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Volumn 388, Issue 4, 2015, Pages 421-436

TRPV4: Physiological role and therapeutic potential in respiratory diseases

Author keywords

Acute lung injury; Transient receptor potential; TRPV4 structure

Indexed keywords

VANILLOID RECEPTOR 4; VANILLOID RECEPTOR ANTAGONIST; VANILLOID RECEPTOR;

EID: 84925481981     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-014-1058-1     Document Type: Article
Times cited : (63)

References (111)
  • 2
    • 66049108304 scopus 로고    scopus 로고
    • TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization
    • 1:CAS:528:DC%2BD1MXmt1Cmurk%3D 19439599
    • Alessandri-Haber N, Dina OA, Chen X, Levine JD (2009) TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci 29:6217-6228. doi: 10.1523/JNEUROSCI.0893-09.2009
    • (2009) J Neurosci , vol.29 , pp. 6217-6228
    • Alessandri-Haber, N.1    Dina, O.A.2    Chen, X.3    Levine, J.D.4
  • 3
    • 0035301778 scopus 로고    scopus 로고
    • Ruthenium in medicine: Current clinical uses and future prospects
    • 1:CAS:528:DC%2BD3MXltVOgsLs%3D
    • Allardyce CS, Dyson PJ (2001) Ruthenium in medicine: current clinical uses and future prospects. Platin Met Rev 45:62-69
    • (2001) Platin Met Rev , vol.45 , pp. 62-69
    • Allardyce, C.S.1    Dyson, P.J.2
  • 4
    • 33750493644 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: A novel mechanism of acute lung injury
    • 1:CAS:528:DC%2BD28XhtFSlur7J 17008604
    • Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI (2006) Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res 99:988-995. doi: 10.1161/01.RES.0000247065.11756.19
    • (2006) Circ Res , vol.99 , pp. 988-995
    • Alvarez, D.F.1    King, J.A.2    Weber, D.3    Addison, E.4    Liedtke, W.5    Townsley, M.I.6
  • 6
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
    • ARDSNet 10.1056/NEJM200005043421801
    • ARDSNet (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301-1308. doi: 10.1056/NEJM200005043421801
    • (2000) N Engl J Med , vol.342 , pp. 1301-1308
  • 7
    • 33644969008 scopus 로고    scopus 로고
    • Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking
    • 1:CAS:528:DC%2BD28XksFOmug%3D%3D 16293632
    • Arniges M, Fernández-Fernández JM, Albrecht N, Schaefer M, Valverde MA (2006) Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 281:1580-1586. doi: 10.1074/jbc.M511456200
    • (2006) J Biol Chem , vol.281 , pp. 1580-1586
    • Arniges, M.1    Fernández-Fernández, J.M.2    Albrecht, N.3    Schaefer, M.4    Valverde, M.A.5
  • 8
    • 11144231273 scopus 로고    scopus 로고
    • Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia
    • 1:CAS:528:DC%2BD2cXhtVyltLnE 15489228
    • Arniges M, Vázquez E, Fernández-Fernández JM, Valverde MA (2004) Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem 279:54062-54068. doi: 10.1074/jbc.M409708200
    • (2004) J Biol Chem , vol.279 , pp. 54062-54068
    • Arniges, M.1    Vázquez, E.2    Fernández-Fernández, J.M.3    Valverde, M.A.4
  • 10
    • 0029039835 scopus 로고
    • Regulation of pulmonary vascular tone
    • 1:CAS:528:DyaK2MXkvF2hsbg%3D 7784481
    • Barnes PJ, Liu SF (1995) Regulation of pulmonary vascular tone. Pharmacol Rev 47:87-131
    • (1995) Pharmacol Rev , vol.47 , pp. 87-131
    • Barnes, P.J.1    Liu, S.F.2
  • 11
    • 0019973551 scopus 로고
    • The gadolinium ion: A potent blocker of calcium channels and catecholamine release from cultured chromaffin cells
    • 1:CAS:528:DyaL38Xltl2gsb4%3D 6289176
    • Bourne GW, Trifaró JM (1982) The gadolinium ion: a potent blocker of calcium channels and catecholamine release from cultured chromaffin cells. Neuroscience 7:1615-1622
    • (1982) Neuroscience , vol.7 , pp. 1615-1622
    • Bourne, G.W.1    Trifaró, J.M.2
  • 13
    • 0347504835 scopus 로고    scopus 로고
    • TRP channels as cellular sensors
    • 1:CAS:528:DC%2BD3sXpsVejtrc%3D 14654832
    • Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517-524. doi: 10.1038/nature02196
    • (2003) Nature , vol.426 , pp. 517-524
    • Clapham, D.E.1
  • 16
    • 57449114954 scopus 로고    scopus 로고
    • The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils
    • 1:CAS:528:DC%2BD1MXns1Sluw%3D%3D
    • Damann N, Owsianik G, Li S, Poll C, Nilius B (2009) The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils. Acta Physiol (Oxf) 195:3-11. doi: 10.1111/j.1748-1716.2008.01918.x
    • (2009) Acta Physiol (Oxf) , vol.195 , pp. 3-11
    • Damann, N.1    Owsianik, G.2    Li, S.3    Poll, C.4    Nilius, B.5
