메뉴 건너뛰기




Volumn 30, Issue 15, 2012, Pages 1879-1887

Dissecting the heterogeneity of triple-negative breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BMN 673; BSI 401; CAPECITABINE; CARBOPLATIN; CEP 9722; CETUXIMAB; CISPLATIN; CLAUDIN; CO 338; CYCLOPHOSPHAMIDE; CYTOKERATIN 14; CYTOKERATIN 17; CYTOKERATIN 6; DOCETAXEL; DOXORUBICIN; E 7016; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; INIPARIB; INO 1001; IXABEPILONE; METHOTREXATE; NIRAPARIB; OLAPARIB; PACLITAXEL; TEMOZOLOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELIPARIB;

EID: 84863994288     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.38.2010     Document Type: Review
Times cited : (393)

References (126)
  • 1
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California Cancer Registry
    • DOI 10.1002/cncr.22618
    • Bauer KR, Brown M, Cress RD, et al: Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California Cancer Registry. Cancer 109: 1721-1728, 2007 (Pubitemid 46668532)
    • (2007) Cancer , vol.109 , Issue.9 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3    Parise, C.A.4    Caggiano, V.5
  • 3
    • 34547860028 scopus 로고    scopus 로고
    • Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: A single-institution compilation compared with the national cancer institute's surveillance, epidemiology, and end results database
    • DOI 10.1002/cncr.22836
    • Morris GJ, Naidu S, Topham AK, et al: Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: A single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Cancer 110:876-884, 2007 (Pubitemid 47257667)
    • (2007) Cancer , vol.110 , Issue.4 , pp. 876-884
    • Morris, G.J.1    Naidu, S.2    Topham, A.K.3    Guiles, F.4    Xu, Y.5    McCue, P.6    Schwartz, G.F.7    Park, P.K.8    Rosenberg, A.L.9    Brill, K.10    Mitchell, E.P.11
  • 4
    • 68149163711 scopus 로고    scopus 로고
    • Triple-negative breast cancers are increased in black women regardless of age or body mass index
    • Stead LA, Lash TL, Sobieraj JE, et al: Triple-negative breast cancers are increased in black women regardless of age or body mass index. Breast Cancer Res 11:R18, 2009
    • (2009) Breast Cancer Res , vol.11
    • Stead, L.A.1    Lash, T.L.2    Sobieraj, J.E.3
  • 5
    • 58149236915 scopus 로고    scopus 로고
    • Race and triple negative threats to breast cancer survival: A population-based study in Atlanta, GA
    • Lund MJ, Trivers KF, Porter PL, et al: Race and triple negative threats to breast cancer survival: A population-based study in Atlanta, GA. Breast Cancer Res Treat 113:357-370, 2009
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 357-370
    • Lund, M.J.1    Trivers, K.F.2    Porter, P.L.3
  • 7
    • 79951962586 scopus 로고    scopus 로고
    • Breast carcinomas arising at a young age: Unique biology or a surrogate for aggressive intrinsic subtypes?
    • Anders CK, Fan C, Parker JS, et al: Breast carcinomas arising at a young age: Unique biology or a surrogate for aggressive intrinsic subtypes? J Clin Oncol 29:e18-e20, 2011
    • (2011) J Clin Oncol , vol.29
    • Anders, C.K.1    Fan, C.2    Parker, J.S.3
  • 8
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature 406: 747-752, 2000
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 9
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR, et al: Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 26:1275-1281, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3
  • 11
    • 77957110787 scopus 로고    scopus 로고
    • Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women (<35 years) with operable breast cancer
    • Cancello G, Maisonneuve P, Rotmensz N, et al: Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women (<35 years) with operable breast cancer. Ann Oncol 21:1974-1981, 2010
    • (2010) Ann Oncol , vol.21 , pp. 1974-1981
    • Cancello, G.1    Maisonneuve, P.2    Rotmensz, N.3
  • 12
    • 67349148556 scopus 로고    scopus 로고
    • Pattern of metastatic spread in triple-negative breast cancer
    • Dent R, Hanna WM, Trudeau M, et al: Pattern of metastatic spread in triple-negative breast cancer. Breast Cancer Res Treat 115:423-428, 2009
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 423-428
    • Dent, R.1    Hanna, W.M.2    Trudeau, M.3
  • 13
    • 33645072444 scopus 로고    scopus 로고
    • Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas
    • Rodriguez-Pinilla SM, Sarrio D, Honrado E, et al: Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas. Clin Cancer Res 12:1533-1539, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 1533-1539
    • Rodriguez-Pinilla, S.M.1    Sarrio, D.2    Honrado, E.3
  • 14
    • 84864023811 scopus 로고    scopus 로고
    • Patterns of breast cancer relapse according to breast cancer subtypes in lymph node-negative breast cancer: Results from International Breast Cancer Study Group trials VIII and IX
    • abstr P5-13-01
    • Metzger O, Sun Z, Viale G, et al: Patterns of breast cancer relapse according to breast cancer subtypes in lymph node-negative breast cancer: Results from International Breast Cancer Study Group trials VIII and IX. Cancer Res 70:24s, 2010 (suppl; abstr P5-13-01)
    • (2010) Cancer Res , vol.70 , Issue.SUPPL.
