메뉴 건너뛰기




Volumn 280, Issue 2 43-2, 2001, Pages

A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle

Author keywords

Carnitine palmitoyltransferase I; Fibrates; Gene expression; Nuclear receptors; Peroxisome proliferator activated receptor

Indexed keywords

APOLIPOPROTEIN C; CARNITINE PALMITOYLTRANSFERASE; FENOFIBRIC ACID; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; UNCLASSIFIED DRUG; UREIDO FIBRATE 5; CARBANILAMIDE DERIVATIVE; CELL RECEPTOR; DRUG DERIVATIVE; FATTY ACID; FENOFIBRATE; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

EID: 0035024343     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.280.2.e270     Document Type: Article
Times cited : (181)

References (35)
  • 1
    • 0026443622 scopus 로고
    • Mechanism of hypertriglyceridemia in human apolipoprotein (Apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased Apo CIII and reduced Apo E on the particles
    • Aalto-Setälä K, Fisher EA, Chen X, Chajek-Shaul T, Hayek T, Zechner R, Walsh A, Ramakrishnan R, Ginsberg HN, and Breslow JL. Mechanism of hypertriglyceridemia in human apolipoprotein (Apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased Apo CIII and reduced Apo E on the particles. J Clin Invest 90: 1889-1900, 1992.
    • (1992) J Clin Invest , vol.90 , pp. 1889-1900
    • Aalto-Setälä, K.1    Fisher, E.A.2    Chen, X.3    Chajek-Shaul, T.4    Hayek, T.5    Zechner, R.6    Walsh, A.7    Ramakrishnan, R.8    Ginsberg, H.N.9    Breslow, J.L.10
  • 2
    • 0032508696 scopus 로고    scopus 로고
    • Fatty acids activate transcription of the muscle carnitine palmitoyltransferase i gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha
    • Brandt JM, Djouadi F, and Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 273: 23786-23792, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 23786-23792
    • Brandt, J.M.1    Djouadi, F.2    Kelly, D.P.3
  • 3
    • 0028904122 scopus 로고
    • Human liver mitochondrial carnitine palmitoyltransferase I: Characterization of its cDNA and chromosomal localization and partial analysis of the gene
    • Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, and Mcgarry JD. Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene. Proc Natl Acad Sci USA 92: 1984-1988, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1984-1988
    • Britton, C.H.1    Schultz, R.A.2    Zhang, B.3    Esser, V.4    Foster, D.W.5    Mcgarry, J.D.6
  • 5
    • 0030027709 scopus 로고    scopus 로고
    • Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes
    • Chatelain F, Kohl C, Esser V, Mcgarry JD, Girard J, and Pegorier JP. Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes. Eur J Biochem 235: 789-798, 1996.
    • (1996) Eur J Biochem , vol.235 , pp. 789-798
    • Chatelain, F.1    Kohl, C.2    Esser, V.3    Mcgarry, J.D.4    Girard, J.5    Pegorier, J.P.6
  • 7
    • 0027418315 scopus 로고
    • Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function
    • Esser V, Britton CH, Weis BC, Foster DW, and Mcgarry JD. Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function. J Biol Chem 268: 5817-5822, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 5817-5822
    • Esser, V.1    Britton, C.H.2    Weis, B.C.3    Foster, D.W.4    Mcgarry, J.D.5
  • 8
    • 0033548216 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene
    • Frohnert BI, Hui TY, and Bernlohr DA. Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene. J Biol Chem 274: 3970-3977, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 3970-3977
    • Frohnert, B.I.1    Hui, T.Y.2    Bernlohr, D.A.3
  • 9
    • 0030764696 scopus 로고    scopus 로고
    • Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism
    • Froyland L, Madsen L, Vaagenes H, Totland GK, Auwerx J, Kryvi H, Staels B, and Berge RK. Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism. J Lipid Res 38: 1851-1858, 1997.
    • (1997) J Lipid Res , vol.38 , pp. 1851-1858
    • Froyland, L.1    Madsen, L.2    Vaagenes, H.3    Totland, G.K.4    Auwerx, J.5    Kryvi, H.6    Staels, B.7    Berge, R.K.8
  • 10
    • 0028033268 scopus 로고
    • The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression
    • Gulick T, Cresci S, Caira T, Moore DD, and Kelly DP. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci USA 91: 11012-11016, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11012-11016
    • Gulick, T.1    Cresci, S.2    Caira, T.3    Moore, D.D.4    Kelly, D.P.5
  • 11
