Genome-wide screening for genes associated with FK506 sensitivity in fission yeast

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Ma, Yan ^a   Jiang, Weijuan ^a   Liu, Qingbin ^a   Ryuko, Sayomi ^a   Kuno, Takayoshi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; HYBRID PROTEIN; MICAFUNGIN; PROTEIN SYB1; RIBOSOME PROTEIN; RNA BINDING PROTEIN; SNARE PROTEIN; SYNAPTOBREVIN; TACROLIMUS; UNCLASSIFIED DRUG; V SNARE PROTEIN; SCHIZOSACCHAROMYCES POMBE PROTEIN;

APL4 GENE; APL6 GENE; APM1 GENE; APS3 GENE; ARTICLE; CELL VACUOLE; CELL WALL; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; CYTOKINESIS; DRUG SENSITIVITY; END4 GENE; ERP2 GENE; ERV15 GENE; FUNGAL GENE; GENE DELETION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC SCREENING; GGA1 GENE; GOS1 GENE; GYP1 GENE; HAPLOIDY; MEMBRANE TRANSPORT; MYO1 GENE; NONHUMAN; PROTEIN LOCALIZATION; RYH1 GENE; SENSITIVITY ANALYSIS; SFT2 GENE; SIGNAL TRANSDUCTION; UBIQUITINATION; VSP1302 GENE; VSP45 GENE; VSP71 GENE; YEAST; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; SCHIZOSACCHAROMYCES;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

CALCINEURIN; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TACROLIMUS;

EID: 79961154489     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023422     Document Type: Article

References (47)

