Novel insights into TRPV4 function in the kidney

Pflugers Archiv European Journal of Physiology

Volumn 465, Issue 2, 2013, Pages 177-186

  Pochynyuk, Oleh ^a   Zaika, Oleg ^a   O'Neil, Roger G ^a   Mamenko, Mykola ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Collecting duct; Connecting tubule; Hypotonicity; Intracellular Ca2+ elevations; Polycystic kidney disease; Tubular flow

Indexed keywords

CALCIUM ION; MESSENGER RNA; POLYCYSTIN; POLYCYSTIN 2; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 4; VASOPRESSIN;

CALCIUM CELL LEVEL; DISEASE ASSOCIATION; HUMAN; HYPOOSMOTIC STRESS; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; MUSCLE HYPOTONIA; NEPHRON; NONHUMAN; OSMORECEPTOR; PLASMA OSMOLALITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TARGETING; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; TUBE FLOW; VANILLOID RECEPTOR 4 GENE;

ANIMALS; CALCIUM; GENE EXPRESSION; HUMANS; KIDNEY; POLYCYSTIC KIDNEY DISEASES; TRPV CATION CHANNELS;

EID: 84873449692     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1190-z     Document Type: Review

References (124)

1. Alessandri-Haber N, Yeh JJ, Boyd AE, Parada CA, Chen X, Reichling DB, Levine JD (2003) Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 39:497-511
2. Andrade YN, Fernandes J, Vazquez E, Fernandez-Fernandez JM, Arniges M, Sanchez TM, Villalon M, Valverde MA (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol 168:869-874
3. Baer PG, Bianchi G, Liliana D (1978) Renal micropuncture study of normotensive and Milan hypertensive rats before and after development of hypertension. Kidney Int 13:452-466
4. Becker D, Bereiter-Hahn J, Jendrach M (2009) Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation. Eur J Cell Biol 88:141-152
5. Becker D, Blase C, Bereiter-Hahn J, Jendrach M (2005) TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435-2440
6. Berrout J, Jin M, Mamenko M, Zaika O, Pochynyuk O, O'Neil RG (2012) Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system. J Biol Chem 287:8782-8791
7. Bichet DG (2012) A defect in vasopressin secretion in autosomal dominant polycystic kidney disease. Kidney Int 82:1051-1053
8. Cheema-Dhadli S, Lin SH, Keong-Chong C, Kamel KS, Halperin ML (2006) Requirements for a high rate of potassium excretion in rats consuming a low electrolyte diet. J Physiol 572:493-501
9. -/- mice. Mol Pain 3:31
10. Chen L, Liu C, Liu L (2009) Osmolality-induced tuning of action potentials in trigeminal ganglion neurons. Neurosci Lett 452:79-83
11. Christensen AP, Corey DP (2007) TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci 8:510-521
12. Ciura S, Liedtke W, Bourque CW (2011) Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. J Neurosci 31:14669-14676
13. Clapham DE, Julius D, Montell C, Schultz G (2005) International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev 57:427-450
14. Clapp JR, Robinson RR (1966) Osmolality of distal tubular fluid in the dog. J Clin Invest 45:1847-1853
15. Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S (2006) PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem 281:18753-18762
16. Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN (2001) Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics 4:165-174
17. Delmas P (2004) Polycystins: from mechanosensation to gene regulation. Cell 118:145-148
18. D'hoedt D, Owsianik G, Prenen J, Cuajungco MP, Grimm C, Heller S, Voets T, Nilius B (2008) Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem 283:6272-6280
19. DiBona GF, Rios LL (1978) Mechanism of exaggerated diuresis in spontaneously hypertensive rats. Am J Physiol 235:409-416
20. 2+ entry into collecting duct cells. J Am Soc Nephrol 23:1172-1180
21. Dwyer TM, Schmidt-Nielsen B (2003) The renal pelvis: machinery that concentrates urine in the papilla. News Physiol Sci 18:1-6
22. Everaerts W, Nilius B, Owsianik G (2010) The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol 103:2-17
23. Fernandes J, Lorenzo IM, Andrade YN, Garcia-Elias A, Serra SA, Fernandez-Fernandez JM, Valverde MA (2008) IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid. J Cell Biol 181:143-155
24. Galizia L, Flamenco MP, Rivarola V, Capurro C, Ford P (2008) Role of AQP2 in activation of calcium entry by hypotonicity: implications in cell volume regulation. Am J Physiol Renal Physiol 294:F582-F590
