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Volumn 47, Issue 2, 2015, Pages 65-72

17β-estradiol attenuates homocysteine-induced oxidative stress and inflammatory response as well as MAPKs cascade via activating PI3-K/Akt signal transduction pathway in Raw 264.7 cells

Author keywords

17 estradiol; homocysteine; MAPKs; PI3 K Akt; reactive oxygen species

Indexed keywords

MURINAE;

EID: 84925146608     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmu124     Document Type: Article
Times cited : (20)

References (54)
  • 2
  • 3
    • 84880305680 scopus 로고    scopus 로고
    • Osteoporosis in the European Union medical management, epidemiology and economic burden A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA)
    • Hernlund E, Svedbom A, Ivergå;rd M, Compston J, Cooper C, Stenmark J, McCloskey EV, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 2013, 8: 136
    • (2013) Arch Osteoporos , vol.8 , pp. 136
    • Hernlund, E.1    Svedbom, A.2    Ivergå3    rd, M.4    Compston, J.5    Cooper, C.6    Stenmark, J.7    McCloskey, E.V.8
  • 4
    • 84863815467 scopus 로고    scopus 로고
    • Homocysteine level and risk of fracture: A meta-Analysis and systematic review
    • Yang J, Hu X, Zhang Q, Cao H, Wang J, Liu B. Homocysteine level and risk of fracture: a meta-Analysis and systematic review. Bone 2012, 51: 376-382
    • (2012) Bone , vol.51 , pp. 376-382
    • Yang, J.1    Hu, X.2    Zhang, Q.3    Cao, H.4    Wang, J.5    Liu, B.6
  • 5
    • 84882451456 scopus 로고    scopus 로고
    • Plasma level of homocysteine associated with severe vertebral fracture in postmenopausal women
    • Kuroda T, Tanaka S, Saito M, Shiraki Y, Shiraki M. Plasma level of homocysteine associated with severe vertebral fracture in postmenopausal women. Calcif Tissue Int 2013, 93: 269-275
    • (2013) Calcif Tissue Int , vol.93 , pp. 269-275
    • Kuroda, T.1    Tanaka, S.2    Saito, M.3    Shiraki, Y.4    Shiraki, M.5
  • 6
    • 73849100277 scopus 로고    scopus 로고
    • Homocysteine oxidative stress and relation to bone mineral density in post-menopausal osteoporosis
    • Yilmaz N, Eren E. Homocysteine oxidative stress and relation to bone mineral density in post-menopausal osteoporosis. Aging Clin Exp Res 2009, 21: 353-357
    • (2009) Aging Clin Exp Res , vol.21 , pp. 353-357
    • Yilmaz, N.1    Eren, E.2
  • 7
    • 77649158888 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson's disease
    • Lee SH, Kim MJ, Kim BJ, Kim SR, Chun S, Ryu JS, Kim GS, et al. Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson's disease. Mov Disord 2010, 25: 332-340
    • (2010) Mov Disord , vol.25 , pp. 332-340
    • Lee, S.H.1    Kim, M.J.2    Kim, B.J.3    Kim, S.R.4    Chun, S.5    Ryu, J.S.6    Kim, G.S.7
  • 8
    • 84860165740 scopus 로고    scopus 로고
    • Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update
    • Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev 2012, 92: 689-737
    • (2012) Physiol Rev , vol.92 , pp. 689-737
    • Kyriakis, J.M.1    Avruch, J.2
  • 9
    • 84876218090 scopus 로고    scopus 로고
    • Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways
    • Lee YS, Lee SJ, Seo KW, Bae JU, Park SY, Kim CD. Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways. Free Radic Res 2013, 47: 422-431
    • (2013) Free Radic Res , vol.47 , pp. 422-431
    • Lee, Y.S.1    Lee, S.J.2    Seo, K.W.3    Bae, J.U.4    Park, S.Y.5    Kim, C.D.6
  • 10
    • 75149129597 scopus 로고    scopus 로고
    • From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis
    • Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 2010, 31: 266-300
    • (2010) Endocr Rev , vol.31 , pp. 266-300
    • Manolagas, S.C.1
  • 11
    • 84855557597 scopus 로고    scopus 로고
    • Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats
    • Yin H, Shi ZG, Yu YS, Hu J, Wang R, Luan ZP, Guo DH. Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats. Eur J Pharmacol 2012, 674: 200-206
    • (2012) Eur J Pharmacol , vol.674 , pp. 200-206
