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Volumn 56, Issue 2, 2015, Pages 125-148

Effects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity

Author keywords

Cytotoxicity; Developmental toxicity; Genotoxicity; Iron oxide nanoparticles; Neurotoxicity

Indexed keywords

DAUNORUBICIN; FERRIC OXIDE; FERRITIN; FERROMAGNETIC MATERIAL; IRON NANOPARTICLE; IRON OXIDE NANOPARTICLE; MAGNETITE NANOPARTICLE; NERVE GROWTH FACTOR; PROTEIN P53; RESAZURIN; UNCLASSIFIED DRUG; CHEMOTACTIC FACTOR; FERRIC ION; METAL NANOPARTICLE; MUTAGENIC AGENT;

EID: 84925247550     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21909     Document Type: Review
Times cited : (148)

References (130)
  • 1
    • 84886530736 scopus 로고    scopus 로고
    • Iron oxide nanoparticle-induced oxidative stress and genotoxicity in human skin epithelial and lung epithelial cell lines
    • Ahamed M, Alhadlaq HA, Alam J, Khan MA, Ali D, Alarafi S. 2013. Iron oxide nanoparticle-induced oxidative stress and genotoxicity in human skin epithelial and lung epithelial cell lines. Curr Pharm Des 2013;19:6681-90.
    • (2013) Curr Pharm Des , vol.19 , pp. 6681-6690
    • Ahamed, M.1    Alhadlaq, H.A.2    Alam, J.3    Khan, M.A.4    Ali, D.5    Alarafi, S.6
  • 2
    • 84867243223 scopus 로고    scopus 로고
    • Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics
    • Alwi R, Telenkov S, Mandelis A, Leshuk T, Gu F, Oladepo S, Michaelian K. 2012. Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics. Biomed Opt Express 3:2500-2509.
    • (2012) Biomed Opt Express , vol.3 , pp. 2500-2509
    • Alwi, R.1    Telenkov, S.2    Mandelis, A.3    Leshuk, T.4    Gu, F.5    Oladepo, S.6    Michaelian, K.7
  • 8
    • 70350662344 scopus 로고    scopus 로고
    • Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
    • Auffan M, Rose J, Bottero J-Y, Lowry GV, Jolivet J-P, Wiesner MR. 2009. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 4:634-641.
    • (2009) Nat Nanotechnol , vol.4 , pp. 634-641
    • Auffan, M.1    Rose, J.2    Bottero, J.-Y.3    Lowry, G.V.4    Jolivet, J.-P.5    Wiesner, M.R.6
  • 9
    • 0041887378 scopus 로고    scopus 로고
    • Dextran and albumin derivatised iron oxide nanoparticles: Influence on fibroblasts in vitro
    • Berry CC, Wells S, Charles S, Curtis ASG. 2003. Dextran and albumin derivatised iron oxide nanoparticles: Influence on fibroblasts in vitro. Biomaterials 24:4551-4557.
    • (2003) Biomaterials , vol.24 , pp. 4551-4557
    • Berry, C.C.1    Wells, S.2    Charles, S.3    Curtis, A.S.G.4
  • 10
    • 67651250041 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells
    • Bhattacharya K, Davoren M, Boertz J, Schins RP, Hoffmann E, Dopp E. 2009. Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. Part Fibre Toxicol 6:17.
    • (2009) Part Fibre Toxicol , vol.6 , pp. 17
    • Bhattacharya, K.1    Davoren, M.2    Boertz, J.3    Schins, R.P.4    Hoffmann, E.5    Dopp, E.6
  • 11
    • 84857559043 scopus 로고    scopus 로고
    • Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease
    • Bigini P, Diana V, Barbera S, Fumagalli E, Micotti E, Sitia L, Paladini A, Bisighini C, De Grada L, Coloca L, et al. 2012. Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease. PLoS One 7:e32326.
    • (2012) PLoS One , vol.7 , pp. e32326
    • Bigini, P.1    Diana, V.2    Barbera, S.3    Fumagalli, E.4    Micotti, E.5    Sitia, L.6    Paladini, A.7    Bisighini, C.8    De Grada, L.9    Coloca, L.10
  • 12
    • 9244227028 scopus 로고    scopus 로고
    • The utility of superparamagnetic contrast agents in MRI: Theoretical consideration and applications in the cardiovascular system
    • Bjørnerud A, Johansson L. 2004. The utility of superparamagnetic contrast agents in MRI: Theoretical consideration and applications in the cardiovascular system. NMR Biomed 17:465-477.