    • 0033520018 scopus 로고    scopus 로고
    • Elevated serum triglyceride levels and long-term mortality in patients with coronary heart disease: The Bezafibrate Infarction Prevention (BIP) registry
    • Haim M, Benderly M, Brunner D, Behar S, Graff E, Reicher-Reiss H, and Goldbourt U. Elevated serum triglyceride levels and long-term mortality in patients with coronary heart disease: the Bezafibrate Infarction Prevention (BIP) Registry. Circulation 100: 475-482, 1999.
    • (1999) Circulation , vol.100 , pp. 475-482
    • Haim, M.1    Benderly, M.2    Brunner, D.3    Behar, S.4    Graff, E.5    Reicher-Reiss, H.6    Goldbourt, U.7
  • 12
    • 0030917135 scopus 로고    scopus 로고
    • Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity
    • Hawke RL, Chapman JM, Winegar DA, Salisbury JA, Welch RM, Brown A, Franzmann KW, and Sigel C. Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity. J Lipid Res 38: 1189-1203, 1997.
    • (1997) J Lipid Res , vol.38 , pp. 1189-1203
    • Hawke, R.L.1    Chapman, J.M.2    Winegar, D.A.3    Salisbury, J.A.4    Welch, R.M.5    Brown, A.6    Franzmann, K.W.7    Sigel, C.8
  • 13
    • 0029838433 scopus 로고    scopus 로고
    • Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A meta-analysis of population-based prospective studies
    • Hokanson JE and Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 3: 213-219, 1996.
    • (1996) J Cardiovasc Risk , vol.3 , pp. 213-219
    • Hokanson, J.E.1    Austin, M.A.2
  • 14
    • 0032941350 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha: Role in rodent liver cancer and species differences
    • Holden PR and Tugwood JD. Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences. J Mol Endocrinol 22: 1-8, 1999.
    • (1999) J Mol Endocrinol , vol.22 , pp. 1-8
    • Holden, P.R.1    Tugwood, J.D.2
  • 15
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone superfamily by peroxisome proliferators
    • Issemann I and Green S. Activation of a member of the steroid hormone superfamily by peroxisome proliferators. Nature 347: 645-650, 1990.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 16
    • 0032171468 scopus 로고    scopus 로고
    • Lack of predictability of classical animal models for hypolipidemic activity: A good time for mice?
    • Krause BR and Princen HMG. Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice? Atherosclerosis 140: 15-24, 1998.
    • (1998) Atherosclerosis , vol.140 , pp. 15-24
    • Krause, B.R.1    Princen, H.M.G.2
  • 17
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee SST, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, and Gonzalez FJ. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15: 3012-3022, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 3012-3022
    • Lee, S.S.T.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 18
    • 0030658022 scopus 로고    scopus 로고
    • Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPAR alpha and PPAR gamma activators
    • Martin G, Schoonjans K, Lefebvre AM, Staels B, and Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPAR alpha and PPAR gamma activators. J Biol Chem 272: 28210-28217, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 28210-28217
    • Martin, G.1    Schoonjans, K.2    Lefebvre, A.M.3    Staels, B.4    Auwerx, J.5
  • 19
    • 0032502704 scopus 로고    scopus 로고
    • Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
    • Mascaro C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG, and Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 273: 8560-8563, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 8560-8563
    • Mascaro, C.1    Acosta, E.2    Ortiz, J.A.3    Marrero, P.F.4    Hegardt, F.G.5    Haro, D.6
  • 20
    • 0023155640 scopus 로고
    • Complementation analysis of fatty acid oxidation disorders
    • Moon A and Rhead WJ. Complementation analysis of fatty acid oxidation disorders. J Clin Invest 79: 59-64, 1987.
    • (1987) J Clin Invest , vol.79 , pp. 59-64
    • Moon, A.1    Rhead, W.J.2
  • 21
    • 0027959552 scopus 로고
    • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators
    • Mukherjee R, Jow L, Noonan D, and McDonnell DP. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51: 157-166, 1994.
    • (1994) J Steroid Biochem Mol Biol , vol.51 , pp. 157-166
    • Mukherjee, R.1    Jow, L.2    Noonan, D.3    McDonnell, D.P.4
  • 22
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