    • Yin, H.1    Shi, Z.G.2    Yu, Y.S.3    Hu, J.4    Wang, R.5    Luan, Z.P.6    Guo, D.H.7
  • 12
    • 13444256417 scopus 로고    scopus 로고
    • Mechanisms of sex steroid effects on bone
    • Syed F, Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 2005, 328: 688-696
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 688-696
    • Syed, F.1    Khosla, S.2
  • 14
    • 0141705375 scopus 로고    scopus 로고
    • Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Women's Health Initiative randomized trial
    • Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix AZ, LeBoff M, et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA 2003, 290: 1729-1738
    • (2003) JAMA , vol.290 , pp. 1729-1738
    • Cauley, J.A.1    Robbins, J.2    Chen, Z.3    Cummings, S.R.4    Jackson, R.D.5    Lacroix, A.Z.6    Leboff, M.7
  • 15
    • 0036845372 scopus 로고    scopus 로고
    • Effect of discontinuation of estrogen, calcitriol, and the combination of both on bone density and bone markers
    • Gallagher JC, Rapuri PB, Haynatzki G, Detter JR. Effect of discontinuation of estrogen, calcitriol, and the combination of both on bone density and bone markers. J Clin Endocrinol Metab 2002, 87: 4914-4923
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4914-4923
    • Gallagher, J.C.1    Rapuri, P.B.2    Haynatzki, G.3    Detter, J.R.4
  • 16
    • 84865623633 scopus 로고    scopus 로고
    • Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine Raw 264.7 macrophage cells
    • Zong Y, Sun L, Liu B, Deng YS, Zhan D, Chen YL, He Y, et al. Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine Raw 264.7 macrophage cells. PLoS One 2012, 7: e44107
    • (2012) PLoS One , vol.7 , pp. e44107
    • Zong, Y.1    Sun, L.2    Liu, B.3    Deng, Y.S.4    Zhan, D.5    Chen, Y.L.6    He, Y.7
  • 17
    • 80052076294 scopus 로고    scopus 로고
    • Folic acid inhibits lipopolysaccharideinduced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-?B activation
    • Feng D, Zhou Y, Xia M, Ma J. Folic acid inhibits lipopolysaccharideinduced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-?B activation. Inflamm Res 2011, 60: 817-822
    • (2011) Inflamm Res , vol.60 , pp. 817-822
    • Feng, D.1    Zhou, Y.2    Xia, M.3    Ma, J.4
  • 18
    • 84879398299 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells
    • Hou GQ, Guo C, Song GH, Fang N, Fan WJ, Chen XD, Yuan L, et al. Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells. Int J Mol Med 2013, 32: 503-510
    • (2013) Int J Mol Med , vol.32 , pp. 503-510
    • Hou, G.Q.1    Guo, C.2    Song, G.H.3    Fang, N.4    Fan, W.J.5    Chen, X.D.6    Yuan, L.7
  • 19
    • 84886839508 scopus 로고    scopus 로고
    • Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells
    • Li DZ, Zhag QX, Dong XX, Li HD, Ma X. Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab 2014, 32: 494-504
    • (2014) J Bone Miner Metab , vol.32 , pp. 494-504
    • Li, D.Z.1    Zhag, Q.X.2    Dong, X.X.3    Li, H.D.4    Ma, X.5
  • 21
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999, 19: 217-246
    • (1999) Annu Rev Nutr , vol.19 , pp. 217-246
    • Selhub, J.1
  • 22
    • 33845919859 scopus 로고    scopus 로고
    • AkessonK.Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women
    • Gerdhem P, Ivaska KK, Isaksson A, Pettersson K, Väänänen HK, Obrant KJ, AkessonK.Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J BoneMiner Res 2007, 22: 127-134
    • (2007) J BoneMiner Res , vol.22 , pp. 127-134
    • Gerdhem, P.1    Ivaska, K.K.2    Isaksson, A.3    Pettersson, K.4    Väänänen, H.K.5    Obrant, K.J.6
  • 25
    • 33745497498 scopus 로고    scopus 로고
    • Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation
    • Koh JM, Lee YS, Kim YS, Kim DJ, Kim HH, Park JY, Lee KU, et al. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res 2006, 21: 1003-1011
    • (2006) J Bone Miner Res , vol.21 , pp. 1003-1011
    • Koh, J.M.1    Lee, Y.S.2    Kim, Y.S.3    Kim, D.J.4    Kim, H.H.5    Park, J.Y.6    Lee, K.U.7
  • 26
