Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway

Pharmaceutical Biology

Volumn 51, Issue 4, 2013, Pages 433-440

  Duan, Xiao Hong ^a   Xu, Chang Qin ^a   Huang, Jian Hua ^a   Zhou, Wen Jiang ^b   Sun, Bing ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI PUBLIC HEALTH CLINICAL CENTER   (China)

Author keywords

Cardiovascular; Epimedium sagittatum; HUVECs

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BETA GALACTOSIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HOMOCYSTEINE; ICARIIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; WORTMANNIN;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; BETA-GALACTOSIDASE; BIOLOGICAL MARKERS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLAVONOIDS; HOMOCYSTEINE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84875125455     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.738332     Document Type: Article

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