Optimization of duplex stability and terminal asymmetry for shRNA design

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Matveeva, Olga V ^a   Kang, Yibin ^b   Spiridonov, Alexey N ^c   Sætrom, Pål ^d   Nemtsov, Vladimir A ^e   Ogurtsov, Aleksey Y ^g   Nechipurenko, Yury D ^f   Shabalina, Svetlana A ^g  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

^f ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ACCURACY; ALGORITHM; ARTICLE; CLASSIFICATION; CONTROLLED STUDY; DATA BASE; GENE SILENCING; PREDICTION; PROCESS OPTIMIZATION; PROTEIN SECONDARY STRUCTURE; RNA INTERFERENCE; RNA STABILITY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; VALIDITY; CHEMISTRY; CONFORMATION; DRUG DESIGN; NUCLEIC ACID DATABASE;

ALGORITHMS; DATABASES, NUCLEIC ACID; DRUG DESIGN; GENE SILENCING; NUCLEIC ACID CONFORMATION; RNA INTERFERENCE; RNA STABILITY; RNA, SMALL INTERFERING; THERMODYNAMICS;

EID: 77950369620     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010180     Document Type: Article

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