IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nature Immunology

Volumn 16, Issue 4, 2015, Pages 354-365

  Nold Petry, Claudia A ^a,b   Lo, Camden Y ^a,b   Rudloff, Ina ^a,b   Elgass, Kirstin D ^b   Li, Suzhao ^c   Gantier, Michael P ^a,b   Lotz Havla, Amelie S ^d   Gersting, Søren W ^d   Cho, Steven X ^a,b   Lao, Jason C ^a,b   Ellisdon, Andrew M ^b   Rotter, Björn ^e   Azam, Tania ^c   Mangan, Niamh E ^a,b   Rossello, Fernando J ^b   Whisstock, James C ^b   Bufler, Philip ^f   Garlanda, Cecilia ^g   Mantovani, Alberto ^g,h   Dinarello, Charles A ^c,i   Nold, Marcel F ^a,b,c   more..

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

^e GENXPRO GMBH   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^h HUMANITAS UNIVERSITY   (Italy)

ⁱ RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR 8; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 37; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; METHANOL EXTRACTION RESIDUE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE FYN; PROTEIN P62; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG; FYN PROTEIN, HUMAN; IL37 PROTEIN, HUMAN; INTERLEUKIN 1; MAP KINASE KINASE KINASE 7; MERTK PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MTOR PROTEIN, HUMAN; ONCOPROTEIN; P62 PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN TYROSINE KINASE; PTEN PROTEIN, HUMAN; RNA BINDING PROTEIN; SMALL INTERFERING RNA; STAT3 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TIR8 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; FEMALE; HUMAN; HUMAN CELL; INNATE SIGNAL TRANSDUCTION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; MONONUCLEAR CELL; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASES; MICE; MICE, TRANSGENIC; NF-KAPPA B; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; PTEN PHOSPHOHYDROLASE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, INTERLEUKIN-1; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES;

EID: 84925671141     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3103     Document Type: Article

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