STING/MPYS mediates host defense against listeria monocytogenes infection by regulating Ly6Chi monocyte migration

Journal of Immunology

Volumn 190, Issue 6, 2013, Pages 2835-2843

  Jin, Lei ^a   Getahun, Andrew ^a   Knowles, Heather M ^a   Mogan, Jennifer ^a   Akerlund, Linda J ^a   Packard, Thomas A ^a   Perraud, Anne Laure ^a   Cambier, John C ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; INTERFERON; MEMBRANE PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PROTEIN MPYS; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOST PATHOGEN INTERACTION; IN VIVO STUDY; LISTERIA MONOCYTOGENES; LISTERIOSIS; LIVER; LY6CHI MONOCYTE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION;

ANIMALS; ANTIGENS, LY; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; LISTERIOSIS; LIVER; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MONOCYTES; SPLEEN;

EID: 84874892789     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201788     Document Type: Article

References (38)

1. Ramaswamy, V., V. M. Cresence, J. S. Rejitha, M. U. Lekshmi, K. S. Dharsana, S. P. Prasad, and H. M. Vijila. 2007. Listeria-review of epidemiology and pathogenesis. J. Microbiol. Immunol. Infect. 40: 4-13
2. Corr, S. C., and L. A. O'Neill. 2009. Listeria monocytogenes infection in the face of innate immunity. Cell. Microbiol. 11: 703-709
3. Rogers, H. W., and E. R. Unanue. 1993. Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect. Immun. 61: 5090-5096
4. Carr, K. D., A. N. Sieve, M. Indramohan, T. J. Break, S. Lee, and R. E. Berg. 2011. Specific depletion reveals a novel role for neutrophil-mediated protection in the liver during Listeria monocytogenes infection. Eur. J. Immunol. 41: 2666-2676
5. Shi, C., T. M. Hohl, I. Leiner, M. J. Equinda, X. Fan, and E. G. Pamer. 2011. Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection. J. Immunol. 187: 5293-5298
6. Shi, C., and E. G. Pamer. 2011. Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11: 762-774
7. Serbina, N. V., C. Shi, and E. G. Pamer. 2012. Monocyte-mediated immune defense against murine Listeria monocytogenes infection. Adv. Immunol. 113: 119-134
8. Jia, T., N. V. Serbina, K. Brandl, M. X. Zhong, I. M. Leiner, I. F. Charo, and E. G. Pamer. 2008. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J. Immunol. 180: 6846-6853
9. Serbina, N. V., and E. G. Pamer. 2006. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7: 311-317
10. Shi, C., P. Velázquez, T. M. Hohl, I. Leiner, M. L. Dustin, and E. G. Pamer. 2010. Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J. Immunol. 184: 6266-6274
11. Ishikawa, H., and G. N. Barber. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455: 674-678
12. Ishikawa, H., Z. Ma, and G. N. Barber. 2009. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461: 788-792
13. Jones, J. W., N. Kayagaki, P. Broz, T. Henry, K. Newton, K. O'Rourke, S. Chan, J. Dong, Y. Qu, M. Roose-Girma, et al. 2010. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc. Natl. Acad. Sci. USA 107: 9771-9776
14. Koppe, U., K. Högner, J. M. Doehn, H. C. Müller, M. Witzenrath, B. Gutbier, S. Bauer, T. Pribyl, S. Hammerschmidt, J. Lohmeyer, et al. 2012. Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs. J. Immunol. 188: 811-817
15. Sharma, S., R. B. DeOliveira, P. Kalantari, P. Parroche, N. Goutagny, Z. Jiang, J. Chan, D. C. Bartholomeu, F. Lauw, J. P. Hall, et al. 2011. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 35: 194-207
16. de Almeida, L. A., N. B. Carvalho, F. S. Oliveira, T. L. Lacerda, A. C. Vasconcelos, L. Nogueira, A. Bafica, A. M. Silva, and S. C. Oliveira. 2011. MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection. PLoS ONE 6: e23135
17. Prantner, D., T. Darville, and U. M. Nagarajan. 2010. Stimulator of IFN gene is critical for induction of IFN-βeta during Chlamydia muridarum infection. J. Immunol. 184: 2551-2560