    • (2004) NMR Biomed , vol.17 , pp. 465-477
    • Bjørnerud, A.1    Johansson, L.2
  • 14
    • 33745915834 scopus 로고    scopus 로고
    • Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent
    • Bourrinet P, Bengele HH, Bonnemain B, Dencausse A, Idee J-M, Jacobs PM, Lewis JM. 2006. Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest Radiol 41:313-324.
    • (2006) Invest Radiol , vol.41 , pp. 313-324
    • Bourrinet, P.1    Bengele, H.H.2    Bonnemain, B.3    Dencausse, A.4    Idee, J.-M.5    Jacobs, P.M.6    Lewis, J.M.7
  • 15
    • 78649579450 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation
    • Buyukhatipoglu K, Clyne AM. 2011. Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation. J Biomed Mater Res A 96:186-195.
    • (2011) J Biomed Mater Res A , vol.96 , pp. 186-195
    • Buyukhatipoglu, K.1    Clyne, A.M.2
  • 16
    • 85123316636 scopus 로고    scopus 로고
    • Nanomaterials and nanoparticles: sources and toxicity
    • Buzea C, Pacheco II, Robbie K. 2007. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2:MR17-MR71.
    • (2007) Biointerphases , vol.2 , pp. MR17-MR71
    • Buzea, C.1    Pacheco, I.I.2    Robbie, K.3
  • 19
    • 84864683208 scopus 로고    scopus 로고
    • Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity
    • Chen Z, Yin J-J, Zhou Y-T, Zhang Y, Song L, Song M, Hu S, Gu N. 2012. Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity. ACS Nano 6:4001-4012.
    • (2012) ACS Nano , vol.6 , pp. 4001-4012
    • Chen, Z.1    Yin, J.-J.2    Zhou, Y.-T.3    Zhang, Y.4    Song, L.5    Song, M.6    Hu, S.7    Gu, N.8
  • 20
    • 84873434943 scopus 로고    scopus 로고
    • Block copolymer cross-linked nanoassemblies improve particle stability and biocompatibility of superparamagnetic iron oxide nanoparticles
    • Dan M, Scott DF, Hardy PA, Wydra RJ, Hilt JZ, Yokel RA, Bae Y. 2013. Block copolymer cross-linked nanoassemblies improve particle stability and biocompatibility of superparamagnetic iron oxide nanoparticles. Pharm Res 30:552-561.
    • (2013) Pharm Res , vol.30 , pp. 552-561
    • Dan, M.1    Scott, D.F.2    Hardy, P.A.3    Wydra, R.J.4    Hilt, J.Z.5    Yokel, R.A.6    Bae, Y.7
  • 21
    • 67651232473 scopus 로고    scopus 로고
    • Emerging trends of nanoparticles application in food technology: Safety paradigms
    • Das M, Saxena N, Dwivedi P D .2009. Emerging trends of nanoparticles application in food technology: Safety paradigms. Nanotoxicology 3:10-18.
    • (2009) Nanotoxicology , vol.3 , pp. 10-18
    • Das, M.1    Saxena, N.2    Dwivedi, P.D.3
  • 23
    • 0036569986 scopus 로고    scopus 로고
    • Molecular bases of cellular iron toxicity
    • Eaton JW, Qian M. 2002. Molecular bases of cellular iron toxicity. Free Radic Biol Med 32:833-840.
    • (2002) Free Radic Biol Med , vol.32 , pp. 833-840
    • Eaton, J.W.1    Qian, M.2
  • 28
    • 84865452207 scopus 로고    scopus 로고
    • Ferritin up-regulation and transient ROS production in cultured brain astrocytes after loading with iron oxide nanoparticles
    • Geppert M, Hohnholt MC, Nürnberger S, Dringen R. 2012. Ferritin up-regulation and transient ROS production in cultured brain astrocytes after loading with iron oxide nanoparticles. Acta Biomater 8:3832-3839.
    • (2012) Acta Biomater , vol.8 , pp. 3832-3839
    • Geppert, M.1    Hohnholt, M.C.2    Nürnberger, S.3    Dringen, R.4
  • 29
    • 33745946994 scopus 로고    scopus 로고
    • Nanomagnetism shows in vivo potential
    • Gould P. 2006. Nanomagnetism shows in vivo potential. Nano Today 1:34-39.
    • (2006) Nano Today , vol.1 , pp. 34-39
    • Gould, P.1
  • 31
    • 11044222650 scopus 로고    scopus 로고
    • Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    • Gupta AK, Gupta M. 2005. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995-4021.
    • (2005) Biomaterials , vol.26 , pp. 3995-4021
    • Gupta, A.K.1    Gupta, M.2
  • 32
    • 23944463473 scopus 로고    scopus 로고
    • Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells
    • Gurr J-R, Wang ASS, Chen C-H, Jan K-Y. 2005. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213:66-73.
