메뉴 건너뛰기




Volumn 28, Issue 2, 2014, Pages 56-69

Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis

Author keywords

Aspergillus; Calcineurin; Candida; Cell wall; Fungi; Septum; Virulence

Indexed keywords

ASPERGILLUS; CANDIDA; FUNGI;

EID: 84926026219     PISSN: 17494613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fbr.2014.02.004     Document Type: Review
Times cited : (101)

References (136)
  • 2
    • 0033651444 scopus 로고    scopus 로고
    • Calcineurin: from structure to function
    • Academic Press, R.S. Earl, P.B. Chock (Eds.)
    • Aramburu J., Rao A., Klee C.B. Calcineurin: from structure to function. Current Topics in Cellular Regulation 2001, 237-295. Academic Press. R.S. Earl, P.B. Chock (Eds.).
    • (2001) Current Topics in Cellular Regulation , pp. 237-295
    • Aramburu, J.1    Rao, A.2    Klee, C.B.3
  • 3
    • 33745625877 scopus 로고    scopus 로고
    • Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
    • Bader T., Schröppel K., Bentink S., Agabian N., Köhler G., Morschhäuser J. Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infect. Immun. 2006, 74:4366-4369.
    • (2006) Infect. Immun. , vol.74 , pp. 4366-4369
    • Bader, T.1    Schröppel, K.2    Bentink, S.3    Agabian, N.4    Köhler, G.5    Morschhäuser, J.6
  • 5
    • 23944511215 scopus 로고    scopus 로고
    • Calcineurin is required for Candida albicans to survive calcium stress in serum
    • Blankenship J.R., Heitman J. Calcineurin is required for Candida albicans to survive calcium stress in serum. Infect. Immun. 2005, 73:5767-5774.
    • (2005) Infect. Immun. , vol.73 , pp. 5767-5774
    • Blankenship, J.R.1    Heitman, J.2
  • 7
    • 84872366918 scopus 로고    scopus 로고
    • The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner
    • Bodvard K., Jörhov A., Blomberg A., Molin M., Käll M. The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner. PLoS One 2013, 8:e53404.
    • (2013) PLoS One , vol.8 , pp. e53404
    • Bodvard, K.1    Jörhov, A.2    Blomberg, A.3    Molin, M.4    Käll, M.5
  • 8
    • 0037093384 scopus 로고    scopus 로고
    • Essential role of calcineurin in response to endoplasmic reticulum stress
    • Bonilla M., Nastase K.K., Cunningham K.W. Essential role of calcineurin in response to endoplasmic reticulum stress. EMBO J. 2002, 21:2343-2353.
    • (2002) EMBO J. , vol.21 , pp. 2343-2353
    • Bonilla, M.1    Nastase, K.K.2    Cunningham, K.W.3
  • 10
    • 84874393358 scopus 로고    scopus 로고
    • The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast
    • Cadou A., Couturier A., Le Goff C., Xie L., Paulson J.R., Le Goff X. The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast. Biol. Cell 2013, 105:129-148.
    • (2013) Biol. Cell , vol.105 , pp. 129-148
    • Cadou, A.1    Couturier, A.2    Le Goff, C.3    Xie, L.4    Paulson, J.R.5    Le Goff, X.6
  • 11
    • 52949098296 scopus 로고    scopus 로고
    • Frequency-modulated nuclear localization bursts coordinate gene regulation
    • Cai L., Dalal C.K., Elowitz M.B. Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature 2008, 455:485-490.
    • (2008) Nature , vol.455 , pp. 485-490
    • Cai, L.1    Dalal, C.K.2    Elowitz, M.B.3
  • 12
    • 78651344488 scopus 로고    scopus 로고
    • Response to environmental stresses, cell-wall integrity, and virulence are orchestrated through the calcineurin pathway in Ustilago hordei
    • Cervantes-Chávez J.A., Ali S., Bakkeren G. Response to environmental stresses, cell-wall integrity, and virulence are orchestrated through the calcineurin pathway in Ustilago hordei. Mol. Plant-Microbe Interact. 2010, 24:219-232.
    • (2010) Mol. Plant-Microbe Interact. , vol.24 , pp. 219-232
    • Cervantes-Chávez, J.A.1    Ali, S.2    Bakkeren, G.3
  • 17
    • 0036678476 scopus 로고    scopus 로고
    • Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function
    • Cheng H., Sugiura R., Wu W., Fujita M., Lu Y., Sio S.O., Kawai R., Takegawa K., Shuntoh H., Kuno T. Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. Mol. Biol. Cell 2002, 13:2963-2976.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2963-2976
    • Cheng, H.1    Sugiura, R.2    Wu, W.3    Fujita, M.4    Lu, Y.5    Sio, S.O.6    Kawai, R.7    Takegawa, K.8    Shuntoh, H.9    Kuno, T.10
  • 18
    • 60649084357 scopus 로고    scopus 로고
    • MoCRZ1, a gene encoding a calcineurin-responsive transcription factor, regulates fungal growth and pathogenicity of Magnaporthe oryzae
    • Choi J., Kim Y., Kim S., Park J., Lee Y.-H. MoCRZ1, a gene encoding a calcineurin-responsive transcription factor, regulates fungal growth and pathogenicity of Magnaporthe oryzae. Fungal Genet. Biol. 2009, 46:243-254.
    • (2009) Fungal Genet. Biol. , vol.46 , pp. 243-254
    • Choi, J.1    Kim, Y.2    Kim, S.3    Park, J.4    Lee, Y.-H.5
  • 19
    • 60649118958 scopus 로고    scopus 로고
    • Functional analysis of MCNA, a gene encoding a catalytic subunit of calcineurin, in the rice blast fungus Magnaporthe oryzae
    • Choi J.H., Kim Y., Lee Y.-H. Functional analysis of MCNA, a gene encoding a catalytic subunit of calcineurin, in the rice blast fungus Magnaporthe oryzae. J. Microbiol. Biotechnol. 2009, 19:11-16.