  • 18
    • 33749836234 scopus 로고    scopus 로고
    • Phosphoinositides in cell regulation and membrane dynamics
    • Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651-657. doi: 10.1038/nature05185
    • (2006) Nature , vol.443 , pp. 651-657
    • Di Paolo, G.1    De Camilli, P.2
  • 19
    • 84912111747 scopus 로고    scopus 로고
    • TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel
    • Du J, Ma X, Shen B, Huang Y, Birnbaumer L, Yao X (2014) TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J. doi: 10.1096/fj.14-251652
    • (2014) FASEB J
    • Du, J.1    Ma, X.2    Shen, B.3    Huang, Y.4    Birnbaumer, L.5    Yao, X.6
  • 20
    • 84863503500 scopus 로고    scopus 로고
    • Protein kinase G inhibits flow-induced Ca2+ entry into collecting duct cells
    • 1:CAS:528:DC%2BC38XhtFOks7rF 22518003
    • Du J, Wong W-Y, Sun L, Huang Y, Yao X (2012) Protein kinase G inhibits flow-induced Ca2+ entry into collecting duct cells. J Am Soc Nephrol 23:1172-1180. doi: 10.1681/ASN.2011100972
    • (2012) J Am Soc Nephrol , vol.23 , pp. 1172-1180
    • Du, J.1    Wong, W.-Y.2    Sun, L.3    Huang, Y.4    Yao, X.5
  • 21
    • 33644671418 scopus 로고    scopus 로고
    • TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels
    • 1:CAS:528:DC%2BD2MXht1yjurbO 16269659
    • Earley S, Heppner TJ, Nelson MT, Brayden JE (2005) TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res 97:1270-1279. doi: 10.1161/01.RES.0000194321.60300.d6
    • (2005) Circ Res , vol.97 , pp. 1270-1279
    • Earley, S.1    Heppner, T.J.2    Nelson, M.T.3    Brayden, J.E.4
  • 23
    • 70350450234 scopus 로고    scopus 로고
    • Activation of the TRPV4 ion channel is enhanced by phosphorylation
    • 1:CAS:528:DC%2BD1MXht1Sqsb%2FM 19661060
    • Fan H-C, Zhang X, McNaughton PA (2009) Activation of the TRPV4 ion channel is enhanced by phosphorylation. J Biol Chem 284:27884-27891. doi: 10.1074/jbc.M109.028803
    • (2009) J Biol Chem , vol.284 , pp. 27884-27891
    • Fan, H.-C.1    Zhang, X.2    McNaughton, P.A.3
  • 24
  • 25
    • 52549101713 scopus 로고    scopus 로고
    • Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines
    • Fernández-Fernández JM, Andrade YN, Arniges M, Fernandes J, Plata C, Rubio-Moscardo F, Vázquez E, Valverde MA (2008) Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch 457:149-159. doi: 10.1007/s00424-008-0516-3
    • (2008) Pflugers Arch , vol.457 , pp. 149-159
    • Fernández-Fernández, J.M.1    Andrade, Y.N.2    Arniges, M.3    Fernandes, J.4    Plata, C.5    Rubio-Moscardo, F.6    Vázquez, E.7    Valverde, M.A.8
  • 26
    • 84867510058 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 4 blockade protects against experimental colitis in mice: A new strategy for inflammatory bowel diseases treatment?
    • 1:CAS:528:DC%2BC3sXhsFajtw%3D%3D 22882778
    • Fichna J, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Małecka-Panas E, Janecka A, Krajewska WM, Storr MA (2012) Transient receptor potential vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment? Neurogastroenterol Motil 24:e557-e560. doi: 10.1111/j.1365-2982.2012.01999.x
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 557-e560
    • Fichna, J.1    Mokrowiecka, A.2    Cygankiewicz, A.I.3    Zakrzewski, P.K.4    Małecka-Panas, E.5    Janecka, A.6    Krajewska, W.M.7    Storr, M.A.8
  • 27
    • 84940981921 scopus 로고    scopus 로고
    • TRPs: Truly remarkable proteins
    • Flockerzi V, Nilius B (2014) TRPs: truly remarkable proteins. Handb Exp Pharmacol 222:1-12. doi: 10.1007/978-3-642-54215-2-1
    • (2014) Handb Exp Pharmacol , vol.222 , pp. 1-12
    • Flockerzi, V.1    Nilius, B.2
  • 34
    • 0033779692 scopus 로고    scopus 로고
    • Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension
    • 1:CAS:528:DC%2BD3cXnsVKisLo%3D 11015616
    • Hampl V, Herget J (2000) Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiol Rev 80:1337-1372
    • (2000) Physiol Rev , vol.80 , pp. 1337-1372
    • Hampl, V.1    Herget, J.2
  • 35
    • 0037450768 scopus 로고    scopus 로고
    • Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6
    • 1:CAS:528:DC%2BD3sXit1yhu7s%3D 12574114
    • Hoenderop JGJ, Voets T, Hoefs S, Weidema F, Prenen J, Nilius B, Bindels RJM (2003) Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J 22:776-785. doi: 10.1093/emboj/cdg080
    • (2003) EMBO J , vol.22 , pp. 776-785
    • Hoenderop, J.G.J.1    Voets, T.2    Hoefs, S.3    Weidema, F.4    Prenen, J.5    Nilius, B.6    Bindels, R.J.M.7