    • (2005) Toxicology , vol.213 , pp. 66-73
    • Gurr, J.-R.1    Wang, A.S.S.2    Chen, C.-H.3    Jan, K.-Y.4
  • 34
    • 74249119481 scopus 로고    scopus 로고
    • Evaluating the cytotoxicity of palladium/magnetite nano-catalysts intended for wastewater treatment
    • Hildebrand H, Kühnel D, Potthoff A, Mackenzie K, Springer A, Schirmer K. 2010. Evaluating the cytotoxicity of palladium/magnetite nano-catalysts intended for wastewater treatment. Environ Pollut 158:65-73.
    • (2010) Environ Pollut , vol.158 , pp. 65-73
    • Hildebrand, H.1    Kühnel, D.2    Potthoff, A.3    Mackenzie, K.4    Springer, A.5    Schirmer, K.6
  • 35
    • 84887959333 scopus 로고    scopus 로고
    • Uptake and metabolism of iron and iron oxide nanoparticles in brain astrocytes
    • Hohnholt MC, Dringen R. 2013. Uptake and metabolism of iron and iron oxide nanoparticles in brain astrocytes. Biochem Soc Trans 41:1588-1592.
    • (2013) Biochem Soc Trans , vol.41 , pp. 1588-1592
    • Hohnholt, M.C.1    Dringen, R.2
  • 36
    • 77955560497 scopus 로고    scopus 로고
    • Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells
    • Hohnholt MC, Geppert M, Dringen R. 2010. Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells. Neurochem Res 35:1259-1268.
    • (2010) Neurochem Res , vol.35 , pp. 1259-1268
    • Hohnholt, M.C.1    Geppert, M.2    Dringen, R.3
  • 37
    • 80053573858 scopus 로고    scopus 로고
    • Treatment with iron oxide nanoparticles induces ferritin synthesis but not oxidative stress in oligodendroglial cells
    • Hohnholt MC, Geppert M, Dringen R. 2011. Treatment with iron oxide nanoparticles induces ferritin synthesis but not oxidative stress in oligodendroglial cells. Acta Biomater 7:3946-3954.
    • (2011) Acta Biomater , vol.7 , pp. 3946-3954
    • Hohnholt, M.C.1    Geppert, M.2    Dringen, R.3
  • 39
    • 84858340262 scopus 로고    scopus 로고
    • Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
    • Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Lee J, Han D-W. 2011. Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups. Int J Nanomed 6:3219-3231.
    • (2011) Int J Nanomed , vol.6 , pp. 3219-3231
    • Hong, S.C.1    Lee, J.H.2    Lee, J.3    Kim, H.Y.4    Park, J.Y.5    Cho, J.6    Lee, J.7    Han, D.-W.8
  • 42
    • 27444446307 scopus 로고    scopus 로고
    • Synthesis, properties, and applications of iron nanoparticles
    • Huber DL. 2005. Synthesis, properties, and applications of iron nanoparticles. Small Weinh Bergstr Ger 1:482-501.
    • (2005) Small Weinh Bergstr Ger , vol.1 , pp. 482-501
    • Huber, D.L.1
  • 44
    • 84862277870 scopus 로고    scopus 로고
    • Toxicological effects of titanium dioxide nanoparticles: A review of in vivo studies
    • Iavicoli I, Leso V, Bergamaschi A. 2012. Toxicological effects of titanium dioxide nanoparticles: A review of in vivo studies. J Nanomater 2012, Article ID 964381, 36 pages. DOI:10.1155/2012/964381.
    • (2012) J Nanomater , vol.2012 , pp. 36
    • Iavicoli, I.1    Leso, V.2    Bergamaschi, A.3
  • 45
    • 33751192451 scopus 로고    scopus 로고
    • Toxicity of metal oxide nanoparticles in mammalian cells
    • Jeng HA, Swanson J. 2006. Toxicity of metal oxide nanoparticles in mammalian cells. J Environ Sci Health Part A 41:2699-2711.
    • (2006) J Environ Sci Health Part A , vol.41 , pp. 2699-2711
    • Jeng, H.A.1    Swanson, J.2
  • 47
    • 0033154142 scopus 로고    scopus 로고
    • Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles
    • Jordan A, Scholz R, Wust P, Fähling H, Roland F. 1999. Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J Magn Magn Mater 201:413-419.
