Lung endothelial dysfunction in congestive heart failure: Role of impaired ca2+ signaling and cytoskeletal reorganization

Circulation Research

Volumn 106, Issue 6, 2010, Pages 1103-1116

  Kerem, Alexander ^a   Yin, Jun ^a,b,c   Kaestle, Stephanie M ^a   Hoffmann, Julia ^a   Schoene, Axel M ^d   Singh, Baljit ^e   Kuppe, Hermann ^b   Borst, Mathias M ^d   Kuebler, Wolfgang M ^a,b,c,f  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ca2+; Congestive heart failure; Endothelial dysfunction; Pulmonary hypertension; Regulation

Indexed keywords

ACETYLCHOLINE; BETA ACTIN; CALCIUM ION; CYTOCHALASIN D; ENDOTHELIAL NITRIC OXIDE SYNTHASE; F ACTIN; HISTAMINE; IONOPHORE; THAPSIGARGIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CONCENTRATION (PARAMETERS); CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; EXPERIMENTAL MODEL; FLUORESCENCE ANALYSIS; LUNG ENDOTHELIUM; LUNG FUNCTION; MALE; MECHANICAL STRESS; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; VASODILATATION;

ACETYLCHOLINE; ACTINS; ANIMALS; BLOOD PRESSURE; CALCIUM SIGNALING; CHOLINERGIC ANTAGONISTS; CYTOCHALASIN D; CYTOSKELETON; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HEART FAILURE; HISTAMINE; HYPERTENSION, PULMONARY; IONOPHORES; LUNG; MALE; MICROSCOPY, FLUORESCENCE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TIME FACTORS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; VASODILATION; VASODILATOR AGENTS;

EID: 77950997232     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.210542     Document Type: Article

References (41)

1. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117:e25-e146.
2. Ghio S, Gavazzi A, Campana C, Inserra C, Klersy C, Sebastiani R, Arbustini E, Recusani F, Tavazzi L. Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol. 2001;37: 183-188. (Pubitemid 32051736)
3. Lam CS, Roger VL, Rodeheffer RJ, Borlaug BA, Enders FT, Redfield MM. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009;53: 1119-1126.
4. Cappola TP, Felker GM, Kao WH, Hare JM, Baughman KL, Kasper EK. Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Circulation. 2002;105:1663-1668.
5. Cody RJ, Haas GJ, Binkley PF, Capers Q, Kelley R. Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation. 1992;85:504-509.
6. Delgado JF, Conde E, Sanchez V, Lopez-Rios F, Gomez-Sanchez MA, Escribano P, Sotelo T, Gomez de la CA, Cortina J, de la Calzada CS. Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure. Eur J Heart Fail. 2005;7:1011-1016. (Pubitemid 41443595)
7. Wood P. An appreciation of mitral stenosis: II. Investigations and results. BMJ. 1954;1:1113-1124.
8. Hentschel T, Yin N, Riad A, Habbazettl H, Weimann J, Koster A, Tschope C, Kuppe H, Kuebler WM. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology. 2007;106:124-131. (Pubitemid 46035412)
9. Huang W, Kingsbury MP, Turner MA, Donnelly JL, Flores NA, Sheridan DJ. Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates. Cardiovasc Res. 2001;49:207-217.
10. Di Salvo TG, Mathier M, Semigran MJ, Dec GW. Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure. J Am Coll Cardiol. 1995;25:1143-1153.
11. Driss AB, Devaux C, Henrion D, Duriez M, Thuillez C, Levy BI, Michel JB. Hemodynamic stresses induce endothelial dysfunction and remodeling of pulmonary artery in experimental compensated heart failure. Circulation. 2000;101:2764-2770. (Pubitemid 30390582)
12. Ontkean M, Gay R, Greenberg B. Diminished endothelium-derived relaxing factor activity in an experimental model of chronic heart failure. Circ Res. 1991;69:1088-1096.
13. Moraes DL, Colucci WS, Givertz MM. Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophys-iology and management. Circulation. 2000;102:1718-1723.
14. Yin N, Kaestle S, Yin J, Hentschel T, Pries AR, Kuppe H, Kuebler WM. Inhaled nitric oxide versus aerosolized iloprost for the treatment of pulmonary hypertension with left heart disease. Crit Care Med. 2009;37: 980-986.
15. 2+ oscillations in lung capillaries. Am J Physiol Lung Cell Mol Physiol. 2002;282:L917-L923. (Pubitemid 34654607)
16. Kuebler WM, Uhlig U, Goldmann T, Schael G, Kerem A, Exner K, Martin C, Vollmer E, Uhlig S. Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ. Am J Respir Crit Care Med. 2003;168:1391-1398. (Pubitemid 37492903)
17. Yin J, Hoffmann J, Kaestle SM, Neye N, Wang L, Baeurle J, Liedtke W, Wu S, Kuppe H, Pries AR, Kuebler WM. Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circ Res. 2008;102:966-974. (Pubitemid 351591552)
18. Safdar Z, Wang P, Ichimura H, Issekutz AC, Quadri S, Bhattacharya J. Hyperosmolarity enhances the lung capillary barrier. J Clin Invest. 2003;112:1541-1549. (Pubitemid 38056280)
19. Kuebler WM, Parthasarathi K, Wang PM, Bhattacharya J. A novel signaling mechanism between gas and blood compartments of the lung. J Clin Invest. 2000;105:905-913. (Pubitemid 30203063)
20. Adnot S, Raffestin B, Eddahibi S, Braquet P, Chabrier PE. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest. 1991;87:155-162.
21. 3 receptor in endothelium-dependent vasodilatation in mouse arteries. J Cardiovasc Pharmacol. 2008;51:505-512.
22. Jian MY, King JA, Al-Mehdi AB, Liedtke W, Townsley MI. High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. Am J Respir Cell Mol Biol. 2008;38: 386-392. (Pubitemid 351758684)
23. 2+ signaling, TRP channels, and endothelial permeability. Microcirculation. 2006;13: 693-708. (Pubitemid 44688424)
24. 2+ to trigger exocytosis in neuroendocrine cells. J Biol Chem. 2002;277:16172-16178.
25. Lange K, Brandt U. Calcium storage and release properties of F-actin: evidence for the involvement of F-actin in cellular calcium signaling. FEBS Lett. 1996;395:137-142. (Pubitemid 26356171)
26. Lange K, Gartzke J. F-actin-based Ca signaling-a critical comparison with the current concept of Ca signaling. J Cell Physiol. 2006;209: 270-287. (Pubitemid 44484617)
27. 2+ channels. Science. 2000;287:1647-1651. (Pubitemid 30127765)
28. Bauersachs J, Widder JD. Endothelial dysfunction in heart failure. Pharmacol Rep. 2008;60:119-126. (Pubitemid 351586550)
29. Kaestle SM, Reich CA, Yin N, Habazettl H, Weimann J, Kuebler WM. Nitric oxide-dependent inhibition of alveolar fluid clearance in hydrostatic lung edema. Am J Physiol Lung Cell Mol Physiol. 2007;293: L859-L869. (Pubitemid 47572234)
30. 3-receptor-mediated contraction of porcine coronary smooth muscle. Cell Calcium. 2005;38:457-467. (Pubitemid 41403662)
31. Giaid A, SalehD. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med. 1995;333:214-221.
32. Xu W, Kaneko FT, Zheng S, Comhair SA, Janocha AJ, Goggans T, Thunnissen FB, Farver C, Hazen SL, Jennings C, Dweik RA, Arroliga AC, Erzurum SC. Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J. 2004;18:1746-1748. (Pubitemid 39561671)
33. 2+ waves in lung capillary endothelium. Circ Res. 1996;79:898-908. (Pubitemid 26317840)
34. Alvarez DF, King JA, Townsley MI. Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. Am J Respir Crit Care Med. 2005;172:1153-1160.
35. 2+ signaling. Am J Physiol. 1998;275:H844-H851. (Pubitemid 28439774)
36. 2+ entry in pulmonary endothelial cells from chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1135-L1142.
37. Carlsson SI, Bertilaccio MT, Ballabio E, Maier JA. Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization. Biochim Biophys Acta. 2003;1642:173-179. (Pubitemid 37315660)
38. Birukov KG, Birukova AA, Dudek SM, Verin AD, Crow MT, Zhan X, DePaola N, Garcia JG. Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 2002;26:453-464. (Pubitemid 34253930)
39. Rivas FV, O'Keefe JP, Alegre ML, Gajewski TF. Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration. Mol Cell Biol. 2004;24:1628-1639.
40. Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature. 2008;456: 116-120.
41. Itagaki K, Kannan KB, Singh BB, Hauser CJ. Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils. J Immunol. 2004;172:601-607 (Pubitemid 38020518)