  • 36
    • 0034747668 scopus 로고    scopus 로고
    • Capillary filtration is reduced in lungs adapted to chronic heart failure: Morphological and haemodynamic correlates
    • 1:CAS:528:DC%2BD3cXovFGqt78%3D 11121813
    • Huang W, Kingsbury MP, Turner MA, Donnelly JL, Flores NA, Sheridan DJ (2001) Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates. Cardiovasc Res 49:207-217
    • (2001) Cardiovasc Res , vol.49 , pp. 207-217
    • Huang, W.1    Kingsbury, M.P.2    Turner, M.A.3    Donnelly, J.L.4    Flores, N.A.5    Sheridan, D.J.6
  • 37
    • 33750885965 scopus 로고    scopus 로고
    • Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca2+ signaling
    • 1:CAS:528:DyaK1cXmtFWjsbs%3D 9724288
    • Ivey CL, Roy BJ, Townsley MI (1998) Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca2+ signaling. Am J Physiol 275:H844-H851
    • (1998) Am J Physiol , vol.275 , pp. 844-H851
    • Ivey, C.L.1    Roy, B.J.2    Townsley, M.I.3
  • 38
    • 41449112586 scopus 로고    scopus 로고
    • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4
    • 1:CAS:528:DC%2BD1cXkt1aisLY%3D 17962608
    • Jian M-Y, King JA, Al-Mehdi A-B, Liedtke W, Townsley MI (2008) High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. Am J Respir Cell Mol Biol 38:386-392. doi: 10.1165/rcmb.2007-0192OC
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 386-392
    • Jian, M.-Y.1    King, J.A.2    Al-Mehdi, A.-B.3    Liedtke, W.4    Townsley, M.I.5
  • 39
    • 35348853274 scopus 로고    scopus 로고
    • Nitric oxide-dependent inhibition of alveolar fluid clearance in hydrostatic lung edema
    • 1:CAS:528:DC%2BD2sXht1WlurzJ 17616651
    • Kaestle SM, Reich CA, Yin N, Habazettl H, Weimann J, Kuebler WM (2007) Nitric oxide-dependent inhibition of alveolar fluid clearance in hydrostatic lung edema. Am J Physiol Lung Cell Mol Physiol 293:L859-L869. doi: 10.1152/ajplung.00008.2007
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293 , pp. 859-L869
    • Kaestle, S.M.1    Reich, C.A.2    Yin, N.3    Habazettl, H.4    Weimann, J.5    Kuebler, W.M.6
  • 40
    • 77950997232 scopus 로고    scopus 로고
    • Lung endothelial dysfunction in congestive heart failure: Role of impaired Ca2+ signaling and cytoskeletal reorganization
    • 1:CAS:528:DC%2BC3cXksVaqsbg%3D 20167930
    • Kerem A, Yin J, Kaestle SM, Hoffmann J, Schoene AM, Singh B, Kuppe H, Borst MM, Kuebler WM (2010) Lung endothelial dysfunction in congestive heart failure: role of impaired Ca2+ signaling and cytoskeletal reorganization. Circ Res 106:1103-1116. doi: 10.1161/CIRCRESAHA.109.210542
    • (2010) Circ Res , vol.106 , pp. 1103-1116
    • Kerem, A.1    Yin, J.2    Kaestle, S.M.3    Hoffmann, J.4    Schoene, A.M.5    Singh, B.6    Kuppe, H.7    Borst, M.M.8    Kuebler, W.M.9
  • 41
    • 57349135392 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response
    • Keserü B, Barbosa-Sicard E, Popp R, Fisslthaler B, Dietrich A, Gudermann T, Hammock BD, Falck JR, Weissmann N, Busse R, Fleming I (2008) Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J 22:4306-4315. doi: 10.1096/fj.08-112821
    • (2008) FASEB J , vol.22 , pp. 4306-4315
    • Keserü, B.1    Barbosa-Sicard, E.2    Popp, R.3    Fisslthaler, B.4    Dietrich, A.5    Gudermann, T.6    Hammock, B.D.7    Falck, J.R.8    Weissmann, N.9    Busse, R.10    Fleming, I.11
  • 45
    • 0032695240 scopus 로고    scopus 로고
    • Pressure is proinflammatory in lung venular capillaries
    • 1:CAS:528:DyaK1MXltlekurg%3D 10449441
    • Kuebler WM, Ying X, Singh B, Issekutz AC, Bhattacharya J (1999) Pressure is proinflammatory in lung venular capillaries. J Clin Invest 104:495-502. doi: 10.1172/JCI6872
    • (1999) J Clin Invest , vol.104 , pp. 495-502
    • Kuebler, W.M.1    Ying, X.2    Singh, B.3    Issekutz, A.C.4    Bhattacharya, J.5
  • 46
    • 0028211303 scopus 로고
    • The stretch-activated ion channel blocker gadolinium also blocks L-type calcium channels in isolated ventricular myocytes of the guinea-pig
    • 1:CAS:528:DyaK2cXivFGhsLw%3D 8155676
    • Lacampagne A, Gannier F, Argibay J, Garnier D, Le Guennec JY (1994) The stretch-activated ion channel blocker gadolinium also blocks L-type calcium channels in isolated ventricular myocytes of the guinea-pig. Biochim Biophys Acta 1191:205-208
    • (1994) Biochim Biophys Acta , vol.1191 , pp. 205-208
    • Lacampagne, A.1    Gannier, F.2    Argibay, J.3    Garnier, D.4    Le Guennec, J.Y.5
  • 47
    • 0023155017 scopus 로고
    • Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?
