Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain

Journal of Immunology

Volumn 181, Issue 1, 2008, Pages 529-536

  Drevets, Douglas A ^a,c   Schawang, Jennifer E ^a   Dillon, Marilyn J ^a   Lerner, Megan R ^b   Bronze, Michael S ^a   Brackett, Daniel J ^b  

^a Department of Medicine ^*  (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTERFERON; CD5 ANTIGEN; CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GENE PRODUCT; HISTONE DEACETYLASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PROTEIN BIRC5; PROTEIN C1QA; PROTEIN IRGM; PROTEIN ISG15; PROTEIN MAP2K7; PROTEIN PIGR; PROTEIN SELE; STAT1 PROTEIN; STAT2 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VITAMIN D RECEPTOR; LY ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BLOOD; BLOOD LEVEL; BONE MARROW; BRAIN INFECTION; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; INNATE IMMUNITY; LISTERIA MONOCYTOGENES; MICROARRAY ANALYSIS; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; UPREGULATION; ANIMAL; BRAIN; CYTOLOGY; DNA MICROARRAY; GENETICS; IMMUNOLOGY; LISTERIOSIS; METABOLISM; MOUSE MUTANT;

ANIMALS; ANTIGENS, LY; BRAIN; CENTRAL NERVOUS SYSTEM; FEMALE; IMMUNITY, NATURAL; INTERFERON TYPE II; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MICE; MICE, KNOCKOUT; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; UP-REGULATION;

EID: 47949128739     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.1.529     Document Type: Article

References (50)