    • (2009) J. Microbiol. Biotechnol. , vol.19 , pp. 11-16
    • Choi, J.H.1    Kim, Y.2    Lee, Y.-H.3
  • 21
    • 25844530060 scopus 로고    scopus 로고
    • Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
    • Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005, 309:2185-2189.
    • (2005) Science , vol.309 , pp. 2185-2189
    • Cowen, L.E.1    Lindquist, S.2
  • 23
    • 47049090269 scopus 로고    scopus 로고
    • Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance
    • Cowen L.E., Steinbach W.J. Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot. Cell 2008, 7:747-764.
    • (2008) Eukaryot. Cell , vol.7 , pp. 747-764
    • Cowen, L.E.1    Steinbach, W.J.2
  • 25
    • 0035282771 scopus 로고    scopus 로고
    • Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans
    • Cruz M.C., Fox D.S., Heitman J. Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J. 2001, 20:1020-1032.
    • (2001) EMBO J. , vol.20 , pp. 1020-1032
    • Cruz, M.C.1    Fox, D.S.2    Heitman, J.3
  • 27
    • 0242355632 scopus 로고    scopus 로고
    • Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress
    • Cyert M.S. Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress. Biochem. Biophys. Res. Commun. 2003, 311:1143-1150.
    • (2003) Biochem. Biophys. Res. Commun. , vol.311 , pp. 1143-1150
    • Cyert, M.S.1
  • 28
    • 0025913953 scopus 로고
    • Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase
    • Cyert M.S., Kunisawa R., Kaim D., Thorner J. Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc. Natl. Acad. Sci. U. S. A. 1991, 88:7376-7380.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 7376-7380
    • Cyert, M.S.1    Kunisawa, R.2    Kaim, D.3    Thorner, J.4
  • 29
    • 84866523093 scopus 로고    scopus 로고
    • Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway
    • Dai B., Wang Y., Li D., Xu Y., Liang R., Zhao L., Cao Y., Jia J., Jiang Y. Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway. PLoS One 2012, 7:e45109.
    • (2012) PLoS One , vol.7 , pp. e45109
    • Dai, B.1    Wang, Y.2    Li, D.3    Xu, Y.4    Liang, R.5    Zhao, L.6    Cao, Y.7    Jia, J.8    Jiang, Y.9
  • 30
    • 33846147991 scopus 로고    scopus 로고
    • The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress
    • Daquinag A., Fadri M., Jung S.Y., Qin J., Kunz J. The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress. Mol. Cell. Biol. 2007, 27:633-650.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 633-650
    • Daquinag, A.1    Fadri, M.2    Jung, S.Y.3    Qin, J.4    Kunz, J.5
  • 32
    • 70249103805 scopus 로고    scopus 로고
    • Calcineurin is an antagonist to PKA protein phosphorylation required for postmating filamentation and virulence, while PP2A is required for viability in Ustilago maydis
    • Egan J.D., García-Pedrajas M.D., Andrews D.L., Gold S.E. Calcineurin is an antagonist to PKA protein phosphorylation required for postmating filamentation and virulence, while PP2A is required for viability in Ustilago maydis. Mol. Plant-Microbe Interact. 2009, 22:1293-1301.
    • (2009) Mol. Plant-Microbe Interact. , vol.22 , pp. 1293-1301
    • Egan, J.D.1    García-Pedrajas, M.D.2    Andrews, D.L.3    Gold, S.E.4
  • 33
    • 0033813390 scopus 로고    scopus 로고
    • Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast
    • Estruch F. Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast. FEMS Microbiol. Rev. 2000, 24:469-486.
    • (2000) FEMS Microbiol. Rev. , vol.24 , pp. 469-486
    • Estruch, F.1
  • 36
    • 77950167265 scopus 로고    scopus 로고
    • Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin
    • Fortwendel J.R., Juvvadi P.R., Perfect B.Z., Rogg L.E., Perfect J.R., Steinbach W.J. Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. Antimicrob. Agents Chemother. 2010, 54:1555-1563.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1555-1563
    • Fortwendel, J.R.1    Juvvadi, P.R.2    Perfect, B.Z.3    Rogg, L.E.4    Perfect, J.R.5    Steinbach, W.J.6
  • 38
    • 0142153855 scopus 로고    scopus 로고
    • Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans
    • Fox D.S., Cox G.M., Heitman J. Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans. Eukaryot. Cell 2003, 2:1025-1035.
    • (2003) Eukaryot. Cell , vol.2 , pp. 1025-1035
    • Fox, D.S.1    Cox, G.M.2    Heitman, J.3
  • 39
    • 25144520524 scopus 로고    scopus 로고
    • Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans
    • Fox D.S., Heitman J. Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. Eukaryot. Cell 2005, 4:1526-1538.
    • (2005) Eukaryot. Cell , vol.4 , pp. 1526-1538
    • Fox, D.S.1    Heitman, J.2
  • 40
    • 0343192437 scopus 로고    scopus 로고
    • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans
    • Gorlach J., Fox D.S., Cutler N.S., Cox G.M., Perfect J.R., Heitman J. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J. 2000, 19:3618-3629.
    • (2000) EMBO J. , vol.19 , pp. 3618-3629
    • Gorlach, J.1    Fox, D.S.2    Cutler, N.S.3    Cox, G.M.4    Perfect, J.R.5    Heitman, J.6
  • 41
    • 56749105612 scopus 로고    scopus 로고
    • Functional analysis of C2H2 zinc finger transcription factor CrzA involved in calcium signaling in Aspergillus nidulans
    • Hagiwara D., Kondo A., Fujioka T., Abe K. Functional analysis of C2H2 zinc finger transcription factor CrzA involved in calcium signaling in Aspergillus nidulans. Curr. Genet. 2008, 54:325-338.
    • (2008) Curr. Genet. , vol.54 , pp. 325-338
    • Hagiwara, D.1    Kondo, A.2    Fujioka, T.3    Abe, K.4
  • 42
    • 79954526400 scopus 로고    scopus 로고
    • Calcineurin signaling and membrane lipid homeostasis regulates iron mediated MultiDrug resistance mechanisms in Candida albicans
    • Hameed S., Dhamgaye S., Singh A., Goswami S.K., Prasad R. Calcineurin signaling and membrane lipid homeostasis regulates iron mediated MultiDrug resistance mechanisms in Candida albicans. PLoS One 2011, 6:e18684.
