메뉴 건너뛰기




Volumn 32, Issue 5, 2014, Pages 494-504

Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells

Author keywords

Cell signaling; Hydrogen molecule; Osteoclast differentiation; Reactive oxygen species; Receptor activator of NF B ligand

Indexed keywords


EID: 84886839508     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-013-0530-1     Document Type: Article
Times cited : (45)

References (39)
  • 2
    • 84874419596 scopus 로고    scopus 로고
    • Hydrogen water consumption prevents osteopenia in ovariectomized rats
    • COI: 1:CAS:528:DC%2BC3sXjvVWqsbo%3D, PID: 23121335
    • Guo JD, Li L, Shi YM, Wang HD, Hou SX (2013) Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol 168:1412–1420
    • (2013) Br J Pharmacol , vol.168 , pp. 1412-1420
    • Guo, J.D.1    Li, L.2    Shi, Y.M.3    Wang, H.D.4    Hou, S.X.5
  • 3
    • 84878823021 scopus 로고    scopus 로고
    • Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats
    • COI: 1:CAS:528:DC%2BC3sXis1Klurs%3D, PID: 22648000
    • Sun Y, Shuang F, Chen DM, Zhou RB (2013) Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int 24:969–978
    • (2013) Osteoporos Int , vol.24 , pp. 969-978
    • Sun, Y.1    Shuang, F.2    Chen, D.M.3    Zhou, R.B.4
  • 5
    • 84887980933 scopus 로고    scopus 로고
    • Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
    • COI: 1:CAS:528:DC%2BC3sXjtVKhurk%3D, PID: 23031079
    • Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, Naritomi Y, Hara H, Nagao T (2012) Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res 2:27
    • (2012) Med Gas Res , vol.2 , pp. 27
    • Ishibashi, T.1    Sato, B.2    Rikitake, M.3    Seo, T.4    Kurokawa, R.5    Hara, Y.6    Naritomi, Y.7    Hara, H.8    Nagao, T.9
  • 6
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • COI: 1:CAS:528:DC%2BD3sXjs1ynu7g%3D, PID: 12748652
    • Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423:337–342
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 7
    • 0033304730 scopus 로고    scopus 로고
    • Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • COI: 1:CAS:528:DyaK1MXktVaqtLg%3D, PID: 10368775
    • Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345–357
    • (1999) Endocr Rev , vol.20 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3    Jimi, E.4    Gillespie, M.T.5    Martin, T.J.6
  • 8
    • 0035965998 scopus 로고    scopus 로고
    • Tumor necrosis factor-α supports the survival of osteoclasts through the activation of Akt and ERK
    • COI: 1:CAS:528:DC%2BD38Xktlekuw%3D%3D, PID: 11675379
    • Lee SE, Chung WJ, Kwak HB, Chung CH, Kwack KB, Lee ZH, Kim HH (2001) Tumor necrosis factor-α supports the survival of osteoclasts through the activation of Akt and ERK. J Biol Chem 276:49343–49349
    • (2001) J Biol Chem , vol.276 , pp. 49343-49349
    • Lee, S.E.1    Chung, W.J.2    Kwak, H.B.3    Chung, C.H.4    Kwack, K.B.5    Lee, Z.H.6    Kim, H.H.7
  • 9
    • 0038706164 scopus 로고    scopus 로고
    • Signal transduction by receptor activator of nuclear factor κ B in osteoclasts
    • COI: 1:CAS:528:DC%2BD3sXjs1ert7g%3D, PID: 12745060
    • Lee ZH, Kim HH (2003) Signal transduction by receptor activator of nuclear factor κ B in osteoclasts. Biochem Biophys Res Comm 305:211–214
    • (2003) Biochem Biophys Res Comm , vol.305 , pp. 211-214
    • Lee, Z.H.1    Kim, H.H.2
  • 10
    • 58049129497 scopus 로고    scopus 로고
    • AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways
    • COI: 1:CAS:528:DC%2BD1cXhsFemtLjL, PID: 18695355
    • Kwak HB, Sun HM, Ha H, Lee JH, Kim HN, Lee ZH (2008) AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways. Mol Cells 26:436–442
    • (2008) Mol Cells , vol.26 , pp. 436-442
