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Angewandte Chemie - International Edition

Volumn 53, Issue 12, 2014, Pages 3259-3263

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry

(8) Mondal, Milon a Radeva, Nedyalka b Köster, Helene b Park, Ahyoung b Potamitis, Constantinos c Zervou, Maria c Klebe, Gerhard b Hirsch, Anna K H a

a UNIVERSITY OF GRONINGEN (Netherlands)

b PHILIPPS UNIVERSITY MARBURG (Germany)

c INSTITUTE OF BIOLOGY (Greece)

Author keywords

dynamic combinatorial chemistry; enzyme inhibitors; STD NMR spectroscopy; structure based design; X ray diffraction

Indexed keywords

BINDING ENERGY; BIOASSAY; BIOCHIPS; DESIGN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTIMIZATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

BIOLOGICAL TARGETS; COCRYSTALLIZATION; DYNAMIC COMBINATORIAL CHEMISTRY; DYNAMIC COMBINATORIAL LIBRARY; ENZYME INHIBITORS; POTENTIAL INHIBITORS; SATURATION-TRANSFER DIFFERENCES; STRUCTURE-BASED DESIGNS;

BINDERS;

ASPARTIC ACID ENDOPEPTIDASES; ENDOTHIA ASPARTIC PROTEINASE;

CHEMICAL SYNTHESIS; CHEMISTRY; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; INSTRUMENTATION; MAGNETIC RESONANCE SPECTROSCOPY; METHODS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

ASPARTIC ACID ENDOPEPTIDASES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

EID: 84896340386 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201309682 Document Type: Article

Times cited : (64)

References (46)

1
- 33846699703
- J.-M. Lehn, Chem. Soc. Rev. 2007, 36, 151-160
- (2007) Chem. Soc. Rev. , vol.36 , pp. 151-160
- Lehn, J.-M.¹

2
- 33750002664
- P. T. Corbett, J. Leclaire, L. Vial, K. R. West, J. Wietor, J. K. M. Sanders, S. Otto, Chem. Rev. 2006, 106, 3652-3711
- (2006) Chem. Rev. , vol.106 , pp. 3652-3711
- Corbett, P.T.¹ Leclaire, J.² Vial, L.³ West, K.R.⁴ Wietor, J.⁵ Sanders, J.K.M.⁶ Otto, S.⁷

3
- 84879518538
- J. Li, P. Nowak, S. Otto, J. Am. Chem. Soc. 2013, 135, 9222-9239.
- (2013) J. Am. Chem. Soc. , vol.135 , pp. 9222-9239
- Li, J.¹ Nowak, P.² Otto, S.³

4
- 84864446995
- O. Ofori, J. Hoskins, M. Nakamori, C. A. Thornton, B. L. Miller, Nucleic Acids Res. 2012, 40, 6380-6390
- (2012) Nucleic Acids Res. , vol.40 , pp. 6380-6390
- Ofori, O.¹ Hoskins, J.² Nakamori, M.³ Thornton, C.A.⁴ Miller, B.L.⁵

5
- 84876225691
- M. Demetriades, I. K. H. Leung, R. Chowdhury, M. C. Chan, M. A. McDonough, K. K. Yeoh, Y. Tian, T. D. W. Claridge, P. J. Ratcliffe, E. C. Y. Woon, C. J. Schofield, Angew. Chem. 2012, 124, 6776-6779
- (2012) Angew. Chem. , vol.124 , pp. 6776-6779
- Demetriades, M.¹ Leung, I.K.H.² Chowdhury, R.³ Chan, M.C.⁴ McDonough, M.A.⁵ Yeoh, K.K.⁶ Tian, Y.⁷ Claridge, T.D.W.⁸ Ratcliffe, P.J.⁹ Woon, E.C.Y.¹⁰ Schofield, C.J.¹¹

6
- 84863208034
- Angew. Chem. Int. Ed. 2012, 51, 6672-6675
- (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 6672-6675

7
- 77952816232
- V. T. Bhat, A. M. Caniard, T. Luksch, R. Brenk, D. J. Campopiano, M. F. Greaney, Nat. Chem. 2010, 2, 490-497
- (2010) Nat. Chem. , vol.2 , pp. 490-497
- Bhat, V.T.¹ Caniard, A.M.² Luksch, T.³ Brenk, R.⁴ Campopiano, D.J.⁵ Greaney, M.F.⁶

8
- 37849008804
- S. Ladame, Org. Biomol. Chem. 2008, 6, 219-226
- (2008) Org. Biomol. Chem. , vol.6 , pp. 219-226
- Ladame, S.¹

9
- 0036047069
- O. Ramström, J.-M. Lehn, Nat. Rev. Drug Discovery 2002, 1, 26-36.
- (2002) Nat. Rev. Drug Discovery , vol.1 , pp. 26-36
- Ramström, O.¹ Lehn, J.-M.²