    • 1:STN:280:DyaL2s7ksVGrtQ%3D%3D 2434860
    • Lansman JB, Hallam TJ, Rink TJ (1987) Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 325:811-813. doi: 10.1038/325811a0
    • (1987) Nature , vol.325 , pp. 811-813
    • Lansman, J.B.1    Hallam, T.J.2    Rink, T.J.3
  • 48
  • 49
    • 0345659198 scopus 로고    scopus 로고
    • Abnormal osmotic regulation in trpv4-/- mice
    • 1:CAS:528:DC%2BD3sXptFOiurw%3D 14581612
    • Liedtke W, Friedman JM (2003) Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A 100:13698-13703. doi: 10.1073/pnas.1735416100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13698-13703
    • Liedtke, W.1    Friedman, J.M.2
  • 50
    • 78149285798 scopus 로고    scopus 로고
    • Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane
    • 1:CAS:528:DC%2BC3cXhtlSqtb3M 20705915
    • Ma X, Cao J, Luo J, Nilius B, Huang Y, Ambudkar IS, Yao X (2010) Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane. Arterioscler Thromb Vasc Biol 30:2249-2255. doi: 10.1161/ATVBAHA.110.212084
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2249-2255
    • Ma, X.1    Cao, J.2    Luo, J.3    Nilius, B.4    Huang, Y.5    Ambudkar, I.S.6    Yao, X.7
  • 52
    • 84896471800 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes
    • McAlexander MA, Luttmann MA, Hunsberger GE, Undem BJ (2014) Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes. J Pharmacol Exp Ther 349:118-125. doi: 10.1124/jpet.113.210203
    • (2014) J Pharmacol Exp Ther , vol.349 , pp. 118-125
    • McAlexander, M.A.1    Luttmann, M.A.2    Hunsberger, G.E.3    Undem, B.J.4
  • 55
    • 85027464767 scopus 로고    scopus 로고
    • Transient receptor potential cation channel vanilloid (TRPV) 4 in ventilator-induced lung injury (VILI)
    • Michalick L, Mertens M, Liedtke W, Kuebler WM (2013) Transient receptor potential cation channel vanilloid (TRPV) 4 in ventilator-induced lung injury (VILI). FASEB J 27:914.12
    • (2013) FASEB J , vol.27 , pp. 91412
    • Michalick, L.1    Mertens, M.2    Liedtke, W.3    Kuebler, W.M.4
  • 57
    • 0027460103 scopus 로고
    • Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells
    • 1:CAS:528:DyaK3sXksVKhsL0%3D 8386448
    • Naruse K, Sokabe M (1993) Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells. Am J Physiol 264:C1037-C1044
    • (1993) Am J Physiol , vol.264 , pp. 1037-C1044
    • Naruse, K.1    Sokabe, M.2
  • 58
    • 0035183983 scopus 로고    scopus 로고
    • Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells
    • 1:CAS:528:DC%2BD3MXotF2hurw%3D 11713648
    • Nilius B, Prenen J, Wissenbach U, Bödding M, Droogmans G (2001) Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227-233. doi: 10.1007/s004240100676
    • (2001) Pflugers Arch , vol.443 , pp. 227-233
    • Nilius, B.1    Prenen, J.2    Wissenbach, U.3    Bödding, M.4    Droogmans, G.5
  • 59
    • 84883487661 scopus 로고    scopus 로고
    • The puzzle of TRPV4 channelopathies
    • 1:CAS:528:DC%2BC3sXht12ju7jO
    • Nilius B, Voets T (2013) The puzzle of TRPV4 channelopathies. EMBO Rep 14:845. doi: 10.1038/embor.2013.134
    • (2013) EMBO Rep , vol.14 , pp. 845
    • Nilius, B.1    Voets, T.2
  • 60
    • 0742288219 scopus 로고    scopus 로고
    • TRPV4 calcium entry channel: A paradigm for gating diversity
    • 1:CAS:528:DC%2BD2cXhsFaku7Y%3D 14707014
    • Nilius B, Vriens J, Prenen J, Droogmans G, Voets T (2004) TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol 286:C195-C205. doi: 10.1152/ajpcell.00365.2003
    • (2004) Am J Physiol Cell Physiol , vol.286 , pp. 195-C205
    • Nilius, B.1    Vriens, J.2    Prenen, J.3    Droogmans, G.4    Voets, T.5
  • 61
    • 26444496051 scopus 로고    scopus 로고
    • The mechanosensitive nature of TRPV channels
    • O'Neil RG, Heller S (2005) The mechanosensitive nature of TRPV channels. Pflugers Arch 451:193-203. doi: 10.1007/s00424-005-1424-4
    • (2005) Pflugers Arch , vol.451 , pp. 193-203
    • O'Neil, R.G.1    Heller, S.2
  • 62
    • 0031456255 scopus 로고    scopus 로고
    • Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs
    • 1:CAS:528:DyaK1cXosVei 9390969
    • Parker JC, Ivey CL (1997) Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 83:1962-1967
    • (1997) J Appl Physiol , vol.83 , pp. 1962-1967
    • Parker, J.C.1    Ivey, C.L.2
  • 63
    • 0031898295 scopus 로고    scopus 로고
    • Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs
    • 1:CAS:528:DyaK1cXisVKhtbk%3D 9516173
    • Parker JC, Ivey CL, Tucker JA (1998) Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 84:1113-1118
    • (1998) J Appl Physiol , vol.84 , pp. 1113-1118
    • Parker, J.C.1    Ivey, C.L.2    Tucker, J.A.3
  • 64
    • 33847181297 scopus 로고    scopus 로고
    • The multiple faces of caveolae
    • 1:CAS:528:DC%2BD2sXitVGrsrk%3D 17318224
    • Parton RG, Simons K (2007) The multiple faces of caveolae. Nat Rev Mol Cell Biol 8:185-194. doi: 10.1038/nrm2122
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 185-194
    • Parton, R.G.1    Simons, K.2
  • 65
    • 73649104785 scopus 로고    scopus 로고
    • Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain
    • 1:CAS:528:DC%2BD1MXhs1SqtrrN 19864432
    • Phelps CB, Wang RR, Choo SS, Gaudet R (2010) Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem 285:731-740. doi: 10.1074/jbc.M109.052548
    • (2010) J Biol Chem , vol.285 , pp. 731-740
    • Phelps, C.B.1    Wang, R.R.2    Choo, S.S.3    Gaudet, R.4
  • 66
    • 84873449692 scopus 로고    scopus 로고
    • Novel insights into TRPV4 function in the kidney
    • 1:CAS:528:DC%2BC3sXhvVyru74%3D 23207579
    • Pochynyuk O, Zaika O, O'Neil RG, Mamenko M (2013) Novel insights into TRPV4 function in the kidney. Pflugers Arch 465:177-186. doi: 10.1007/s00424-012-1190-z
    • (2013) Pflugers Arch , vol.465 , pp. 177-186
    • Pochynyuk, O.1    Zaika, O.2    O'Neil, R.G.3    Mamenko, M.4
  • 67
    • 79956329875 scopus 로고    scopus 로고
    • The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells
    • 1:CAS:528:DC%2BC3MXmsVKrt7s%3D 21562271
    • Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentería RC, Liedtke W, Krizaj D (2011) The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. J Neurosci 31:7089-7101. doi: 10.1523/JNEUROSCI.0359-11.2011
    • (2011) J Neurosci , vol.31 , pp. 7089-7101
    • Ryskamp, D.A.1    Witkovsky, P.2    Barabas, P.3    Huang, W.4    Koehler, C.5    Akimov, N.P.6    Lee, S.H.7    Chauhan, S.8    Xing, W.9    Rentería, R.C.10    Liedtke, W.11    Krizaj, D.12
  • 68
    • 40749155420 scopus 로고    scopus 로고
    • Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells
    • 1:CAS:528:DC%2BD1cXhvVyltbk%3D 18268148
    • Saliez J, Bouzin C, Rath G, Ghisdal P, Desjardins F, Rezzani R, Rodella LF, Vriens J, Nilius B, Feron O, Balligand J-L, Dessy C (2008) Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells. Circulation 117:1065-1074. doi: 10.1161/CIRCULATIONAHA.107.731679
    • (2008) Circulation , vol.117 , pp. 1065-1074
    • Saliez, J.1    Bouzin, C.2    Rath, G.3    Ghisdal, P.4    Desjardins, F.5    Rezzani, R.6    Rodella, L.F.7    Vriens, J.8    Nilius, B.9    Feron, O.10    Balligand, J.-L.11    Dessy, C.12
  • 69
    • 0035368773 scopus 로고    scopus 로고
    • Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions
    • 2278647 1:CAS:528:DC%2BD3MXltVSktb0%3D 11389203
    • Sandoval R, Malik AB, Minshall RD, Kouklis P, Ellis CA, Tiruppathi C (2001) Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions. J Physiol Lond 533:433-445
    • (2001) J Physiol Lond , vol.533 , pp. 433-445
    • Sandoval, R.1    Malik, A.B.2    Minshall, R.D.3    Kouklis, P.4    Ellis, C.A.5    Tiruppathi, C.6
  • 70
    • 26444457870 scopus 로고    scopus 로고
    • Homo- and heteromeric assembly of TRP channel subunits
    • 1:CAS:528:DC%2BD2MXhtVKqu7rF 15971080
    • Schaefer M (2005) Homo- and heteromeric assembly of TRP channel subunits. Pflugers Arch 451:35-42. doi: 10.1007/s00424-005-1467-6
    • (2005) Pflugers Arch , vol.451 , pp. 35-42
    • Schaefer, M.1
  • 72
    • 77951248588 scopus 로고    scopus 로고
    • A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy
    • 1:CAS:528:DC%2BC3cXktFGlsLo%3D 20044482
    • Shigematsu H, Sokabe T, Danev R, Tominaga M, Nagayama K (2010) A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy. J Biol Chem 285:11210-11218. doi: 10.1074/jbc.M109.090712
    • (2010) J Biol Chem , vol.285 , pp. 11210-11218
    • Shigematsu, H.1    Sokabe, T.2    Danev, R.3    Tominaga, M.4    Nagayama, K.5
  • 73
    • 84855598356 scopus 로고    scopus 로고
    • Phosphorylation on the ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area
    • 1:CAS:528:DC%2BC38XpsFyksQ%3D%3D 22101010
