Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of wnt co-receptors

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 26464-26477

  Holdsworth, Gill ^a   Slocombe, Patrick ^a   Doyle, Carl ^a   Sweeney, Bernadette ^a   Veverka, Vaclav ^b   Le Riche, Kelly ^a   Franklin, Richard J ^a   Compson, Joanne ^a   Brookings, Daniel ^a   Turner, James ^a   Kennedy, Jeffery ^a   Garlish, Rachael ^a   Shi, Jiye ^a   Newnham, Laura ^a   McMillan, David ^a   Muzylak, Mariusz ^a   Carr, Mark D ^b,c   Henry, Alistair J ^a   Ceska, Thomas ^a   Robinson, Martyn K ^a  

^a UCB PHARMA   (Belgium)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO-TERMINAL REGION; CARBOXYL-TERMINAL; CENTRAL CORE; CORE REGION; CORECEPTORS; FLEXIBLE ARM; LAMININ; LOOP REGIONS; LOW DENSITY LIPOPROTEINS; SCLEROSTIN; WNT SIGNALING;

BIOCHEMISTRY; BIOLOGY;

PROTEINS;

LAMININ; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 4; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; SCLEROSTIN; UNCLASSIFIED DRUG; WNT1 PROTEIN; WNT3A PROTEIN; WNT9B PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; WNT SIGNALING PATHWAY;

AMINO ACID SEQUENCE; BONE MORPHOGENETIC PROTEINS; CALORIMETRY; CELL LINE; CRYSTALLOGRAPHY; DNA, COMPLEMENTARY; GENETIC MARKERS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; WNT1 PROTEIN;

EID: 84864532895     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.350108     Document Type: Article

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