25. Galizia L, Pizzoni A, Fernandez J, Rivarola V, Capurro C, Ford P (2012) Functional interaction between AQP2 and TRPV4 in renal cells. J Cell Biochem 113:580-589
26. Gallagher AR, Germino GG, Somlo S (2010) Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis 17:118-130
27. Gao X, Wu L, O'Neil RG (2003) Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem 278:27129-27137
28. i oscillations reflect nucleotide release from renal epithelia. Pflugers Arch 455:1105-1117
29. Gottschalk CW (1961) Micropuncture studies of tubular function in the mammalian kidney. Physiologist 4:35-55
30. Gottschalk CW, Mylle M (1959) Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol 196:927-936
31. Gradilone SA, Masyuk TV, Huang BQ, Banales JM, Lehmann GL, Radtke BN, Stroope A, Masyuk AI, Splinter PL, Larusso NF (2010) Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. Gastroenterology 139:304-314
32. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG (2000) Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408:990-994
33. Harris PC, Torres VE (2009) Polycystic kidney disease. Annu Rev Med 60:321-337
34. + channel of cortical collecting ducts of the rat. Pflugers Arch 422:492-498
35. Ho TA, Godefroid N, Gruzon D, Haymann JP, Marechal C, Wang X, Serra A, Pirson Y, Devuyst O (2012) Autosomal dominant polycystic kidney disease is associated with central and nephrogenic defects in osmoregulation. Kidney Int 82:1121-1129
36. Hoffmann EK, Lambert IH, Pedersen SF (2009) Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193-277
37. Holstein-Rathlou NH, Marsh DJ (1990) A dynamic model of the tubuloglomerular feedback mechanism. Am J Physiol 258:F1448-F1459
38. Jia Y, Wang X, Varty L, Rizzo CA, Yang R, Correll CC, Phelps PT, Egan RW, Hey JA (2004) Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 287:L272-L278
39. Karlsen FM, Holstein-Rathlou NH, Leyssac PP (1995) A re-evaluation of the determinants of glomerular filtration rate. Acta Physiol Scand 155:335-350
40. Kohler R, Heyken WT, Heinau P, Schubert R, Si H, Kacik M, Busch C, Grgic I, Maier T, Hoyer J (2006) Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arterioscler Thromb Vasc Biol 26:1495-1502
41. Kottgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182:437-447
42. Kung C (2005) A possible unifying principle for mechanosensation. Nature 436:647-654
43. Lambert IH, Hoffmann EK, Pedersen SF (2008) Cell volume regulation: physiology and pathophysiology. Acta Physiol (Oxf) 194:255-282
44. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D (1998) Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247-306
45. Lechner SG, Markworth S, Poole K, Smith ES, Lapatsina L, Frahm S, May M, Pischke S, Suzuki M, Ibanez-Tallon I, Luft FC, Jordan J, Lewin GR (2011) The molecular and cellular identity of peripheral osmoreceptors. Neuron 69:332-344
46. Leyssac PP, Karlsen FM, Holstein-Rathlou NH, Skott O (1994) On determinants of glomerular filtration rate after inhibition of proximal tubular reabsorption. Am J Physiol 266:R1544-R1550
47. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525-535
48. -/- mice. Proc Natl Acad Sci U S A 100:13698-13703
49. Liedtke W, Tobin DM, Bargmann CI, Friedman JM (2003) Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A 100(Suppl 2):14531-14536
50. Liu X, Bandyopadhyay BC, Nakamoto T, Singh B, Liedtke W, Melvin JE, Ambudkar I (2006) A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem 281:15485-15495
51. 2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct. Am J Physiol Renal Physiol 293:F227-F235
52. i response of principal and intercalated cells in cortical collecting duct. Am J Physiol Renal Physiol 285:F998-F1012
53. 2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron. PLoS One 6:e22824
54. Marrelli SP, O'Neil RG, Brown RC, Bryan RM Jr (2007) PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. Am J Physiol Heart Circ Physiol 292:H1390-H1397
55. McCarty NA, O'Neil RG (1992) Calcium signaling in cell volume regulation. Physiol Rev 72:1037-1061
56. Mizuno A, Matsumoto N, Imai M, Suzuki M (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285:C96-C101
57. Montell C (2005) The TRP superfamily of cation channels. Sci STKE 2005: re3
58. Morimoto T, Liu W, Woda C, Carattino MD, Wei Y, Hughey RP, Apodaca G, Satlin LM, Kleyman TR (2006) Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol Renal Physiol 291:F663-F669