    • (2011) PLoS One , vol.6 , pp. e18684
    • Hameed, S.1    Dhamgaye, S.2    Singh, A.3    Goswami, S.K.4    Prasad, R.5
  • 43
    • 33646878069 scopus 로고    scopus 로고
    • Calcineurin is required for sclerotial development and pathogenicity of Sclerotinia sclerotiorum in an oxalic acid-independent manner
    • Harel A., Bercovich S., Yarden O. Calcineurin is required for sclerotial development and pathogenicity of Sclerotinia sclerotiorum in an oxalic acid-independent manner. Mol. Plant-Microbe Interact. 2006, 19:682-693.
    • (2006) Mol. Plant-Microbe Interact. , vol.19 , pp. 682-693
    • Harel, A.1    Bercovich, S.2    Yarden, O.3
  • 44
    • 29144484163 scopus 로고    scopus 로고
    • Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease
    • Harris C.D., Ermak G., Davies K.J.A. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell. Mol. Life Sci. CMLS 2005, 62:2477-2486.
    • (2005) Cell. Mol. Life Sci. CMLS , vol.62 , pp. 2477-2486
    • Harris, C.D.1    Ermak, G.2    Davies, K.J.A.3
  • 45
    • 0023758460 scopus 로고
    • Regulatory interactions of calmodulin-binding proteins: phosphorylation of calcineurin by autophosphorylated Ca2+/calmodulin-dependent protein kinase II
    • Hashimoto Y., King M.M., Soderling T.R. Regulatory interactions of calmodulin-binding proteins: phosphorylation of calcineurin by autophosphorylated Ca2+/calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:7001-7005.
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 7001-7005
    • Hashimoto, Y.1    King, M.M.2    Soderling, T.R.3
  • 46
    • 0024468921 scopus 로고
    • Regulation of calcineurin by phosphorylation. Identification of the regulatory site phosphorylated by Ca2+/calmodulin-dependent protein kinase II and protein kinase C
    • Hashimoto Y., Soderling T.R. Regulation of calcineurin by phosphorylation. Identification of the regulatory site phosphorylated by Ca2+/calmodulin-dependent protein kinase II and protein kinase C. J. Biol. Chem. 1989, 264:16524-16529.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16524-16529
    • Hashimoto, Y.1    Soderling, T.R.2
  • 47
    • 2942633721 scopus 로고    scopus 로고
    • Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae
    • Heath V.L., Shaw S.L., Roy S., Cyert M.S. Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Eukaryot. Cell 2004, 3:695-704.
    • (2004) Eukaryot. Cell , vol.3 , pp. 695-704
    • Heath, V.L.1    Shaw, S.L.2    Roy, S.3    Cyert, M.S.4
  • 48
    • 84155188933 scopus 로고    scopus 로고
    • Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond
    • Heineke J., Ritter O. Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond. J. Mol. Cell Cardiol. 2012, 52:62-73.
    • (2012) J. Mol. Cell Cardiol. , vol.52 , pp. 62-73
    • Heineke, J.1    Ritter, O.2
  • 49
    • 34948905247 scopus 로고    scopus 로고
    • Calcineurin/NFAT signaling in the β-cell: from diabetes to new therapeutics
    • Heit J.J. Calcineurin/NFAT signaling in the β-cell: from diabetes to new therapeutics. BioEssays 2007, 29:1011-1021.
    • (2007) BioEssays , vol.29 , pp. 1011-1021
    • Heit, J.J.1
  • 51
    • 84880833862 scopus 로고    scopus 로고
    • Phospho-regulation and nucleocytoplasmic trafficking of CrzA in response to calcium and alkaline-pH stress in Aspergillus nidulans
    • Hernández-Ortiz P., Espeso E.A. Phospho-regulation and nucleocytoplasmic trafficking of CrzA in response to calcium and alkaline-pH stress in Aspergillus nidulans. Mol. Microbiol. 2013, 89:532-551.
    • (2013) Mol. Microbiol. , vol.89 , pp. 532-551
    • Hernández-Ortiz, P.1    Espeso, E.A.2
  • 52
    • 0028234434 scopus 로고
    • The antimicrobial activities of cyclosporine, FK506, and rapamycin
    • High K.P. The antimicrobial activities of cyclosporine, FK506, and rapamycin. Transplantation 1994, 57:1689-1700.
    • (1994) Transplantation , vol.57 , pp. 1689-1700
    • High, K.P.1
  • 53
    • 0031024618 scopus 로고    scopus 로고
    • Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin)
    • High K.P., Washburn R.G. Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). J. Infect. Dis. 1997, 175:222-225.
    • (1997) J. Infect. Dis. , vol.175 , pp. 222-225
    • High, K.P.1    Washburn, R.G.2
  • 55
    • 0034458959 scopus 로고    scopus 로고
    • Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin
    • Imai J., Yahara I. Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin. Mol. Cell. Biol. 2000, 20:9262-9270.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9262-9270
    • Imai, J.1    Yahara, I.2
  • 57
    • 84868109141 scopus 로고    scopus 로고
    • Calcium-activated-calcineurin reduces the invitro and invivo sensitivity of fluconazole to Candida albicans via Rta2p
    • Jia Y., Tang R.-J., Wang L., Zhang X., Wang Y., Jia X.-M., Jiang Y.-Y. Calcium-activated-calcineurin reduces the invitro and invivo sensitivity of fluconazole to Candida albicans via Rta2p. PLoS One 2012, 7:e48369.
    • (2012) PLoS One , vol.7 , pp. e48369
    • Jia, Y.1    Tang, R.-J.2    Wang, L.3    Zhang, X.4    Wang, Y.5    Jia, X.-M.6    Jiang, Y.-Y.7
  • 58
    • 0035899973 scopus 로고    scopus 로고
    • Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae
    • Juvvadi P.R., Arioka M., Nakajima H., Kitamoto K. Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae. FEMS Microbiol. Lett. 2001, 204:169-174.