1. Vazquez-Boland, J. A., M. Kuhn, P. Berche, T. Chakraborty, G. Dominguez-Bemal, W. Goebel, B. Gonzalez-Zorn, J. Wehland, and J. Kreft. 2001. Listeria pathogenesis and molecular virulence determinants. Clin. Microbiol. Rev. 14: 584-640.
2. Siegman-Igra, Y., R. Levin, M. Weinberger, Y. Golan, D. Schwartz, Z. Samra, H. Konigsberger, A. Yinnon, G. Rahav, N. Keller, et al. 2002. Lisieria monocylogenes infection in Israel and review of cases worldwide. Emerg. Infect. Dis. 8: 305-310.
3. Schuchat, A., K. Robinson, J. D. Wenger, L. H. Harrison, M. Farley, A. L. Reingold, L. Lefkowitz, and B. A. Perkins. 1997. Bacterial meningitis in the United States in 1995: active surveillance team. N. Engl. J. Med. 337: 970-976.
4. Drevets, D. A., T. A. Jelinek, and N. E. Freitag. 2001. Listeria monocytogenes-infected phagocytes can initiate central nervous system infection in mice. Infect. Immun. 69: 1344-1350.
5. high monocyte subpopu-lation transports Lisleria monocylogenes into the brain during systemic infection of mice. J. Immunol. 172: 4418-4424.
6. Join-Lambert, O. F., S. Ezine, A. Le Monnier, F. Jaubert, M. Okabe, P. Berche, and S. Kayal. 2005. Listeria monocylogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system. Cell. Microbiol. 7: 167-180.
7. Rosen, H., S. Gordon, and R. J. North. 1989. Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells: absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells. J. Exp. Med. 170: 27-37.
8. Gregory, S. H., A. J. Sagnimeni, and E. J. Wing. 1996. Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils. J. Immunol. 157: 2514-2520.
9. Berche, P. 1995. Bacteremia is required for invasion of the murine central nervous system by Lisleria monocytogenes. Microb. Pathog. 18: 323-336.
10. de Bruijn, M. F., W. van Vianen, R. E. Ploemacher, I. A. Bakker-Woudenberg, P. A. Campbell, W. van Ewijk, and P. J. Leenen. 1998. Bone marrow cellular composition in Listeria monocytogenes infected mice detected using ER-MP12 and ER-MP20 antibodies: a flow cytometric alternative to differential counting. J. Immunol. Methods 217: 27-39.
11. Sunderkotter, C., T. Nikolic, M. J. Dillon, N. van Rooijen, M. Stehling, D. A. Drevets, and P. J. M. Leenen. 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172: 4410-4417.
12. Chakravarty, S., and M. Herkenham. 2005. Toll-like receptor 4 on nonhemato-poietic cells sustains cns inflammation during endotoxemia, independent of systemic cytokines. J. Neurosci. 25: 1788-1796.
13. Laflamme, N., and S. Rivest. 2001. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J. 15: 155-163.
14. Carvalho-Tavares, J., M. J. Hickey, J. Hutchison, J. Michaud, I. T. Sutcliffe, and P. Kubes. 2000. A role for platelets and endothelial selectins in tumor necrosis factor-α-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87: 1141-1148.
15. Chandrasekharan, U. M., M. Siemionow, M. Unsal, L. Yang, E. Poptic, J. Bohn, K. Ozer, Z. Zhou, P, H. Howe, M. Penn, and P. E. DiCorleto. 2007. Tumor necrosis factor a (TNF-α) receptor-II is required for TNF-α-induced leukocyle-endothelial interaction in vivo. Blood 109: 1938-1944.
16. Drevets, D. A., and P. J. Leenen. 2000. Leukocyte-facilitated entry of intracellular pathogens into the central nervous system. Microbes. Infect. 2: 1609-1618.
17. Lopez, S., N. Prats, and A. J. Marco. 1999. Expression of E-selectin, P-selectin, and intercellular adhesion molecule-1 during experimental murine listeriosis. Am. J. Pathol. 155: 1391-1397.
18. Kayal, S., A. Lilienbaum, C. Poyart, S. Memet, A. Israel, and P. Berche. 1999. Listeriolysin O-dependent activation of endothelial cells during infection with Listeria monocylogenes: activation of NF-κB and upregulation of adhesion molecules and chemokines. Mol. Microbiol. 31: 1709-1722.
19. Kwok, L. Y., H. Miletic, S. Lutjen, S. Soltek, M. Deckert, and D. Schluter. 2002. Protective immunosurveillance of the central nervous system by Lisreria-specific CD4 and CD8 T cells in systemic listeriosis in the absence of intracerebral Listeria. J. Immunol. 169: 2010-2019.
20. Jones, S., and D. A. Portnoy. 1994. Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O. Infect. Immun. 62: 5608-5613.
21. Brundage, R., G. Smith, A. Camilli, J. Theriot, and D. Portnoy. 1993. Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells. Proc. Natl. Acad. Sci. USA 90: 11890-11894.
22. Portnoy, D. A., P. S. Jacks, and D. J. Hinrichs. 1988. Role of hemolysin for the intracellular growth of Listeria monocytogenes. J. Exp. Med. 167: 1459-1471.
23. Kocks, C., E. Gouin, M. Tabouret, P. Berche, H. Ohayon, and P. Cossart. 1992. L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein. Cell 68: 521-531.
