Insights how monocytes and dendritic cells contribute and regulate immune defense against microbial pathogens

Immunobiology

Volumn 220, Issue 2, 2015, Pages 215-226

  Bieber, Kristin ^a   Autenrieth, Stella E ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Dendritic cells; Inflammatory DCs; Inflammatory monocytes; Innate immunity; Microbial infection; Monocytes; Tip DCs

Indexed keywords

CD115 ANTIGEN; CYTOKINE; LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; COLONY STIMULATING FACTOR RECEPTOR; LY ANTIGEN; LY-6C ANTIGEN, MOUSE;

ADAPTIVE IMMUNITY; ANTIMICROBIAL ACTIVITY; BACTERIAL TRANSMISSION; CELL FUNCTION; CELL MATURATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; DENDRITIC CELL; HEMATOPOIESIS; HUMAN; IMMUNE EVASION; IMMUNOREGULATION; INFECTION; INNATE IMMUNITY; LISTERIOSIS; LYMPHOID ORGAN; MONOCYTE; MONOPOIESIS; MYELOPOIESIS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTECTION; REVIEW; STEADY STATE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; IMMUNOMODULATION; METABOLISM; MICROBIOLOGY; MOUSE; PHENOTYPE;

ANIMALS; ANTIGENS, LY; CELL DIFFERENTIATION; DENDRITIC CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; IMMUNOMODULATION; INFECTION; MICE; MONOCYTES; PHENOTYPE; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 84926295763     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2014.10.025     Document Type: Review

References (159)

1. Adams S., O'Neill D.W., Bhardwaj N. Recent advances in dendritic cell biology. J. Clin. Immunol. 2005, 25:87-98. 10.1007/s10875-005-2814-2.
2. Akashi K., Traver D., Miyamoto T., Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000, 404:193-197. 10.1038/35004599.
3. Auffray C., Fogg D., Garfa M., Elain G., Join-Lambert O., Kayal S., Sarnacki S., Cumano A., Lauvau G., Geissmann F. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 2007, 317:666-670. 10.1126/science.1142883.
4. Auffray C., Fogg D.K., Narni-Mancinelli E., Senechal B., Trouillet C., Saederup N., Leemput J., Bigot K., Campisi L., Abitbol M., Molina T., Charo I., Hume D.A., Cumano A., Lauvau G., Geissmann F. CX3CR1+CD115+CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J. Exp. Med. 2009, 206:595-606. 10.1084/jem.20081385.
5. Auffray C., Sieweke M.H., Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu. Rev. Immunol. 2009, 27:669-692. 10.1146/annurev.immunol.021908.132557.
6. Autenrieth I.B., Tingle A., Reske-Kunz A., Heesemann J. T lymphocytes mediate protection against Yersinia enterocolitica in mice: characterization of murine T-cell clones specific for Y. enterocolitica. Infect. Immun. 1992, 60:1140-1149.
7. Autenrieth S.E., Linzer T.-R., Hiller C., Keller B., Warnke P., Köberle M., Bohn E., Biedermann T., Bühring H.-J., Hämmerling G.J., Rammensee H.-G., Autenrieth I.B. Immune evasion by Yersinia enterocolitica: differential targeting of dendritic cell subpopulations in vivo. PLoS Pathog. 2010, 6:e1001212. 10.1371/journal.ppat.1001212.g008.
8. Autenrieth S.E., Warnke P., Wabnitz G.H., Lucero Estrada C., Pasquevich K.A., Drechsler D., Günter M., Hochweller K., Novakovic A., Beer-Hammer S., Samstag Y., Hämmerling G.J., Garbi N., Autenrieth I.B. Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis. PLoS Pathog. 2012, 8:e1002552. 10.1371/journal.ppat.1002552.
9. Bakri Y. Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate. Blood 2005, 105:2707-2716. 10.1182/blood-2004-04-1448.
10. Baldridge M.T., King K.Y., Goodell M.A. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2011, 32:57-65. 10.1016/j.it.2010.12.003.
11. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252. 10.1038/32588.
12. Beckerman K.P., Rogers H.W., Corbett J.A., Schreiber R.D., McDaniel M.L., Unanue E.R. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J. Immunol. 1993, 150:888-895.