    • (2001) FEMS Microbiol. Lett. , vol.204 , pp. 169-174
    • Juvvadi, P.R.1    Arioka, M.2    Nakajima, H.3    Kitamoto, K.4
  • 59
    • 51649125240 scopus 로고    scopus 로고
    • Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development
    • Juvvadi P.R., Fortwendel J.R., Pinchai N., Perfect B.Z., Heitman J., Steinbach W.J. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryot. Cell 2008, 7:1606-1610.
    • (2008) Eukaryot. Cell , vol.7 , pp. 1606-1610
    • Juvvadi, P.R.1    Fortwendel, J.R.2    Pinchai, N.3    Perfect, B.Z.4    Heitman, J.5    Steinbach, W.J.6
  • 60
    • 82155166247 scopus 로고    scopus 로고
    • Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus
    • Juvvadi P.R., Fortwendel J.R., Rogg L.E., Burns K.A., Randell S.H., Steinbach W.J. Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol. Microbiol. 2011, 82:1235-1259.
    • (2011) Mol. Microbiol. , vol.82 , pp. 1235-1259
    • Juvvadi, P.R.1    Fortwendel, J.R.2    Rogg, L.E.3    Burns, K.A.4    Randell, S.H.5    Steinbach, W.J.6
  • 62
    • 0037524328 scopus 로고    scopus 로고
    • Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation
    • Juvvadi P.R., Kuroki Y., Arioka M., Nakajima H., Kitamoto K. Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation. Arch. Microbiol. 2003, 179:416-422.
    • (2003) Arch. Microbiol. , vol.179 , pp. 416-422
    • Juvvadi, P.R.1    Kuroki, Y.2    Arioka, M.3    Nakajima, H.4    Kitamoto, K.5
  • 64
    • 16544379233 scopus 로고    scopus 로고
    • Loss of Apm1, the μ1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast
    • Kita A., Sugiura R., Shoji H., He Y., Deng L., Lu Y., Sio S.O., Takegawa K., Sakaue M., Shuntoh H., Kuno T. Loss of Apm1, the μ1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast. Mol. Biol. Cell 2004, 15:2920-2931.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 2920-2931
    • Kita, A.1    Sugiura, R.2    Shoji, H.3    He, Y.4    Deng, L.5    Lu, Y.6    Sio, S.O.7    Takegawa, K.8    Sakaue, M.9    Shuntoh, H.10    Kuno, T.11
  • 65
    • 0037326390 scopus 로고    scopus 로고
    • Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth invitro in Aspergillus species
    • Kontoyiannis D.P., Lewis R.E., Osherov N., Albert N.D., May G.S. Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth invitro in Aspergillus species. J. Antimicrob. Chemother. 2003, 51:313-316.
    • (2003) J. Antimicrob. Chemother. , vol.51 , pp. 313-316
    • Kontoyiannis, D.P.1    Lewis, R.E.2    Osherov, N.3    Albert, N.D.4    May, G.S.5
  • 67
    • 0032051455 scopus 로고    scopus 로고
    • Calcineurin subunit B is required for normal vegetative growth in Neurospora crassa
    • Kothe G.O., Free S.J. Calcineurin subunit B is required for normal vegetative growth in Neurospora crassa. Fungal Genet. Biol. 1998, 23:248-258.
    • (1998) Fungal Genet. Biol. , vol.23 , pp. 248-258
    • Kothe, G.O.1    Free, S.J.2
  • 68
    • 80053448765 scopus 로고    scopus 로고
    • Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans
    • Kozubowski L., Aboobakar E.F., Cardenas M.E., Heitman J. Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryot. Cell 2011, 10:1396-1402.
    • (2011) Eukaryot. Cell , vol.10 , pp. 1396-1402
    • Kozubowski, L.1    Aboobakar, E.F.2    Cardenas, M.E.3    Heitman, J.4
  • 69
    • 83355173987 scopus 로고    scopus 로고
    • Profiling a killer, the development of Cryptococcus neoformans
    • Kozubowski L., Heitman J. Profiling a killer, the development of Cryptococcus neoformans. FEMS Microbiol. Rev. 2012, 36:78-94.
    • (2012) FEMS Microbiol. Rev. , vol.36 , pp. 78-94
    • Kozubowski, L.1    Heitman, J.2
  • 70
    • 80053439003 scopus 로고    scopus 로고
    • Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics
    • Kozubowski L., Thompson J.W., Cardenas M.E., Moseley M.A., Heitman J. Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. PLoS One 2011, 6:e25280.
    • (2011) PLoS One , vol.6 , pp. e25280
    • Kozubowski, L.1    Thompson, J.W.2    Cardenas, M.E.3    Moseley, M.A.4    Heitman, J.5
  • 71
    • 0038460048 scopus 로고    scopus 로고
    • The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function
    • Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol. Microbiol. 2003, 48:1377-1387.
    • (2003) Mol. Microbiol. , vol.48 , pp. 1377-1387
    • Kraus, P.R.1    Fox, D.S.2    Cox, G.M.3    Heitman, J.4
  • 72
    • 35748968775 scopus 로고    scopus 로고
    • Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways
    • Kullas A.L., Martin S.J., Davis D. Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways. Mol. Microbiol. 2007, 66:858-871.
    • (2007) Mol. Microbiol. , vol.66 , pp. 858-871
    • Kullas, A.L.1    Martin, S.J.2    Davis, D.3
  • 73
    • 79952283368 scopus 로고    scopus 로고
    • Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth
    • Kume K., Koyano T., Kanai M., Toda T., Hirata D. Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth. Nat. Cell. Biol. 2011, 13:234-242.
    • (2011) Nat. Cell. Biol. , vol.13 , pp. 234-242
    • Kume, K.1    Koyano, T.2    Kanai, M.3    Toda, T.4    Hirata, D.5
  • 74
    • 84868130707 scopus 로고    scopus 로고
    • Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus
    • Lamoth F., Juvvadi P.R., Fortwendel J.R., Steinbach W.J. Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot. Cell. 2012, 11:1324-1332.
