Δnp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

Nature Cell Biology

Volumn 16, Issue 10, 2014, Pages 1004-1015

  Chakrabarti, Rumela ^a   Wei, Yong ^a   Hwang, Julie ^a   Hang, Xiang ^a   Andres Blanco, Mario ^a,b   Choudhury, Abrar ^a   Tiede, Benjamin ^a   Romano, Rose Anne ^c   Decoste, Christina ^a   Mercatali, Laura ^d   Ibrahim, Toni ^d   Amadori, Dino ^d   Kannan, Nagarajan ^e   Eaves, Connie J ^e   Sinha, Satrajit ^c   Kang, Yibin ^a,f  

^a PRINCETON UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d DEPARTMENT OF MEDICAL ONCOLOGY   (Italy)

^e BRITISH COLUMBIA CANCER AGENCY   (Canada)

^f RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE RECEPTOR; PROTEIN DELTANP63; PROTEIN FZD7; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN; FRIZZLED PROTEIN; FZD7 PROTEIN, HUMAN; GREEN FLUORESCENT PROTEIN; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA; TP63 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL LIKE BREAST CANCER; BREAST CELL; BREAST DEVELOPMENT; BREAST EPITHELIUM CELL; CELL ACTIVITY; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAMMARY STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; TUMOR PROMOTION; ANIMAL; BREAST TUMOR; C57BL MOUSE; CANCER STEM CELL; CONFOCAL MICROSCOPY; CYTOLOGY; DEFICIENCY; DNA MICROARRAY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MAMMARY GLAND; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; TRANSGENIC MOUSE; TUMOR CELL LINE; UDDER; WESTERN BLOTTING; WNT SIGNALING PATHWAY; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; EPITHELIAL CELLS; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MAMMARY GLANDS, ANIMAL; MAMMARY GLANDS, HUMAN; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS; WNT SIGNALING PATHWAY;

EID: 84925298125     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3040     Document Type: Article

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