13. Belyaev N.N., Biró J., Langhorne J., Potocnik A.J. Extramedullary myelopoiesis in malaria depends on mobilization of myeloid-restricted progenitors by IFN-γ induced chemokines. PLoS Pathog. 2013, 9:e1003406. 10.1371/journal.ppat.1003406.s009.
14. Belz G.T., Nutt S.L. Transcriptional programming of the dendritic cell network. Nat. Rev. Immunol. 2012, 12:101-113. 10.1038/nri3149.
15. Belz G.T., Zhang L., Lay M.D.H., Kupresanin F., Davenport M.P. Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+T cell. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:6341-6346. 10.1073/pnas.0609990104.
16. Birnberg T., Bar-On L., Sapoznikov A., Caton M.L., Cervantes-Barragán L., Makia D., Krauthgamer R., Brenner O., Ludewig B., Brockschnieder D., Riethmacher D., Reizis B., Jung S. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 2008, 29:986-997. 10.1016/j.immuni.2008.10.012.
17. Boettcher S., Ziegler P., Schmid M.A., Takizawa H., van Rooijen N., Kopf M., Heikenwalder M., Manz M.G. Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells. J. Immunol. 2012, 188:5824-5828. 10.4049/jimmunol.1103253.
18. Bosschaerts T., Guilliams M., Stijlemans B., Morias Y., Engel D., Tacke F., Hérin M., De Baetselier P., Beschin A. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-γ and MyD88 signaling. PLoS Pathog. 2010, 6:e1001045. 10.1371/journal.ppat.1001045.t001.
19. Brocker T., Riedinger M., Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 1997, 185:541-550.
20. Cambi A., Gijzen K., de Vries I.J.M., Torensma R., Joosten B., Adema G.J., Netea M.G., Kullberg B.-J., Romani L., Figdor C.G. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur. J. Immunol. 2003, 33:532-538. 10.1002/immu.200310029.
21. Carotta S., Dakic A., Amico A.D., Pang S.H.M., Greig K.T., Nutt S.L., Wu L. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity 2010, 32:628-641. 10.1016/j.immuni.2010.05.005.
22. Cecchini M.G., Dominguez M.G., Mocci S., Wetterwald A., Felix R., Fleisch H., Chisholm O., Hofstetter W., Pollard J.W., Stanley E.R. Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 1994, 120:1357-1372.
23. Ciavarra R.P., Taylor L., Greene A.R., Yousefieh N., Horeth D., van Rooijen N., Steel C., Gregory B., Birkenbach M., Sekellick M. Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon. Virology 2005, 342:177-189. 10.1016/j.virol.2005.07.031.
24. Copin R., De Baetselier P., Carlier Y., Letesson J.-J., Muraille E. MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection. J. Immunol. 2007, 178:5182-5191.
25. Copin R., Vitry M.-A., Hanot Mambres D., Machelart A., De Trez C., Vanderwinden J.-M., Magez S., Akira S., Ryffel B., Carlier Y., Letesson J.-J., Muraille E. In situ microscopy analysis reveals local innate immune response developed around brucella infected cells in resistant and susceptible mice. PLoS Pathog. 2012, 8:e1002575. 10.1371/journal.ppat.1002575.g009.
26. Courret N. CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain. Blood 2006, 107:309-316. 10.1182/blood-2005-02-0666.
27. Dai X.-M., Ryan G.R., Hapel A.J., Dominguez M.G., Russell R.G., Kapp S., Sylvestre V., Stanley E.R. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 2002, 99:111-120.
28. Davey G.M., Wojtasiak M., Proietto A.I., Carbone F.R., Heath W.R., Bedoui S. Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo. J. Immunol. 2010, 184:2243-2246. 10.4049/jimmunol.0903013.
29. de Bruin A.M., Libregts S.F., Valkhof M., Boon L., Touw I.P., Nolte M.A. IFN induces monopoiesis and inhibits neutrophil development during inflammation. Blood 2012, 119:1543-1554. 10.1182/blood-2011-07-367706.
30. De Smedt T., Pajak B., Muraille E., Lespagnard L., Heinen E., De Baetselier P., Urbain J., Leo O., Moser M. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 1996, 184:1413-1424.