    • Shin SH, Lee EJ, Hyun S, Chun J, Kim Y, Kang SS (2012) Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area. Cell Signal 24:641-651. doi: 10.1016/j.cellsig.2011.11.002
    • (2012) Cell Signal , vol.24 , pp. 641-651
    • Shin, S.H.1    Lee, E.J.2    Hyun, S.3    Chun, J.4    Kim, Y.5    Kang, S.S.6
  • 74
    • 77956919285 scopus 로고    scopus 로고
    • Arresting a transient receptor potential (TRP) channel: -Arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    • 1:CAS:528:DC%2BC3cXhtFKksLzP 20650893
    • Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ (2010) Arresting a transient receptor potential (TRP) channel: -Arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem 285:30115-30125. doi: 10.1074/jbc.M110.141549
    • (2010) J Biol Chem , vol.285 , pp. 30115-30125
    • Shukla, A.K.1    Kim, J.2    Ahn, S.3    Xiao, K.4    Shenoy, S.K.5    Liedtke, W.6    Lefkowitz, R.J.7
  • 77
  • 78
    • 57249101994 scopus 로고    scopus 로고
    • Quantitative real-time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects
    • Spinsanti G, Zannolli R, Panti C, Ceccarelli I, Marsili L, Bachiocco V, Frati F, Aloisi AM (2008) Quantitative real-time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects. Mol Pain 4:51. doi: 10.1186/1744-8069-4-51
    • (2008) Mol Pain , vol.4 , pp. 51
    • Spinsanti, G.1    Zannolli, R.2    Panti, C.3    Ceccarelli, I.4    Marsili, L.5    Bachiocco, V.6    Frati, F.7    Aloisi, A.M.8
  • 79
    • 77955667713 scopus 로고    scopus 로고
    • Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer
    • 1:CAS:528:DC%2BC3cXpvFWnurg%3D 20682256
    • Stewart AP, Smith GD, Sandford RN, Edwardson JM (2010) Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys J 99:790-797. doi: 10.1016/j.bpj.2010.05.012
    • (2010) Biophys J , vol.99 , pp. 790-797
    • Stewart, A.P.1    Smith, G.D.2    Sandford, R.N.3    Edwardson, J.M.4
  • 80
    • 0034306198 scopus 로고    scopus 로고
    • OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
    • 1:CAS:528:DC%2BD3cXnsVyntL8%3D 11025659
    • Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702. doi: 10.1038/35036318
    • (2000) Nat Cell Biol , vol.2 , pp. 695-702
    • Strotmann, R.1    Harteneck, C.2    Nunnenmacher, K.3    Schultz, G.4    Plant, T.D.5
  • 81
    • 0038712568 scopus 로고    scopus 로고
    • Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site
    • 1:CAS:528:DC%2BD3sXltlKqs7g%3D 12724311
    • Strotmann R, Schultz G, Plant TD (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem 278:26541-26549. doi: 10.1074/jbc.M302590200
    • (2003) J Biol Chem , vol.278 , pp. 26541-26549
    • Strotmann, R.1    Schultz, G.2    Plant, T.D.3
  • 82
    • 84856991347 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction
    • 1:CAS:528:DC%2BC38Xjs12jtrc%3D 22298659
    • Sylvester JT, Shimoda LA, Aaronson PI, Ward JPT (2012) Hypoxic pulmonary vasoconstriction. Physiol Rev 92:367-520. doi: 10.1152/physrev.00041.2010
    • (2012) Physiol Rev , vol.92 , pp. 367-520
    • Sylvester, J.T.1    Shimoda, L.A.2    Aaronson, P.I.3    Ward, J.P.T.4
  • 83
    • 77957920016 scopus 로고    scopus 로고
    • A role for receptor-operated Ca2+ entry in human pulmonary artery smooth muscle cells in response to hypoxia
    • 1:CAS:528:DC%2BC3MXhs1aqtr4%3D 20533864
    • Tang C, To WK, Meng F, Wang Y, Gu Y (2010) A role for receptor-operated Ca2+ entry in human pulmonary artery smooth muscle cells in response to hypoxia. Physiol Res 59:909-918
    • (2010) Physiol Res , vol.59 , pp. 909-918
    • Tang, C.1    To, W.K.2    Meng, F.3    Wang, Y.4    Gu, Y.5
  • 84
    • 84925479057 scopus 로고    scopus 로고
    • Role of Transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury
    • Tang C, Yin J, Kuebler WM (2013) Role of Transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury. FASEB J 27
    • (2013) FASEB J , vol.27
    • Tang, C.1    Yin, J.2    Kuebler, W.M.3
  • 85
    • 66149088448 scopus 로고    scopus 로고
    • TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling
    • 1:CAS:528:DC%2BD1MXltFelsbs%3D 19359599
    • Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE (2009) TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104:1123-1130. doi: 10.1161/CIRCRESAHA.108.192930
    • (2009) Circ Res , vol.104 , pp. 1123-1130
    • Thodeti, C.K.1    Matthews, B.2    Ravi, A.3    Mammoto, A.4    Ghosh, K.5    Bracha, A.L.6    Ingber, D.E.7
  • 88