    • (1999) J Magn Magn Mater , vol.201 , pp. 413-419
    • Jordan, A.1    Scholz, R.2    Wust, P.3    Fähling, H.4    Roland, F.5
  • 48
    • 53549086404 scopus 로고    scopus 로고
    • Copper oxide nanoparticles are highly toxic: A comparison between metal oxide nanoparticles and carbon nanotubes
    • Karlsson HL, Cronholm P, Gustafsson J, Möller L. 2008. Copper oxide nanoparticles are highly toxic: A comparison between metal oxide nanoparticles and carbon nanotubes. Chem Res Toxicol 21:1726-1732.
    • (2008) Chem Res Toxicol , vol.21 , pp. 1726-1732
    • Karlsson, H.L.1    Cronholm, P.2    Gustafsson, J.3    Möller, L.4
  • 49
    • 67349144664 scopus 로고    scopus 로고
    • Size-dependent toxicity of metal oxide particles-A comparison between nano- and micrometer size
    • Karlsson HL, Gustafsson J, Cronholm P, Möller L. 2009. Size-dependent toxicity of metal oxide particles-A comparison between nano- and micrometer size. Toxicol Lett 188:112-118.
    • (2009) Toxicol Lett , vol.188 , pp. 112-118
    • Karlsson, H.L.1    Gustafsson, J.2    Cronholm, P.3    Möller, L.4
  • 50
    • 84555202693 scopus 로고    scopus 로고
    • Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells
    • Kenzaoui BH, Bernasconi CC, Hofmann H, Juillerat-Jeanneret L. 2012. Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells. Nanomed 7:39-53.
    • (2012) Nanomed , vol.7 , pp. 39-53
    • Kenzaoui, B.H.1    Bernasconi, C.C.2    Hofmann, H.3    Juillerat-Jeanneret, L.4
  • 51
  • 52
    • 84862850519 scopus 로고    scopus 로고
    • Magnetic nanoparticles: An update of application for drug delivery and possible toxic effects
    • Kim J-E, Shin J-Y, Cho M-H. 2012. Magnetic nanoparticles: An update of application for drug delivery and possible toxic effects. Arch Toxicol 86:685-700.
    • (2012) Arch Toxicol , vol.86 , pp. 685-700
    • Kim, J.-E.1    Shin, J.-Y.2    Cho, M.-H.3
  • 59
    • 77958614390 scopus 로고    scopus 로고
    • Degradability of superparamagnetic nanoparticles in a model of intracellular environment: Follow-up of magnetic, structural and chemical properties
    • Levy M, Lagarde F, Maraloiu VA, Blanchin MG, Gendron F, Wilhelm C, Gazeau F. 2010. Degradability of superparamagnetic nanoparticles in a model of intracellular environment: Follow-up of magnetic, structural and chemical properties. Nanotechnology 21:395103.
    • (2010) Nanotechnology , vol.21 , pp. 395103
    • Levy, M.1    Lagarde, F.2    Maraloiu, V.A.3    Blanchin, M.G.4    Gendron, F.5    Wilhelm, C.6    Gazeau, F.7
  • 60
    • 84875035239 scopus 로고    scopus 로고
    • Comparative in vitro cytotoxicity study on uncoated magnetic nanoparticles: effects on cell viability, cell morphology, and cellular uptake
    • Li L, Mak K Y, Shi J, Koon HK, Leung CH, Wong CM, Leung CW, Mak CSK, Chan NMM, Zhong W, et al. 2012. Comparative in vitro cytotoxicity study on uncoated magnetic nanoparticles: effects on cell viability, cell morphology, and cellular uptake. J Nanosci Nanotechnol 12:9010-9017.
    • (2012) J Nanosci Nanotechnol , vol.12 , pp. 9010-9017
    • Li, L.1    Mak, K.Y.2    Shi, J.3    Koon, H.K.4    Leung, C.H.5    Wong, C.M.6    Leung, C.W.7    Mak, C.S.K.8    Chan, N.M.M.9    Zhong, W.10
  • 67
    • 84864554713 scopus 로고    scopus 로고
    • Stabilising fluorescent silica nanoparticles against dissolution effects for biological studies
    • Mahon E, Hristov DL, Dawson KA. 2012. Stabilising fluorescent silica nanoparticles against dissolution effects for biological studies. Chem Commun 48:7970-7972.
    • (2012) Chem Commun , vol.48 , pp. 7970-7972
    • Mahon, E.1    Hristov, D.L.2    Dawson, K.A.3
  • 72
    • 84856206196 scopus 로고    scopus 로고
    • Multidentate catechol-based polyethylene glycol oligomers provide enhanced stability and biocompatibility to iron oxide nanoparticles
    • Na HB, Palui G, Rosenberg JT, Ji X, Grant SC, Mattoussi H. 2012. Multidentate catechol-based polyethylene glycol oligomers provide enhanced stability and biocompatibility to iron oxide nanoparticles. ACS Nano 6:389-399.