31. De Trez C., Magez S., Akira S., Ryffel B., Carlier Y., Muraille E. iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice. PLoS Pathog. 2009, 5:e1000494. 10.1371/journal.ppat.1000494.s007.
32. De Trez C., Pajak B., Brait M., Glaichenhaus N., Urbain J., Moser M., Lauvau G., Muraille E. TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo. J. Immunol. 2005, 175:839-846.
33. Dinauer M.C., Deck M.B., Unanue E.R. Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes. J. Immunol. 1997, 158:5581-5583.
34. Drevets D.A. Dissemination of Listeria monocytogenes by infected phagocytes. Infect. Immun. 1999, 67:3512-3517.
35. Drevets D.A., Dillon M.J., Schawang J.E., Stoner J.A., Leenen P.J.M. IFN-gamma triggers CCR2-independent monocyte entry into the brain during systemic infection by virulent Listeria monocytogenes. Brain Behav. Immun. 2010, 24:919-929. 10.1016/j.bbi.2010.02.011.
36. Drevets D.A., Dillon M.J., Schawang J.S., van Rooijen N., Ehrchen J., Sunderkötter C., Leenen P.J.M. The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J. Immunol. 2004, 172:4418-4424.
37. Drevets D.A., Schawang J.E., Dillon M.J., Lerner M.R., Bronze M.S., Brackett D.J. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J. Immunol. 2008, 181:529-536.
38. Drevets D.A., Schawang J.E., Mandava V.K., Dillon M.J., Leenen P.J.M. Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features. J. Immunol. 2010, 185:2432-2441. 10.4049/jimmunol.1000486.
39. Dubois B., Massacrier C., Vanbervliet B., Fayette J., Briere F., Banchereau J., Caux C. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. J. Immunol. 1998, 161:2223-2231.
40. Dubois B., Vanbervliet B., Fayette J., Massacrier C., Van Kooten C., Briere F., Banchereau J., Caux C. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Immunol. 1997, 185:941-951.
41. Dudziak D., Kamphorst A.O., Heidkamp G.F., Buchholz V.R., Trumpfheller C., Yamazaki S., Cheong C., Liu K., Lee H.W., Park C.G., Steinman R.M., Nussenzweig M.C. Differential antigen processing by dendritic cell subsets in vivo. Science 2007, 315:107-111. 10.1126/science.1136080.
42. Edwards A.D., Chaussabel D., Tomlinson S., Schulz O., Sher A., Reis e Sousa C. Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J. Immunol. 2003, 171:47-60.
43. Efron P.A., Martins A., Minnich D., Tinsley K., Ungaro R., Bahjat F.R., Hotchkiss R., Clare-Salzler M., Moldawer L.L. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J. Immunol. 2004, 173:3035-3043.
44. -/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 1997, 7:419-432.
45. Flohe S.B. Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J. Leukoc. Biol. 2005, 79:473-481. 10.1189/jlb.0705413.
46. Fogg D.K. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 2006, 311:83-87. 10.1126/science.1117729.
47. Geissmann F., Jung S., Littman D.R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003, 19:71-82.
48. Ginhoux F., Liu K., Helft J., Bogunovic M., Greter M., Hashimoto D., Price J., Yin N., Bromberg J., Lira S.A., Stanley E.R., Nussenzweig M., Merad M. The origin and development of nonlymphoid tissue CD103+ DCs. J. Exp. Med. 2009, 206:3115-3130. 10.1084/jem.20091756.
49. Goldszmid R.S., Caspar P., Rivollier A., White S., Dzutsev A., Hieny S., Kelsall B., Trinchieri G., Sher A. NK cell-derived interferon-g orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection. Immunity 2012, 36:1047-1059. 10.1016/j.immuni.2012.03.026.
50. Goodyear A., Jones A., Troyer R., Bielefeldt-Ohmann H., Dow S. Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. J. Immunol. 2010, 184:1445-1454. 10.4049/jimmunol.0900411.
51. Gordon S., Taylor P.R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 2005, 5:953-964. 10.1038/nri1733.
52. Greter M., Helft J., Chow A., Hashimoto D., Mortha A., Agudo-Cantero J., Bogunovic M., Gautier E.L., Miller J., Leboeuf M., Lu G., Aloman C., Brown B.D., Pollard J.W., Xiong H., Randolph G.J., Chipuk J.E., Frenette P.S., Merad M. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 2012, 36:1031-1046. 10.1016/j.immuni.2012.03.027.