24. Leenen, P. J., M. Melis, W. A. Slieker, and W. Van Ewijk. 1990. Murine macrophage precursor characterization: II. Monoclonal antibodies against macrophage precursor antigens. Eur. J. Immunol. 20: 27-34.
25. Nakane, A., A. Numata, and T. Minagawa, 1992. Endogenous tumor necrosis factor, interleukin-6, and γ interferon levels during Listeria monocytogenes infection in mice. Infect. Immun. 60: 523-528.
26. Nishimura, M., and S. Naito. 2005. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol. Pharm. Bull. 28: 886-892.
27. Cousens, L. P., and E. J. Wing. 2000. Innate defenses in the liver during Listeria infection. Immunol. Rev. 174: 150-159.
28. Berg, R. E., E. Crossley, S. Murray, and J. Forman. 2005. Relative contributions of NK and CDS T cells to IFN-γ mediated innate immune protection against Listeria monocylogenes. J. Immunol. 175: 1751-1757.
29. Serbina, N. V., T. P. Salazar-Mather, C. A. Biron, W. A. Kuziel, and E. G. Pamer. 2003. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19: 59-70.
30. Pamer, E. G. 2004. Immune responses to Listeria monocytogenes. Nat. Rev. Immunol. 4: 812-823.
31. Riedemann, N. C., R. F. Guo, and P. A. Ward. 2003. Novel strategies for the treatment of sepsis. Nat. Med. 9: 517-524.
32. Hotchkiss, R. S., and I. E. Karl. 2003. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348: 138-150.
33. McCaffrey, R. L., P. Fawcett, M. O'Riordan, K. D. Lee, E. A. Havell, P. O. Brown, and D. A. Portnoy. 2004. A specific gene expression program triggered by Gram-positive bacteria in the cytosol. Proc. Natl. Acad. Sci. USA 101: 11386-11391.
34. Schuerch, D. W., E. M. Wilson-Kubalek, and R. K. Tweten. 2005. Molecular basis of listeriolysin O pH dependence. Proc. Natl. Acad. Sci. USA 102: 12537-12542.
35. Clay, C. C., D. S. Rodrigues, Y. S. Ho, B. A. Fallert, K. Janatpour, T. A. Reinhart, and U. Esser. 2007. Neuroinvasion of fluorescein-positive monocytes in acute simian immunodeficiency virus infection. J. Virol. 81: 12040-12048.
36. Janatpour, M. J., S. Hudak, M. Sathe, J. D. Sedgwick, and L. M. McEvoy. 2001. Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J. Exp. Med. 194: 1375-1218.
37. Koedel, U., T. Rupprecht, B. Angele, J. Heesemann, H. Wagner, H. W. Pfister, and C. J. Kirschning. 2004. MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. Brain 127: 1437-1445.
38. Olson, J. K., and S. D. Miller. 2004. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173: 3916-3924.
39. Zhou, H., B. M. Lapointe, S. R. Clark, L. Zbytnuik, and P. Kubes. 2006. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J. Immunol. 177: 8103-8110.
40. Esen, N., and T. Kielian. 2006. Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns. J. Immunol. 176: 6802-6811.
41. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376.
42. Franchi, L., J. H. Park, M. H. Shaw, N. Marina-Garcia, G. Chen, Y. G. Kim, and G. Nunez. 2008. Intracellular NOD-like receptors in innate immunity, infection and disease. Cell. Microbiol. 10: 1-8.
43. Bockaert, J., S. Claeysen, C. Becamel, A. Dumuis, and P. Marin. 2006. Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. Cell Tissue Res. 326: 553-572.
44. Perry, V. H., T. A. Newman, and C. Cunningham. 2003. The impact of systemic infection on the progression of neurodegenerative disease. Nat. Rev. Neurosci. 4: 103-112.
45. van der Flier, M., S. P. M. Geelen, J. L. L. Kimpen, I. M. Hoepelman, and E. I. Tuomanen. 2003. Reprogramming the host response in bacterial meningitis: how best to improve outcome? Clin. Microbiol. Rev. 16: 415-429.
46. Braun, J. S., R. Novak, K. H. Herzog, S. M. Bodner, J. L. Cleveland, and E. I. Tuomanen. 1999. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat. Med. 5: 298-302.
47. Leib, S. L., J. M. Clements, R. L. P. Lindberg, C. Heimgartner, J. M. Loeffler, L. A. Pfister, M. G. Tauber, and D. Leppert. 2001. Inhibition of matrix metalIoproteinases and tumour necrosis factor α converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 124: 1734-1742.
48. Hoffmann, O., J. Priller, T. Prozorovski, U. Schulze-Topphoff, N. Baeva, J, D. Lunemann, O. Aktas, C. Mahrhofer, S. Stricker, F. Zipp, and J. R. Weber. 2007. TRAIL limits excessive host immune responses in bacterial meningitis. J. Clin. Invest. 117: 2004-2013.
49. Brandt, C. T., D. Holm, M. Liptrot, C. Ostergaard, J. D. Lundgren, N. Frimodt-Moller, I. C. Skovsted, and I. J. Rowland. 2008. Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis. J. Infect. Dis. 197: 235-244.
50. Wang, T., T. Town, L. Alexopoulou, J. F. Anderson, E. Fikrig. and R. A. Flavell. 2004. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 10: 1366-1373.