Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic

Biotechnology and Bioengineering

Volumn 108, Issue 6, 2011, Pages 1413-1420

  Zhang, Ning ^a   Palmer, Andre F ^b  

^a Ohio State University   (United States)

^b Koffolt Laboratories   (United States)

Author keywords

CD 163 receptor; Dichloroacetic acid; Hemoglobin; Macrophage; Monocyte; Targeted drug delivery

Indexed keywords

ANTICANCER DRUG; CANCER CELL LINES; CANCEROUS CELLS; CD-163 RECEPTOR; DICHLOROACETIC ACID; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOCYTE; TARGETED DRUG DELIVERY; TETRAMERS; WORK FOCUS;

BODY FLUIDS; CELL CULTURE; CELL MEMBRANES; DISEASES; DRUG DELIVERY; GROWTH KINETICS; MACROPHAGES; OLIGOMERS;

HEMOGLOBIN;

ANTINEOPLASTIC AGENT; DICHLOROACETIC ACID; DICHLOROACETIC ACID HEMOGLOBIN CONJUGATE; HAPTOGLOBIN; HEMOGLOBIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; MACROPHAGE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOCYTE; MONOCYTIC LEUKEMIA; NONHUMAN;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DICHLOROACETATE; DRUG DELIVERY SYSTEMS; HAPTOGLOBINS; HEMOGLOBIN A; HUMANS; MACROPHAGES; MONOCYTES; NEOPLASMS; PROTEIN BINDING;

EID: 79954536452     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23071     Document Type: Article

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