Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 6, 2012, Pages

  Yang, Xiao Ru ^a   Lin, Amanda H Y ^a   Hughes, Jennifer M ^b   Flavahan, Nicholas A ^b   Cao, Yuan Ning ^a   Liedtke, Wolfgang ^c   Sham, James S K ^a  

^a Division of Pulmonary and Critical Care Medicine   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

Transient receptor potential vanilloid 4 channels; Trpv4 knockout mice

Indexed keywords

CALCIUM; CYTOCHROME P450 INHIBITOR; RUTHENIUM RED; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; VANILLOID RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MUSCLE; ARTICLE; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; MECHANICAL STRESS; MOUSE; MUSCLE HYPOTONIA; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE TONE;

ANIMALS; ANOXIA; CALCIUM; CELLS, CULTURED; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; HYPOTONIC SOLUTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROVESSELS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, WISTAR; TRPV CATION CHANNELS; UP-REGULATION;

EID: 84863251242     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00005.2011     Document Type: Article

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