Calcineurin colocalizes with P-bodies and stress granules during thermal stress in cryptococcus neoformans

Eukaryotic Cell

Volumn 10, Issue 11, 2011, Pages 1396-1402

  Kozubowski, Lukasz ^a   Aboobakar, Eanas F ^a   Cardenas, Maria E ^a   Heitman, Joseph ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; DIPEPTIDYL CARBOXYPEPTIDASE; POLYADENYLIC ACID BINDING PROTEIN; PROTEINASE;

ARTICLE; CELL GRANULE; CRYPTOCOCCUS NEOFORMANS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HEAT; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

CALCINEURIN; CRYPTOCOCCUS NEOFORMANS; CYTOPLASMIC GRANULES; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, FUNGAL; HOT TEMPERATURE; POLY(A)-BINDING PROTEINS; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC;

FILOBASIDIELLA NEOFORMANS;

EID: 80053448765     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.05087-11     Document Type: Article

References (39)

1. Alspaugh, J. A., J. R. Perfect, and J. Heitman. 1997. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev. 11:3206-3217.
2. Aramburu, J., J. Heitman, and G. R. Crabtree. 2004. Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep. 5:343-348.
3. Biswas, A., et al. 2011. Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6. J. Biol. Chem. 286:3129-3138.
4. Bollo, M., et al. 2010. Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs. PLoS One 5:e11925.
5. Buchan, J. R., T. Nissan, and R. Parker. 2010. Analyzing P-bodies and stress granules in Saccharomyces cerevisiae. Methods Enzymol. 470:619-640.
6. Buchan, J. R., and R. Parker. 2009. Eukaryotic stress granules: the ins and outs of translation. Mol. Cell 36:932-941.
7. 2+ flux. Cell 83:463-472.
8. Cao, Q., J. H. Kim, and J. D. Richter. 2006. CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression. Nat. Struct. Mol. Biol. 13:1128-1134.
9. Crabtree, G. R., and E. N. Olson. 2002. NFAT signaling: choreographing the social lives of cells. Cell 109(Suppl.):S67-S79.
10. 2+-calcineurin-NFAT signaling. Cell 138:210, 210 e211.
11. Cyert, M. S. 2003. Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress. Biochem. Biophys. Res. Commun. 311:1143-1150.
12. Davidson, R. C., et al. 2000. Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. Fungal Genet. Biol. 29:38-48.
13. Fox, D. S., G. M. Cox, and J. Heitman. 2003. Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans. Eukaryot. Cell 2:1025-1035.
14. Fox, D. S., et al. 2001. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol. Microbiol. 39:835-849.
15. Fox, D. S., and J. Heitman. 2002. Good fungi gone bad: the corruption of calcineurin. Bioessays 24:894-903.
16. Fox, D. S., and J. Heitman. 2005. Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. Eukaryot. Cell 4:1526-1538.
17. Frey, N., J. A. Richardson, and E. N. Olson. 2000. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc. Natl. Acad. Sci. U. S. A. 97:14632-14637.
18. Gladfelter, A. S., J. R. Pringle, and D. J. Lew. 2001. The septin cortex at the yeast mother-bud neck. Curr. Opin. Microbiol. 4:681-689.
19. Gorlach, J., et al. 2000. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J. 19:3618-3629.
20. Granger, D. L., J. R. Perfect, and D. T. Durack. 1985. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J. Clin. Invest. 76:508-516.
21. Heath, V. L., S. L. Shaw, S. Roy, and M. S. Cyert. 2004. Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Eukaryot. Cell 3:695-704.
22. Hilioti, Z., and K. W. Cunningham. 2003. The RCN family of calcineurin regulators. Biochem. Biophys. Res. Commun. 311:1089-1093.
23. Idnurm, A., S. S. Giles, J. R. Perfect, and J. Heitman. 2007. Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans. Eukaryot. Cell 6:60-72.
24. Idnurm, A., and J. Heitman. 2010. Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi. Microbiology 156:2393-2407.
25. Juvvadi, P. R., et al. 2008. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryot. Cell 7:1606-1610.
26. Kahl, C. R., and A. R. Means. 2004. Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. Mol. Biol. Cell 15:1833-1842.
27. Kedersha, N., et al. 2005. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J. Cell Biol. 169:871-884.
28. 2+ induce multiple P-bodies. Mol. Biol. Cell 21:2624-2638.
29. Kojima, K., Y. S. Bahn, and J. Heitman. 2006. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152:591-604.
30. Kozubowski, L., and J. Heitman. 2009. Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. Mol. Microbiol. 2010 75:658-675.
31. Nielsen, K., et al. 2003. Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect. Immun. 71:4831-4841.
32. Odom, A., et al. 1997. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16:2576-2589.
33. Oliveria, S. F., L. L. Gomez, and M. L. Dell'Acqua. 2003. Imaging kinase- AKAP79-phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J. Cell Biol. 160:101-112.
34. Parry, R. V., and C. H. June. 2003. Calcium-independent calcineurin regulation. Nat. Immunol. 4:821-823.
35. Sans, M. D., and J. A. Williams. 2004. Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. Am. J. Physiol. 287:C310-C319.
36. Steinbach, W. J., J. L. Reedy, R. A. Cramer Jr., J. R. Perfect, and J. Heitman. 2007. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat. Rev. Microbiol. 5:418-430.
37. Wang, X., et al. 2010. Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes Dev. 24:2566-2582.
38. Xue, C., Y. S. Bahn, G. M. Cox, and J. Heitman. 2006. G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol. Biol. Cell 17:667-679.
39. Zelter, A., M. Bencina, B. J. Bowman, O. Yarden, and N. D. Read. 2004. A comparative genomic analysis of the calcium signaling machinery in Neurospora crassa, Magnaporthe grisea, and Saccharomyces cerevisiae. Fungal Genet. Biol. 41:827-841.