    • 33750620307 scopus 로고    scopus 로고
    • Ca2+ signaling, TRP channels, and endothelial permeability
    • 1:CAS:528:DC%2BD2sXhvVynsg%3D%3D 17085428
    • Tiruppathi C, Ahmmed GU, Vogel SM, Malik AB (2006) Ca2+ signaling, TRP channels, and endothelial permeability. Microcirculation 13:693-708. doi: 10.1080/10739680600930347
    • (2006) Microcirculation , vol.13 , pp. 693-708
    • Tiruppathi, C.1    Ahmmed, G.U.2    Vogel, S.M.3    Malik, A.B.4
  • 89
    • 84862796084 scopus 로고    scopus 로고
    • Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction
    • 1:CAS:528:DC%2BC38Xit12isrs%3D 22280812
    • Urban N, Hill K, Wang L, Kuebler WM, Schaefer M (2012) Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction. Cell Calcium 51:194-206. doi: 10.1016/j.ceca.2012.01.001
    • (2012) Cell Calcium , vol.51 , pp. 194-206
    • Urban, N.1    Hill, K.2    Wang, L.3    Kuebler, W.M.4    Schaefer, M.5
  • 91
    • 0347719316 scopus 로고    scopus 로고
    • Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
    • 1:CAS:528:DC%2BD2cXjvFaksQ%3D%3D 14691263
    • Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B (2004) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A 101:396-401. doi: 10.1073/pnas.0303329101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 396-401
    • Vriens, J.1    Watanabe, H.2    Janssens, A.3    Droogmans, G.4    Voets, T.5    Nilius, B.6
  • 93
    • 37549002929 scopus 로고    scopus 로고
    • OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum
    • 1:CAS:528:DC%2BD2sXhsVSgtrnP 17932042
    • Wang Y, Fu X, Gaiser S, Kottgen M, Kramer-Zucker A, Walz G, Wegierski T (2007) OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. J Biol Chem 282:36561-36570. doi: 10.1074/jbc.M703903200
    • (2007) J Biol Chem , vol.282 , pp. 36561-36570
    • Wang, Y.1    Fu, X.2    Gaiser, S.3    Kottgen, M.4    Kramer-Zucker, A.5    Walz, G.6    Wegierski, T.7
  • 94
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • 1:STN:280:DC%2BD3c3jvFGhsw%3D%3D 10793167
    • Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334-1349. doi: 10.1056/NEJM200005043421806
    • (2000) N Engl J Med , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 96
    • 0043267987 scopus 로고    scopus 로고
    • Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    • 1:CAS:528:DC%2BD3sXls1aqsbs%3D 12879072
    • Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003b) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434-438. doi: 10.1038/nature01807
    • (2003) Nature , vol.424 , pp. 434-438
    • Watanabe, H.1    Vriens, J.2    Prenen, J.3    Droogmans, G.4    Voets, T.5    Nilius, B.6
  • 97
    • 0037033077 scopus 로고    scopus 로고
    • Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    • 1:CAS:528:DC%2BD38XptFSktrc%3D 12354759
    • Watanabe H, Vriens J, Suh SH, Benham CD, Droogmans G, Nilius B (2002) Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem 277:47044-47051. doi: 10.1074/jbc.M208277200
    • (2002) J Biol Chem , vol.277 , pp. 47044-47051
    • Watanabe, H.1    Vriens, J.2    Suh, S.H.3    Benham, C.D.4    Droogmans, G.5    Nilius, B.6
  • 98
    • 33845694340 scopus 로고    scopus 로고
    • The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels
    • 1:CAS:528:DC%2BD28XhtlShsbzM 17110928
    • Wegierski T, Hill K, Schaefer M, Walz G (2006) The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J 25:5659-5669. doi: 10.1038/sj.emboj.7601429
    • (2006) EMBO J , vol.25 , pp. 5659-5669
    • Wegierski, T.1    Hill, K.2    Schaefer, M.3    Walz, G.4
  • 100
    • 84884254628 scopus 로고    scopus 로고
    • TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension
    • Xia Y, Fu Z, Hu J, Huang C, Paudel O, Cai S, Liedtke W, Sham JSK (2013) TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. Am J Physiol Cell Physiol. doi: 10.1152/ajpcell.00099.2013
    • (2013) Am J Physiol Cell Physiol
    • Xia, Y.1    Fu, Z.2    Hu, J.3    Huang, C.4    Paudel, O.5    Cai, S.6    Liedtke, W.7    Sham, J.S.K.8
  • 101
    • 84863251242 scopus 로고    scopus 로고
    • Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension
    • 1:CAS:528:DC%2BC38XkslSqs78%3D 22207590
    • Yang X-R, Lin AHY, Hughes JM, Flavahan NA, Cao Y-N, Liedtke W, Sham JSK (2012) Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 302:L555-L568. doi: 10.1152/ajplung.00005.2011
