Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells

Kidney International

Volumn 72, Issue 2, 2007, Pages 182-192

  Lech, M ^a   Garlanda, C ^b   Mantovani, A ^b   Kirschning, C J ^c   Schlondorff D ^a   Anders, H J ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Infection; Lipopolysaccharide; SIGIRR; Toll like receptor

Indexed keywords

TOLL LIKE RECEPTOR 8;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; GLYCOSYLATION; INNATE IMMUNITY; KIDNEY INFECTION; KIDNEY TUBULE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA SPLICING; UROPATHOGENIC ESCHERICHIA COLI;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELLS, CULTURED; EPITHELIAL CELLS; IMMUNITY, NATURAL; KIDNEY; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MONOCYTES; MYELOID CELLS; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 34447507719     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002293     Document Type: Article

References (31)

1. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124: 783-801.
2. Anders HJ, Banas B, Schlondorff D. Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15: 854-867.
3. Tsuboi N, Yoshikai Y, Matsuo S et al. Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol 2002; 169: 2026-2033.
4. Zhang DG, Zhang MS, Hayden MB et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303: 1522-1526.
5. Hung CC, Chang CT, Chen KH et al. Upregulation of chemokine CXCL1/KC by leptospiral membrane lipoprotein preparation in renal tubule epithelial cells. Kidney Int 2006; 69: 1814-1822.
6. Yang CW, Hung CC, Wu MS et al. Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells. Kidney Int 2006; 69: 815-822.
7. Saemann MD, Weichhart T, Zeyda M et al. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005; 115: 468-475.
8. Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
9. Patole PS, Schubert S, Meßmer K et al. Toll-like receptor-4: intrinsic renal cells and bone marrow-derived cells signal for neutrophil recruitment during infective pyelonephritis. Kidney Int 2005; 68: 2582-2587.
10. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5: 987-995.
11. Muzio M, Polentarutti N, Bosisio D et al. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J Leukoc Biol 2000; 67: 450-456.
12. Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005; 5: 446-458.
13. Wells CA, Chalk AM, Forrest A et al. Alternate transcription of the Toll-like receptor signaling cascade. Genome Biol 2006; 7: R10.
14. Thomassen E, Renshaw BR, Sims JE. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine 1999; 11: 389-399.
15. Polentarutti N, Rol GP, Muzio M et al. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw 2003; 14: 211-218.
16. Norris JL, Manley JL. Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal. Genes Dev 1996; 10: 862-872.
17. Wald D, Qin J, Zhao Z et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2003; 4: 920-927.
18. Qin J, Qian Y, Yao J et al. SIGIRR inhibits interleukin-1 receptor- and tolllike receptor 4-mediated signaling through different mechanisms. J Biol Chem 2005; 280: 25233-25241.
19. Garlanda C, Riva F, Polentarutti N et al. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci USA 2004; 101: 3522-3526.
20. Huang X, Hazlett LD, Du W, Barrett RP. SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. J Immunol 2006; 177: 548-556.
21. Renshaw M, Rockwell J, Engleman C et al. Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 2002; 169: 4697-4701.
22. Kruger T, Benke D, Eitner F et al. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 2004; 15: 613-621.
23. Soos TJ, Sims TN, Barisoni L et al. CX(3)CR1(+) interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int 2006; 70: 591-596.
24. Mutant mice and neuroscience: recommendations concerning genetic background. Banbury conference on genetic background in mice. Neuron 1997; 19: 755-759.
25. Sigmund CD. Viewpoint: are studies in genetically altered mice out of control? Arterioscler Thromb Vasc Biol 2000; 20: 1425-1429.
26. Bergers G, Reikerstorfer A, Braselmann S et al. Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J 1994; 13: 1176-1188.
27. Rossler U, Thomassen E, Hultner L et al. Secreted and membrane-bound isoforms of T1, an orphan receptor related to IL-1-binding proteins, are differently expressed in vivo. Dev Biol 1995; 168: 86-97.
28. Daniels MA, Hogquist KA, Jameson SC. Sweet 'n' sour: the impact of differential glycosylation on T-cell responses. Nat Immunol 2002; 3: 903-910.
29. Scheiffele P, Peranen J, Simons K. N-glycans as apical sorting signals in epithelial cells. Nature 1995; 378: 96-98.
30. Adib-Conquy M, Adrie C, Fitting C et al. Up-regulation of MyD88s and SIGIRR, molecules inhibiting toll-like receptor signaling, in monocytes from septic patients. Crit Care Med 2006; 34: 2377-2385.
31. Fagerlund R, Kinnunen L, Kohler M et al. NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4. J Biol Chem 2005; 280: 15942-15951.