    • (2012) ACS Nano , vol.6 , pp. 389-399
    • Na, H.B.1    Palui, G.2    Rosenberg, J.T.3    Ji, X.4    Grant, S.C.5    Mattoussi, H.6
  • 73
    • 79954466823 scopus 로고    scopus 로고
    • Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress
    • Naqvi S, Samim M, Abdin M, Ahmed FJ, Maitra A, Prashant C, Dinda AK. 2010. Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress. Int J Nanomed 5:983-989.
    • (2010) Int J Nanomed , vol.5 , pp. 983-989
    • Naqvi, S.1    Samim, M.2    Abdin, M.3    Ahmed, F.J.4    Maitra, A.5    Prashant, C.6    Dinda, A.K.7
  • 75
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622-627.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Mädler, L.3    Li, N.4
  • 77
    • 34147106483 scopus 로고    scopus 로고
    • Toxicology of nanoparticles: A historical perspective
    • Oberdorster G, Stone V, Donaldson K. 2008. Toxicology of nanoparticles: A historical perspective. Nanotoxicology 1:2-25.
    • (2008) Nanotoxicology , vol.1 , pp. 2-25
    • Oberdorster, G.1    Stone, V.2    Donaldson, K.3
  • 81
    • 38449121513 scopus 로고    scopus 로고
    • Studies on free radicals, antioxidants, and co-factors
    • Rahman K. 2007. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging 2:219-236.
    • (2007) Clin Interv Aging , vol.2 , pp. 219-236
    • Rahman, K.1
  • 82
    • 84855860055 scopus 로고    scopus 로고
    • Altering iron oxide nanoparticle surface properties induce cortical neuron cytotoxicity
    • Rivet CJ, Yuan Y, Borca-Tasciuc D-A, Gilbert RJ. 2012. Altering iron oxide nanoparticle surface properties induce cortical neuron cytotoxicity. Chem Res Toxicol 25:153-161.
    • (2012) Chem Res Toxicol , vol.25 , pp. 153-161
    • Rivet, C.J.1    Yuan, Y.2    Borca-Tasciuc, D.-A.3    Gilbert, R.J.4
  • 83
    • 84858735986 scopus 로고    scopus 로고
    • Intracellular SPIO labeling of microglia: High field considerations and limitations for MR microscopy
    • Rosenberg JT, Sachi-Kocher A, Davidson MW, Grant SC. 2012. Intracellular SPIO labeling of microglia: High field considerations and limitations for MR microscopy. Contrast Media Mol Imaging 7:121-129.
    • (2012) Contrast Media Mol Imaging , vol.7 , pp. 121-129
    • Rosenberg, J.T.1    Sachi-Kocher, A.2    Davidson, M.W.3    Grant, S.C.4
  • 84
    • 17944366258 scopus 로고    scopus 로고
    • Nanostructures in biodiagnostics
    • Rosi NL, Mirkin CA. 2005. Nanostructures in biodiagnostics. Chem Rev 105:1547-1562.
    • (2005) Chem Rev , vol.105 , pp. 1547-1562
    • Rosi, N.L.1    Mirkin, C.A.2
  • 85
    • 14844311280 scopus 로고    scopus 로고
    • Genotoxicity and inflammatory investigation in mice treated with magnetite nanoparticles surface coated with polyaspartic acid
    • Sadeghiani N, Barbosa LS, Silva LP, Azevedo RB, Morais PC, Lacava ZGM. 2005. Genotoxicity and inflammatory investigation in mice treated with magnetite nanoparticles surface coated with polyaspartic acid. J Magn Magn Mater 289:466-468.
    • (2005) J Magn Magn Mater , vol.289 , pp. 466-468
    • Sadeghiani, N.1    Barbosa, L.S.2    Silva, L.P.3    Azevedo, R.B.4    Morais, P.C.5    Lacava, Z.G.M.6
  • 86
    • 2942577499 scopus 로고    scopus 로고
    • Applications of nanoparticles in biology and medicine
    • Salata O. 2004. Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:3.
    • (2004) J Nanobiotechnol , vol.2 , pp. 3
    • Salata, O.1
  • 87
    • 84878964638 scopus 로고    scopus 로고
    • Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics
    • Santhosh PB, Ulrih NP. 2013. Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics. Cancer Lett 336:8-17.
