Characterization of the structural features and interactions of sclerostin. Molecular insight into a key regulator of Wnt-mediated bone formation

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10890-10900

  Veverka, Vaclav ^a   Henry, Alistair J ^b   Slocombe, Patrick M ^b   Ventom, Andrew ^b   Mulloy, Barbara ^c   Muskett, Frederick W ^a   Muzylak, Mariusz ^b   Greenslade, Kevin ^b   Moore, Adrian ^b   Zhang, Li ^d   Gong, Jianhua ^d   Qian, Xueming ^d   Paszty, Chris ^d   Taylor, Richard J ^b   Robinson, Martyn K ^b   Carr, Mark D ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^d AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; BONE MASS; HEPARIN BINDING; HEPARIN-BINDING SITE; INTERACTION SITE; KEY REGULATORS; MOLECULAR INSIGHTS; NEGATIVE REGULATORS; PROTEIN INTERACTION; SCLEROSTIN; STABILIZING INTERACTIONS; STRUCTURAL FEATURE; TARGET CELLS; TARGET PROTEINS; WNT SIGNALING;

BINDING ENERGY; BONE; INTERNET; POLYSACCHARIDES; SIGNALING; TARGETS;

BINDING SITES;

HEPARIN; SCLEROSTIN; WNT PROTEIN; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; SOST PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; MOLECULAR MECHANICS; NONHUMAN; OSSIFICATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BONE DEVELOPMENT; CELL STRAIN 3T3; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC MARKER; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BETA CATENIN; BINDING SITES; BONE MORPHOGENETIC PROTEINS; GENETIC MARKERS; HEPARIN; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OSTEOGENESIS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 67449092566     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807994200     Document Type: Article

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