    • 59749090027 scopus 로고    scopus 로고
    • Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone
    • Herrmann M, Tami A, Wildemann B, Wolny M, Wagner A, Schorr H, Taban-Shomal O, et al. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone 2009, 44: 467-475
    • (2009) Bone , vol.44 , pp. 467-475
    • Herrmann, M.1    Tami, A.2    Wildemann, B.3    Wolny, M.4    Wagner, A.5    Schorr, H.6    Taban-Shomal, O.7
  • 27
    • 79953131277 scopus 로고    scopus 로고
    • Homocysteine suppresses the expression of the collagen crosslinker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation
    • Thaler R, Agsten M, Spitzer S, Paschalis EP, Karlic H, Klaushofer K, Varga F. Homocysteine suppresses the expression of the collagen crosslinker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation. J Biol Chem 2011, 286: 5578-5588
    • (2011) J Biol Chem , vol.286 , pp. 5578-5588
    • Thaler, R.1    Agsten, M.2    Spitzer, S.3    Paschalis, E.P.4    Karlic, H.5    Klaushofer, K.6    Varga, F.7
  • 28
    • 0347627146 scopus 로고    scopus 로고
    • Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women
    • Cagnacci A, Baldassari F, Rivolta G, Arangino S, Volpe A. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone 2003, 6: 956-959
    • (2003) Bone , vol.6 , pp. 956-959
    • Cagnacci, A.1    Baldassari, F.2    Rivolta, G.3    Arangino, S.4    Volpe, A.5
  • 30
    • 84888596841 scopus 로고    scopus 로고
    • The effects of dematerialized bone matrix proteins, estrogen, and an antagonist to neuropeptide y on osteoblast and osteoclast viability and function related to osteoporosis
    • White J, Morton V, Whittington K, Wilson G, Tucci M, Benghuzzi H. The effects of dematerialized bone matrix proteins, estrogen, and an antagonist to neuropeptide y on osteoblast and osteoclast viability and function related to osteoporosis. Biomed Sci Instrum 2012, 48: 478-484
    • (2012) Biomed Sci Instrum , vol.48 , pp. 478-484
    • White, J.1    Morton, V.2    Whittington, K.3    Wilson, G.4    Tucci, M.5    Benghuzzi, H.6
  • 32
    • 79952467245 scopus 로고    scopus 로고
    • Estrogen enhances the functions of CD4(+) CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro
    • Luo CY, Wang L, Sun C, Li DJ. Estrogen enhances the functions of CD4(+) CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro. Cell Mol Immunol 2011, 8: 50-58
    • (2011) Cell Mol Immunol , vol.8 , pp. 50-58
    • Luo, C.Y.1    Wang, L.2    Sun, C.3    Li, D.J.4
  • 33
    • 56549092475 scopus 로고    scopus 로고
    • Efficacy of baze-doxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: Results from a 3-year, randomized, placebo-, and active-controlled clinical trial
    • Silverman SL, Christiansen C, Genant HK, Vukicevic S, Zanchetta JR, de Villiers TJ, Constantine GD, et al. Efficacy of baze-doxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: results from a 3-year, randomized, placebo-, and active-controlled clinical trial. J Bone Miner Res 2008, 23: 1923-1934
    • (2008) J Bone Miner Res , vol.23 , pp. 1923-1934
    • Silverman, S.L.1    Christiansen, C.2    Genant, H.K.3    Vukicevic, S.4    Zanchetta, J.R.5    De Villiers, T.J.6    Constantine, G.D.7
  • 34
    • 84857366519 scopus 로고    scopus 로고
    • Sustained efficacy and safety of bazedoxifene in preventing fractures in postmeno-pausal women with osteoporosis: Results of a 5-year, randomized, placebo-controlled study
    • Silverman SL, Chines AA, Kendler DL, Kung AW, Teglbjærg CS, Felsenberg D, Mairon N. Sustained efficacy and safety of bazedoxifene in preventing fractures in postmeno-pausal women with osteoporosis: results of a 5-year, randomized, placebo-controlled study. Osteoporos Int 2012, 23: 351-363
    • (2012) Osteoporos Int , vol.23 , pp. 351-363
    • Silverman, S.L.1    Chines, A.A.2    Kendler, D.L.3    Kung, A.W.4    Teglbjærg, C.S.5    Felsenberg, D.6    Mairon, N.7
  • 35
    • 84877040655 scopus 로고    scopus 로고
