Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: Implications for age-related hearing loss

Neurobiology of Aging

Volumn 36, Issue 4, 2015, Pages 1692-1701

  Xiong, Hao ^a   Pang, Jiaqi ^a   Yang, Haidi ^a   Dai, Min ^b   Liu, Yimin ^c   Ou, Yongkang ^a   Huang, Qiuhong ^a   Chen, Suijun ^a   Zhang, Zhigang ^a   Xu, Yaodong ^a   Lai, Lan ^a   Zheng, Yiqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c Guangzhou Occupational Diseases Prevention and Treatment Center   (China)

Author keywords

Cochlea; MicroRNA; P53; Presbycusis; SIRT1

Indexed keywords

MICRORNA 34A; PROTEIN P53; RESVERATROL; SIRTUIN 1; MICRORNA; MIRN34 MICRORNA, MOUSE; SIRT1 PROTEIN, MOUSE; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUDITORY THRESHOLD; CELL DEATH; CELL LOSS; CELL PROTECTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DRUG EFFECT; GENE OVEREXPRESSION; GROUPS BY AGE; HAIR CELL; INNER HAIR CELL; MOUSE; NONHUMAN; OUTER HAIR CELL; PRESBYACUSIS; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; UPREGULATION; ACETYLATION; AGING; ANIMAL; C57BL MOUSE; CELL LINE; COCHLEAR HAIR CELL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HEARING LOSS, SENSORINEURAL; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ACETYLATION; AGING; ANIMALS; APOPTOSIS; CELL LINE; GENE EXPRESSION; HAIR CELLS, AUDITORY; HEARING LOSS, SENSORINEURAL; MICE, INBRED C57BL; MICRORNAS; SIGNAL TRANSDUCTION; SIRTUIN 1; STILBENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84925293953     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.12.034     Document Type: Article

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