18. Jin, L., K. K. Hill, H. Filak, J. Mogan, H. Knowles, B. Zhang, A. L. Perraud, J. C. Cambier, and L. L. Lenz. 2011. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J. Immunol. 187: 2595-2601
19. Jin, L., P. M. Waterman, K. R. Jonscher, C. M. Short, N. A. Reisdorph, and J. C. Cambier. 2008. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol. Cell. Biol. 28: 5014-5026
20. O'Connell, R. M., S. K. Saha, S. A. Vaidya, K. W. Bruhn, G. A. Miranda, B. Zarnegar, A. K. Perry, B. O. Nguyen, T. F. Lane, T. Taniguchi, et al. 2004. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J. Exp. Med. 200: 437-445
21. Carrero, J. A., B. Calderon, and E. R. Unanue. 2004. Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection. J. Exp. Med. 200: 535-540
22. Auerbuch, V., D. G. Brockstedt, N. Meyer-Morse, M. O'Riordan, and D. A. Portnoy. 2004. Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J. Exp. Med. 200: 527-533
23. Cousens, L. P., and E. J. Wing. 2000. Innate defenses in the liver during Listeria infection. Immunol. Rev. 174: 150-159
24. Chen, H., H. Sun, F. You, W. Sun, X. Zhou, L. Chen, J. Yang, Y. Wang, H. Tang, Y. Guan, et al. 2011. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 147: 436-446
25. Auffray, C., D. K. Fogg, E. Narni-Mancinelli, B. Senechal, C. Trouillet, N. Saederup, J. Leemput, K. Bigot, L. Campisi, M. Abitbol, et al. 2009. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J. Exp. Med. 206: 595-606
26. Dresing, P., S. Borkens, M. Kocur, S. Kropp, and S. Scheu. 2010. A fluorescence reporter model defines "Tip-DCs" as the cellular source of interferon b in murine listeriosis. PLoS ONE 5: e15567
27. Stockinger, S., R. Kastner, E. Kernbauer, A. Pilz, S. Westermayer, B. Reutterer, D. Soulat, G. Stengl, C. Vogl, T. Frenz, et al. 2009. Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog. 5: e1000355
28. Solodova, E., J. Jablonska, S. Weiss, and S. Lienenklaus. 2011. Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/ macrophage lineage. PLoS ONE 6: e18543
29. Herskovits, A. A., V. Auerbuch, and D. A. Portnoy. 2007. Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog. 3: e51
30. O'Riordan, M., C. H. Yi, R. Gonzales, K. D. Lee, and D. A. Portnoy. 2002. Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc. Natl. Acad. Sci. USA 99: 13861-13866
31. Woodward, J. J., A. T. Iavarone, and D. A. Portnoy. 2010. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328: 1703-1705
32. Stetson, D. B., and R. Medzhitov. 2006. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24: 93-103
33. Sauer, J. D., K. Sotelo-Troha, J. von Moltke, K. M. Monroe, C. S. Rae, S. W. Brubaker, M. Hyodo, Y. Hayakawa, J. J. Woodward, D. A. Portnoy, and R. E. Vance. 2011. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79: 688-694
34. Deshmane, S. L., S. Kremlev, S. Amini, and B. E. Sawaya. 2009. Monocyte chemoattractant protein-1 (MCP-1): an overview. J. Interferon Cytokine Res. 29: 313-326
35. Shi, C., T. Jia, S. Mendez-Ferrer, T. M. Hohl, N. V. Serbina, L. Lipuma, I. Leiner, M. O. Li, P. S. Frenette, and E. G. Pamer. 2011. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity 34: 590-601
36. Serbina, N. V., W. Kuziel, R. Flavell, S. Akira, B. Rollins, and E. G. Pamer. 2003. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. Immunity 19: 891-901
37. Van der Goes, A., D. Wouters, S. M. Van Der Pol, R. Huizinga, E. Ronken, P. Adamson, J. Greenwood, C. D. Dijkstra, and H. E. De Vries. 2001. Reactive oxygen species enhance the migration of monocytes across the blood-brain barrier in vitro. FASEB J. 15: 1852-1854
38. Jin, L., L. L. Lenz, and J. C. Cambier. 2010. Cellular reactive oxygen species inhibit MPYS induction of IFNβ. PLoS ONE 5: e15142