    • Metzger, O.1    Sun, Z.2    Viale, G.3
  • 16
    • 77954526150 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
    • Hammond ME, Hayes DF, Dowsett M, et al: American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol 28:2784-2795, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2784-2795
    • Hammond, M.E.1    Hayes, D.F.2    Dowsett, M.3
  • 19
    • 33745948105 scopus 로고    scopus 로고
    • Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients
    • Calza S, Hall P, Auer G, et al: Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients. Breast Cancer Res 8:R34, 2006
    • (2006) Breast Cancer Res , vol.8
    • Calza, S.1    Hall, P.2    Auer, G.3
  • 21
    • 33646874546 scopus 로고    scopus 로고
    • The molecular portraits of breast tumors are conserved across microarray platforms
    • Hu Z, Fan C, Oh DS, et al: The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7:96, 2006
    • (2006) BMC Genomics , vol.7 , pp. 96
    • Hu, Z.1    Fan, C.2    Oh, D.S.3
  • 22
    • 4143089281 scopus 로고    scopus 로고
    • Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations
    • DOI 10.1158/1078-0432.CCR-04-0085
    • Yu K, Lee CH, Tan PH, et al: Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations. Clin Cancer Res 10:5508-5517, 2004 (Pubitemid 39100489)
    • (2004) Clinical Cancer Research , vol.10 , Issue.16 , pp. 5508-5517
    • Yu, K.1    Lee, C.H.2    Tan, P.H.3    Tan, P.4
  • 24
    • 33847292843 scopus 로고    scopus 로고
    • Breast carcinoma with basal differentiation: A proposal for pathology definition based on basal cytokeratin expression
    • DOI 10.1111/j.1365-2559.2007.02638.x
    • Rakha EA, El-Sayed ME, Green AR, et al: Breast carcinoma with basal differentiation: A proposal for pathology definition based on basal cytokeratin expression. Histopathology 50:434-438, 2007 (Pubitemid 46328193)
    • (2007) Histopathology , vol.50 , Issue.4 , pp. 434-438
    • Rakha, E.A.1    El-Sayed, M.E.2    Green, A.R.3    Paish, E.C.4    Lee, A.H.S.5    Ellis, I.O.6
  • 26
    • 65249104546 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Distinguishing between basal and nonbasal subtypes
    • Rakha EA, Elsheikh SE, Aleskandarany MA, et al: Triple-negative breast cancer: Distinguishing between basal and nonbasal subtypes. Clin Cancer Res 15:2302-2310, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 2302-2310
    • Rakha, E.A.1    Elsheikh, S.E.2    Aleskandarany, M.A.3
  • 27
    • 44949196762 scopus 로고    scopus 로고
    • Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes
    • Moinfar F: Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes. Pathobiology 75:119-131, 2008
    • (2008) Pathobiology , vol.75 , pp. 119-131
    • Moinfar, F.1
  • 28
    • 34248197651 scopus 로고    scopus 로고
    • Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers
    • Jumppanen M, Gruvberger-Saal S, Kauraniemi P, et al: Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers. Breast Cancer Res 9:R16, 2007
    • (2007) Breast Cancer Res , vol.9
    • Jumppanen, M.1    Gruvberger-Saal, S.2    Kauraniemi, P.3
  • 29
    • 33747819585 scopus 로고    scopus 로고
    • Clinicopathologic significance of the basal-like subtype of breast cancer: A comparison with hormone receptor and Her2/neu-overexpressing phenotypes
    • DOI 10.1016/j.humpath.2006.04.015, PII S0046817706002644
    • Kim MJ, Ro JY, Ahn SH, et al: Clinicopathologic significance of the basal-like subtype of breast cancer: A comparison with hormone receptor and Her2/neu-overexpressing phenotypes. Hum Pathol 37:1217-1226, 2006 (Pubitemid 44286991)
    • (2006) Human Pathology , vol.37 , Issue.9 , pp. 1217-1226
    • Kim, M.-J.1    Ro, J.Y.2    Ahn, S.-H.3    Kim, H.H.4    Kim, S.-B.5    Gong, G.6
  • 30
    • 32044473265 scopus 로고    scopus 로고
    • Prognostic relevance of basal cytokeratin expression in operable breast cancer
    • Potemski P, Kusinska R, Watala C, et al: Prognostic relevance of basal cytokeratin expression in operable breast cancer. Oncology 69:478-485, 2005
    • (2005) Oncology , vol.69 , pp. 478-485
    • Potemski, P.1    Kusinska, R.2    Watala, C.3
  • 31
    • 34248218713 scopus 로고    scopus 로고
    • Basal-like grade III invasive ductal carcinoma of the breast: Patterns of metastasis and long-term survival