10
- 82455212567
- J. Angulo, P. M. Nieto, Eur. Biophys. J. 2011, 40, 1357-1369
- (2011) Eur. Biophys. J. , vol.40 , pp. 1357-1369
- Angulo, J.¹ Nieto, P.M.²

11
- 12444289530
- B. Claasen, M. Axmann, R. Meinecke, B. Meyer, J. Am. Chem. Soc. 2005, 127, 916-919
- (2005) J. Am. Chem. Soc. , vol.127 , pp. 916-919
- Claasen, B.¹ Axmann, M.² Meinecke, R.³ Meyer, B.⁴

12
- 53849124992
- S. Di Micco, C. Bassarello, G. Bifulco, R. Riccio, L. Gomez-Paloma, Angew. Chem. 2006, 118, 230-234
- (2006) Angew. Chem. , vol.118 , pp. 230-234
- Di Micco, S.¹ Bassarello, C.² Bifulco, G.³ Riccio, R.⁴ Gomez-Paloma, L.⁵

13
- 29544434772
- Angew. Chem. Int. Ed. 2006, 45, 224-228
- (2006) Angew. Chem. Int. Ed. , vol.45 , pp. 224-228

14
- 67049171200
- T. Diercks, J. P. Ribeiro, F. J. Canada, S. Andre, J. Jimenez-Barbero, H. Gabius, Chem. Eur. J. 2009, 15, 5666-5668
- (2009) Chem. Eur. J. , vol.15 , pp. 5666-5668
- Diercks, T.¹ Ribeiro, J.P.² Canada, F.J.³ Andre, S.⁴ Jimenez-Barbero, J.⁵ Gabius, H.⁶

15
- 24744462802
- S. Mari, D. Serrano-Gomez, F. J. Canada, A. L. Corbi, J. Jimenez-Barbera, Angew. Chem. 2005, 117, 300-302
- (2005) Angew. Chem. , vol.117 , pp. 300-302
- Mari, S.¹ Serrano-Gomez, D.² Canada, F.J.³ Corbi, A.L.⁴ Jimenez-Barbera, J.⁵

16
- 33748348952
- Angew. Chem. Int. Ed. 2005, 44, 296-298
- (2005) Angew. Chem. Int. Ed. , vol.44 , pp. 296-298

17
- 0346996643
- B. Meyer, T. Peters, Angew. Chem. 2003, 115, 890-918
- (2003) Angew. Chem. , vol.115 , pp. 890-918
- Meyer, B.¹ Peters, T.²

18
- 0037463033
- Angew. Chem. Int. Ed. 2003, 42, 864-890.
- (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 864-890

19
- 77955143737
- R. Caraballo, H. Dong, J. P. Ribeiro, J. Jimenez-Barbero, O. Ramström, Angew. Chem. 2010, 122, 599-603
- (2010) Angew. Chem. , vol.122 , pp. 599-603
- Caraballo, R.¹ Dong, H.² Ribeiro, J.P.³ Jimenez-Barbero, J.⁴ Ramström, O.⁵

20
- 74549200492
- Angew. Chem. Int. Ed. 2010, 49, 589-593.
- (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 589-593

21
- 84872298537
- A. Kondaskar, S. Kondaskar, J. C. Fishbein, B. A. Carter-Cooper, R. G. Lapidus, M. Sadowska, M. J. Edelman, R. S. Hosmane, Bioorg. Med. Chem. 2013, 21, 618-631
- (2013) Bioorg. Med. Chem. , vol.21 , pp. 618-631
- Kondaskar, A.¹ Kondaskar, S.² Fishbein, J.C.³ Carter-Cooper, B.A.⁴ Lapidus, R.G.⁵ Sadowska, M.⁶ Edelman, M.J.⁷ Hosmane, R.S.⁸

22
- 80052858265
- S. Kalyaanamoorthy, Y. P. Chen, Drug Discovery Today 2011, 16, 831-839
- (2011) Drug Discovery Today , vol.16 , pp. 831-839
- Kalyaanamoorthy, S.¹ Chen, Y.P.²

23
- 23844449940
- G. Schneider, U. Fechner, Nat. Rev. Drug Discovery 2005, 4, 649-663.
- (2005) Nat. Rev. Drug Discovery , vol.4 , pp. 649-663
- Schneider, G.¹ Fechner, U.²