53. Grivennikov S.I., Tumanov A.V., Liepinsh D.J., Kruglov A.A., Marakusha B.I., Shakhov A.N., Murakami T., Drutskaya L.N., Förster I., Clausen B.E., Tessarollo L., Ryffel B., Kuprash D.V., Nedospasov S.A. Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils. Immunity 2005, 22:93-104. 10.1016/j.immuni.2004.11.016.
54. Guilliams M., Ginhoux F., Jakubzick C., Naik S.H., Onai N., Schraml B.U., Segura E., Tussiwand R., Yona S. Perspectives. Nat. Rev. Immunol. 2014, 14:571-578. 10.1038/nri3712.
55. Guilliams M., Movahedi K., Bosschaerts T., VandenDriessche T., Chuah M.K., Hérin M., Acosta-Sanchez A., Ma L., Moser M., Van Ginderachter J.A., Brys L., De Baetselier P., Beschin A. IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection. J. Immunol. 2009, 182:1107-1118.
56. Heath W.R., Carbone F.R. Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat. Immunol. 2009, 10:1237-1244. 10.1038/ni.1822.
57. Helft J., Ginhoux F., Bogunovic M., Merad M. Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol. Rev. 2010, 234:55-75. 10.1111/j.0105-2896.2009.00885.x.
58. Henderson R.B., Hobbs J.A.R., Mathies M., Hogg N. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 2003, 102:328-335. 10.1182/blood-2002-10-3228.
59. Hochweller K., Striegler J., Hämmerling G.J., Garbi N. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur. J. Immunol. 2008, 38:2776-2783. 10.1002/eji.200838659.
60. Hotchkiss R.S., Tinsley K.W., Swanson P.E., Grayson M.H., Osborne D.F., Wagner T.H., Cobb J.P., Coopersmith C., Karl I.E. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J. Immunol. 2002, 168:2493-2500.
61. Hsieh C.-S., Lee H.-M., Lio C.-W.J. Selection of regulatory T cells in the thymus. Nat. Rev. Immunol. 2012, 12:157-167. 10.1038/nri3155.
62. Idoyaga J., Suda N., Suda K., Park C.G., Steinman R.M. Antibody to langerin/CD207 localizes large numbers of CD8+ dendritic cells to the marginal zone of mouse spleen. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:1524-1529. 10.1073/pnas.0812247106.
63. Indramohan M., Sieve A.N., Break T.J., Berg R.E. Inflammatory monocyte recruitment is regulated by interleukin-23 during systemic bacterial infection. Infect. Immun. 2012, 80:4099-4105. 10.1128/IAI.00589-12.
64. Ishikawa H., Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008, 455:674-678. 10.1038/nature07317.
65. Ishikawa H., Ma Z., Barber G.N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009, 461:788-792. 10.1038/nature08476.
66. Izon D., Rudd K., DeMuth W., Pear W.S., Clendenin C., Lindsley R.C., Allman D. A common pathway for dendritic cell and early B cell development. J. Immunol. 2001, 167:1387-1392.
67. Jia T., Leiner I., Dorothee G., Brandl K., Pamer E.G. MyD88 and type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection. J. Immunol. 2009, 183:1271-1278. 10.4049/jimmunol.0900460.
68. Jiao X., Lo-Man R., Guermonprez P., Fiette L., Deriaud E., Burgaud S., Gicquel B., Winter N., Leclerc C. Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity. J. Immunol. 2002, 168:1294-1301.
69. Jin L., Getahun A., Knowles H.M., Mogan J., Akerlund L.J., Packard T.A., Perraud A.-L., Cambier J.C. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J. Immunol. 2013, 190:2835-2843. 10.4049/jimmunol.1201788.
70. Join-Lambert O.F., Ezine S., Le Monnier A., Jaubert F., Okabe M., Berche P., Kayal S. Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system. Cell. Microbiol. 2004, 7:167-180. 10.1111/j.1462-5822.2004.00444.x.
71. + T cells by exogenous cell-associated antigens. Immunity 2002, 17:211-220.