59. Mozaffari MS, Jirakulsomchok S, Shao ZH, Wyss JM (1991) High-NaCl diets increase natriuretic and diuretic responses in salt-resistant but not salt-sensitive SHR. Am J Physiol 260:F890-F897
60. Muto S (2001) Potassium transport in the mammalian collecting duct. Physiol Rev 81:85-116
61. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33:129-137
62. Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J (2006) Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol 17:1015-1025
63. Nilius B, Honore E (2012) Sensing pressure with ion channels. Trends Neurosci 35:477-486
64. Nilius B, Prenen J, Wissenbach U, Bodding M, Droogmans G (2001) Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227-233
65. Pedersen SF, Kapus A, Hoffmann EK (2011) Osmosensory mechanisms in cellular and systemic volume regulation. J Am Soc Nephrol 22:1587-1597
66. Pedersen SF, Nilius B (2007) Transient receptor potential channels in mechanosensing and cell volume regulation. Methods Enzymol 428:183-207
67. Pedersen SF, Owsianik G, Nilius B (2005) TRP channels: an overview. Cell Calcium 38:233-252
68. Plant TD, Strotmann R (2007) TRPV4. Handb Exp Pharmacol 179:189-205
69. Plant TD, Strotmann R (2007) TRPV4: a multifunctional nonselective cation channel with complex regulation. In: Liedtke WB, Heller S (eds) TRP ion channel function in sensory transduction and cellular signaling cascades. CRC Press, Boca Raton, pp 129-140
70. + channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem 283:36599-36607
71. Pollock CA, Lawrence JR, Field MJ (1991) Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus. Am J Physiol 260:F946-F952
72. i response in MDCK cells. Acta Physiol (Oxf) 197:241-251
73. Praetorius HA, Leipziger J (2010) Intrarenal purinergic signaling in the control of renal tubular transport. Annu Rev Physiol 72:377-393
74. Praetorius HA, Spring KR (2003) The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens 12:517-520
75. Praetorius HA, Spring KR (2005) A physiological view of the primary cilium. Annu Rev Physiol 67:515-529
76. Rieg T, Vallon V (2009) ATP and adenosine in the local regulation of water transport and homeostasis by the kidney. Am J Physiol Regul Integr Comp Physiol 296:R419-R427
77. Satlin LM (2004) Developmental regulation of expression of renal potassium secretory channels. Curr Opin Nephrol Hypertens 13:445-450
78. Seney FD Jr, Persson EG, Wright FS (1987) Modification of tubuloglomerular feedback signal by dietary protein. Am J Physiol 252:F83-F90
79. Silva GB, Garvin JL (2008) TRPV4 mediates hypotonicity-induced ATP release by the thick ascending limb. Am J Physiol Renal Physiol 295:F1090-F1095
80. Sinke AP, Deen PM (2011) The physiological implication of novel proteins in systemic osmoregulation. FASEB J 25:3279-3289
81. Sipos A, Vargas SL, Toma I, Hanner F, Willecke K, Peti-Peterdi J (2009) Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis. J Am Soc Nephrol 20:1724-1732
82. Stewart AP, Smith GD, Sandford RN, Edwardson JM (2010) Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys J 99:790-797
83. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O (2010) Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol 21:1903-1911
84. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702
85. 2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem 278:26541-26549
86. 2+-dependent potentiation in the cation channel TRPV4. PLoS One 5:e10580
87. Suzuki M, Hirao A, Mizuno A (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem 278:51448-51453
88. Suzuki M, Mizuno A, Kodaira K, Imai M (2003) Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 278:22664-22668
89. Sweeney WE Jr, Avner ED (2006) Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD). Cell Tissue Res 326:671-685
90. Tamma G, Procino G, Svelto M, Valenti G (2007) Hypotonicity causes actin reorganization and recruitment of the actin-binding ERM protein moesin in membrane protrusions in collecting duct principal cells. Am J Physiol Cell Physiol 292:C1476-C1484
91. + secretion from the cortical collecting duct. Am J Physiol Renal Physiol 292:F667-F673
92. Teilmann SC, Byskov AG, Pedersen PA, Wheatley DN, Pazour GJ, Christensen ST (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev 71:444-452
