. Xing, Y., Clements, W.K., Le Trong, I. et al. (2004) "Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function." Molecular Cell, 15 (4), 523-533.
53. Xing, Y., Takemaru, K., Liu, J. et al. (2008) "Crystal structure of a full-length beta-catenin." Structure, 16 (3), 478-487.
54. Xu, W. and Kimelman, D. (2007) "Mechanistic insights from structural studies of beta-catenin and its binding partners." Journal of Cell Science, 120 (Pt 19), 3337-3344.
55. Yu, A., Xing, Y., Harrison, S.C., and Kirchhausen, T. (2010) "Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling." Structure, 18 (10), 1311-1320.
56. Zeng, X., Tamai, K., Doble, B. et al. (2005) "A dualkinase mechanism for Wnt co-receptor phosphorylation and activation." Nature, 438 (7069), 873-877.