Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function

Science

Volumn 336, Issue 6081, 2012, Pages 597-601

  Sonkusare, Swapnil K ^a   Bonev, Adrian D ^a   Ledoux, Jonathan ^a,b,c   Liedtke, Wolfgang ^d   Kotlikoff, Michael I ^e   Heppner, Thomas J ^a   Hill Eubanks, David C ^a   Nelson, Mark T ^a,f  

^a UNIVERSITY OF VERMONT   (United States)

^b MONTREAL HEART INSTITUTE   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; VANILLOID RECEPTOR 4; CALCIUM; DRUG DERIVATIVE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LEUCINE; MUSCARINIC RECEPTOR; N (1 ((4 (2 (((2,4 DICHLOROPHENYL)SULFONYL)AMINO) 3 HYDROXYPROPANOYL) 1 PIPERAZINYL)CARBONYL) 3 METHYLBUTYL) 1 BENZOTHIOPHENE 2 CARBOXAMIDE; N-(1-((4-(2-(((2,4-DICHLOROPHENYL)SULFONYL)AMINO)-3-HYDROXYPROPANOYL)-1-PIPERAZINYL)CARBONYL)-3-METHYLBUTYL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; SULFONAMIDE; TRPV4 PROTEIN, MOUSE; VANILLOID RECEPTOR;

BIOCHEMISTRY; CALCIUM; CARDIOVASCULAR SYSTEM; CATION; CYTOLOGY; MEMBRANE; MUSCLE; PHYSIOLOGY; POTASSIUM; SIGNALING;

ARTICLE; CARDIOVASCULAR FUNCTION; ENDOTHELIUM; PRIORITY JOURNAL; VASCULAR RESISTANCE; VASODILATATION; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENDOTHELIUM CELL; MESENTERIC ARTERY; METABOLISM; MOUSE; PATCH CLAMP; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM;

ANIMALS; CALCIUM; CALCIUM SIGNALING; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; LEUCINE; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PATCH-CLAMP TECHNIQUES; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; SULFONAMIDES; TRPV CATION CHANNELS; VASODILATION;

EID: 84860476825     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1216283     Document Type: Article

References (22)

1. V. Hartmannsgruber et al., PLoS ONE 2, e827 (2007).
2. S. A. Mendoza et al., Am. J. Physiol. Heart Circ. Physiol. 298, H466 (2010).
3. J. Saliez et al., Circulation 117, 1065 (2008).
4. D. X. Zhang et al., Hypertension 53, 532 (2009).
5. S. Earley et al., Am. J. Physiol. Heart Circ. Physiol. 297, H1096 (2009).
6. I. Fleming, R. Busse, J. Mol. Cell. Cardiol. 31, 5 (1999).
7. N. V. Bogatcheva, M. G. Sergeeva, S. M. Dudek, A. D. Verin, Microvasc. Res. 69, 107 (2005).
8. G. Edwards, M. Félétou, A. H. Weston, Pflugers Arch. 459, 863 (2010).
9. H. A. Coleman, M. Tare, H. C. Parkington, Clin. Exp. Pharmacol. Physiol. 31, 641 (2004).
10. J. Ledoux et al., Proc. Natl. Acad. Sci. U.S.A. 105, 9627 (2008).
11. Y. N. Tallini et al., Circ. Res. 101, 1300 (2007).
12. Materials and methods are available as supplementary materials on Science Online.
13. GlaxoSmithKline compound GSK1016790A: (N-((1S)-1-{[4-((2S)-2-{[(2,4- dichlorophenyl)sulfonyl] amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}- 3-methylbutyl)-1-benzothiophene-2-carboxamide; HydraBiosciences compound HC067047: (2-methyl- 1-[3-{4-morpholinyl}propyl]-5-phenyl-N-[3-{trifluoromethyl} phenyl]-1H-pyrrole-3-carboxamide.
14. R. N. Willette et al., J. Pharmacol. Exp. Ther. 326, 443 (2008).
15. W. Everaerts et al., Proc. Natl. Acad. Sci. U.S.A. 107, 19084 (2010).
16. I. Parker, I. F. Smith, J. Gen. Physiol. 136, 119 (2010).
17. W. Everaerts, B. Nilius, G. Owsianik, Prog. Biophys. Mol. Biol. 103, 2 (2010).
18. S. Q. Wang, L. S. Song, E. G. Lakatta, H. Cheng, Nature 410, 592 (2001).
19. R. Strotmann, M. Semtner, F. Kepura, T. D. Plant, T. Schöneberg, PLoS ONE 5, e10580 (2010).
20. J. Ledoux, M. E. Werner, J. E. Brayden, M. T. Nelson, Physiology (Bethesda) 21, 69 (2006).
21. K. A. Dora et al., J. Vasc. Res. 40, 480 (2003).
22. S. L. Sandow, C. B. Neylon, M. X. Chen, C. J. Garland, J. Anat. 209, 689 (2006).