Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 36, 2012, Pages 14598-14603

  Murakami, Yusuke ^a   Matsumoto, Hidetaka ^a   Roh, Miin ^a   Suzuki, Jun ^a   Hisatomi, Toshio ^b   Ikeda, Yasuhiro ^b   Miller, Joan W ^a   Vavvas, Demetrios G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Inflammation; Neurodegeneration; Neuroprotection; Oxidation

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN; RECEPTOR INTERACTING PROTEIN 140; RECEPTOR INTERACTING PROTEIN KINASE; RIP 3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL STRUCTURE; FEMALE; GENE MUTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA CONE; RETINA DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY; VISUAL IMPAIRMENT;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; DNA PRIMERS; ELECTRORETINOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; NECROSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RETINA; RETINAL CONE PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC;

MUS;

EID: 84865973897     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206937109     Document Type: Article

References (53)

1. Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. Lancet 368:1795-1809. (Pubitemid 44739028)
2. Berson EL, Rosner B, Sandberg MA, Weigel-Difranco C, Willett WC (2012) ω-3 Intakeand visual acuity in patients with retinitis pigmentosa receiving vitamin A. Arch Ophthalmol 130:707-711.
3. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
4. Kroemer G, et al.; Nomenclature Committee on Cell Death 2009 (2009) Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16:3-11.
5. Holler N, et al. (2000) Fas triggers an alternative, caspase-8- independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1:489-495.
6. Matsumura H, et al. (2000) Necrotic death pathway in Fas receptor signaling. J Cell Biol 151:1247-1256.
7. Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G (2010) Molecular mechanisms of necroptosis: An ordered cellular explosion. Nat Rev Mol Cell Biol 11:700-714.
8. Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181-190. (Pubitemid 36936912)
9. Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81:513-523.
10. Cho YS, et al. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137:1112-1123.
11. He S, et al. (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137:1100-1111.
12. Zhang DW, et al. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325:332-336.
13. Zhang H, et al. (2011) Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471:373-376.
14. Kaiser WJ, et al. (2011) RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471:368-372.
15. Oberst A, et al. (2011) Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471:363-367.
16. Upton JW, Kaiser WJ, Mocarski ES (2010) Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 7:302-313.
17. Welz PS, et al. (2011) FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477:330-334.
18. Günther C, et al. (2011) Caspase-8 regulates TNF-α-induced epithelial necroptosis andterminal ileitis. Nature 477:335-339.
19. Degterev A, et al. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1:112-119.
20. Rosenbaum DM, et al. (2010) Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 88:1569-1576.
21. Trichonas G, et al. (2010) Receptor interacting protein kinases mediate retinal de-tachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci USA 107:21695-21700.
22. Chang GQ, Hao Y, Wong F (1993) Apoptosis: Final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 11:595- 605.
23. Doonan F, Donovan M, Cotter TG (2003) Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 23:5723-5731. (Pubitemid 36807851)
24. Zeiss CJ, Neal J, Johnson EA (2004) Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 45:964-970. (Pubitemid 38868399)
25. Sanges D, Comitato A, Tammaro R, Marigo V (2006) Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Proc Natl Acad Sci USA 103:17366-17371. (Pubitemid 44788975)
26. Paquet-Durand F, et al. (2007) Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. J Neurosci 27:10311-10319. (Pubitemid 47450474)
27. Léveillard T, et al. (2004) Identification and characterization of rod-derived cone viability factor. Nat Genet 36:755-759.
28. Komeima K, Rogers BS, Lu L, Campochiaro PA (2006) Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci USA 103:11300-11305. (Pubitemid 44159928)
29. Punzo C, Kornacker K, Cepko CL (2009) Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12:44-52.
30. Chang B, et al. (2002) Retinal degeneration mutants in the mouse. Vision Res 42: 517-525. (Pubitemid 34169709)
31. McLaughlin ME, Sandberg MA, Berson EL, Dryja TP (1993) Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet 4:130-134. (Pubitemid 23179094)
32. Usui S, et al. (2009) Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Mol Ther 17:778-786.
33. Newton K, Sun X, Dixit VM (2004) Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol 24:1464-1469. (Pubitemid 38167070)
34. Feoktistova M, et al. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43:449-463.
35. Degterev A, et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4:313-321. (Pubitemid 351550892)
36. Grasl-Kraupp B, et al. (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 21:1465-1468.
37. Artus C, et al. (2010) AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J 29:1585-1599.
38. Portera-Cailliau C, Sung CH, Nathans J, Adler R (1994) Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA 91:974-978. (Pubitemid 24048491)
39. Blanks JC, Johnson LV (1984) Specific binding of peanut lectin to a class of retinal photoreceptor cells. A species comparison. Invest Ophthalmol Vis Sci 25:546-557. (Pubitemid 14149146)
40. Lee SY, et al. (2011) N-Acetylcysteine promotes long-term survival of cones in a model of retinitis pigmentosa. J Cell Physiol 226:1843-1849.
41. Kim YS, Morgan MJ, Choksi S, Liu ZG (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 26: 675-687. (Pubitemid 46856240)
42. Zitvogel L, Kepp O, Kroemer G (2010) Decoding cell death signals in inflammation and immunity. Cell 140:798-804.
43. Szamier RB, Berson EL (1982) Histopathologic study of an unusual form of retinitis pigmentosa. Invest Ophthalmol Vis Sci 22:559-570. (Pubitemid 12075361)
44. Szamier RB, Berson EL, Klein R, Meyers S (1979) Sex-linked retinitis pigmentosa: Ultrastructure of photoreceptors and pigment epithelium. Invest Ophthalmol Vis Sci 18: 145-160. (Pubitemid 9098562)
45. To K, Adamian M, Berson EL (2004) Histologic study of retinitis pigmentosa due to a mutation in the RP13 gene (PRPC8): Comparison with rhodopsin Pro23His, Cys110Arg, and Glu181Lys. Am J Ophthalmol 137:946-948. (Pubitemid 38582056)
46. Lin Y, et al. (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279:10822-10828. (Pubitemid 38372695)
47. Vanlangenakker N, et al. (2011) cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ 18:656-665.
48. Vince JE, et al. (2012) Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 36:215-227.
49. Yu L, et al. (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304:1500-1502. (Pubitemid 38720930)
50. Mizushima N, Levine B (2010) Autophagy in mammalian development and differentiation. Nat Cell Biol 12:823-830.
51. Erickson PA, Fisher SK, Anderson DH, Stern WH, Borgula GA (1983) Retinal detachment in the cat: The outer nuclear and outer plexiform layers. Invest Ophthalmol Vis Sci 24:927-942. (Pubitemid 13036946)
52. Sancho-Pelluz J, et al. (2010) Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis 1:e24.
53. Hoglen NC, et al. (2004) Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenyl-aminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5, 6-tetrafluoro-phenoxy)-pentanoic acid): A liver-targeted caspase inhibitor. J Pharmacol Exp Ther 309:634-640. (Pubitemid 38542617)