72. Kang S.-J., Liang H.-E., Reizis B., Locksley R.M. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 2008, 29:819-833. 10.1016/j.immuni.2008.09.017.
73. Kassim S.H., Rajasagi N.K., Ritz B.W., Pruett S.B., Gardner E.M., Chervenak R., Jennings S.R. Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1. J. Virol. 2009, 83:3175-3186. 10.1128/JVI.01907-08.
74. Klein L., Hinterberger M., Wirnsberger G., Kyewski B. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat. Rev. Immunol. 2009, 9:833-844. 10.1038/nri2669.
75. Kondo M., Weissman I.L., Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997, 91:661-672.
76. Krutzik S.R., Tan B., Li H., Ochoa M.T., Liu P.T., Sharfstein S.E., Graeber T.G., Sieling P.A., Liu Y.-J., Rea T.H., Bloom B.R., Modlin R.L. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat. Med. 2005, 11:653-660. 10.1038/nm1246.
77. Kurihara T., Warr G., Loy J., Bravo R. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med 1997, 186:1757-1762.
78. Kushwah R., Hu J. Role of dendritic cells in the induction of regulatory T cells. Cell Biosci. 2011, 1:20. 10.1186/2045-3701-1-20.
79. + T cell crosspriming in vivo. Immunity 2006, 24:191-201. 10.1016/j.immuni.2006.01.005.
80. León B., López-Bravo M., Ardavín C. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity 2007, 26:519-531. 10.1016/j.immuni.2007.01.017.
81. Liu C.H., Fan Y., Dias A., Esper L., Corn R.A. Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice. J. Immunol. 2006, 177:31-35.
82. Liu K., Iyoda T., Saternus M., Kimura Y., Inaba K., Steinman R.M. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 2002, 196:1091-1097.
83. Liu K., Nussenzweig M.C. Development and homeostasis of dendritic cells. Eur. J. Immunol. 2010, 40:2099-2102. 10.1002/eji.201040501.
84. Liu K., Victora G.D., Schwickert T.A., Guermonprez P., Meredith M.M., Yao K., Chu F.F., Randolph G.J., Rudensky A.Y., Nussenzweig M. In vivo analysis of dendritic cell development and homeostasis. Science 2009, 10.1126/science.1170540.
85. Loof T.G., Rohde M., Chhatwal G.S., Jung S., Medina E. The contribution of dendritic cells to host defenses against Streptococcus pyogenes. J. Infect. Dis. 2007, 196:1794-1803. 10.1086/523647.
86. Lucas M., Schachterle W., Oberle K., Aichele P., Diefenbach A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 2007, 26:503-517. 10.1016/j.immuni.2007.03.006.
87. Mackarehtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., Lemischka I.R. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 1995, 3:147-161.
88. MacNamara K.C., Oduro K., Martin O., Jones D.D., McLaughlin M., Choi K., Borjesson D.L., Winslow G.M. Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-signaling. J. Immunol. 2011, 186:1032-1043. 10.4049/jimmunol.1001893.
89. Majer O., Bourgeois C., Zwolanek F., Lassnig C., Kerjaschki D., Mack M., Müller M., Kuchler K. Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog. 2012, 8:e1002811. 10.1371/journal.ppat.1002811.s005.
90. Manz M.G., Traver D., Miyamoto T., Weissman I.L., Akashi K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001, 97:3333-3341.
91. + dendritic cells initiating cytokine expression. Eur. J. Immunol. 1999, 29:1107-1125.
92. Mellman I., Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001, 106:255-258.
93. Merad M., Ginhoux F., Collin M. Origin, homeostasis and function of Langerhans cells and other Langerin-expressing dendritic cells. Nat. Rev. Immunol. 2008, 8:935-947. 10.1038/nri2455.
94. Merad M., Sathe P., Helft J., Miller J., Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 2013, 31:563-604. 10.1146/annurev-immunol-020711-074950.
95. Miller J.C., Brown B.D., Shay T., Gautier E.L., Jojic V., Cohain A., Pandey G., Leboeuf M., Elpek K.G., Helft J., Hashimoto D., Chow A., Price J., Greter M., Bogunovic M., Bellemare-Pelletier A., Frenette P.S., Randolph G.J., Turley S.J., Merad M. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 2012, 13:1-14. 10.1038/ni.2370.