    • Homocysteine alters the osteoprotegerin/RANKL system in the osteoblast to promote bone loss: Pivotal role of the redox regulator forkhead O1
    • Vijayan V, Khandelwal M, Manglani K, Singh RR, Gupta S, Surolia A. Homocysteine alters the osteoprotegerin/RANKL system in the osteoblast to promote bone loss: pivotal role of the redox regulator forkhead O1. Free Radic Biol Med 2013, 61: 72-84
    • (2013) Free Radic Biol Med , vol.61 , pp. 72-84
    • Vijayan, V.1    Khandelwal, M.2    Manglani, K.3    Singh, R.R.4    Gupta, S.5    Surolia, A.6
  • 36
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso R, Okkenhaug K, Ahmadi K, White S, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001, 17: 615-675
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3    White, S.4    Waterfield, M.D.5
  • 37
    • 84888029064 scopus 로고    scopus 로고
    • Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/AKT and Erk pathways in association with signaling adaptor DAP12
    • Kinjo M, Minami A, Iwasaki N. Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/AKT and Erk pathways in association with signaling adaptor DAP12. J Bone Miner Res 2013, 28: 2463-2475
    • (2013) J Bone Miner Res , vol.28 , pp. 2463-2475
    • Kinjo, M.1    Minami, A.2    Iwasaki, N.3
  • 38
    • 84855368584 scopus 로고    scopus 로고
    • AKT induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade
    • Moon JB, Kim JH, Kim K, Youn BU, Ko A, Lee SY, Kim N. AKT induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade. J Immunol 2012, 188: 163-169
    • (2012) J Immunol , vol.188 , pp. 163-169
    • Moon, J.B.1    Kim, J.H.2    Kim, K.3    Youn, B.U.4    Ko, A.5    Lee, S.Y.6    Kim, N.7
  • 39
    • 79952642781 scopus 로고    scopus 로고
    • TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1 AKT, and MEK/ERK signaling pathways
    • Cicek M, Vrabel A, Sturchio C, Pederson L, Hawse JR, Subramaniam M, Spelsberg TC, et al. TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways. PLoS One 2011, 6: e17522
    • (2011) PLoS One , vol.6 , pp. e17522
    • Cicek, M.1    Vrabel, A.2    Sturchio, C.3    Pederson, L.4    Hawse, J.R.5    Subramaniam, M.6    Spelsberg, T.C.7
  • 40
    • 84875125455 scopus 로고    scopus 로고
    • Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway
    • Xiao-Hong D, Chang-Qin X, Jian-Hua H, Wen-Jiang Z, Bing S. Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway. Pharm Biol 2013, 51: 433-440
    • (2013) Pharm Biol , vol.51 , pp. 433-440
    • Xiao-Hong, D.1    Chang-Qin, X.2    Jian-Hua, H.3    Wen-Jiang, Z.4    Bing, S.5
  • 42
    • 78049302601 scopus 로고    scopus 로고
    • Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/AKT/endothelial nitric oxide synthase signaling
    • Yan TT, Li Q, Zhang XH, Wu WK, Sun J, Li L, Zhang Q, et al. Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/AKT/endothelial nitric oxide synthase signaling. Clin Exp Pharmacol Physiol 2010, 37: 1071-1077
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 1071-1077
    • Yan, T.T.1    Li, Q.2    Zhang, X.H.3    Wu, W.K.4    Sun, J.5    Li, L.6    Zhang, Q.7
  • 43
    • 67649398797 scopus 로고    scopus 로고
    • Amlodipine inhibits TNF-Alpha production and attenuates cardiac dysfunction induced by lipopolysac-charide involving PI3K/AKT pathway
    • Li XQ, Cao W, Li T, Zeng AG, Hao LL, Zhang XN, Mei QB. Amlodipine inhibits TNF-Alpha production and attenuates cardiac dysfunction induced by lipopolysac-charide involving PI3K/AKT pathway. Int Immunopharmacol 2009, 9: 1032-1041
    • (2009) Int Immunopharmacol , vol.9 , pp. 1032-1041
    • Li, X.Q.1    Cao, W.2    Li, T.3    Zeng, A.G.4    Hao, L.L.5    Zhang, X.N.6    Mei, Q.B.7
  • 44
    • 70350304572 scopus 로고    scopus 로고
    • Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK
    • Shastry S, James LR. Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK. J Inflamm (Lond) 2009, 6: 27
    • (2009) J Inflamm (Lond , vol.6 , pp. 27
    • Shastry, S.1    James, L.R.2
  • 46
    • 84884888723 scopus 로고    scopus 로고