    • Kwak, H.B.1    Sun, H.M.2    Ha, H.3    Lee, J.H.4    Kim, H.N.5    Lee, Z.H.6
  • 11
    • 22144457305 scopus 로고    scopus 로고
    • A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
    • COI: 1:CAS:528:DC%2BD2MXntVSntbc%3D, PID: 15817678
    • Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY (2005) A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106:852–859
    • (2005) Blood , vol.106 , pp. 852-859
    • Lee, N.K.1    Choi, Y.G.2    Baik, J.Y.3    Han, S.Y.4    Jeong, D.W.5    Bae, Y.S.6    Kim, N.7    Lee, S.Y.8
  • 12
    • 33646044648 scopus 로고    scopus 로고
    • Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha
    • COI: 1:CAS:528:DC%2BD28Xjsl2mtbg%3D, PID: 16632109
    • Kim HJ, Chang EJ, Kim HM, Lee SB, Kim HD, Su Kim G, Kim HH (2006) Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic Biol Med 40:1483–1493
    • (2006) Free Radic Biol Med , vol.40 , pp. 1483-1493
    • Kim, H.J.1    Chang, E.J.2    Kim, H.M.3    Lee, S.B.4    Kim, H.D.5    Su Kim, G.6    Kim, H.H.7
  • 13
    • 37648999717 scopus 로고    scopus 로고
    • Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways
    • COI: 1:CAS:528:DC%2BD1cXlt1egtA%3D%3D, PID: 18083161
    • Hu JP, Nishishita K, Sakai E, Yoshida H, Kato Y, Tsukuba T, Okamoto K (2008) Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways. Eur J Pharmacol 580:70–79
    • (2008) Eur J Pharmacol , vol.580 , pp. 70-79
    • Hu, J.P.1    Nishishita, K.2    Sakai, E.3    Yoshida, H.4    Kato, Y.5    Tsukuba, T.6    Okamoto, K.7
  • 15
    • 2442536008 scopus 로고    scopus 로고
    • Expression of nonphagocytic NADPH oxidase system in the ocular lens
    • COI: 1:CAS:528:DC%2BD2cXjvFSgsLg%3D, PID: 14978478
    • Rao PV, Maddala R, John F, Zigler JS Jr (2004) Expression of nonphagocytic NADPH oxidase system in the ocular lens. Mol Vis 10:112–121
    • (2004) Mol Vis , vol.10 , pp. 112-121
    • Rao, P.V.1    Maddala, R.2    John, F.3    Zigler, J.S.4
  • 16
    • 0037403319 scopus 로고    scopus 로고
    • Nitric oxide priming protects nitric oxide-mediated apoptosis via heme-oxygenase-1 induction
    • COI: 1:CAS:528:DC%2BD3sXivFGjtr4%3D, PID: 12706494
    • Choi BM, Pae HO, Chung HT (2003) Nitric oxide priming protects nitric oxide-mediated apoptosis via heme-oxygenase-1 induction. Free Radic Biol Med 34:1136–1145
    • (2003) Free Radic Biol Med , vol.34 , pp. 1136-1145
    • Choi, B.M.1    Pae, H.O.2    Chung, H.T.3
  • 18
    • 0028173214 scopus 로고
    • c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling
    • COI: 1:CAS:528:DyaK2cXmslyisr8%3D, PID: 7939685
    • Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF (1994) c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266:443–448
    • (1994) Science , vol.266 , pp. 443-448
    • Grigoriadis, A.E.1    Wang, Z.Q.2    Cecchini, M.G.3    Hofstetter, W.4    Felix, R.5    Fleisch, H.A.6    Wagner, E.F.7
  • 19
    • 77951213242 scopus 로고    scopus 로고
    • RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis
    • COI: 1:CAS:528:DC%2BC3cXisFaltbs%3D, PID: 20048168
    • Kim MS, Yang YM, Son A, Tian YS, Lee SI, Kang SW, Muallem S, Shin DM (2010) RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem 285:6913–6921
    • (2010) J Biol Chem , vol.285 , pp. 6913-6921
    • Kim, M.S.1    Yang, Y.M.2    Son, A.3    Tian, Y.S.4    Lee, S.I.5    Kang, S.W.6    Muallem, S.7    Shin, D.M.8
  • 20
    • 0025236484 scopus 로고
    • Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
    • COI: 1:CAS:528:DyaK3cXhslaktrs%3D, PID: 2312718
    • Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632–639
    • (1990) J Clin Invest , vol.85 , pp. 632-639
    • Garrett, I.R.1    Boyce, B.F.2    Oreffo, R.O.3    Bonewald, L.4    Poser, J.5    Mundy, G.R.6
  • 21