96. Muraille E., Giannino R., Guirnalda P., Leiner I., Jung S., Pamer E.G., Lauvau G. Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes. Eur. J. Immunol. 2005, 35:1463-1471. 10.1002/eji.200526024.
97. Murray P.J., Young R.A., Daley G.Q. Hematopoietic remodeling in interferon-γ - deficient mice infected with mycobacteria. Blood 1998, 91:1-12.
98. Nagai Y., Garrett K.P., Ohta S., Bahrun U., Kouro T., Akira S., Takatsu K., Kincade P.W. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 2006, 24:801-812. 10.1016/j.immuni.2006.04.008.
99. Naik S.H., Metcalf D., van Nieuwenhuijze A., Wicks I., Wu L., O'Keeffe M., Shortman K. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat. Immunol. 2006, 7:663-671. 10.1038/ni1340.
100. Naik S.H., Sathe P., Park H.-Y., Metcalf D., Proietto A.I., Dakic A., Carotta S., O'Keeffe M., Bahlo M., Papenfuss A., Kwak J.-Y., Wu L., Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 2007, 8:1217-1226. 10.1038/ni1522.
101. + phagocytes. J. Exp. Med. 2007, 204:2075-2087. 10.1084/jem.20070204.
102. Neuenhahn M., Kerksiek K.M., Nauerth M., Suhre M.H., Schiemann M., Gebhardt F.E., Stemberger C., Panthel K., Schröder S., Chakraborty T., Jung S., Hochrein H., Rüssmann H., Brocker T., Busch D.H. CD8α+ dendritic cells are required for efficient entry of Listeria monocytogenes into the Spleen. Immunity 2006, 25:619-630. 10.1016/j.immuni.2006.07.017.
103. North R.J. The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection. J. Exp. Med. 1970, 132:521-534.
104. Obayashi K., Doi T., Koyasu S. Dendritic cells suppress IgE production in B cells. Int. Immunol. 2006, 19:217-226. 10.1093/intimm/dxl138.
105. Ocuin L.M., Bamboat Z.M., et al. Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis. J. Immunol. 2011, 83:423-432.
106. Olekhnovitch R., Ryffel B., Müller A.J., Bousso P. Collective nitric oxide production provides tissue-wide immunity during Leishmania infection. J. Clin. Invest. 2014, 124:1711-1722. 10.1172/JCI72058DS1.
107. Onai N., Obata-Onai A., Schmid M.A., Manz M.G. Flt3 in regulation of type I interferon-producing cell and dendritic cell development. Ann. N.Y. Acad. Sci. 2007, 1106:253-261. 10.1196/annals.1392.015.
108. Onai N., Obata-Onai A., Schmid M.A., Ohteki T., Jarrossay D., Manz M.G. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 2007, 8:1207-1216. 10.1038/ni1518.
109. Palframan R.T., Jung S., Cheng G., Weninger W., Luo Y., Dorf M., Littman D.R., Rollins B.J., Zweerink H., Rot A., Von Andrian U.H. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med 2001, 194:1361-1373.
110. Palucka A.K. Dendritic cells as the terminal stage of monocyte differentiation. J. Immunol. 1998, 160:4587-4595.
111. Peters W., Scott H.M., Chambers H.F., Flynn J.L., Charo I.F., Ernst J.D. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:7958-7963. 10.1073/pnas.131207398.
112. Pène F., Courtine E., Ouaaz F., Zuber B., Sauneuf B., Sirgo G., Rousseau C., Toubiana J., Balloy V., Chignard M., Mira J.P., Chiche J.D. Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells. Infect. Immun. 2009, 77:5651-5658. 10.1128/IAI.00238-09.
113. Phythian-Adams A.T., Cook P.C., Lundie R.J., Jones L.H., Smith K.A., Barr T.A., Hochweller K., Anderton S.M., Hammerling G.J., Maizels R.M., MacDonald A.S. CD11c depletion severely disrupts Th2 induction and development in vivo. J. Exp. Med. 2010, 207:2089-2096. 10.1084/jem.20100734.
114. Probst H.-C., van den Broek M. Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J. Immunol. 2005, 174:3920-3924.
115. Proietto A.I., van Dommelen S., Zhou P., Rizzitelli A., D'Amico A., Steptoe R.J., Naik S.H., Lahoud M.H., Liu Y., Zheng P., Shortman K., Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:19869-19874. 10.1073/pnas.0810268105.