24
- 34547925743
- A. K. H. Hirsch, S. Lauw, P. Gersbach, W. B. Schweizer, F. Rohdich, W. Eisenreich, A. Bacher, F. Diederich, ChemMedChem 2007, 2, 806-810
- (2007) ChemMedChem , vol.2 , pp. 806-810
- Hirsch, A.K.H.¹ Lauw, S.² Gersbach, P.³ Schweizer, W.B.⁴ Rohdich, F.⁵ Eisenreich, W.⁶ Bacher, A.⁷ Diederich, F.⁸

25
- 69949084535
- S. Ni, Y. Yuan, J. Huang, X. Mao, M. Lv, J. Zhu, X. Shen, J. Pei, L. Lai, H. Jiang, J. Li, J. Med. Chem. 2009, 52, 5295-5298.
- (2009) J. Med. Chem. , vol.52 , pp. 5295-5298
- Ni, S.¹ Yuan, Y.² Huang, J.³ Mao, X.⁴ Lv, M.⁵ Zhu, J.⁶ Shen, X.⁷ Pei, J.⁸ Lai, L.⁹ Jiang, H.¹⁰ Li, J.¹¹

26
- 0036218648
- J. B. Cooper, Curr. Drug Targets 2002, 3, 155-173.
- (2002) Curr. Drug Targets , vol.3 , pp. 155-173
- Cooper, J.B.¹

27
- 33748535416
- L. Coates, P. T. Erskine, S. Mall, R. Gill, S. P. Wood, D. A. A. Myles, J. B. Cooper, Eur. Biophys. J. 2006, 35, 559-566
- (2006) Eur. Biophys. J. , vol.35 , pp. 559-566
- Coates, L.¹ Erskine, P.T.² Mall, S.³ Gill, R.⁴ Wood, S.P.⁵ Myles, D.A.A.⁶ Cooper, J.B.⁷

28
- 0035818441
- L. Coates, P. T. Erskine, S. P. Wood, D. A. A. Myles, J. B. Cooper, Biochemistry 2001, 40, 13149-13157
- (2001) Biochemistry , vol.40 , pp. 13149-13157
- Coates, L.¹ Erskine, P.T.² Wood, S.P.³ Myles, D.A.A.⁴ Cooper, J.B.⁵

29
- 44949239669
- L. Coates, H. Tuan, S. Tomanicek, A. Kovalevsky, M. Mustyakimov, P. Erskine, J. Cooper, J. Am. Chem. Soc. 2008, 130, 7235-7237.
- (2008) J. Am. Chem. Soc. , vol.130 , pp. 7235-7237
- Coates, L.¹ Tuan, H.² Tomanicek, S.³ Kovalevsky, A.⁴ Mustyakimov, M.⁵ Erskine, P.⁶ Cooper, J.⁷

30
- 0026699837
- J. Cooper, W. Quail, C. Frazao, S. I. Foundling, T. L. Blundell, C. Humblet, E. A. Lunney, W. T. Lowther, B. M. Dunn, Biochemistry 1992, 31, 8142-8150.
- (1992) Biochemistry , vol.31 , pp. 8142-8150
- Cooper, J.¹ Quail, W.² Frazao, C.³ Foundling, S.I.⁴ Blundell, T.L.⁵ Humblet, C.⁶ Lunney, E.A.⁷ Lowther, W.T.⁸ Dunn, B.M.⁹

31
- 37848998796
- S. Geschwindner, L. Olsson, J. S. Albert, J. Deinum, P. D. Edwards, T. de Beer, R. H. A. Folmer, J. Med. Chem. 2007, 50, 5903-5911.
- (2007) J. Med. Chem. , vol.50 , pp. 5903-5911
- Geschwindner, S.¹ Olsson, L.² Albert, J.S.³ Deinum, J.⁴ Edwards, P.D.⁵ De Beer, T.⁶ Folmer, R.H.A.⁷

32
- 0033592059
- G. R. L. Cousins, S. A. Poulsen, J. K. M. Sanders, Chem. Commun. 1999, 1575-1576.
- (1999) Chem. Commun. , pp. 1575-1576
- Cousins, G.R.L.¹ Poulsen, S.A.² Sanders, J.K.M.³

33
- 84873888803
- M. Sindelar, T. A. Lutz, M. Petrera, K. T. Wanner, J. Med. Chem. 2013, 56, 1323-1340
- (2013) J. Med. Chem. , vol.56 , pp. 1323-1340
- Sindelar, M.¹ Lutz, T.A.² Petrera, M.³ Wanner, K.T.⁴

34
- 0037133560
- M. Hochgürtel, H. Kroth, D. Piecha, M. W. Hofmann, C. Nicolau, S. Krause, O. Schaaf, G. Sonnenmoser, A. V. Eliseev, Proc. Natl. Acad. Sci. USA 2002, 99, 3382-3387
- (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3382-3387
- Hochgürtel, M.¹ Kroth, H.² Piecha, D.³ Hofmann, M.W.⁴ Nicolau, C.⁵ Krause, S.⁶ Schaaf, O.⁷ Sonnenmoser, G.⁸ Eliseev, A.V.⁹