    • Fulford LG, Reis-Filho JS, Ryder K, et al: Basal-like grade III invasive ductal carcinoma of the breast: Patterns of metastasis and long-term survival. Breast Cancer Res 9:R4, 2007
    • (2007) Breast Cancer Res , vol.9
    • Fulford, L.G.1    Reis-Filho, J.S.2    Ryder, K.3
  • 32
    • 33745660509 scopus 로고    scopus 로고
    • Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast
    • DOI 10.1111/j.1365-2559.2006.02453.x
    • Fulford LG, Easton DF, Reis-Filho JS, et al: Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast. Histopathology 49:22-34, 2006 (Pubitemid 43972917)
    • (2006) Histopathology , vol.49 , Issue.1 , pp. 22-34
    • Fulford, L.G.1    Easton, D.F.2    Reis-Filho, J.S.3    Sofronis, A.4    Gillett, C.E.5    Lakhani, S.R.6    Hanby, A.7
  • 34
    • 33646390671 scopus 로고    scopus 로고
    • Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers
    • Bertucci F, Finetti P, Cervera N, et al: Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers. Cancer Res 66:4636-4644, 2006
    • (2006) Cancer Res , vol.66 , pp. 4636-4644
    • Bertucci, F.1    Finetti, P.2    Cervera, N.3
  • 36
    • 80054861468 scopus 로고    scopus 로고
    • Prognosis of medullary breast cancer: Analyses of 13 International Breast Cancer Study Group (IBCSG) trials
    • abstr 630
    • Huober JB, Gelber S, Thürlimann B, et al: Prognosis of medullary breast cancer: Analyses of 13 International Breast Cancer Study Group (IBCSG) trials. J Clin Oncol 28:99s, 2010 (suppl; abstr 630)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Huober, J.B.1    Gelber, S.2    Thürlimann, B.3
  • 38
    • 0036296878 scopus 로고    scopus 로고
    • Adenoid cystic breast cancer
    • DOI 10.1016/S0002-9610(02)00858-9, PII S0002961002008589
    • McClenathan JH, de la Roza G: Adenoid cystic breast cancer. Am J Surg 183:646-649, 2002 (Pubitemid 34722530)
    • (2002) American Journal of Surgery , vol.183 , Issue.6 , pp. 646-649
    • McClenathan, J.H.1    De La, R.G.2
  • 39
    • 53149133527 scopus 로고    scopus 로고
    • Refinement of breast cancer classification by molecular characterization of histological special types
    • Weigelt B, Horlings HM, Kreike B, et al: Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol 216:141-150, 2008
    • (2008) J Pathol , vol.216 , pp. 141-150
    • Weigelt, B.1    Horlings, H.M.2    Kreike, B.3
  • 43
    • 25144516817 scopus 로고    scopus 로고
    • Cytokeratin 5/14-positive breast cancer: True basal phenotype confined to BRCA1 tumors
    • DOI 10.1038/modpathol.3800456, PII 3800456
    • Laakso M, Loman N, Borg A, et al: Cytokeratin 5/14-positive breast cancer: True basal phenotype confined to BRCA1 tumors. Mod Pathol 18: 1321-1328, 2005 (Pubitemid 41348650)
    • (2005) Modern Pathology , vol.18 , Issue.10 , pp. 1321-1328
    • Laakso, M.1    Loman, N.2    Borg, A.3    Isola, J.4
  • 45
    • 0342940785 scopus 로고    scopus 로고
    • Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases - Breast Cancer Linkage Consortium
    • Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases - Breast Cancer Linkage Consortium. Lancet 349:1505-1510, 1997
    • (1997) Lancet , vol.349 , pp. 1505-1510
  • 47
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L: Gene-expression signatures in breast cancer. N Engl J Med 360:790-800, 2009
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 48
    • 51349088017 scopus 로고    scopus 로고
    • Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes
    • Desmedt C, Haibe-Kains B, Wirapati P, et al: Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin Cancer Res 14:5158-5165, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 5158-5165
    • Desmedt, C.1    Haibe-Kains, B.2    Wirapati, P.3
  • 49
    • 84863993236 scopus 로고    scopus 로고
    • Transcriptome analysis of triple negative breast cancers identifies six distinct biological subgroups and reveals therapeutic strategies
    • abstr PD01-07
    • Lehmann BD, Bauer JA, Chen X, et al: Transcriptome analysis of triple negative breast cancers identifies six distinct biological subgroups and reveals therapeutic strategies. Cancer Res 70:24s, 2010 (suppl; abstr PD01-07)
    • (2010) Cancer Res , vol.70 , Issue.SUPPL.