    • (2012) Eukaryot. Cell. , vol.11 , pp. 1324-1332
    • Lamoth, F.1    Juvvadi, P.R.2    Fortwendel, J.R.3    Steinbach, W.J.4
  • 75
    • 84892648838 scopus 로고    scopus 로고
    • Transcriptional activation of heat-shock protein 90 (Hsp90) mediated via a proximal promoter region confers caspofungin resistance in Aspergillus fumigatus
    • Lamoth F., Juvvadi P.R., Gehrke C., Asfaw Y.G., Steinbach W.J. Transcriptional activation of heat-shock protein 90 (Hsp90) mediated via a proximal promoter region confers caspofungin resistance in Aspergillus fumigatus. J. Infect. Dis. 2014, 209:473-481.
    • (2014) J. Infect. Dis. , vol.209 , pp. 473-481
    • Lamoth, F.1    Juvvadi, P.R.2    Gehrke, C.3    Asfaw, Y.G.4    Steinbach, W.J.5
  • 76
    • 84872876874 scopus 로고    scopus 로고
    • Invitro activity of calcineurin and heat shock protein 90 inhibitors against Aspergillus fumigatus azole - and echinocandin-resistant strains
    • Lamoth F., Juvvadi P.R., Gehrke C., Steinbach W.J. Invitro activity of calcineurin and heat shock protein 90 inhibitors against Aspergillus fumigatus azole - and echinocandin-resistant strains. Antimicrob. Agents Chemother. 2013, 57:1035-1039.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 1035-1039
    • Lamoth, F.1    Juvvadi, P.R.2    Gehrke, C.3    Steinbach, W.J.4
  • 77
    • 84871240855 scopus 로고    scopus 로고
    • The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
    • Lev S., Desmarini D., Chayakulkeeree M., Sorrell T.C., Djordjevic J.T. The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity. PLoS One 2012, 7:e51403.
    • (2012) PLoS One , vol.7
    • Lev, S.1    Desmarini, D.2    Chayakulkeeree, M.3    Sorrell, T.C.4    Djordjevic, J.T.5
  • 78
    • 0025809351 scopus 로고
    • TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B
    • Liu Y., Ishii S., Tokai M., Tsutsumi H., Ohki O., Akada R., Tanaka K., Tsuchiya E., Fukui S., Miyakawa T. TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Mol. Gen. Genet. 1991, 227:52-59.
    • (1991) Mol. Gen. Genet. , vol.227 , pp. 52-59
    • Liu, Y.1    Ishii, S.2    Tokai, M.3    Tsutsumi, H.4    Ohki, O.5    Akada, R.6    Tanaka, K.7    Tsuchiya, E.8    Fukui, S.9    Miyakawa, T.10
  • 79
    • 0036786062 scopus 로고    scopus 로고
    • Calcineurin is implicated in the regulation of the septation initiation network in fission yeast
    • Lu Y., Sugiura R., Yada T., Cheng H., Sio S.O., Shuntoh H., Kuno T. Calcineurin is implicated in the regulation of the septation initiation network in fission yeast. Genes. Cells 2002, 7:1009-1019.
    • (2002) Genes. Cells , vol.7 , pp. 1009-1019
    • Lu, Y.1    Sugiura, R.2    Yada, T.3    Cheng, H.4    Sio, S.O.5    Shuntoh, H.6    Kuno, T.7
  • 80
    • 79961154489 scopus 로고    scopus 로고
    • Genome-wide screening for genes associated with FK506 sensitivity in fission yeast
    • Ma Y., Jiang W., Liu Q., Ryuko S., Kuno T. Genome-wide screening for genes associated with FK506 sensitivity in fission yeast. PLoS One 2011, 6:e23422.
    • (2011) PLoS One , vol.6
    • Ma, Y.1    Jiang, W.2    Liu, Q.3    Ryuko, S.4    Kuno, T.5
  • 81
    • 0842345632 scopus 로고    scopus 로고
    • Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: The importance of Mn2+ homeostasis
    • Maeda T., Sugiura R., Kita A., Saito M., Deng L., He Y., Yabin L., Fujita Y., Takegawa K., Shuntoh H., Kuno T. Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: The importance of Mn2+ homeostasis. Genes. Cells 2004, 9:71-82.
    • (2004) Genes. Cells , vol.9 , pp. 71-82
    • Maeda, T.1    Sugiura, R.2    Kita, A.3    Saito, M.4    Deng, L.5    He, Y.6    Yabin, L.7    Fujita, Y.8    Takegawa, K.9    Shuntoh, H.10    Kuno, T.11
  • 83
    • 0033751965 scopus 로고    scopus 로고
    • Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans
    • Marchetti O., Entenza J.M., Sanglard D., Bille J., Glauser M.P., Moreillon P. Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans. Antimicrob. Agents Chemother. 2000, 44:2932-2938.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2932-2938
    • Marchetti, O.1    Entenza, J.M.2    Sanglard, D.3    Bille, J.4    Glauser, M.P.5    Moreillon, P.6
  • 85
    • 0032543766 scopus 로고    scopus 로고
    • Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals
    • Marks B., McMahon H.T. Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals. Curr. Biol. 1998, 8:740-749.
    • (1998) Curr. Biol. , vol.8 , pp. 740-749
    • Marks, B.1    McMahon, H.T.2
  • 87
    • 0024311002 scopus 로고
    • Identification of the site on calcineurin phosphorylated by calcium/CaM-dependent kinase II: modification of the CaM-binding domain
    • Martensen T.M., Martin B.M., Kincaid R.L. Identification of the site on calcineurin phosphorylated by calcium/CaM-dependent kinase II: modification of the CaM-binding domain. Biochemistry 1989, 28:9243-9247.