    • (2013) Cancer Lett , vol.336 , pp. 8-17
    • Santhosh, P.B.1    Ulrih, N.P.2
  • 89
    • 70349545970 scopus 로고    scopus 로고
    • Iron overload and toxicity: The hidden risk of multiple blood transfusions
    • Shander A, Cappellini MD, Goodnough LT. 2009. Iron overload and toxicity: The hidden risk of multiple blood transfusions. Vox Sang 97:185-197.
    • (2009) Vox Sang , vol.97 , pp. 185-197
    • Shander, A.1    Cappellini, M.D.2    Goodnough, L.T.3
  • 92
    • 78649904711 scopus 로고    scopus 로고
    • Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
    • Singh N, Jenkins GJS, Asadi R, Doak SH. 2010. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Reviews 2010, 1:5358. DOI: 10.3402/nano.v1i0.5358.
    • (2010) Nano Reviews , vol.1 , pp. 5358
    • Singh, N.1    Jenkins, G.J.S.2    Asadi, R.3    Doak, S.H.4
  • 94
    • 84870174971 scopus 로고    scopus 로고
    • Comparative study of genotoxicity and tissue distribution of nano and micron sized iron oxide in rats after acute oral treatment
    • Singh SP, Rahman MF, Murty USN, Mahboob M, Grover P. 2013. Comparative study of genotoxicity and tissue distribution of nano and micron sized iron oxide in rats after acute oral treatment. Toxicol Appl Pharmacol 266:56-66.
    • (2013) Toxicol Appl Pharmacol , vol.266 , pp. 56-66
    • Singh, S.P.1    Rahman, M.F.2    Murty, U.S.N.3    Mahboob, M.4    Grover, P.5
  • 95
    • 0033402469 scopus 로고    scopus 로고
    • Excitotoxicity, oxidative stress, and the neuroprotective potential of melatonin
    • Skaper SD, Floreani M, Ceccon M, Facci L, Giusti P. 1999. Excitotoxicity, oxidative stress, and the neuroprotective potential of melatonin. Ann NY Acad Sci 890:107-118.
    • (1999) Ann NY Acad Sci , vol.890 , pp. 107-118
    • Skaper, S.D.1    Floreani, M.2    Ceccon, M.3    Facci, L.4    Giusti, P.5
  • 96
    • 71649084288 scopus 로고    scopus 로고
    • Assessing cytotoxicity of (iron oxide-based) nanoparticles: An overview of different methods exemplified with cationic magnetoliposomes
    • Soenen SJH, De Cuyper M. 2009. Assessing cytotoxicity of (iron oxide-based) nanoparticles: An overview of different methods exemplified with cationic magnetoliposomes. Contrast Media Mol Imaging 4:207-219.
    • (2009) Contrast Media Mol Imaging , vol.4 , pp. 207-219
    • Soenen, S.J.H.1    De Cuyper, M.2
  • 97
    • 78149308762 scopus 로고    scopus 로고
    • Assessing iron oxide nanoparticle toxicity in vitro: Current status and future prospects
    • Soenen SJH, De Cuyper M. 2010. Assessing iron oxide nanoparticle toxicity in vitro: Current status and future prospects. Nanomedicine 5:1261-1275.
    • (2010) Nanomedicine , vol.5 , pp. 1261-1275
    • Soenen, S.J.H.1    De Cuyper, M.2
  • 98
    • 78349312714 scopus 로고    scopus 로고
    • Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labeling
    • Soenen SJH, Himmelreich U, Nuytten N, De Cuyper M. 2011. Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labeling. Biomaterials 32:195-205.
    • (2011) Biomaterials , vol.32 , pp. 195-205
    • Soenen, S.J.H.1    Himmelreich, U.2    Nuytten, N.3    De Cuyper, M.4
  • 99
    • 0028798434 scopus 로고
    • Oxidative mechanisms in the toxicity of metal ions
    • Stohs SJ, Bagchi D. 1995. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18:321-336.
    • (1995) Free Radic Biol Med , vol.18 , pp. 321-336
    • Stohs, S.J.1    Bagchi, D.2
  • 102
    • 46749142847 scopus 로고    scopus 로고
    • Magnetic nanoparticles in MR imaging and drug delivery
    • Sun C, Lee JSH, Zhang M. 2008. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:1252-1265.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1252-1265
    • Sun, C.1    Lee, J.S.H.2    Zhang, M.3
  • 103
    • 84875043885 scopus 로고    scopus 로고
    • Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models
    • Sun Z, Yathindranath V, Worden M, Thliveris JA, Chu S, Parkinson FE, Hegmann T, Miller DW. 2013. Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models. Int J Nanomed 8:961-970.