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 50
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudinlow intrinsic subtype of breast cancer
    • Prat A, Parker JS, Karginova O, et al: Phenotypic and molecular characterization of the claudinlow intrinsic subtype of breast cancer. Breast Cancer Res 12:R68, 2010
    • (2010) Breast Cancer Res , vol.12
    • Prat, A.1    Parker, J.S.2    Karginova, O.3
  • 51
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim E, Vaillant F, Wu D, et al: Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15:907-913, 2009
    • (2009) Nat Med , vol.15 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3
  • 52
    • 68349150810 scopus 로고    scopus 로고
    • Mammary development meets cancer genomics
    • Prat A, Perou CM: Mammary development meets cancer genomics. Nat Med 15:842-844, 2009
    • (2009) Nat Med , vol.15 , pp. 842-844
    • Prat, A.1    Perou, C.M.2
  • 53
    • 77955770116 scopus 로고    scopus 로고
    • DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
    • Rodriguez AA, Makris A, Wu MF, et al: DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Breast Cancer Res Treat 123:189-196, 2010
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 189-196
    • Rodriguez, A.A.1    Makris, A.2    Wu, M.F.3
  • 54
    • 34648829133 scopus 로고    scopus 로고
    • An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    • Teschendorff AE, Miremadi A, Pinder SE, et al: An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. Genome Biol 8:R157, 2007
    • (2007) Genome Biol , vol.8
    • Teschendorff, A.E.1    Miremadi, A.2    Pinder, S.E.3
  • 55
    • 77957759237 scopus 로고    scopus 로고
    • A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer
    • Yau C, Esserman L, Moore DH, et al: A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer. Breast Cancer Res 12:R85, 2010
    • (2010) Breast Cancer Res , vol.12
    • Yau, C.1    Esserman, L.2    Moore, D.H.3
  • 56
    • 83255179611 scopus 로고    scopus 로고
    • Identification of a clinically relevant gene signature in triple negative and basal-like breast cancer
    • abstr S5-5
    • Rody A, Karn T, Liedtke C, et al: Identification of a clinically relevant gene signature in triple negative and basal-like breast cancer. Cancer Res 70:24s, 2010 (suppl; abstr S5-5)
    • (2010) Cancer Res , vol.70 , Issue.SUPPL.
    • Rody, A.1    Karn, T.2    Liedtke, C.3
  • 57
    • 73949092850 scopus 로고    scopus 로고
    • Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
    • Denkert C, Loibl S, Noske A, et al: Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol 28:105-113, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 105-113
    • Denkert, C.1    Loibl, S.2    Noske, A.3
  • 58
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer P, Bonnefoi H, Anderle P, et al: A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med 15:68-74, 2009
    • (2009) Nat Med , vol.15 , pp. 68-74
    • Farmer, P.1    Bonnefoi, H.2    Anderle, P.3
  • 59
    • 79955008762 scopus 로고    scopus 로고
    • Multifactorial approach to predicting resistance to anthracyclines
    • Desmedt C, Di Leo A, de Azambuja E, et al: Multifactorial approach to predicting resistance to anthracyclines. J Clin Oncol 29:1578-1586, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 1578-1586
    • Desmedt, C.1    Di Leo, A.2    De Azambuja, E.3
  • 60
    • 77149129286 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Role of the androgen receptor
    • Gucalp A, Traina TA: Triple-negative breast cancer: Role of the androgen receptor. Cancer J 16:62-65, 2010
    • (2010) Cancer J , vol.16 , pp. 62-65
    • Gucalp, A.1    Traina, T.A.2
  • 61
    • 36549004041 scopus 로고    scopus 로고
    • Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
    • Kreike B, van Kouwenhove M, Horlings H, et al: Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res 9:R65, 2007
    • (2007) Breast Cancer Res , vol.9
    • Kreike, B.1    Van Kouwenhove, M.2    Horlings, H.3
  • 63
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker JS, Mullins M, Cheang MC, et al: Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27:1160-1167, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3
  • 65
    • 77954740501 scopus 로고    scopus 로고
    • Metastatic behavior of breast cancer subtypes