    • (1989) Biochemistry , vol.28 , pp. 9243-9247
    • Martensen, T.M.1    Martin, B.M.2    Kincaid, R.L.3
  • 88
    • 0037031829 scopus 로고    scopus 로고
    • An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiae
    • Matsumoto T.K., Ellsmore A.J., Cessna S.G., Low P.S., Pardo J.M., Bressan R.A., Hasegawa P.M. An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiae. J. Biol. Chem. 2002, 277:33075-33080.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33075-33080
    • Matsumoto, T.K.1    Ellsmore, A.J.2    Cessna, S.G.3    Low, P.S.4    Pardo, J.M.5    Bressan, R.A.6    Hasegawa, P.M.7
  • 89
    • 0029789841 scopus 로고    scopus 로고
    • Activated calcineurin confers high tolerance to ion stress and alters the budding pattern and cell morphology of yeast cells
    • Mendoza I., Quintero F.J., Bressan R.A., Hasegawa P.M., Pardo J.M. Activated calcineurin confers high tolerance to ion stress and alters the budding pattern and cell morphology of yeast cells. J. Biol. Chem. 1996, 271:23061-23067.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23061-23067
    • Mendoza, I.1    Quintero, F.J.2    Bressan, R.A.3    Hasegawa, P.M.4    Pardo, J.M.5
  • 90
    • 0028286249 scopus 로고
    • The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae
    • Mendoza I., Rubio F., Rodriguez-Navarro A., Pardo J.M. The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae. J. Biol. Chem. 1994, 269:8792-8796.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8792-8796
    • Mendoza, I.1    Rubio, F.2    Rodriguez-Navarro, A.3    Pardo, J.M.4
  • 91
    • 84875058619 scopus 로고    scopus 로고
    • Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata
    • Miyazaki T., Nakayama H., Nagayoshi Y., Kakeya H., Kohno S. Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. PLoS Pathog. 2013, 9:e1003160.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003160
    • Miyazaki, T.1    Nakayama, H.2    Nagayoshi, Y.3    Kakeya, H.4    Kohno, S.5
  • 93
    • 84857840998 scopus 로고    scopus 로고
    • Molecular diagnostics of calcineurin-related pathologies
    • Musson R.E.A., Cobbaert C.M., Smit N.P.M. Molecular diagnostics of calcineurin-related pathologies. Clin. Chem. 2012, 58:511-522.
    • (2012) Clin. Chem. , vol.58 , pp. 511-522
    • Musson, R.E.A.1    Cobbaert, C.M.2    Smit, N.P.M.3
  • 94
    • 79953876732 scopus 로고    scopus 로고
    • Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host
    • Naderer T., Dandash O., McConville M.J. Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host. Mol. Microbiol. 2011, 80:471-480.
    • (2011) Mol. Microbiol. , vol.80 , pp. 471-480
    • Naderer, T.1    Dandash, O.2    McConville, M.J.3
  • 95
    • 0027385382 scopus 로고
    • Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions
    • Nakamura T., Liu Y., Hirata D., Namba H., Harada S., Hirokawa T., T., M. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J. 1993, 12:4063-4071.
    • (1993) EMBO J. , vol.12 , pp. 4063-4071
    • Nakamura, T.1    Liu, Y.2    Hirata, D.3    Namba, H.4    Harada, S.5    Hirokawa, T.T.M.6
  • 96
    • 0030308969 scopus 로고    scopus 로고
    • Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation
    • Nanthakumar N.N., Dayton J.S., Means A.R. Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation. Prog. Cell. Cycle Res. 1996, 2:217-228.
    • (1996) Prog. Cell. Cycle Res. , vol.2 , pp. 217-228
    • Nanthakumar, N.N.1    Dayton, J.S.2    Means, A.R.3
  • 97
    • 0031008864 scopus 로고    scopus 로고
    • Calcineurin is required for virulence of Cryptococcus neoformans
    • Odom A., Muir S., Lim E., Toffaletti D.L., Perfect J., Heitman J. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 1997, 16:2576-2589.
    • (1997) EMBO J. , vol.16 , pp. 2576-2589
    • Odom, A.1    Muir, S.2    Lim, E.3    Toffaletti, D.L.4    Perfect, J.5    Heitman, J.6
  • 98
    • 33746364784 scopus 로고    scopus 로고
    • Structure and mechanism of the Hsp90 molecular chaperone machinery
    • Pearl L.H., Prodromou C. Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu. Rev. Biochem. 2006, 75:271-294.
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 271-294
    • Pearl, L.H.1    Prodromou, C.2
  • 99
    • 77649288776 scopus 로고    scopus 로고
    • The Aspergillus fumigatus P-Type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis
    • Pinchai N., Juvvadi P.R., Fortwendel J.R., Perfect B.Z., Rogg L.E., Asfaw Y.G., Steinbach W.J. The Aspergillus fumigatus P-Type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Eukaryot. Cell 2010, 9:472-476.
    • (2010) Eukaryot. Cell , vol.9 , pp. 472-476
    • Pinchai, N.1    Juvvadi, P.R.2    Fortwendel, J.R.3    Perfect, B.Z.4    Rogg, L.E.5    Asfaw, Y.G.6    Steinbach, W.J.7
  • 101
    • 0030667518 scopus 로고    scopus 로고
    • Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient
    • Prokisch H., Yarden O., Dieminger M., Tropschug M., Barthelmess I.B. Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient. Mol. Gen. Genet. 1997, 256:104-114.
    • (1997) Mol. Gen. Genet. , vol.256 , pp. 104-114
    • Prokisch, H.1    Yarden, O.2    Dieminger, M.3    Tropschug, M.4    Barthelmess, I.B.5
  • 102
    • 82955245629 scopus 로고    scopus 로고
    • A role for calcineurin in Alzheimer's disease
    • Reese L.C., Taglialatela G. A role for calcineurin in Alzheimer's disease. Curr. Neuropharmacol. 2011, 9:685-692.
    • (2011) Curr. Neuropharmacol. , vol.9 , pp. 685-692
    • Reese, L.C.1    Taglialatela, G.2
  • 103
    • 0036459015 scopus 로고    scopus 로고
    • Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology
    • Reynolds N.J., Al-Daraji W.I. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin. Exp. Dermatol. 2002, 27:555-561.
    • (2002) Clin. Exp. Dermatol. , vol.27 , pp. 555-561
    • Reynolds, N.J.1    Al-Daraji, W.I.2
  • 104
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: form and function
    • Rusnak F., Mertz P. Calcineurin: form and function. Physiol. Rev. 2000, 80:1483-1521.