    • SOCS3 expression correlates with severity of inflammation, expression of proinflammatory cytokines, and activation of STAT3 and p38 MAPK in LPS-induced inflammation in vivo
    • Chaves de Souza JA, Nogueira AV, Chaves de Souza PP, Kim YJ, Silva Lobo C, Pimentel Lopes de OGJ, Cirelli JA, et al. SOCS3 expression correlates with severity of inflammation, expression of proinflammatory cytokines, and activation of STAT3 and p38 MAPK in LPS-induced inflammation in vivo. Mediators Inflamm 2013, 2013: 650812
    • (2013) Mediators Inflamm , vol.2013 , pp. 650812
    • Chaves De Souza, J.A.1    Nogueira, A.V.2    Chaves De Souza, P.P.3    Kim, Y.J.4    Silva Lobo, C.5    Pimentel Lopes De, O.G.J.6    Cirelli, J.A.7
  • 47
    • 84872138624 scopus 로고    scopus 로고
    • Shrimp anti-lipopolysaccharide factor (SALF), an antimicrobial peptide, inhibits proinflammatory cytokine expressions through the MAPK and NF-?B pathways in LPS-induced HeLa cells
    • Lin MC, Pan CY, Hui CF, Chen JY, Wu JL. Shrimp anti-lipopolysaccharide factor (SALF), an antimicrobial peptide, inhibits proinflammatory cytokine expressions through the MAPK and NF-?B pathways in LPS-induced HeLa cells. Peptides 2013, 40: 42-48
    • (2013) Peptides , vol.40 , pp. 42-48
    • Lin, M.C.1    Pan, C.Y.2    Hui, C.F.3    Chen, J.Y.4    Wu, J.L.5
  • 48
    • 79960170945 scopus 로고    scopus 로고
    • Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways
    • Dai JN, Zong Y, Zhong LM, Li YM, Zhang W, Bian LG, Ai QL, et al. Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One 2011, 6: e21891
    • (2011) PLoS One , vol.6 , pp. e21891
    • Dai, J.N.1    Zong, Y.2    Zhong, L.M.3    Li, Y.M.4    Zhang, W.5    Bian, L.G.6    Ai, Q.L.7
  • 49
    • 84880139498 scopus 로고    scopus 로고
    • The role of inflammatory cytokines, the RANKL/OPG Axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis
    • Weitzmann MN. The role of inflammatory cytokines, the RANKL/OPG Axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis. Scientifica (Cairo) 2013, 2013: 125705
    • (2013) Scientifica (Cairo , vol.2013 , pp. 125705
    • Weitzmann, M.N.1
  • 50
    • 84862787110 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease
    • Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition 2012, 28: 767-772
    • (2012) Nutrition , vol.28 , pp. 767-772
    • Lee, B.J.1    Huang, Y.C.2    Chen, S.J.3    Lin, P.T.4
  • 51
    • 84862489081 scopus 로고    scopus 로고
    • Effectsof ghrelin on homocysteine-induced dysfunction and inflammatory response in rat cardiac microvascular endothelial cells
    • Wang D, Wang H, Luo P, Hwang A, Sun D, Wang Y, Zhang Z, et al. Effectsof ghrelin on homocysteine-induced dysfunction and inflammatory response in rat cardiac microvascular endothelial cells. Cell Biol Int 2012, 36: 511-517
    • (2012) Cell Biol Int , vol.36 , pp. 511-517
    • Wang, D.1    Wang, H.2    Luo, P.3    Hwang, A.4    Sun, D.5    Wang, Y.6    Zhang, Z.7
  • 52
    • 77954088570 scopus 로고    scopus 로고
    • Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration
    • da Cunha AA, Ferreira AG, Wyse AT. Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration. Metab Brain Dis 2010, 25: 199-206
    • (2010) Metab Brain Dis , vol.25 , pp. 199-206
    • Da Cunha, A.A.1    Ferreira, A.G.2    Wyse, A.T.3
  • 53
    • 84856253626 scopus 로고    scopus 로고
    • Cross-Talk between mitogenicRas/MAPK and survival PI3K/AKT pathways: A fine balance
    • Aksamitiene E, Kiyatkin A, Kholodenko BN. Cross-Talk between mitogenicRas/MAPK and survival PI3K/AKT pathways: a fine balance. Biochem Soc Trans 2012, 40: 139-146
    • (2012) Biochem Soc Trans , vol.40 , pp. 139-146
    • Aksamitiene, E.1    Kiyatkin, A.2    Kholodenko, B.N.3
  • 54
    • 84895451862 scopus 로고    scopus 로고
    • Crosstalk between ERK AKT, and cell survival
    • Dent P. Crosstalk between ERK, AKT, and cell survival. Cancer Biol Ther 2014, 15: 245-246
    • (2014) Cancer Biol Ther , vol.15 , pp. 245-246
    • Dent, P.1


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