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , pp. 555-L568
    • Yang, X.-R.1    Lin, A.H.Y.2    Hughes, J.M.3    Flavahan, N.A.4    Cao, Y.-N.5    Liedtke, W.6    Sham, J.S.K.7
  • 102
    • 33744806049 scopus 로고    scopus 로고
    • Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle
    • 1:CAS:528:DC%2BD28XlvVeitLc%3D 16399784
    • Yang X-R, Lin M-J, McIntosh LS, Sham JSK (2006) Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. Am J Physiol Lung Cell Mol Physiol 290:L1267-L1276. doi: 10.1152/ajplung.00515.2005
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290 , pp. 1267-L1276
    • Yang, X.-R.1    Lin, M.-J.2    McIntosh, L.S.3    Sham, J.S.K.4
  • 103
    • 0024539514 scopus 로고
    • Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions
    • 1:CAS:528:DyaL1MXhsFWqt78%3D 2466333
    • Yang XC, Sachs F (1989) Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science 243:1068-1071
    • (1989) Science , vol.243 , pp. 1068-1071
    • Yang, X.C.1    Sachs, F.2
  • 104
    • 0037026489 scopus 로고    scopus 로고
    • The voltage-gated potassium channels and their relatives
    • 1:CAS:528:DC%2BD38Xmslahtbs%3D 12214225
    • Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419:35-42. doi: 10.1038/nature00978
    • (2002) Nature , vol.419 , pp. 35-42
    • Yellen, G.1
  • 106
    • 42549098958 scopus 로고    scopus 로고
    • Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4
    • 1:CAS:528:DC%2BD1cXkvVenu7c%3D 18323527
    • Yin J, Hoffmann J, Kaestle SM, Neye N, Wang L, Baeurle J, Liedtke W, Wu S, Kuppe H, Pries AR, Kuebler WM (2008) Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circ Res 102:966-974. doi: 10.1161/CIRCRESAHA.107.168724
    • (2008) Circ Res , vol.102 , pp. 966-974
    • Yin, J.1    Hoffmann, J.2    Kaestle, S.M.3    Neye, N.4    Wang, L.5    Baeurle, J.6    Liedtke, W.7    Wu, S.8    Kuppe, H.9    Pries, A.R.10    Kuebler, W.M.11
  • 107
    • 76949104257 scopus 로고    scopus 로고
    • Mechanotransduction by TRP channels: General concepts and specific role in the vasculature
    • 1:CAS:528:DC%2BD1MXhsFyjt7rE 19842065
    • Yin J, Kuebler WM (2010) Mechanotransduction by TRP channels: general concepts and specific role in the vasculature. Cell Biochem Biophys 56:1-18. doi: 10.1007/s12013-009-9067-2
    • (2010) Cell Biochem Biophys , vol.56 , pp. 1-18
    • Yin, J.1    Kuebler, W.M.2
  • 108
    • 84925479056 scopus 로고    scopus 로고
    • Role of CFTR and sphingolipids in hypoxic pulmonary vasoconstriction
    • Yu H, Wang L, Kapus A, Kuebler WM (2012) Role of CFTR and sphingolipids in hypoxic pulmonary vasoconstriction. FASEB J 26:700.3
    • (2012) FASEB J , vol.26 , pp. 7003
    • Yu, H.1    Wang, L.2    Kapus, A.3    Kuebler, W.M.4
  • 109
    • 84875756832 scopus 로고    scopus 로고
    • TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease
    • 1:CAS:528:DC%2BC3sXmslWgsr4%3D 23411787
    • Zaika O, Mamenko M, Berrout J, Boukelmoune N, O'Neil RG, Pochynyuk O (2013) TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease. J Am Soc Nephrol 24:604-616. doi: 10.1681/ASN.2012050442
    • (2013) J Am Soc Nephrol , vol.24 , pp. 604-616
    • Zaika, O.1    Mamenko, M.2    Berrout, J.3    Boukelmoune, N.4    O'Neil, R.G.5    Pochynyuk, O.6
  • 110
    • 84901747430 scopus 로고    scopus 로고
    • Calcineurin/NFAT-coupled TRPV4 Ca(2+) sparklets stimulate airway smooth muscle cell proliferation
    • Zhao L, Sullivan MN, Chase M, Gonzales AL, Earley S (2014) Calcineurin/NFAT-coupled TRPV4 Ca(2+) sparklets stimulate airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2013-0416OC
    • (2014) Am J Respir Cell Mol Biol
    • Zhao, L.1    Sullivan, M.N.2    Chase, M.3    Gonzales, A.L.4    Earley, S.5
  • 111
    • 65549109223 scopus 로고    scopus 로고
    • Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease
    • ICGN Investigators 10.1093/hmg/ddp111 1:CAS:528:DC%2BD1MXlslWqtr4%3D 19279160
    • Zhu G, ICGN Investigators, Gulsvik A, Bakke P, Ghatta S, Anderson W, Lomas DA, Silverman EK, Pillai SG (2009) Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Genet 18:2053-2062. doi: 10.1093/hmg/ddp111
    • (2009) Hum Mol Genet , vol.18 , pp. 2053-2062
    • Zhu, G.1    Gulsvik, A.2    Bakke, P.3    Ghatta, S.4    Anderson, W.5    Lomas, D.A.6    Silverman, E.K.7    Pillai, S.G.8


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