93. Tian W, Salanova M, Xu H, Lindsley JN, Oyama TT, Anderson S, Bachmann S, Cohen DM (2004) Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol 287:F17-F24
94. Tinel H, Kinne-Saffran E, Kinne RK (2000) Calcium signalling during RVD of kidney cells. Cell Physiol Biochem 10:297-302
95. Tinel H, Kinne-Saffran E, Kinne RH (2002) Calcium-induced calcium release participates in cell volume regulation of rabbit TALH cells. Pflugers Arch 443:754-761
96. Torres VE, Harris PC (2011) Polycystic kidney disease in 2011: connecting the dots toward a polycystic kidney disease therapy. Nat Rev Nephrol 8:66-68
97. Torres VE, Harris PC, Pirson Y (2007) Autosomal dominant polycystic kidney disease. Lancet 369:1287-1301
98. Torres VE, Wang X, Qian Q, Somlo S, Harris PC, Gattone VH (2004) Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med 10:363-364
99. Urbach V, Leguen I, O'Kelly I, Harvey BJ (1999) Mechanosensitive calcium entry and mobilization in renal A6 cells. J Membr Biol 168:29-37
100. 2+-permeable cation channel. J Biol Chem 276:4093-4101
101. Vandorpe DH, Wilhelm S, Jiang L, Ibraghimov-Beskrovnaya O, Chernova MN, Stuart-Tilley AK, Alper SL (2002) Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiol Genomics 8:87-98
102. Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387-417
103. Verani RR, Silva FG (1988) Histogenesis of the renal cysts in adult (autosomal dominant) polycystic kidney disease: a histochemical study. Mod Pathol 1:457-463
104. Verani R, Walker P, Silva FG (1989) Renal cystic disease of infancy: results of histochemical studies. A report of the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol 3:37-42
105. Voets T, Prenen J, Vriens J, Watanabe H, Janssens A, Wissenbach U, Bodding M, Droogmans G, Nilius B (2002) Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem 277:33704-33710
106. 2+ permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97:908-915
107. Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B (2004) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A 101:396-401
108. Wang S, Zhang J, Nauli SM, Li X, Starremans PG, Luo Y, Roberts KA, Zhou J (2007) Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol 27:3241-3252
109. Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, Flockerzi V, Droogmans G, Benham CD, Nilius B (2002) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277:13569-13577
110. 2+. Cell Calcium 33:489-495
111. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434-438
112. Wegierski T, Lewandrowski U, Muller B, Sickmann A, Walz G (2009) Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem 284:2923-2933
113. Wehner F, Olsen H, Tinel H, Kinne-Saffran E, Kinne RK (2003) Cell volume regulation: osmolytes, osmolyte transport, and signal transduction. Rev Physiol Biochem Pharmacol 148:1-80
114. Wilson PD, Goilav B (2007) Cystic disease of the kidney. Annu Rev Pathol 2:341-368
115. Wissenbach U, Bodding M, Freichel M, Flockerzi V (2000) Trp12, a novel Trp related protein from kidney. FEBS Lett 485:127-134
116. Woda CB, Leite M Jr, Rohatgi R, Satlin LM (2002) Effects of luminal flow and nucleotides on [Ca(2+)](i) in rabbit cortical collecting duct. Am J Physiol Renal Physiol 283:F437-F446
117. Wu L, Gao X, Brown RC, Heller S, O'Neil RG (2007) Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Am J Physiol Renal Physiol 293:F1699-F1713
118. Wu LJ, Sweet TB, Clapham DE (2010) International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 62:381-404
119. Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, Cohen DM (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278:11520-11527
120. Yamaguchi T, Hempson SJ, Reif GA, Hedge AM, Wallace DP (2006) Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells. J Am Soc Nephrol 17:178-187
121. Yang J, Zhang S, Zhou Q, Guo H, Zhang K, Zheng R, Xiao C (2007) PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease. J Biochem Mol Biol 40:467-474
122. Yip KP, Holstein-Rathlou NH, Marsh DJ (1993) Mechanisms of temporal variation in single-nephron blood flow in rats. Am J Physiol 264:F427-F434
123. Zerres K, Rudnik-Schoneborn S, Steinkamm C, Becker J, Mucher G (1998) Autosomal recessive polycystic kidney disease. J Mol Med (Berl) 76:303-309
124. Zhang Y, Sands JM, Kohan DE, Nelson RD, Martin CF, Carlson NG, Kamerath CD, Ge Y, Klein JD, Kishore BK (2008) Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Renal Physiol 295:F1715-F1724