    • (2000) Physiol. Rev. , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 105
    • 0038016755 scopus 로고    scopus 로고
    • Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
    • Sanglard D., Ischer F., Marchetti O., Entenza J., Bille J. Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol. Microbiol. 2003, 48:959-976.
    • (2003) Mol. Microbiol. , vol.48 , pp. 959-976
    • Sanglard, D.1    Ischer, F.2    Marchetti, O.3    Entenza, J.4    Bille, J.5
  • 106
    • 27644560976 scopus 로고    scopus 로고
    • Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor
    • Santos M., Larrinoa I. Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor. Curr. Genet. 2005, 48:88-100.
    • (2005) Curr. Genet. , vol.48 , pp. 88-100
    • Santos, M.1    Larrinoa, I.2
  • 107
    • 42249104885 scopus 로고    scopus 로고
    • Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants
    • Schumacher J., de Larrinoa I.F., Tudzynski B. Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants. Eukaryot. Cell 2008, 7:584-601.
    • (2008) Eukaryot. Cell , vol.7 , pp. 584-601
    • Schumacher, J.1    de Larrinoa, I.F.2    Tudzynski, B.3
  • 108
    • 0036886546 scopus 로고    scopus 로고
    • The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling
    • Serrano R., Ruiz A., Bernal D., Chambers J.R., Ariño J. The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling. Mol. Microbiol. 2002, 46:1319-1333.
    • (2002) Mol. Microbiol. , vol.46 , pp. 1319-1333
    • Serrano, R.1    Ruiz, A.2    Bernal, D.3    Chambers, J.R.4    Ariño, J.5
  • 109
    • 84883219318 scopus 로고    scopus 로고
    • The calcineurin pathway inhibitor tacrolimus enhances the invitro activity of azoles against mucorales via apoptosis
    • Shirazi F., Kontoyiannis D.P. The calcineurin pathway inhibitor tacrolimus enhances the invitro activity of azoles against mucorales via apoptosis. Eukaryot. Cell 2013, 12:1225-1234.
    • (2013) Eukaryot. Cell , vol.12 , pp. 1225-1234
    • Shirazi, F.1    Kontoyiannis, D.P.2
  • 111
    • 84890231119 scopus 로고    scopus 로고
    • Role of calcineurin and actin dynamics in regulated secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte invasion
    • Singh S., More K.R., Chitnis C.E. Role of calcineurin and actin dynamics in regulated secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte invasion. Cell. Microbiol. 2014, 16:50-63.
    • (2014) Cell. Microbiol. , vol.16 , pp. 50-63
    • Singh, S.1    More, K.R.2    Chitnis, C.E.3
  • 112
    • 70049109583 scopus 로고    scopus 로고
    • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
    • Singh S.D., Robbins N., Zaas A.K., Schell W.A., Perfect J.R., Cowen L.E. Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS Pathog. 2009, 5:e1000532.
    • (2009) PLoS Pathog. , vol.5 , pp. e1000532
    • Singh, S.D.1    Robbins, N.2    Zaas, A.K.3    Schell, W.A.4    Perfect, J.R.5    Cowen, L.E.6
  • 113
    • 0023574780 scopus 로고
    • Phosphorylation of calcineurin by glycogen synthase (casein) kinase-1
    • Singh T.J., Wang J.H. Phosphorylation of calcineurin by glycogen synthase (casein) kinase-1. Biochem. Cell. Biol. 1987, 65:917-921.
    • (1987) Biochem. Cell. Biol. , vol.65 , pp. 917-921
    • Singh, T.J.1    Wang, J.H.2
  • 115
    • 52449128668 scopus 로고    scopus 로고
    • Two zinc finger transcription factors, CrzA and SltA, are involved in cation homoeostasis and detoxification in Aspergillus nidulans
    • Spielvogel A., Findon H., Arst H.N., Araújo-bazán L., Hernández-ortíz P., Stahl U., Meyer V., Espeso E.A. Two zinc finger transcription factors, CrzA and SltA, are involved in cation homoeostasis and detoxification in Aspergillus nidulans. Biochem. J. 2008, 414:419-429.
    • (2008) Biochem. J. , vol.414 , pp. 419-429
    • Spielvogel, A.1    Findon, H.2    Arst, H.N.3    Araújo-bazán, L.4    Hernández-ortíz, P.5    Stahl, U.6    Meyer, V.7    Espeso, E.A.8
  • 116
    • 0033118396 scopus 로고    scopus 로고
    • Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation
    • Stathopoulos-Gerontides A., Guo J.J., Cyert M.S. Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. Genes. Dev. 1999, 13:798-803.
    • (1999) Genes. Dev. , vol.13 , pp. 798-803
    • Stathopoulos-Gerontides, A.1    Guo, J.J.2    Cyert, M.S.3
  • 117
    • 0031438164 scopus 로고    scopus 로고
    • Calcineurin acts through theCRZ1/TCN1-encoded transcription factor to regulate gene expression inyeast
    • Stathopoulos A.M., Cyert M.S. Calcineurin acts through theCRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes. Dev. 1997, 11:3432-3444.
    • (1997) Genes. Dev. , vol.11 , pp. 3432-3444
    • Stathopoulos, A.M.1    Cyert, M.S.2
  • 120
    • 34249069582 scopus 로고    scopus 로고
    • Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
    • Steinbach W.J., Reedy J.L., Cramer R.A., Perfect J.R., Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat. Rev. Microbiol. 2007, 5:418-430.
