AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Blood

Volumn 125, Issue 13, 2015, Pages 2120-2130

  Sriskanthadevan, Shrivani ^a   Jeyaraju, Danny V ^a   Chung, Timothy E ^a   Prabha, Swayam ^a   Xu, Wei ^a   Skrtic, Marko ^a   Jhas, Bozhena ^a   Hurren, Rose ^a   Gronda, Marcela ^a   Wang, Xiaoming ^a   Jitkova, Yulia ^a   Sukhai, Mahadeo A ^a   Lin, Feng Hsu ^a   Maclean, Neil ^a   Laister, Rob ^a   Goard, Carolyn A ^a   Mullen, Peter J ^a   Xie, Stephanie ^a   Penn, Linda Z ^a   Rogers, Ian M ^b   Dick, John E ^a   Minden, Mark D ^a   Schimmer, Aaron D ^a   more..

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CITRININ; MITOCHONDRIAL DNA; OLIGOMYCIN; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; REACTIVE OXYGEN METABOLITE; ROTENONE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MYELOID LEUKEMIA CELL; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; FATTY ACID OXIDATION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; METABOLIC STRESS; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; TUMOR VOLUME; TUMOR XENOGRAFT; ACUTE MYELOBLASTIC LEUKEMIA; CELL RESPIRATION; METABOLISM; MITOCHONDRIAL VOLUME; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

CELL DEATH; CELL RESPIRATION; ELECTRON TRANSPORT; HUMANS; LEUKEMIA, MYELOID, ACUTE; MITOCHONDRIAL SIZE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 84926201780     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-08-594408     Document Type: Article

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