    • Kennecke H, Yerushalmi R, Woods R, et al: Metastatic behavior of breast cancer subtypes. J Clin Oncol 28:3271-3277, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 3271-3277
    • Kennecke, H.1    Yerushalmi, R.2    Woods, R.3
  • 66
    • 65649151690 scopus 로고    scopus 로고
    • Survival outcomes for patients with metastatic triple-negative breast cancer: Implications for clinical practice and trial design
    • Kassam F, Enright K, Dent R, et al: Survival outcomes for patients with metastatic triple-negative breast cancer: Implications for clinical practice and trial design. Clin Breast Cancer 9:29-33, 2009
    • (2009) Clin Breast Cancer , vol.9 , pp. 29-33
    • Kassam, F.1    Enright, K.2    Dent, R.3
  • 67
    • 84863994088 scopus 로고    scopus 로고
    • Anthracycline (A) use among women with breast cancer (BC)
    • abstr 1019
    • Giordano SH, Lin Y, Kuo Y, et al: Anthracycline (A) use among women with breast cancer (BC). J Clin Oncol 29:84s, 2011 (suppl; abstr 1019)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Giordano, S.H.1    Lin, Y.2    Kuo, Y.3
  • 68
    • 77149129324 scopus 로고    scopus 로고
    • Anthracyclines in basal breast cancer: The NCIC-CTG trial MA5 comparing adjuvant CMF to CEF
    • abtr 519
    • Cheang M, Chia SK, Tu D, et al: Anthracyclines in basal breast cancer: The NCIC-CTG trial MA5 comparing adjuvant CMF to CEF. J Clin Oncol 27:11s, 2009 (suppl; abtr 519)
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Cheang, M.1    Chia, S.K.2    Tu, D.3
  • 69
    • 82155176359 scopus 로고    scopus 로고
    • The responsiveness of intrinsic subtypes to adjuvant anthracyclines versus nonanthracyclines in NCIC.CTG MA.5 randomized trial
    • abstr 1032
    • Cheang M, Voduc D, Tu D, et al: The responsiveness of intrinsic subtypes to adjuvant anthracyclines versus nonanthracyclines in NCIC.CTG MA.5 randomized trial. J Clin Oncol 29:88s, 2011 (suppl; abstr 1032)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Cheang, M.1    Voduc, D.2    Tu, D.3
  • 70
    • 80051856121 scopus 로고    scopus 로고
    • Final results of a meta-analysis testing HER2 and topoisomerase IIalpha genes as predictors of incremental benefit from anthracyclines in breast cancer
    • abstr 519
    • Di Leo A, Desmedt C, Bartlett JM, et al: Final results of a meta-analysis testing HER2 and topoisomerase IIalpha genes as predictors of incremental benefit from anthracyclines in breast cancer. J Clin Oncol 28:72s, 2010 (suppl; abstr 519)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Di Leo, A.1    Desmedt, C.2    Bartlett, J.M.3
  • 71
    • 82155199632 scopus 로고    scopus 로고
    • Benefit from CMF with or without anthracyclines in relation to biologic profiles in early breast cancer
    • abstr 1031
    • Rocca A, Paradiso A, Sismondi P, et al: Benefit from CMF with or without anthracyclines in relation to biologic profiles in early breast cancer. J Clin Oncol 29:87s, 2011 (suppl; abstr 1031)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Rocca, A.1    Paradiso, A.2    Sismondi, P.3
  • 72
    • 37849035252 scopus 로고    scopus 로고
    • Taxane-based combinations as adjuvant chemotherapy of early breast cancer: A meta-analysis of randomized trials
    • De Laurentiis M, Cancello G, D'Agostino D, et al: Taxane-based combinations as adjuvant chemotherapy of early breast cancer: A meta-analysis of randomized trials. J Clin Oncol 26:44-53, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 44-53
    • De Laurentiis, M.1    Cancello, G.2    D'Agostino, D.3
  • 78
    • 77953025896 scopus 로고    scopus 로고
    • Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer
    • Perez EA, Patel T, Moreno-Aspitia A: Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer. Breast Cancer Res Treat 121:261-271, 2010
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 261-271
    • Perez, E.A.1    Patel, T.2    Moreno-Aspitia, A.3
  • 79
    • 84920754992 scopus 로고    scopus 로고
    • Integration of capecitabine into anthracycline- and taxane-based adjuvant therapy for triple-negative early breast cancer: Final subgroup analysis of the FinXX Study
    • abstr PD01-02
    • Lindman H, Kellokumpu-Lehtinen P-L, Huovinen R, et al: Integration of capecitabine into anthracycline- and taxane-based adjuvant therapy for triple-negative early breast cancer: Final subgroup analysis of the FinXX Study. Cancer Res 70:24s, 2010 (suppl; abstr PD01-02)
    • (2010) Cancer Res , vol.70 , Issue.SUPPL.