    • (2007) Nat. Rev. Microbiol. , vol.5 , pp. 418-430
    • Steinbach, W.J.1    Reedy, J.L.2    Cramer, R.A.3    Perfect, J.R.4    Heitman, J.5
  • 122
    • 9644287933 scopus 로고    scopus 로고
    • Invitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients
    • Steinbach W.J., Singh N., Miller J.L., Benjamin D.K., Schell W.A., Heitman J., Perfect J.R. Invitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients. Antimicrob. Agents Chemother. 2004, 48:4922-4925.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 4922-4925
    • Steinbach, W.J.1    Singh, N.2    Miller, J.L.3    Benjamin, D.K.4    Schell, W.A.5    Heitman, J.6    Perfect, J.R.7
  • 123
    • 33748695822 scopus 로고    scopus 로고
    • Escape of Candida from caspofungin inhibition at concentrations above the MIC (Paradoxical Effect) accomplished by increased cell wall chitin; evidence for β-1,6-glucan synthesis inhibition by caspofungin
    • Stevens D.A., Ichinomiya M., Koshi Y., Horiuchi H. Escape of Candida from caspofungin inhibition at concentrations above the MIC (Paradoxical Effect) accomplished by increased cell wall chitin; evidence for β-1,6-glucan synthesis inhibition by caspofungin. Antimicrob. Agents Chemother. 2006, 50:3160-3161.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3160-3161
    • Stevens, D.A.1    Ichinomiya, M.2    Koshi, Y.3    Horiuchi, H.4
  • 124
    • 0035985031 scopus 로고    scopus 로고
    • Calcineurin phosphatase in signal transduction: lessons from fission yeast
    • Sugiura R., Sio S.O., Shuntoh H., Kuno T. Calcineurin phosphatase in signal transduction: lessons from fission yeast. Genes. Cells 2002, 7:619-627.
    • (2002) Genes. Cells , vol.7 , pp. 619-627
    • Sugiura, R.1    Sio, S.O.2    Shuntoh, H.3    Kuno, T.4
  • 125
    • 0026318385 scopus 로고
    • The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression
    • Torre-Cisneros J., Manez R., Kusne S., Alessiani M., Martin M., Starzl T.E. The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression. Transplant Proc. 1991, 23:3040-3041.
    • (1991) Transplant Proc. , vol.23 , pp. 3040-3041
    • Torre-Cisneros, J.1    Manez, R.2    Kusne, S.3    Alessiani, M.4    Martin, M.5    Starzl, T.E.6
  • 126
    • 0036199384 scopus 로고    scopus 로고
    • The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late golgi membrane proteins
    • Valdivia R.H., Baggott D., Chuang J.S., Schekman R.W. The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late golgi membrane proteins. Dev. Cell 2002, 2:283-294.
    • (2002) Dev. Cell , vol.2 , pp. 283-294
    • Valdivia, R.H.1    Baggott, D.2    Chuang, J.S.3    Schekman, R.W.4
  • 127
    • 75649088107 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of calcineurin inhibition therapy: principles, performance, and perspectives
    • van Rossum H.H., de Fijter J.W., van Pelt J. Pharmacodynamic monitoring of calcineurin inhibition therapy: principles, performance, and perspectives. Ther. Drug. Monit. 2010, 32:3-10. 10.1097/FTD.1090b1013e3181c1090eecb.
    • (2010) Ther. Drug. Monit. , vol.32 , pp. 3-10
    • van Rossum, H.H.1    de Fijter, J.W.2    van Pelt, J.3
  • 128
    • 84884935904 scopus 로고    scopus 로고
    • Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast
    • Viana R.A., Pinar M., Soto T., Coll P.M., Cansado J., Pérez P. Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast. Genetics 2013, 195:421-432.
    • (2013) Genetics , vol.195 , pp. 421-432
    • Viana, R.A.1    Pinar, M.2    Soto, T.3    Coll, P.M.4    Cansado, J.5    Pérez, P.6
  • 129
    • 6344278689 scopus 로고    scopus 로고
    • Characterization of the Calcium-mediated response to alkaline stress in Saccharomyces cerevisiae
    • Viladevall L., Serrano R., Ruiz A., Domenech G., Giraldo J., Barceló A., Ariño J. Characterization of the Calcium-mediated response to alkaline stress in Saccharomyces cerevisiae. J. Biol. Chem. 2004, 279:43614-43624.
    • (2004) J. Biol. Chem. , vol.279 , pp. 43614-43624
    • Viladevall, L.1    Serrano, R.2    Ruiz, A.3    Domenech, G.4    Giraldo, J.5    Barceló, A.6    Ariño, J.7
  • 130
    • 84867426212 scopus 로고    scopus 로고
    • Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans
    • Wang S., Cao J., Liu X., Hu H., Shi J., Zhang S., Keller N.P., Lu L. Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans. PLoS One 2012, 7:e46564.
    • (2012) PLoS One , vol.7
    • Wang, S.1    Cao, J.2    Liu, X.3    Hu, H.4    Shi, J.5    Zhang, S.6    Keller, N.P.7    Lu, L.8
  • 131
    • 4944230721 scopus 로고    scopus 로고
    • Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity
    • Wiederhold N.P., Kontoyiannis D.P., Chi J., Prince R.A., Tam V.H., Lewis R.E. Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity. J. Infect. Dis. 2004, 190:1464-1471.
    • (2004) J. Infect. Dis. , vol.190 , pp. 1464-1471
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Chi, J.3    Prince, R.A.4    Tam, V.H.5    Lewis, R.E.6
  • 132
    • 84874530824 scopus 로고    scopus 로고
    • Calcineurin inhibitors and immunosuppression - a tale of two isoforms
    • Williams C.R., Gooch J.L. Calcineurin inhibitors and immunosuppression - a tale of two isoforms. Expert Rev. Mol. Med. 2012, 14. e14.
    • (2012) Expert Rev. Mol. Med. , vol.14
    • Williams, C.R.1    Gooch, J.L.2
  • 133
    • 0028200722 scopus 로고
    • A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning
    • Yoshida T., Toda T., Yanagida M. A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning. J. Cell Sci. 1994, 107:1725-1735.
    • (1994) J. Cell Sci. , vol.107 , pp. 1725-1735
    • Yoshida, T.1    Toda, T.2    Yanagida, M.3
  • 134
    • 18044382523 scopus 로고    scopus 로고
    • Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan
    • Zakrzewska A., Boorsma A., Brul S., Hellingwerf K.J., Klis F.M. Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan. Eukaryot. Cell 2005, 4:703-715.
    • (2005) Eukaryot. Cell , vol.4 , pp. 703-715
    • Zakrzewska, A.1    Boorsma, A.2    Brul, S.3    Hellingwerf, K.J.4    Klis, F.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.