Loss of Apm1, the μ1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast

Molecular Biology of the Cell

Volumn 15, Issue 6, 2004, Pages 2920-2931

  Kita, Ayako ^a,b   Sugiura, Reiko ^a,b   Shoji, Hiromi ^a   He, Yi ^a   Deng, Lu ^a   Lu, Yabin ^a   Sio, Susie O ^a,c   Takegawa, Kaoru ^d   Sakaue, Motoyoshi ^e   Shuntoh, Hisato ^f   Kuno, Takayoshi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^d KAGAWA UNIVERSITY   (Japan)

^e UNIVERSITY OF HYOGO   (Japan)

^f KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ADAPTOR PROTEIN; CALCINEURIN; CHLORIDE; CLATHRIN; CLATHRIN ASSOCIATED ADAPTOR PROTEIN 1; PROTEIN; SNARE PROTEIN; SYB PROTEIN; TACROLIMUS; UNCLASSIFIED DRUG; APM1 PROTEIN, S CEREVISIAE; MEMBRANE PROTEIN; MU ADAPTIN; PROTEIN SUBUNIT; RAB PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SCHIZOSACCHAROMYCES POMBE PROTEIN; SYNAPTOBREVIN; YPT3 PROTEIN, S POMBE;

ALLELE; APM1 GENE; ARTICLE; CALCINEURIN GENE; CALCIUM SIGNALING; CELL SECRETION; CELL VACUOLE; CELL WALL; CHLORIDE TRANSPORT; CIS1 APM1 GENE; CYTOKINESIS; ENDOSOME; EUKARYOTE; EXOCYTOSIS; GENE; GENE DELETION; GENE INTERACTION; GENE LOSS; GOLGI COMPLEX; LETHALITY; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SECRETORY VESICLE; SPINDLE POLE BODY; TEMPERATURE SENSITIVITY; YEAST; YEAST CELL; AMINO ACID SEQUENCE; CHEMISTRY; ENDOCYTOSIS; FUNGAL GENE; GENETICS; LETHAL GENE; METABOLISM; MITOSIS SPINDLE; MOLECULAR GENETICS; OSMOTIC PRESSURE; PHYSIOLOGY; PROMOTER REGION; SCHIZOSACCHAROMYCES; SECRETION; ULTRASTRUCTURE;

EUKARYOTA; MAMMALIA; SCHIZOSACCHAROMYCES POMBE;

ACID PHOSPHATASE; ADAPTOR PROTEIN COMPLEX 1; ADAPTOR PROTEIN COMPLEX MU SUBUNITS; AMINO ACID SEQUENCE; CALCINEURIN; CELL WALL; CYTOKINESIS; ENDOCYTOSIS; ENDOSOMES; GENE DELETION; GENES, FUNGAL; GENES, LETHAL; GOLGI APPARATUS; MEMBRANE PROTEINS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; OSMOTIC PRESSURE; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTEIN SUBUNITS; R-SNARE PROTEINS; RAB GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SECRETORY VESICLES;

EID: 16544379233     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-09-0659     Document Type: Article

References (45)

