Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent

Infection and Immunity

Volumn 68, Issue 12, 2000, Pages 6954-6961

  Bekker, Linda Gail ^a,b   Moreira, Andre L ^a   Bergtold, Amy ^a   Freeman, Sherry ^a   Ryffel, Bernard ^b   Kaplan, Gilla ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOPATHOGENESIS; INFLAMMATORY DISEASE; LUNG GRANULOMA; MOUSE; MYCOBACTERIOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN DISEASE; SURVIVAL;

ANIMALS; ANTIGENS, CD; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM BOVIS; ORGAN SIZE; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SPLEEN; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034440521     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.12.6954-6961.2000     Document Type: Article

References (32)

1. Bean, A. G., D. R. Roach, H. Briscoe, M. P. France, H. Korner, J. D. Sedgwick, and W. J. Britton. 1999. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J. Immunol. 162:3504-3511.
2. Bekker, L. G., G. Maartens, L. Steyn, and G. Kaplan. 1998. Selective increase in plasma TNF-α and concomitant clinical deterioration after initiating therapy in patients with severe tuberculosis. J. Infect. Dis. 178:580-584.
3. Beutler, B., and A. Cerami. 1988. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu. Rev. Biochem. 57:505-518.
4. Britton, W. J., N. Meadows, D. A. Rathjen, D. R. Roach, and H. Briscoe. 1998. A tumor necrosis factor mimetic peptide activates a murine macrophage cell line to inhibit mycobacterial growth in a nitric oxide-dependent fashion. Infect. Immun. 66:2122-2127.
5. Clark, I. A., W. B. Cowden, G. A. Butcher, and N. H. Hunt. 1987. Possible roles of tumor necrosis factor in the pathology of malaria. Am. J. Pathol. 129:192-199.
6. Contreras, M., N. Hariharan, J. R. Lewandoski, W. Ciesielski, R. Koscik, and J. J. Zimmerman. 1996. Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia. Crit. Care Med. 24:29-37.
7. Denis, M., E. O. Gregg, and E. Ghandirian. 1990. Cytokine modulation of Mycobacterium tuberculosis growth in human macrophages. Int. J. Immunopharmacol. 12:721-727.
8. Denis, M. 1991. Involvement of cytokines in determining resistance and acquired immunity in murine tuberculosis. J. Leukoc. Biol. 50:495-501.
9. Flynn, J. L., M. M. Goldstein, J. Chan, K. J. Triebold, K. Pfeffer, C. J. Lowenstein, R. Schreiber, T. W. Mak, and B. R. Bloom. 1995. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561-572.
10. Garcia, I., Y. Miyazaki, G. Marchal, W. Lesslauer, and P. Vassalli. 1997. High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: synergistic action of TNF and IFN-γ in the differentiation of protective granulomas. Eur. J. Immunol. 27:3182-3190.
11. Josien, R., B. R. Wong, H. L. Li, R. M. Steinman, and Y. Choi. 1999. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells. J. Immunol. 162:2562-2568.
12. Kaplan, G., A. D. Luster, G. Hancock, and Z. A. Cohn. 1987. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J. Exp. Med. 166:1098-1108.
13. Kindler, V., A.-P. Sappino, G. E. Grau, P. F. Pignet, and P. Vassalli. 1989. The inducing role of tumour necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56:731-740.
14. Kristof, A. S., P. Goldberg, V. Laubach, and S. N. Hussain. 1998. Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 158:1883-1889.
15. Laochumroonvorapong, P., J. Wang, C.-C. Liu, W. Ye, A. L. Moreira, K. B. Elkon, V. H. Freedman, and G. Kaplan. 1997. Perform, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect. Immun. 65:127-132.
16. Loetscher, M., B. Gerber, P. Loetscher, S. A. Jones, L. Piali, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1996. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J. Exp. Med. 184:963-969.
17. Luster, A. D., S. M. Greenberg, and P. Leder. 1995. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med. 182:219-231.
18. MacMicking, J. D., R. J. North, R. LaCourse, J. S. Mudgett, S. K. Shah, and C. F. Nathan. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA 94:5243-5248.
19. Marino, M. W., A. Dunn, D. Grail, M. Inglese, Y. Noguchi, E. Richards, A. Jungbluth, H. Wada, M. Moore, B. Williamson, S. Basu, and L. J. Old. 1997. Characterization of tumor necrosis factor-deficient mice. Proc. Natl. Acad. Sci. USA 94:8093-8098.
20. Ming, W. J., L. Bersani, and A. Mantovani. 1987. Tumor necrosis factor is chemotactic for monocyte and polymorphonuclear leukocytes. J. Immunol. 138:1469-1474.
21. Moreira, A. L., L. Tsenova, P. J. Murray, S. Freeman, A. Bergtold, L. Chiriboga, and G. Kaplan. 2000. Aerosol infection of mice with recombinant BCG secreting murine IFN-γ reconstitutes local protective immunity. Microb. Pathog. 29:175-185.
22. Moreira, A. L., L. Tsenova-Berkova, J. Wang, P. Laochumroonvorapong, S. Freeman, V. H. Freedman, and G. Kaplan. 1997. Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. Tuber. Lung Dis. 78:47-55.
23. Murray, P. J., A. Aldovini, and R. A. Young. 1996. Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guerin strains that secrete cytokines. Proc. Natl. Acad. Sci. USA 93:934-939.
24. O'Donnell, M. A., A. Aldovini, R. B. Duda, H. Yang, A. Szilvasi, R. A. Young, and W. C. DeWolf. 1994. Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect. Immun. 62:2508-2514.
25. Roach, D. R., H. Briscoe, K. Baumgart, D. A. Rathjen, and W. J. Britton. 1999. Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo. Infect. Immun. 67:5473-5476.
26. Rothe, J., W. Lesslauer, H. Lotscher, Y. Lang, P. Koebel, F. Kontgen, A. Althage, R. Zinkernagel, M. Steinmetz, and H. Bluethmann. 1993. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Usteria monocytogenes. Nature 364:798-802.
27. Taub, D. D., D. L. Longo, and W. J. Murphy. 1996. Human interferon-inducible protein-120 induces mononuclear cell infiltration in mice and promotes the migration of human T lymphocytes into the peripheral tissues and human peripheral blood lymphocytes-SCID mice. Blood 87:1423-1431.
28. Tracey, K. J., and A. Cerami. 1992. Tumor necrosis factor and regulation of metabolism in infection: role of systemic versus tissue levels. Proc. Soc. Exp. Biol. Med. 200:233-239.
29. Tsenova, L., A. Bergtold, V. H. Freedman, R. A. Young, and G. Kaplan. 1999. Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. Proc. Natl. Acad. Sci. USA 96:5657-5662.
30. Ueta, C., H. Kawasumi, H. Fujiwara, T. Miyagawa, H. Kida, Y. Ohmoto, S. Kishimoto, and I. Tsuyuguchi. 1996. Interleukin-12 activates human gamma delta T cells: synergistic effect of tumor necrosis factor-alpha. Eur. J. Immunol. 26:3066-3073.
31. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411-452.
32. Wuyts, A., P. Proost, and J. VanDamme. 1998. Interleukin-8 and other CXC-chemokines, p. 271-311. In A. Thomson (ed.), The cytokine handbook. Academic Press, New York, N.Y.