    • Lindman, H.1    Kellokumpu-Lehtinen, P.-L.2    Huovinen, R.3
  • 81
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al: Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357:2666-2676, 2007
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 82
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, et al: Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 28:3239-3247, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 83
    • 70249097518 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC)
    • abstr 1005
    • Robert NJ, Dieras V, Glaspy J, et al: RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC). J Clin Oncol 27:42s, 2009 (suppl; abstr 1005)
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 84
    • 76949108277 scopus 로고    scopus 로고
    • RIBBON-2: A randomized, double-blind, placebocontrolled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of HER2-negative metastatic breast cancer
    • abstr 42
    • Brufsky A, Bondarenko IN, Smirnov V, et al: RIBBON-2: A randomized, double-blind, placebocontrolled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of HER2-negative metastatic breast cancer. Cancer Res 69:24s, 2009 (suppl; abstr 42)
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Brufsky, A.1    Bondarenko, I.N.2    Smirnov, V.3
  • 85
    • 77949686134 scopus 로고    scopus 로고
    • Comparison of subgroup analyses of PFS from three phase III studies of bevacizumab in combination with chemotherapy in patients with HER2-negative metastatic breast cancer (MBC)
    • abstr 207
    • O'Shaughnessy J, Dieras V, Glaspy J, et al: Comparison of subgroup analyses of PFS from three phase III studies of bevacizumab in combination with chemotherapy in patients with HER2-negative metastatic breast cancer (MBC). Cancer Res 69:24s, 2009 (suppl; abstr 207)
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • O'Shaughnessy, J.1    Dieras, V.2    Glaspy, J.3
  • 86
    • 67649211199 scopus 로고    scopus 로고
    • Invasive ductal carcinoma of the breast with the "triple- negative" phenotype: Prognostic implications of EGFR immunoreactivity
    • Viale G, Rotmensz N, Maisonneuve P, et al: Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: Prognostic implications of EGFR immunoreactivity. Breast Cancer Res Treat 116:317-328, 2009
    • (2009) Breast Cancer Res Treat , vol.116 , pp. 317-328
    • Viale, G.1    Rotmensz, N.2    Maisonneuve, P.3
  • 87
    • 61349152550 scopus 로고    scopus 로고
    • TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer
    • abstr 1009
    • Carey LA, Rugo HS, Marcom PK, et al: TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer. J Clin Oncol 26:43s, 2008 (suppl; abstr 1009)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 88
    • 78649760941 scopus 로고    scopus 로고
    • The addition of cetuximab to cisplatin increases overall response rate (ORR) and progression-free survival (PFS) in metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II study (BALI-1)
    • abstr 274
    • Baselga J, Gomez P, Awada A, et al: The addition of cetuximab to cisplatin increases overall response rate (ORR) and progression-free survival (PFS) in metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II study (BALI-1). Ann Oncol 21:8s, 2010 (suppl; abstr 274)
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL.
    • Baselga, J.1    Gomez, P.2    Awada, A.3
  • 90
    • 79952306458 scopus 로고    scopus 로고
    • Uncovering a tumor suppressor for triple-negative breast cancers
    • Albeck JG, Brugge JS: Uncovering a tumor suppressor for triple-negative breast cancers. Cell 144:638-640, 2011
    • (2011) Cell , vol.144 , pp. 638-640
    • Albeck, J.G.1    Brugge, J.S.2
  • 91
    • 68149157511 scopus 로고    scopus 로고
    • Neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
    • abstr 502
    • Gronwald J, Byrski T, Huzarski T, et al: Neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. J Clin Oncol 27:7s, 2009 (suppl; abstr 502)
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Gronwald, J.1    Byrski, T.2    Huzarski, T.3
  • 92
    • 75749143502 scopus 로고    scopus 로고
    • Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
    • Byrski T, Gronwald J, Huzarski T, et al: Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 28:375-379, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 375-379
    • Byrski, T.1    Gronwald, J.2    Huzarski, T.3
  • 93
    • 67349284098 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
    • Byrski T, Huzarski T, Dent R, et al: Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 115:359-363, 2009
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 359-363
    • Byrski, T.1    Huzarski, T.2    Dent, R.3
  • 94
    • 77949908546 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant cisplatin in triple-negative breast cancer