116. Qiu C.H., Miyake Y., Kaise H., Kitamura H., Ohara O., Tanaka M. Novel Subset of CD8+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J. Immunol. 2009, 182:4127-4136. 10.4049/jimmunol.0803364.
117. Randolph G.J., Furie M.B. Mononuclear phagocytes egress from an in vitro model of the vascular wall by migrating across endothelium in the basal to apical direction: role of intercellular adhesion molecule 1 and the CD11/CD18 integrins. J. Exp. Med. 1996, 183:451-462.
118. Randolph G.J., Inaba K., Robbiani D.F., Steinman R.M., Muller W.A. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 1999, 11:753-761.
119. Reizis B., Bunin A., Ghosh H.S., Lewis K.L., Sisirak V. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 2011, 29:163-183. 10.1146/annurev-immunol-031210-101345.
120. Robben P.M. Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J. Exp. Med. 2005, 201:1761-1769. 10.1084/jem.20050054.
121. Salazar-Gonzalez R.M., Niess J.H., Zammit D.J., Ravindran R., Srinivasan A., Maxwell J.R., Stoklasek T., Yadav R., Williams I.R., Gu X. CCR6 - mediated dendritic cell activation of pathogen-specific T cells in Peyer's Patches. Immunity 2006, 24:623-632. 10.1016/j.immuni.2006.02.015.
122. Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994, 179:1109-1118.
123. Samstein M., Schreiber H.A., Leiner I.M., Susac B., Glickman M.S., Pamer E.G. Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming. eLife 2013, 2:e01086. 10.7554/eLife.01086.
124. Sancho D., Joffre O.P., Keller A.M., Rogers N.C., Martínez D., Hernanz-Falcón P., Rosewell I., Sousa C.R.E. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009, 458:899-903. 10.1038/nature07750.
125. Sathe P., Metcalf D., Vremec D., Naik S.H., Langdon W.Y., Huntington N.D., Wu L., Shortman K. Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor. Immunity 2014, 41:104-115. 10.1016/j.immuni.2014.05.020.
126. Schindler D., Gutierrez M.G., Beineke A., Rauter Y., Rohde M., Foster S., Goldmann O., Medina E. Dendritic cells are central coordinators of the host immune response to Staphylococcus aureus bloodstream infection. Am. J. Pathol. 2012, 181:1327-1337. 10.1016/j.ajpath.2012.06.039.
127. Schleicher U., Liese J., Knippertz I., Kurzmann C., Hesse A., Heit A., Fischer J.A.A., Weiss S., Kalinke U., Kunz S., Bogdan C. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J. Exp. Med. 2007, 204:893-906. 10.1084/jem.20061293.
128. Schmid M.A., Kingston D., Boddupalli S., Manz M.G. Instructive cytokine signals in dendritic cell lineage commitment. Immunol. Rev. 2010, 234:32-44. 10.1111/j.0105-2896.2009.00877.x.
129. Schmid M.A., Takizawa H., Baumjohann D.R., Saito Y., Manz M.G. Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes. Blood 2011, 118:4829-4840. 10.1182/blood-2011-03-344960.
130. Scott H.M., Flynn J.L. Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infect. Immun. 2002, 70:5946-5954.
131. Segura E., Amigorena S. Inflammatory dendritic cells in mice and humans. Trends Immunol. 2013, 34:1-6. 10.1016/j.it.2013.06.001.
132. Serbina N.V., Hohl T.M., Cherny M., Pamer E.G. Selective expansion of the monocytic lineage directed by bacterial infection. J. Immunol. 2009, 183:1900-1910. 10.4049/jimmunol.0900612.
133. Serbina N.V., Pamer E.G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 2006, 7:311-317. 10.1038/ni1309.
134. Serbina N.V., Salazar-Mather T.P., Biron C.A., Kuziel W.A., Pamer E.G. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 2003, 19:59-70.
135. Shi C., Jia T., Mendez-Ferrer S., Hohl T.M., Serbina N.V., Lipuma L., Leiner I., Li M.O., Frenette P.S., Pamer E.G. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity 2011, 34:590-601. 10.1016/j.immuni.2011.02.016.