    • 67349083947 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues
    • COI: 1:CAS:528:DC%2BD1MXmvFCqu74%3D, PID: 19409483
    • Sasaki H, Yamamoto H, Tominaga K, Masuda K, Kawai T, Teshima-Kondo S, Matsuno K, Yabe-Nishimura C, Rokutan K (2009) Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues. Free Radic Biol Med 47:189–199
    • (2009) Free Radic Biol Med , vol.47 , pp. 189-199
    • Sasaki, H.1    Yamamoto, H.2    Tominaga, K.3    Masuda, K.4    Kawai, T.5    Teshima-Kondo, S.6    Matsuno, K.7    Yabe-Nishimura, C.8    Rokutan, K.9
  • 22
    • 63349098916 scopus 로고    scopus 로고
    • NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts
    • PID: 19262012
    • Sasaki H, Yamamoto H, Tominaga K, Masuda K, Kawai T, Teshima-Kondo S, Rokutan K (2009) NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts. J Med Invest 56:33–41
    • (2009) J Med Invest , vol.56 , pp. 33-41
    • Sasaki, H.1    Yamamoto, H.2    Tominaga, K.3    Masuda, K.4    Kawai, T.5    Teshima-Kondo, S.6    Rokutan, K.7
  • 24
    • 81855204961 scopus 로고    scopus 로고
    • Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation
    • COI: 1:CAS:528:DC%2BC3MXhsV2rsL%2FK, PID: 22020111
    • Hybertson BM, Gao B, Bose SK, McCord JM (2011) Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med 32:234–246
    • (2011) Mol Aspects Med , vol.32 , pp. 234-246
    • Hybertson, B.M.1    Gao, B.2    Bose, S.K.3    McCord, J.M.4
  • 25
    • 84870211726 scopus 로고    scopus 로고
    • Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL
    • COI: 1:CAS:528:DC%2BC38Xhsl2jurvP, PID: 23085426
    • Rana T, Schultz MA, Freeman ML, Biswas S (2012) Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL. Free Radic Biol Med 53:2298–2307
    • (2012) Free Radic Biol Med , vol.53 , pp. 2298-2307
    • Rana, T.1    Schultz, M.A.2    Freeman, M.L.3    Biswas, S.4
  • 26
    • 84855554307 scopus 로고    scopus 로고
    • Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis
    • COI: 1:CAS:528:DC%2BC38XjvVSkuw%3D%3D, PID: 21928347
    • Sakai E, Shimada-Sugawara M, Nishishita K, Fukuma Y, Naito M, Okamoto K, Nakayama K, Tsukuba T (2012) Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis. J Cell Biochem 113:486–498
    • (2012) J Cell Biochem , vol.113 , pp. 486-498
    • Sakai, E.1    Shimada-Sugawara, M.2    Nishishita, K.3    Fukuma, Y.4    Naito, M.5    Okamoto, K.6    Nakayama, K.7    Tsukuba, T.8
  • 27
    • 33744922969 scopus 로고    scopus 로고
    • RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone resorption
    • COI: 1:CAS:528:DC%2BD28Xlt1CktLo%3D, PID: 16613848
    • Zheng H, Yu X, Collin-Osdoby P, Osdoby P (2006) RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone resorption. J Biol Chem 281:15809–15820
    • (2006) J Biol Chem , vol.281 , pp. 15809-15820
    • Zheng, H.1    Yu, X.2    Collin-Osdoby, P.3    Osdoby, P.4
  • 28
    • 0031810842 scopus 로고    scopus 로고
    • Effect of stem cell factor, interleukin-6, nitric oxide and transforming growth factor-beta on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures
    • COI: 1:CAS:528:DyaK1cXjsVynurg%3D, PID: 9646327
    • Chae HJ, Park RK, Kang JS, Shin HS, Kim SC, Chung HT, Son DW, Ko KI, Kim JB, Park YC, Kim HR (1998) Effect of stem cell factor, interleukin-6, nitric oxide and transforming growth factor-beta on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures. Pharmacol Toxicol 82:223–229
    • (1998) Pharmacol Toxicol , vol.82 , pp. 223-229
    • Chae, H.J.1    Park, R.K.2    Kang, J.S.3    Shin, H.S.4    Kim, S.C.5    Chung, H.T.6    Son, D.W.7    Ko, K.I.8    Kim, J.B.9    Park, Y.C.10    Kim, H.R.11
  • 31
    • 21344443280 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats
    • PID: 15948691
    • Leitão RF, Ribeiro RA, Chaves HV, Rocha FA, Lima V, Brito GA (2005) Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats. J Periodontol 76:956–963
    • (2005) J Periodontol , vol.76 , pp. 956-963
    • Leitão, R.F.1    Ribeiro, R.A.2    Chaves, H.V.3    Rocha, F.A.4    Lima, V.5    Brito, G.A.6
  • 32
    • 84861999243 scopus 로고    scopus 로고
    • Constitutively active canonical NF-κB pathway induces severe bone loss in mice
    • COI: 1:CAS:528:DC%2BC38Xos12ktrk%3D, PID: 22685599
    • Otero JE, Chen T, Zhang K, Abu-Amer Y (2012) Constitutively active canonical NF-κB pathway induces severe bone loss in mice. PLoS ONE 7:e38694
    • (2012) PLoS ONE , vol.7 , pp. e38694
    • Otero, J.E.1    Chen, T.2    Zhang, K.3    Abu-Amer, Y.4
  • 33
    • 41449101904 scopus 로고    scopus 로고
    • Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss
    • COI: 1:CAS:528:DC%2BD1cXjs12ktLg%3D, PID: 18365833
    • Abu-Amer Y, Darwech I, Otero J (2008) Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss. Autoimmunity 41:204–211
    • (2008) Autoimmunity , vol.41 , pp. 204-211
    • Abu-Amer, Y.1    Darwech, I.2    Otero, J.3
  • 34
    • 0036085510 scopus 로고    scopus 로고
    • NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis
    • COI: 1:CAS:528:DC%2BD38XlsF2nu78%3D, PID: 12096833
    • Xing L, Bushnell TP, Carlson L, Tai Z, Tondravi M, Siebenlist U, Young F, Boyce BF (2002) NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis. J Bone Miner Res 17:1200–1210
    • (2002) J Bone Miner Res , vol.17 , pp. 1200-1210
    • Xing, L.1    Bushnell, T.P.2    Carlson, L.3    Tai, Z.4    Tondravi, M.5    Siebenlist, U.6    Young, F.7    Boyce, B.F.8
  • 35
    • 0142027643 scopus 로고    scopus 로고
    • Role of osteoclast extracellular signal-regulated kinase (ERK) in cell survival and maintenance of cell polarity
    • COI: 1:CAS:528:DC%2BD3sXlsFGktL4%3D, PID: 12854829
    • Nakamura H, Hirata A, Tsuji T, Yamamoto T (2003) Role of osteoclast extracellular signal-regulated kinase (ERK) in cell survival and maintenance of cell polarity. J Bone Miner Res 18:1198–1205
    • (2003) J Bone Miner Res , vol.18 , pp. 1198-1205
    • Nakamura, H.1    Hirata, A.2    Tsuji, T.3    Yamamoto, T.4
  • 36
    • 84855368584 scopus 로고    scopus 로고
    • Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade
    • COI: 1:CAS:528:DC%2BC3MXhs1GlsbfF, PID: 22131333
    • Moon JB, Kim JH, Kim K, Youn BU, Ko A, Lee SY, Kim N (2012) Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade. J Immunol 188:163–169
    • (2012) J Immunol , vol.188 , pp. 163-169
    • Moon, J.B.1    Kim, J.H.2    Kim, K.3    Youn, B.U.4    Ko, A.5    Lee, S.Y.6    Kim, N.7
  • 37
    • 70349748784 scopus 로고    scopus 로고
    • Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells
    • COI: 1:CAS:528:DC%2BD1MXht1Gmt7vJ, PID: 19766097
    • Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M (2009) Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun 389:651–656
    • (2009) Biochem Biophys Res Commun , vol.389 , pp. 651-656
    • Itoh, T.1    Fujita, Y.2    Ito, M.3    Masuda, A.4    Ohno, K.5    Ichihara, M.6    Kojima, T.7    Nozawa, Y.8    Ito, M.9
  • 39
    • 79960560345 scopus 로고    scopus 로고
    • Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages
    • COI: 1:CAS:528:DC%2BC3MXptlCksr4%3D, PID: 21723254
    • Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M (2011) Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun 411:143–149
    • (2011) Biochem Biophys Res Commun , vol.411 , pp. 143-149
    • Itoh, T.1    Hamada, N.2    Terazawa, R.3    Ito, M.4    Ohno, K.5    Ichihara, M.6    Nozawa, Y.7    Ito, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.