TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension

American Journal of Physiology - Cell Physiology

Volumn 305, Issue 7, 2013, Pages

  Xia, Yang ^a,b   Fu, Zhenzhen ^b   Hu, Jinxing ^b   Huang, Chun ^b   Paudel, Omkar ^b   Cai, Shaoxi ^a   Liedtke, Wolfgang ^c   Sham, James S K ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

Chronic hypoxia; Pulmonary arteries; Pulmonary hypertension; Serotonin; TRPV4

Indexed keywords

CALCIUM; HC 067047; NIFEDIPINE; RN 1734; SEROTONIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR ANTAGONIST; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BLOOD VESSEL REACTIVITY; CALCIUM MOBILIZATION; CONTROLLED STUDY; GENE DELETION; HYPOXIA; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; MALE; MOUSE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE TONE; WILD TYPE;

CHRONIC HYPOXIA; PULMONARY ARTERIES; PULMONARY HYPERTENSION; SEROTONIN; TRPV4;

ANIMALS; ANOXIA; CALCIUM SIGNALING; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION, PULMONARY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; PULMONARY ARTERY; PYRROLES; SEROTONIN; SULFONAMIDES; TIME FACTORS; TRPV CATION CHANNELS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 84884254628     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00099.2013     Document Type: Article

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