1. Armstrong, J., Craighead, M.W., Watson, R., Ponnambalam, S., and Bowden, S. (1993). Schizosaccharomyces pombe ypt5: a homologue of the rab5 endosome fusion regulator. Mol. Biol. Cell 4, 583-592.
2. Beach, D., Piper, M., and Nurse, P. (1982). Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol. Gen. Genet. 187, 326-329.
3. Boehm, M., and Bonifacino, J.S. (2001). Adaptins: the final recount. Mol. Biol. Cell 12, 2907-2920.
4. Bone, N., Millar, J.B., Toda, T., and Armstrong, J. (1998). Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases. Curr. Biol. 8, 135-144.
5. Cheng, H., Sugiura, R., Wu, W., Fujita, M., Lu, Y., Sio, S.O., Kawai, R., Takegawa, K., Shuntoh, H., and Kuno, T. (2002). Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. Mol. Biol. Cell 13, 2963-2976.
6. Conboy, M.J., and Cyert, M.S. (2000). Luv1p/Rki1p/Tcs3p/Vps54p, a yeast protein that localizes to the late Golgi and early endosome, is required for normal vacuolar morphology. Mol. Biol. Cell 11, 2429-2443.
7. Crabtree, G.R., and Olson, E.N. (2002). NFAT signaling: choreographing the social lives of cells. Cell 109 (suppl), S67-S79.
8. Craighead, M.W., Bowden, S., Watson, R., and Armstrong, J. (1993). Function of the ypt2 gene in the exocytic pathway of Schizosaccharomyces pombe. Mol. Biol. Cell 4, 1069-1076.
9. Edamatsu, M., and Toyoshima, Y.Y. (2003). Fission yeast synaptobrevin is involved in cytokinesis and cell elongation. Biochem. Biophys. Res. Commun. 301, 641-645.
10. + associates with the fission yeast spindle pole body and is essential for viability. J. Cell Biol. 129, 1033-1047.
11. Hagan, I.M., and Hyams, J.S. (1988). The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 89, 343-357.
12. - homeostasis in fission yeast: identification of distinct branches of calcineurin signaling pathway in fission yeast. J. Biol. Chem. 278, 18078-18084.
13. Kaiser, C.A., and Schekman, R. (1990). Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell 61, 723-733.
14. Keeney, J.B., and Boeke, J.D. (1994). Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe. Genetics 136, 849-856.
15. Klee, C.B., Crouch, T.H., and Krinks, M.H. (1979). Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc. Natl. Acad. Sci. USA 76, 6270-6273.
16. Levin, D.E., and Bartlett-Heubusch, E. (1992). Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect. J. Cell Biol. 116, 1221-1229.
17. Liu, J., Farmer, JD, Jr., Lane, W.S., Friedman, J., Weissman, I., Schreiber, S.L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
18. Matz, M.V., Fradkov, A.F., Labas, Y.A., Savitsky, A.P., Zaraisky, A.G., Markelov, M.L., and Lukyanov, S.A. (1999). Nat. Biotechnol. 17, 969-973.
19. Maundrell, K. (1993). Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene 123, 127-130.
20. Mendoza, I., Rubio, F., Rodriguez-Navarro, A., and Pardo, J.M. (1994). The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae. J. Biol. Chem. 269, 8792-8796.
21. Meyer, C., Zizioli, D., Lausmann, S., Eskelinen, E.L., Hamann, J., Saftig, P., von Figura, K., and Schu, P. (2000). mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 19, 2193-2203.
22. Moreno, S., Klar, A., and Nurse, P. (1991). Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194, 795-823.
23. Murray, J.M., and Johnson, D.I. (2001). The Cdc42p GTPase and its regulators Nrf1p and Scd1p are involved in endocytic trafficking in the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 276, 3004-3009.
24. Nabeshima, K., Nakagawa, T., Straight, A.F., Murray, A., Chikashige, Y., Yamashita, Y.M., Hiraoka, Y., and Yanagida, M. (1998). Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Mol. Biol. Cell 11, 3211-3225.
25. Nakamura, T., Liu, Y., Hirata, D., Namba, H., Harada, S., Hirokawa, T., Miyakawa, T. (1993). Protein phosphatase type 2B. (calcineurin)-mediated, F.K506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J. 12, 4063-4071.
26. Novick, P., Ferro, S., and Schekman, R. (1981). Order of events in the yeast secretory pathway. Cell 25, 461-469.
27. Ohno, H., Stewart, J., Fournier, M.C., Bosshart, H., Rhee, I., Miyatake, S., Saito, T., Gallusser, A., Kirchhausen, T., and Bonifacino, J.S. (1995). Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269, 1872-1875.
28. 2- exchangers. Mol. Cell. Biol. 16, 3730-3741.
29. Riezman, H. (1985). Endocytosis in yeast: several of the yeast secretory mutants are defective in endocytosis. Cell 40, 1001-1009.
30. Rothstein, R.J. (1983). One-step gene disruption in yeast. Methods Enzymol. 101, 202-211.
31. Sato, M., Kobori, H., Ishijima, S.A., Feng, Z.H., Hamada, K., Shimada, S., and Osumi, M. (1996). Schizosaccharomyces pombe is more sensitive to pressure stress than Saccharomyces cerevisiae. Cell Struct. Funct. 21, 167-174.
32. Stathopoulos, A.M., and Cyert, M.S. (1997). Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev. 11, 3432-3444.
33. Sugiura, R., Kita, A., Shimizu, Y., Shuntoh, H., Sio, S.O., and Kuno, T. (2003). Feedback regulation of MAPK signalling by an RNA-binding protein. Nature, 424, 961-965.
34. Sugiura, R., Sio, S.O., Shuntoh, H., and Kuno, T. (2002). Calcineurin phosphatase in signal transduction: lessons from fission yeast. Genes Cells 7, 619-627.
35. Sugiura, R., Toda, T., Dhut, S., Shuntoh, H., and Kuno, T. (1999). The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch. Nature 399, 479-483.
36. +, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast. EMBO J. 17, 140-148.
37. Tanaka, K., and Okayama, H. (2000). A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast. Mol. Biol. Cell 11, 2845-2862.
38. Tian, J., Karin, M. (1999). Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). J. Biol. Chem. 274, 15173-15180.
39. + gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Mol. Cell. Biol. 16, 6752-6764.
40. Valdivia, R.H., Baggott, D., Chuang, J.S., and Schekman, R.W. (2002). The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late Golgi membrane proteins. Dev. Cell 2, 283-294.
41. Vida, T.A., and Emr, S.D. (1995). A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J. Cell Biol. 128, 779-792.
42. Yada, T., Sugiura, R., Kita, A., Itoh, Y., Lu, Y., Hong, Y., Kinoshita, T., Shuntoh, H., and Kuno, T. (2001). Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis. J. Biol. Chem. 276, 13579-13586.
43. Yeung, B.G., Phan, H.L., and Payne, G.S. (1999). Adaptor complex-independent clathrin function in yeast. Mol. Biol. Cell 10, 3643-3659.
44. + in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning. J. Cell Sci. 107, 1725-1735.
45. Zizioli, D., Meyer, C., Guhde, G., Saftig, P., von Figura, K., and Schu, P. (1999). Early embryonic death of mice deficient in gamma-adaptin. J. Biol. Chem. 274, 5385-5390.