1. Shibasaki F, Hallin U, Uchino H, (2002) Calcineurin as a multifunctional regulator. J Bio Chem 131: 1-15.
2. Crabtree GR, (2001) Calcium, calcineurin, and the control of transcription. J Biol Chem 276: 2313-2316.
3. Groth RD, Dunbar RL, Mermelstein PG, (2003) Calcineurin regulation of neuronal plasticity. Biochem Biophys Res Commun 311: 1159-1171.
4. Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, et al. (2007) Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. J Biol Chem 282: 10068-10078.
5. Filosto S, Fry W, Knowlton AA, Goldkorn T, (2010) Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B). J Biol Chem 285: 10213-10222.
6. Knoll GA, (2009) Proteinuria in kidney transplant recipients: prevalence, prognosis, and evidence-based management. Am J Kidney Dis 54: 1131-1144.
7. Schonenberger E, Ehrich JH, Haller H, Schiffer M, (2011) The podocyte as a direct target of immunosuppressive agents. Nephrol Dial Transplant 26: 18-24.
8. McCourtie AS, Merry HE, Wolf PS, FitzSullivan E, Keech JC, et al. (2010) Synergistic protection in lung ischemia-reperfusion injury with calcineurin and thrombin inhibition. Ann Thorac Surg 89: 1766-1771.
9. Nakamura T, Liu Y, Hirata D, Namba H, Harada S, et al. (1993) Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J 12: 4063-4071.
10. Park SY, Seo SB, Lee SJ, Na JG, Kim YJ, (2001) Mutation in PMR1, a Ca(2+)-ATPase in Golgi, confers salt tolerance in Saccharomyces cerevisiae by inducing expression of PMR2, an Na(+)-ATPase in plasma membrane. J Biol Chem 276: 28694-28699.
11. Bonilla M, Nastase KK, Cunningham KW, (2002) Essential role of calcineurin in response to endoplasmic reticulum stress. EMBO J 21: 2343-2353.
12. Zhao C, Jung US, Garrett-Engele P, Roe T, Cyert MS, et al. (1998) Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin. Mol Cell Biol 18: 1013-1022.
13. Stathopoulos AM, Cyert MS, (1997) CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev 11: 3432-3444.
14. Heath VL, Shaw SL, Roy S, Cyert MS, (2004) Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Eukaryot Cell 3: 695-704.
15. Bultynck G, Heath VL, Majeed AP, Galan JM, Haguenauer-Tsapis R, et al. (2006) Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Mol Cell Biol 26: 4729-4745.
16. Yoshida T, Toda T, Yanagida M, (1994) A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning. J Cell Sci 107 (Pt7): 1725-1735.
17. Sugiura R, Toda T, Shuntoh H, Yanagida M, Kuno T, (1998) pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast. EMBO J 17: 140-148.
18. Sugiura R, Toda T, Dhut S, Shuntoh H, Kuno T, (1999) The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch. Nature 399: 479-483.
19. Ma Y, Kuno T, Kita A, Asayama Y, Sugiura R, (2006) Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast. Mol Biol Cell 17: 5028-5037.
20. Hirayama S, Sugiura R, Lu Y, Maeda T, Kawagishi K, et al. (2003) Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast. J Biol Chem 278: 18078-18084.
21. Lu Y, Sugiura R, Yada T, Cheng H, Sio SO, et al. (2002) Calcineurin is implicated in the regulation of the septation initiation network in fission yeast. Genes Cells 7: 1009-1019.
22. Fujita M, Sugiura R, Lu Y, Xu L, Xia Y, et al. (2002) Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast. Genetics 161: 971-981.
23. He Y, Sugiura R, Ma Y, Kita A, Deng L, et al. (2006) Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway. Genes Cells 11: 207-221.
24. Ma Y, Kuno T, Kita A, Nabata T, Uno S, et al. (2006) Genetic evidence for phospholipid-mediated regulation of the Rab GDP-dissociation inhibitor in fission yeast. Genetics 174: 1259-1271.
25. Fang Y, Sugiura R, Ma Y, Yada-Matsushima T, Umeno H, et al. (2008) Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeast. Mol Biol Cell 19: 1295-1303.
26. Kim DU, Hayles J, Kim D, Wood V, Park HO, et al. (2010) Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol 28: 617-623.
27. Toda T, Dhut S, Superti-Furga G, Gotoh Y, Nishida E, et al. (1996) The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Mol Cell Biol 16: 6752-6764.
28. Edamatsu M, Toyoshima YY, (2003) Fission yeast synaptobrevin is involved in cytokinesis and cell elongation. Biochem Biophys Res Commun 301: 641-645.
29. Kita A, Sugiura R, Shoji H, He Y, Deng L, et al. (2004) Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast. Mol Biol Cell 15: 2920-2931.
30. Deng L, Sugiura R, Takeuchi M, Suzuki M, Ebina H, et al. (2006) Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast. Mol Biol Cell 17: 4790-4800.
31. Ma Y, Sugiura R, Zhang L, Zhou X, Takeuchi M, et al. (2010) Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase. Mol Genet Genomics 284: 161-171.
32. Cheng H, Sugiura R, Wu W, Fujita M, Lu Y, et al. (2002) Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. Mol Biol Cell 13: 2963-2976.
33. Ma Y, Takeuchi M, Sugiura R, Sio SO, Kuno T, (2009) Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeast. Genes Cells 14: 1015-1028.
34. Geli MI, Riezman H, (1996) Role of type I myosins in receptor-mediated endocytosis in yeast. Science 272: 533-535.
35. Attanapola SL, Alexander CJ, Mulvihill DP, (2009) Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1. J Cell Sci 122: 3856-3861.
36. Iwaki T, Tanaka N, Takagi H, Giga-Hama Y, Takegawa K, (2004) Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe. Yeast 21: 867-881.
37. Singer-Kruger B, Stenmark H, Dusterhoft A, Philippsen P, Yoo JS, et al. (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol 125: 283-298.
38. Du LL, Novick P, (2001) Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. Mol Biol Cell 12: 1215-1226.
39. Staub O, Rotin D, (2006) Role of ubiquitylation in cellular membrane transport. Physiol Rev 86: 669-707.
40. Sugiura R, Sio SO, Shuntoh H, Kuno T, (2002) Calcineurin phosphatase in signal transduction: lessons from fission yeast. Genes Cells 7: 619-627.
41. Mazur P, Morin N, Baginsky W, el Sherbeini M, Clemas JA, et al. (1995) Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol 15: 5671-5681.
42. Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB, et al. (1994) The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. Proc Natl Acad Sci USA 91: 12907-12911.
43. Eidelman BH, Abu-Elmagd K, Wilson J, Fung JJ, Alessiani M, et al. (1991) Neurologic complications of FK506. Transplant Proc 23: 3175-3178.
44. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Chapman JR, et al. (2004) Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 78: 557-565.
45. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, et al. (2003) The natural history of chronic allograft nephropathy. N Engl J Med 349: 2326-2333.
46. Ulrich C, Kanitakis J, Stockfleth E, Euvrard S, (2008) Skin cancer in organ transplant recipients-where do we stand today? Am J Transplant 8: 2192-2198.
47. Webster AC, Wong G, Craig JC, Chapman JR, (2008) Managing cancer risk and decision making after kidney transplantation. Am J Transplant 8: 2185-2191.