136. Sponaas A.-M., Freitas do Rosario A.P., Voisine C., Mastelic B., Thompson J., Koernig S., Jarra W., Renia L., Mauduit M., Potocnik A.J., Langhorne J. Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria. Blood 2009, 114:5522-5531. 10.1182/blood-2009-04-217489.
137. Sponaas A.M. Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells. J. Exp. Med. 2006, 203:1427-1433. 10.1084/jem.20052450.
138. Steinman R.M., et al. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:351-358.
139. Steinman R.M., Banchereau J. Taking dendritic cells into medicine. Nature 2007, 449:419-426. 10.1038/nature06175.
140. Sunderkötter C., Nikolic T., Dillon M.J., van Rooijen N., Stehling M., Drevets D.A., Leenen P.J.M. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 2004, 172:4410-4417.
141. + cells during oral Salmonella infection. J. Immunol. 2005, 175:3287-3298.
142. + inflammatory cells in vivo via MyD88 and TNFR1. J. Leukoc. Biol. 2009, 85:225-234. 10.1189/jlb.0708413.
143. Tam M.A., Wick M.J. Dendritic cells and immunity to Listeria: TipDCs are a new recruit. Trends Immunol. 2004, 25:335-339. 10.1016/j.it.2004.05.004.
144. Tam M.A., Wick M.J. Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes. Cell. Microbiol. 2006, 8:1172-1187. 10.1111/j.1462-5822.2006.00700.x.
145. Taylor P.R., Brown G.D., Geldhof A.B., Martinez-Pomares L., Gordon S. Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo. Eur. J. Immunol. 2003, 33:2090-2097. 10.1002/eji.200324003.
146. + T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection. J. Immunol. 2005, 175:3268-3272.
147. Tittel A.E.P., Heuser C., Ohliger C., Llanto C., Yona S., Hämmerling G.U.N.J.H.A., Engel D.R., Garbi N., Kurts C. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat. Methods 2012, 1-7. 10.1038/nmeth.1905.
148. Tripp C.S., Wolf S.F., Unanue E.R. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:3725-3729.
149. Tsou C.-L., Peters W., Si Y., Slaymaker S., Aslanian A.M., Weisberg S.P., Mack M., Charo I.F. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J. Clin. Invest. 2007, 117:902-909. 10.1172/JCI29919.
150. Varol C., Landsman L., Fogg D.K., Greenshtein L., Gildor B., Margalit R., Kalchenko V., Geissmann F., Jung S. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 2007, 204:171-180. 10.1084/jem.20061011.
151. Verschoor A., Neuenhahn M., Navarini A.A., Graef P., Plaumann A., Seidlmeier A., Nieswandt B., Massberg S., Zinkernagel R.M., Hengartner H., Busch D.H. A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat. Immunol. 2011, 12:1194-1201. 10.1038/ni.2140.
152. Villadangos J.A., Schnorrer P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 2007, 7:543-555. 10.1038/nri2103.
153. Vremec D., Pooley J., Hochrein H., Wu L., Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 2000, 164:2978-2986.
154. Wan S., Zhou Z., Duan B., Morel L. Direct B cell stimulation by dendritic cells in a mouse model of lupus. Arthr. Rheum. 2008, 58:1741-1750. 10.1002/art.23515.
155. Waskow C., Liu K., Darrasse-Jèze G., Guermonprez P., Ginhoux F., Merad M., Shengelia T., Yao K., Nussenzweig M. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 2008, 9:676-683. 10.1038/ni.1615.
156. Wu L., D'Amico A., Hochrein H., O'Keeffe M., Shortman K., Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 2001, 98:3376-3382.
157. Yarovinsky F. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005, 308:1626-1629. 10.1126/science.1109893.
158. Yáñez A., Megías J., O'Connor J.-E., Gozalbo D., Gil M.L. Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling. PLoS ONE 2011, 6:e24761. 10.1371/journal.pone.0024761.g009.
159. Yáñez A., Murciano C., O'Connor J.-E., Gozalbo D., Gil M.L. Candida albicans triggers proliferation and differentiation of hematopoietic stem and progenitor cells by a MyD88-dependent signaling. Microb. Infect. 2009, 11:531-535. 10.1016/j.micinf.2009.01.011.