    • Peters JM, Hennuyer N, Staels B, Fruchart JC, Fievet C, Gonzalez FJ, and Auwerx J. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 272: 27307-27312, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 27307-27312
    • Peters, J.M.1    Hennuyer, N.2    Staels, B.3    Fruchart, J.C.4    Fievet, C.5    Gonzalez, F.J.6    Auwerx, J.7
  • 24
    • 0028276397 scopus 로고
    • Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
    • Rodriguez JC, Gil-Gomez G, Hegardt FG, and Haro D. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J Biol Chem 269: 18767-18772, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 18767-18772
    • Rodriguez, J.C.1    Gil-Gomez, G.2    Hegardt, F.G.3    Haro, D.4
  • 25
    • 0029144018 scopus 로고
    • Induction of the acyl-coenzyme A synthetase gene by flbrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
    • Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, and Auwerx J. Induction of the acyl-coenzyme A synthetase gene by flbrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 270: 19269-19276, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 19269-19276
    • Schoonjans, K.1    Watanabe, M.2    Suzuki, H.3    Mahfoudi, A.4    Krey, G.5    Wahli, W.6    Grimaldi, P.7    Staels, B.8    Yamamoto, T.9    Auwerx, J.10
  • 26
    • 0025950963 scopus 로고
    • Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway
    • Sehayek E and Eisenberg S. Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem 266: 18259-18267, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 18259-18267
    • Sehayek, E.1    Eisenberg, S.2
  • 28
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
    • Staels B, Vu-Dac N, Kosykh VA, Saladin R, Fruchart JC, Dallongeville J, and Auwerx J. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J Clin Invest 95: 705-712, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 705-712
    • Staels, B.1    Vu-Dac, N.2    Kosykh, V.A.3    Saladin, R.4    Fruchart, J.C.5    Dallongeville, J.6    Auwerx, J.7
  • 30
    • 0029119082 scopus 로고
    • Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
    • Vu-Dac N, Schoonjans K, Kosykh V, Dallongeville J, Fruchart JC, Staels B, and Auwerx J. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest 96: 741-750, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 741-750
    • Vu-Dac, N.1    Schoonjans, K.2    Kosykh, V.3    Dallongeville, J.4    Fruchart, J.C.5    Staels, B.6    Auwerx, J.7
  • 31
    • 0030451011 scopus 로고    scopus 로고
    • Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens
    • Williams GM and Perrone C. Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens. Ann NY Acad Sci 804: 554-572, 1996.
    • (1996) Ann NY Acad Sci , vol.804 , pp. 554-572
    • Williams, G.M.1    Perrone, C.2
  • 32
    • 0019138139 scopus 로고
    • Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins
    • Windler E, Chao Y, and Havel RJ. Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins. J Biol Chem 255: 8303-8307, 1980.
    • (1980) J Biol Chem , vol.255 , pp. 8303-8307
    • Windler, E.1    Chao, Y.2    Havel, R.J.3
  • 33
    • 0028902957 scopus 로고
    • High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: Isolation and characterization of its cDNA clone
    • Yamazaki N, Shinohara Y, Shima A, and Terada H. High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: isolation and characterization of its cDNA clone. FEBS Lett 363: 41-45, 1995.
    • (1995) FEBS Lett , vol.363 , pp. 41-45
    • Yamazaki, N.1    Shinohara, Y.2    Shima, A.3    Terada, H.4
  • 34
    • 0029954776 scopus 로고    scopus 로고
    • Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I
    • Yamazaki N, Shinohara Y, Shima A, Yamanaka Y, and Terada H. Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I. Biochim Biophys Acta 1307: 157-161, 1996.
    • (1996) Biochim Biophys Acta , vol.1307 , pp. 157-161
    • Yamazaki, N.1    Shinohara, Y.2    Shima, A.3    Yamanaka, Y.4    Terada, H.5
  • 35
    • 0032484002 scopus 로고    scopus 로고
    • Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase I beta gene promoters by fatty acid enzyme substrate
    • Yu GS, Lu YC, and Gulick T. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase I beta gene promoters by fatty acid enzyme substrate. J Biol Chem 273: 32901-32909, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 32901-32909
    • Yu, G.S.1    Lu, Y.C.2    Gulick, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.