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Angewandte Chemie - International Edition

Volumn 53, Issue 9, 2014, Pages 2489-2493

Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction

(6) Glas, Adrian a Bier, David a Hahne, Gernot a Rademacher, Christoph b Ottmann, Christian c Grossmann, Tom N a,d

a CHEMICAL GENOMICS CENTRE OF THE MAX PLANCK SOCIETY (Germany)

b MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES (Germany)

c EINDHOVEN UNIVERSITY OF TECHNOLOGY (Netherlands)

d TU DORTMUND UNIVERSITY (Germany)

Author keywords

cyclic peptides; hydrophobic cross links; protein protein interactions; Pseudomonas aeruginosa; ring closing metathesis

Indexed keywords

BACTERIAL TOXIN; CYCLOPEPTIDE; EXOENZYME S; MACROCYCLIC COMPOUND; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN 14 3 3;

AMINO ACID SEQUENCE; ARTICLE; CALORIMETRY; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIC PEPTIDES; DRUG EFFECT; HUMAN; HYDROPHOBIC CROSS-LINKS; METABOLISM; MICROBIOLOGY; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN-PROTEIN INTERACTIONS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RING-CLOSING METATHESIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CYCLIC PEPTIDES; HYDROPHOBIC CROSS-LINKS; PROTEIN-PROTEIN INTERACTIONS; PSEUDOMONAS AERUGINOSA; RING-CLOSING METATHESIS;

14-3-3 PROTEINS; ADP RIBOSE TRANSFERASES; AMINO ACID SEQUENCE; BACTERIAL TOXINS; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN INTERACTION MAPS; PROTEIN STRUCTURE, SECONDARY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; THERMODYNAMICS;

EID: 84894431432 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201310082 Document Type: Article

Times cited : (116)

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