35
- 0346996358
- T. Bunyapaiboonsri, H. Ramström, O. Ramström, J. Haiech, J.-M. Lehn, J. Med. Chem. 2003, 46, 5803-5811.
- (2003) J. Med. Chem. , vol.46 , pp. 5803-5811
- Bunyapaiboonsri, T.¹ Ramström, H.² Ramström, O.³ Haiech, J.⁴ Lehn, J.-M.⁵

36
- 33845461876
- A. Dirksen, S. Dirksen, T. M. Hackeng, P. E. Dawson, J. Am. Chem. Soc. 2006, 128, 15602-15603.
- (2006) J. Am. Chem. Soc. , vol.128 , pp. 15602-15603
- Dirksen, A.¹ Dirksen, S.² Hackeng, T.M.³ Dawson, P.E.⁴

37
- 81555228214
- H. Köster, T. Craan, S. Brass, C. Herhaus, M. Zentgraf, L. Neumann, A. Heine, G. Klebe, J. Med. Chem. 2011, 54, 7784-7796.
- (2011) J. Med. Chem. , vol.54 , pp. 7784-7796
- Köster, H.¹ Craan, T.² Brass, S.³ Herhaus, C.⁴ Zentgraf, M.⁵ Neumann, L.⁶ Heine, A.⁷ Klebe, G.⁸

38
- 0029315603
- P. R. Gerber, K. Müller, J. Comput.-Aided Mol. Des. 1995, 9, 251-268.
- (1995) J. Comput.-Aided Mol. Des. , vol.9 , pp. 251-268
- Gerber, P.R.¹ Müller, K.²

39
- 84896332112
- BioSolveIT GmbH, Sankt Augustin. LeadIT, version 2.1.3
- BioSolveIT GmbH, Sankt Augustin. http://www.biosolveit.de, LeadIT, version 2.1.3.

40
- 0033668689
- H. Gohlke, M. Hendlich, G. Klebe, Perspect. Drug Discovery Des. 2000, 20, 115-144.
- (2000) Perspect. Drug Discovery Des. , vol.20 , pp. 115-144
- Gohlke, H.¹ Hendlich, M.² Klebe, G.³

41
- 79961064173
- Y. Perez-Fuertes, J. E. Taylor, D. A. Tickell, M. F. Mahon, S. D. Bull, T. D. James, J. Org. Chem. 2011, 76, 6038-6047.
- (2011) J. Org. Chem. , vol.76 , pp. 6038-6047
- Perez-Fuertes, Y.¹ Taylor, J.E.² Tickell, D.A.³ Mahon, M.F.⁴ Bull, S.D.⁵ James, T.D.⁶

42
- 24944518599
- C. Godoy-Alcantar, A. K. Yatsimirsky, J.-M. Lehn, J. Phys. Org. Chem. 2005, 18, 979-985.
- (2005) J. Phys. Org. Chem. , vol.18 , pp. 979-985
- Godoy-Alcantar, C.¹ Yatsimirsky, A.K.² Lehn, J.-M.³

43
- 0025663423
- M. V. Toth, G. R. Marshall, Int. J. Pept. Protein Res. 1990, 36, 544-550.
- (1990) Int. J. Pept. Protein Res. , vol.36 , pp. 544-550
- Toth, M.V.¹ Marshall, G.R.²

44
- 0035527674
- H. C. Cheng, J. Pharmacol. Toxicol. Methods 2001, 46, 61-71.
- (2001) J. Pharmacol. Toxicol. Methods , vol.46 , pp. 61-71
- Cheng, H.C.¹

45
- 85135598922
- Aided Mol. Des. 2012, 701- 723
- N. Schneider, S. Hindle, G. Lange, R. Klein, J. Albrecht, H. Briem, K. Beyer, H. Claussen, M. Gastreich, C. Lemmen, M. Rarey, J. Comput. -Aided Mol. Des. 2012, 26, 701- 723
- J. Comput. , pp. 26
- Schneider, N.¹ Hindle, S.² Lange, G.³ Klein, R.⁴ Albrecht, J.⁵ Briem, H.⁶ Beyer, K.⁷ Claussen, H.⁸ Gastreich, M.⁹ Lemmen, C.¹⁰ Rarey, M.¹¹

46
- 48149114539
- I. Reulecke, G. Lange, J. Albrecht, R. Klein, M. Rarey, ChemMedChem 2008, 3, 885-897.
- (2008) ChemMedChem , vol.3 , pp. 885-897
- Reulecke, I.¹ Lange, G.² Albrecht, J.³ Klein, R.⁴ Rarey, M.⁵

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