    • (2013) Int J Nanomed , vol.8 , pp. 961-970
    • Sun, Z.1    Yathindranath, V.2    Worden, M.3    Thliveris, J.A.4    Chu, S.5    Parkinson, F.E.6    Hegmann, T.7    Miller, D.W.8
  • 104
    • 84860237913 scopus 로고    scopus 로고
    • Potential toxic effects of iron oxide nanoparticles in in vivo and in vitro experiments
    • Szalay B, Tátrai E, Nyíro G, Vezér T, Dura G. 2012. Potential toxic effects of iron oxide nanoparticles in in vivo and in vitro experiments. J Appl Toxicol 32:446-453.
    • (2012) J Appl Toxicol , vol.32 , pp. 446-453
    • Szalay, B.1    Tátrai, E.2    Nyíro, G.3    Vezér, T.4    Dura, G.5
  • 105
    • 0036629179 scopus 로고    scopus 로고
    • Nanostructures as tailored biological probes
    • Taton TA. 2002. Nanostructures as tailored biological probes. Trends Biotechnol 20:277-279.
    • (2002) Trends Biotechnol , vol.20 , pp. 277-279
    • Taton, T.A.1
  • 106
    • 84255188530 scopus 로고    scopus 로고
    • Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer
    • Tong L, Zhao M, Zhu S, Chen J. 2011. Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer. Front Med 5:379-387.
    • (2011) Front Med , vol.5 , pp. 379-387
    • Tong, L.1    Zhao, M.2    Zhu, S.3    Chen, J.4
  • 108
    • 35048893279 scopus 로고    scopus 로고
    • Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation
    • Wang B, Feng WY, Wang M, Shi JW, Zhang F, Ouyang H, Zhao YL, Chai ZF, Huang YY, Xie YN, et al. 2007. Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res 118:233-243.
    • (2007) Biol Trace Elem Res , vol.118 , pp. 233-243
    • Wang, B.1    Feng, W.Y.2    Wang, M.3    Shi, J.W.4    Zhang, F.5    Ouyang, H.6    Zhao, Y.L.7    Chai, Z.F.8    Huang, Y.Y.9    Xie, Y.N.10
  • 109
    • 77955872792 scopus 로고    scopus 로고
    • Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1
    • Wang D, Wang L-H, Zhao Y, Lu Y-P, Zhu L. 2010a. Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1. IUBMB Life 62:629-636.
    • (2010) IUBMB Life , vol.62 , pp. 629-636
    • Wang, D.1    Wang, L.-H.2    Zhao, Y.3    Lu, Y.-P.4    Zhu, L.5
  • 112
    • 0034753215 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging
    • Wang YX, Hussain SM, Krestin GP. 2001. Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging. Eur Radiol 11:2319-2331.
    • (2001) Eur Radiol , vol.11 , pp. 2319-2331
    • Wang, Y.X.1    Hussain, S.M.2    Krestin, G.P.3
  • 114
    • 84884179447 scopus 로고    scopus 로고
    • Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells
    • Wu H-Y, Chung M-C, Wang C-C, Huang C-H, Liang H-J, Jan T-R. 2013a. Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells. Part Fibre Toxicol 10:46.
    • (2013) Part Fibre Toxicol , vol.10 , pp. 46
    • Wu, H.-Y.1    Chung, M.-C.2    Wang, C.-C.3    Huang, C.-H.4    Liang, H.-J.5    Jan, T.-R.6
  • 115
    • 84884179447 scopus 로고    scopus 로고
    • Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells
    • Wu H-Y, Chung M-C, Wang C-C, Huang C-H, Liang H-J, Jan T-R. 2013b. Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells. Part Fibre Toxicol 10:46.
    • (2013) Part Fibre Toxicol , vol.10 , pp. 46
    • Wu, H.-Y.1    Chung, M.-C.2    Wang, C.-C.3    Huang, C.-H.4    Liang, H.-J.5    Jan, T.-R.6
  • 116
    • 84863120396 scopus 로고    scopus 로고
    • Investigation on mechanism of growth arrest induced by iron oxide nanoparticles in PC12 cells
    • Wu J, Sun J. 2011. Investigation on mechanism of growth arrest induced by iron oxide nanoparticles in PC12 cells. J Nanosci Nanotechnol 11:11079-11083.
    • (2011) J Nanosci Nanotechnol , vol.11 , pp. 11079-11083
    • Wu, J.1    Sun, J.2
  • 117
    • 84872675495 scopus 로고    scopus 로고
    • Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus
    • Wu J, Ding T, Sun J. 2013c. Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus. Neurotoxicology 34:243-253.
    • (2013) Neurotoxicology , vol.34 , pp. 243-253
    • Wu, J.1    Ding, T.2    Sun, J.3
  • 119
    • 70350639581 scopus 로고    scopus 로고
    • Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs
    • Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE. 2009. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 3:3273-3286.
