Beyond affinity: Enthalpy-entropy factorization unravels complexity of a flat structure-activity relationship for inhibition of a tRNA-modifying enzyme

Journal of Medicinal Chemistry

Volumn 57, Issue 13, 2014, Pages 5566-5578

  Neeb, Manuel ^a   Betz, Michael ^a   Heine, Andreas ^a   Barandun, Luzi Jakob ^b   Hohn, Christoph ^b   Diederich, François ^b   Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLTRANSFERASE; GUANINE; PURINE DERIVATIVE; TRANSFER RNA;

ADAPTATION; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENTHALPY; ENTROPY; INHIBITION KINETICS; NONHUMAN; RNA CONFORMATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; ZYMOMONAS MOBILIS;

BENZIMIDAZOLES; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENTROPY; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PENTOSYLTRANSFERASES; PROTEIN BINDING; PROTEIN CONFORMATION; QUINAZOLINONES; RNA, TRANSFER; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84904330219     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5006868     Document Type: Article

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