Homocysteine oxidative stress and relation to bone mineral density in post-menopausal osteoporosis

Aging Clinical and Experimental Research

Volumn 21, Issue 4-5, 2009, Pages 353-357

  Yılmaz, Necat ^a   Eren, Esin ^b  

^a GAZIANTEP UNIVERSITY   (Turkey)

^b Center of Public Health and Women's Health Laboratory   (Turkey)

Author keywords

Antioxidant; Deoxypyridinoline; DEXA; Homocysteine; Osteoporosis

Indexed keywords

ANTIOXIDANT; COLLAGEN TYPE 1; DEOXYPYRIDINOLINE; HOMOCYSTEINE; PARATHYROID HORMONE; PEROXIDE;

ADULT; AGING; ARTICLE; BONE DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; FEMALE; HUMAN; OXIDATIVE STRESS; POSTMENOPAUSE OSTEOPOROSIS; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; RISK FACTOR;

EID: 73849100277     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324927     Document Type: Article

References (35)

1. Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD. Low bone mineral density and fracture burden in postmenopausal women. CMAJ 2007; 177: 575-580 (Pubitemid 47437054)
2. Herrmann M, Widmann T, Herrmann W. Homocysteine - a newly recognised risk factor for osteoporosis. Clin Chem Lab Med 2005; 43: 1111-1117 (Pubitemid 41581970)
3. Yilmaz N, Kepkep N, Cicek HK et al. Relation of parity and homocysteine to bone mineral density of postmenopausal women. Clin Lab 2006; 52: 49-54.
4. Herrmann M, Kraenzlin M, Pape G, Sand-Hill M, Herrmann W. Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women. Clin Chem Lab Med 2005; 43: 1118-1123 (Pubitemid 41581971)
5. Lean JM, Davies JT, Fuller K et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 2003; 112: 915-923 (Pubitemid 38063749)
6. Altindag O, Erel O, Soran N, Celik H, Selek S. Total oxidative/anti- oxidative status and relation to bone mineral density in osteoporosis. Rheumatol Int 2008; 28: 317-321
7. Koh JM, Lee YS, Kim YS et al. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res 2006; 21: 1003-1011
8. Muthusami S, Ramachandran I, Muthusamy B, Vasudevan G, Prabhu V, Subramaniam. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 2005; 360: 81-86
9. Yilmaz N, Bayram M, Erbagci AB, Kilincer MS. Diagnostic value of biochemical markers of bone turnover and postmenopausal osteoporosis.Clin Chem Lab Med 1999; 37: 137-43.
10. Atmaca A, Gedlik O. Effects of alendronate and risedronate on bone mineral density and bone turnover markers in late postmenopausal women with osteoporosis. Adv Ther 2006; 23: 842-853 (Pubitemid 46341042)
11. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004; 37: 112-119 (Pubitemid 38077161)
12. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38: 1103-1111 (Pubitemid 41797751)
13. Herrmann M, Widmann T, Colaianni G, Colucci S, Zallone A, Herrmann W. Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin Chem 2005; 51: 2348-2353 (Pubitemid 41692580)
14. Kim DJ, Koh JM, Lee O. Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 2006; 39: 582-590 (Pubitemid 44149276)
15. Krumdieck CL, Prince CW. Mechanisms of homocysteine toxicity on connective tissues: implications for the morbidity of aging. J Nutr 2000; 130: 365S-8.
16. Lean JM, Jagger CJ, Kirstein B, Fuller K ,Chambers TJ. Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 2005; 146: 728-735 (Pubitemid 40129828)
17. Abdelfatah A, Dudoux D, Toubin G, Motte G, Alber D, Chalopin JM. Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients. Transplantation 2002; 73: 663-665 (Pubitemid 34193636)
18. Alvares Delfino VD, de Andrade Vianna AC, Mocelin AJ, Barbosa DS, Mise RA, Matsuo T. Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients. Nutrition 2007; 23: 242-247 (Pubitemid 46367571)
19. Hill CH, Mecham R, Starcher B. Fibrillin-2 defects impair elastic fiber assembly in a homocysteinemic chick model. J Nutr 2002; 132: 2143-2150 (Pubitemid 34851641)
20. Majors AK, Pyeritz RE. A deficiency of cysteine impairs fibrillin-1 deposition: implications for the pathogenesis of cystathionine β-synthase deficiency. Mol Genet Metab 2000; 70: 252-260
21. Kim HJ, Chang EJ, Kim HM et al. Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic Biol Med 2006; 40: 1483-1493
22. Saito M, Fujii K, Marumo K. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tissue Int 2006; 79: 160-168 (Pubitemid 44440444)
23. McLean RR, Jacques PF, Selhub J et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004; 350: 2042-2049 (Pubitemid 38596555)
24. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004; 350: 2033-2041
25. Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P, Smit JH, van Staveren WA. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 2005; 20: 921-929 (Pubitemid 40712815)
26. Tucker KL, Hannan MT, Qiao N et al. Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res 2005; 20: 152-158 (Pubitemid 41716230)
27. Dhonukshe-Rutten RA, van Dusseldorp M, Schneede J, de Groot LC, van Staveren WA. Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur J Nutr 2005; 44: 341-346
28. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000; 289: 1504-1508
29. Maggio D, Barabani M, Pierandrei M. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study, J Clin Endocrinol Metab 2003; 88: 1523-1527 (Pubitemid 36623364)
30. Oh B, Kim SY, Kim DJ et al. Associations of catalase gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women. J Med Genet 2007; 44: 62.
31. Bednarek-Tupikowska G, Bohdanowicz-Pawlak A, Bidzinska B, Milewicz A, Antonowicz-Juchniewicz J, Andrzejak R. Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and post-menopausal women. Gynecol Endocrinol 2001; 15: 298-303. (Pubitemid 32835654)
32. Ozgocmen S, Kaya H, Fadillioglu E, Yilmaz Z. Effects of calcitonin, risedronate, and raloxifene on erythrocyte antioxidant enzyme activity, lipid peroxidation, and nitric oxide in post-menopausal osteoporosis. Arch Med Res 2007; 38: 196-205. (Pubitemid 46080543)
33. Rao LG, Mackinnon ES, Josse RG, Murray TM, Strauss A, Rao AV. Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos Int. 2007; 18: 109-115 (Pubitemid 44885502)
34. Pasco JA, Henry MJ, Wilkinson LK, Nicholson GC, Schneider HG, Kotowicz MA. Antioxidant vitamin supplements and markers of bone turnover in a community sample of nonsmoking women. J Womens Health (Larchmt) 2006; 15: 295-300.
35. Sheweita SA, Khoshhal KI. Calcium metabolism and oxidative stress in bone fractures: role of antioxidants. Curr Drug Metab 2007; 8: 519-525 (Pubitemid 47603416)