    • Silver DP, Richardson AL, Eklund AC, et al: Efficacy of neoadjuvant cisplatin in triple-negative breast cancer. J Clin Oncol 28:1145-1153, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 1145-1153
    • Silver, D.P.1    Richardson, A.L.2    Eklund, A.C.3
  • 95
    • 80054120482 scopus 로고    scopus 로고
    • Efficacy of gemcitabine and cisplatin (GP) as first-line combination therapy in patients with triple-negative metastatic breast cancer: Preliminary results report of a phase II trial
    • abstr 1100
    • Wang Z, Hu X, Chen L, et al: Efficacy of gemcitabine and cisplatin (GP) as first-line combination therapy in patients with triple-negative metastatic breast cancer: Preliminary results report of a phase II trial. J Clin Oncol 28:138s, 2010 (suppl; abstr 1100)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Wang, Z.1    Hu, X.2    Chen, L.3
  • 96
    • 77957169419 scopus 로고    scopus 로고
    • Single institute phase II study of weekly cisplatinum and metronomic dosing of Endoxan and methotrexate in second line metastatic breast cancer triple-negative
    • abstr 41
    • Bhattacharyya GS, Basu S, Agarwal V, et al: Single institute phase II study of weekly cisplatinum and metronomic dosing of Endoxan and methotrexate in second line metastatic breast cancer triple-negative. Eur J Cancer Suppl 7:18, 2009 (abstr 41)
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 18
    • Bhattacharyya, G.S.1    Basu, S.2    Agarwal, V.3
  • 97
    • 82155199636 scopus 로고    scopus 로고
    • Chemotherapy (CT) with or without carboplatin as neoadjuvant treatment in patients with basal-like breast cancer: GEICAM 2006-03-A multicenter, randomized phase II study
    • abstr 1015
    • Alba E, Chacon J, Lluch A, et al: Chemotherapy (CT) with or without carboplatin as neoadjuvant treatment in patients with basal-like breast cancer: GEICAM 2006-03-A multicenter, randomized phase II study. J Clin Oncol 29:83s, 2011 (suppl; abstr 1015)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Alba, E.1    Chacon, J.2    Lluch, A.3
  • 100
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature 411:366-374, 2001
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 101
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth A: A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 26:3785-3790, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 3785-3790
    • Ashworth, A.1
  • 102
    • 4444226253 scopus 로고    scopus 로고
    • Cancer chromosomes in crisis
    • DOI 10.1038/ng0904-932
    • DePinho RA, Polyak K: Cancer chromosomes in crisis. Nat Genet 36:932-934, 2004 (Pubitemid 39167483)
    • (2004) Nature Genetics , vol.36 , Issue.9 , pp. 932-934
    • DePinho, R.A.1    Polyak, K.2
  • 103
    • 79952253747 scopus 로고    scopus 로고
    • Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer
    • Gonzalez-Angulo AM, Timms KM, Liu S, et al: Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer. Clin Cancer Res 17:1082-1089, 2011
    • (2011) Clin Cancer Res , vol.17 , pp. 1082-1089
    • Gonzalez-Angulo, A.M.1    Timms, K.M.2    Liu, S.3
  • 105
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • DOI 10.1038/nrc1457
    • Turner N, Tutt A, Ashworth A: Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 4:814-819, 2004 (Pubitemid 39331153)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 106
    • 79952747328 scopus 로고    scopus 로고
    • Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
    • Patel AG, Sarkaria JN, Kaufmann SH: Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A 108:3406-3411, 2011
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3406-3411
    • Patel, A.G.1    Sarkaria, J.N.2    Kaufmann, S.H.3
  • 107
    • 79959733228 scopus 로고    scopus 로고
    • An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients
    • Vollebergh MA, Lips EH, Nederlof PM, et al: An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients. Ann Oncol 22:1561-1570, 2010
    • (2010) Ann Oncol , vol.22 , pp. 1561-1570
    • Vollebergh, M.A.1    Lips, E.H.2    Nederlof, P.M.3
  • 108
    • 34547617889 scopus 로고    scopus 로고
    • BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II
    • DOI 10.1158/0008-5472.CAN-07-0601
    • Treszezamsky AD, Kachnic LA, Feng Z, et al: BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res 67:7078-7081, 2007 (Pubitemid 47206532)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7078-7081
    • Treszezamsky, A.D.1    Kachnic, L.A.2    Feng, Z.3    Zhang, J.4    Tokadjian, C.5    Powell, S.N.6
  • 109
    • 0033580432 scopus 로고    scopus 로고
    • Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: Correlation with disease characteristics
    • Catteau A, Harris WH, Xu CF, et al: Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: Correlation with disease characteristics. Oncogene 18:1957-1965, 1999 (Pubitemid 29150082)
    • (1999) Oncogene , vol.18 , Issue.11 , pp. 1957-1965
    • Catteau, A.1    Harris, W.H.2    Xu, C.-F.3    Solomon, E.4
  • 111
