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Angewandte Chemie - International Edition

Volumn 52, Issue 6, 2013, Pages 1822-1828

Dissecting the hydrophobic effect on the molecular level: The role of water, enthalpy, and entropy in ligand binding to thermolysin

(6) Biela, Adam a Nasief, Nader N b Betz, Michael a Heine, Andreas a Hangauer, David b Klebe, Gerhard a

a PHILIPPS UNIVERSITY MARBURG (Germany)

b UNIVERSITY AT BUFFALO (United States)

Author keywords

crystal structure analysis; enthalpy entropy compensation; hydrophobic effect; protein ligand interactions; water solvation

Indexed keywords

CRYSTAL STRUCTURE ANALYSIS; ENTHALPY-ENTROPY COMPENSATION; HYDROPHOBIC EFFECT; HYDROPHOBIC GROUPS; LIGAND BINDING; MODEL SYSTEM; MOLECULAR LEVELS; PROTEIN-LIGAND INTERACTIONS; ROLE OF WATER; STRUCTURAL CHANGE; THERMOLYSIN; WATER MOLECULE;

ENTHALPY; ENTROPY; LIGANDS; MOLECULES; THERMODYNAMICS;

HYDROPHOBICITY;

LIGAND; THERMOLYSIN; WATER;

ARTICLE; BINDING SITE; CHEMICAL PHENOMENA; CHEMISTRY; ENTROPY; HYDROGEN BOND; METABOLISM; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENTROPY; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; PROTEIN STRUCTURE, TERTIARY; THERMOLYSIN; WATER;

EID: 84873351927 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201208561 Document Type: Article

Times cited : (121)

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