Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice

Journal of Clinical Investigation

Volumn 125, Issue 4, 2015, Pages 1446-1458

  Venkatesh, Aditya ^a   Ma, Shan ^a,b   Le, Yun Z ^c   Hall, Michael N ^d   Rüegg, Markus A ^d   Punzo, Claudio ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 2; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE TRANSPORTER 1; GROWTH FACTOR RECEPTOR; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL TRISPHOSPHATE; PROTEIN KINASE B; PTEN; PYRUVATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UNCLASSIFIED DRUG; CASP2 PROTEIN, MOUSE; GLUCOSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; RPTOR PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL FUNCTION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEEDBACK SYSTEM; GENE DELETION; GENE EXPRESSION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOLYSIS; GROWTH REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RETINA CONE; RETINA DEGENERATION; RETINITIS PIGMENTOSA; SIGNAL TRANSDUCTION; THERAPY EFFECT; TUMOR SUPPRESSOR GENE; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; C57BL MOUSE; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; PHYSIOLOGY; RETINA ROD;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CASPASE 2; CELL SURVIVAL; GLUCOSE; INSULIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MODELS, NEUROLOGICAL; MULTIPROTEIN COMPLEXES; NADP; PTEN PHOSPHOHYDROLASE; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84926300780     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI79766     Document Type: Article

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