    • (2009) ACS Nano , vol.3 , pp. 3273-3286
    • Xia, T.1    Kovochich, M.2    Liong, M.3    Meng, H.4    Kabehie, S.5    George, S.6    Zink, J.I.7    Nel, A.E.8
  • 121
    • 84862287613 scopus 로고    scopus 로고
    • The real-time neurotoxicity analysis of Fe3O4 nanoparticles combined with daunorubicin for rat brain in vivo
    • Xu P, Li J, Chen B, Wang X, Cai X, Jiang H, Wang C, Zhang H. 2012. The real-time neurotoxicity analysis of Fe3O4 nanoparticles combined with daunorubicin for rat brain in vivo. J Biomed Nanotechnol 8:417-423.
    • (2012) J Biomed Nanotechnol , vol.8 , pp. 417-423
    • Xu, P.1    Li, J.2    Chen, B.3    Wang, X.4    Cai, X.5    Jiang, H.6    Wang, C.7    Zhang, H.8
  • 122
    • 79956202875 scopus 로고    scopus 로고
    • Direct labeling of hMSC with SPIO: the long-term influence on toxicity, chondrogenic differentiation capacity, and intracellular distribution
    • Yang C-Y, Hsiao J-K, Tai M-F, Chen S-T, Cheng H-Y, Wang J-L, Liu H-M. 2011. Direct labeling of hMSC with SPIO: the long-term influence on toxicity, chondrogenic differentiation capacity, and intracellular distribution. Mol Imaging Biol 13:443-451.
    • (2011) Mol Imaging Biol , vol.13 , pp. 443-451
    • Yang, C.-Y.1    Hsiao, J.-K.2    Tai, M.-F.3    Chen, S.-T.4    Cheng, H.-Y.5    Wang, J.-L.6    Liu, H.-M.7
  • 123
    • 77955927833 scopus 로고    scopus 로고
    • In vitro evaluation of the cytotoxicity of iron oxide nanoparticles with different coatings and different sizes in A3 human T lymphocytes
    • Ying E, Hwang H-M. 2010. In vitro evaluation of the cytotoxicity of iron oxide nanoparticles with different coatings and different sizes in A3 human T lymphocytes. Sci Total Environ 408:4475-4481.
    • (2010) Sci Total Environ , vol.408 , pp. 4475-4481
    • Ying, E.1    Hwang, H.-M.2
  • 124
    • 84861537584 scopus 로고    scopus 로고
    • Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture
    • Yu M, Huang S, Yu KJ, Clyne AM. 2012. Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture. Int J Mol Sci 13:5554-5570.
    • (2012) Int J Mol Sci , vol.13 , pp. 5554-5570
    • Yu, M.1    Huang, S.2    Yu, K.J.3    Clyne, A.M.4
  • 125
    • 84863005033 scopus 로고    scopus 로고
    • Evaluation on cytotoxicity and genotoxicity of the l-glutamic acid coated iron oxide nanoparticles
    • Zhang T, Qian L, Tang M, Xue Y, Kong L, Zhang S, Pu Y. 2012. Evaluation on cytotoxicity and genotoxicity of the l-glutamic acid coated iron oxide nanoparticles. J Nanosci Nanotechnol 12:2866-2873.
    • (2012) J Nanosci Nanotechnol , vol.12 , pp. 2866-2873
    • Zhang, T.1    Qian, L.2    Tang, M.3    Xue, Y.4    Kong, L.5    Zhang, S.6    Pu, Y.7
  • 127
    • 79952110405 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells
    • Zhu M-T, Wang Y, Feng W-Y, Wang B, Wang M, Ouyang H, Chai Z-F. 2010. Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells. J Nanosci Nanotechnol 10:8584-8590.
    • (2010) J Nanosci Nanotechnol , vol.10 , pp. 8584-8590
    • Zhu, M.-T.1    Wang, Y.2    Feng, W.-Y.3    Wang, B.4    Wang, M.5    Ouyang, H.6    Chai, Z.-F.7
  • 129
    • 84866893182 scopus 로고    scopus 로고
    • Toxicity assessment of iron oxide nanoparticles in zebrafish (Danio rerio) early life stages
    • Zhu X, Tian S, Cai Z. 2012a. Toxicity assessment of iron oxide nanoparticles in zebrafish (Danio rerio) early life stages. PLoS One 7: e46286.
    • (2012) PLoS One , vol.7 , pp. e46286
    • Zhu, X.1    Tian, S.2    Cai, Z.3


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