    • 0032542339 scopus 로고    scopus 로고
    • Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
    • Magdinier F, Ribieras S, Lenoir GM, et al: Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. Oncogene 17:3169-3176, 1998 (Pubitemid 29020812)
    • (1998) Oncogene , vol.17 , Issue.24 , pp. 3169-3176
    • Magdinier, F.1    Ribieras, S.2    Lenoir, G.M.3    Frappart, L.4    Dante, R.5
  • 112
    • 0033857349 scopus 로고    scopus 로고
    • Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens
    • Rice JC, Ozcelik H, Maxeiner P, et al: Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis 21:1761-1765, 2000
    • (2000) Carcinogenesis , vol.21 , pp. 1761-1765
    • Rice, J.C.1    Ozcelik, H.2    Maxeiner, P.3
  • 113
    • 77957583101 scopus 로고    scopus 로고
    • Evaluation of BRCA1 inactivation by promoter methylation as a marker of triple-negative and basal-like breast cancers
    • abstr 10510
    • Grushko TA, Nwachukwu C, Charoenthammaraksa S, et al: Evaluation of BRCA1 inactivation by promoter methylation as a marker of triple-negative and basal-like breast cancers. J Clin Oncol 28:725s, 2010 (suppl; abstr 10510)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Grushko, T.A.1    Nwachukwu, C.2    Charoenthammaraksa, S.3
  • 114
    • 4344685333 scopus 로고    scopus 로고
    • The PARP superfamily
    • DOI 10.1002/bies.20085
    • Ame JC, Spenlehauer C, de Murcia G: The PARP superfamily. Bioessays 26:882-893, 2004 (Pubitemid 39128102)
    • (2004) BioEssays , vol.26 , Issue.8 , pp. 882-893
    • Ame, J.-C.1    Spenlehauer, C.2    De Murcia, G.3
  • 115
    • 69849097500 scopus 로고    scopus 로고
    • PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
    • Bryant HE, Petermann E, Schultz N, et al: PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. Embo J 28:2601-2615, 2009
    • (2009) Embo J , vol.28 , pp. 2601-2615
    • Bryant, H.E.1    Petermann, E.2    Schultz, N.3
  • 118
    • 67650476607 scopus 로고    scopus 로고
    • Synthetic lethality: A new direction in cancer-drug development
    • Iglehart JD, Silver DP: Synthetic lethality: A new direction in cancer-drug development. N Engl J Med 361:189-191, 2009
    • (2009) N Engl J Med , vol.361 , pp. 189-191
    • Iglehart, J.D.1    Silver, D.P.2
  • 119
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, et al: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet 376:235-244, 2010
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 120
    • 77955877185 scopus 로고    scopus 로고
    • A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer
    • abstr 1019
    • Isakoff SJ, Overmoyer B, Tung NM, et al: A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer. J Clin Oncol 28:118s, 2010 (suppl; abstr 1019)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Isakoff, S.J.1    Overmoyer, B.2    Tung, N.M.3
  • 121
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE, et al: Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 364:205-214, 2011
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 122
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC)
    • abstr 1007
    • O'Shaughnessy J, Schwartzberg LS, Danso MA, et al: A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC). J Clin Oncol 29:81s, 2011 (suppl; abstr 1007)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • O'Shaughnessy, J.1    Schwartzberg, L.S.2    Danso, M.A.3
  • 123
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361:123-134, 2009
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 124
    • 67650688146 scopus 로고    scopus 로고
    • Targeting the DNA damage response in cancer
    • Ljungman M: Targeting the DNA damage response in cancer. Chem Rev 109:2929-2950, 2009
    • (2009) Chem Rev , vol.109 , pp. 2929-2950
    • Ljungman, M.1
  • 125
    • 84857092267 scopus 로고    scopus 로고
    • Pharmacodynamic and pathway analysis of three presumed inhibitors of poly (ADP-ribose) polymerase: ABT-888, AZD2281, and BSI201
    • abstr 4527
    • Ji J, Lee MP, Kadota M, et al: Pharmacodynamic and pathway analysis of three presumed inhibitors of poly (ADP-ribose) polymerase: ABT-888, AZD2281, and BSI201. Proc Am Assoc Cancer Res 1:71, 2011 (abstr 4527)
    • (2011) Proc Am Assoc Cancer Res , vol.1 , pp. 71
    • Ji, J.1    Lee, M.P.2    Kadota, M.3
  • 126
    • 84860201897 scopus 로고    scopus 로고
    • Cell cycle effects of iniparib, a PARP inhibitor, in combination with gemcitabine and carboplatin in the MDA-MB-468(-) triple-negative breast cancer (TNBC) cell line
    • abstr P5-06-09
    • Ossovskaya V, Lim C, Schools G, et al: Cell cycle effects of iniparib, a PARP inhibitor, in combination with gemcitabine and carboplatin in the MDA-MB-468(-) triple-negative breast cancer (TNBC) cell line. Cancer Res 70:24s, 2010 (suppl; abstr P5-06-09)
    • (2010) Cancer Res , vol.70 , Issue.SUPPL.
    • Ossovskaya, V.1    Lim, C.2    Schools, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.