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Volumn 89, Issue 7, 2015, Pages 3584-3597

Effective lethal mutagenesis of influenza virus by three nucleoside analogs

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; FLUOROURACIL; MYCOPHENOLIC ACID; RIBAVIRIN; NUCLEOSIDE;

EID: 84924767317     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03483-14     Document Type: Article
Times cited : (50)

References (67)
  • 1
    • 0036953373 scopus 로고    scopus 로고
    • Genetics of influenza virus
    • Steinhauer DA, Skehel JJ. 2002. Genetics of influenza virus. Annu Rev Genet 36:305-332. http://dx.doi.org/10.1146/annurev.genet.36.052402.152757.
    • (2002) Annu Rev Genet , vol.36 , pp. 305-332
    • Steinhauer, D.A.1    Skehel, J.J.2
  • 2
    • 77956405791 scopus 로고    scopus 로고
    • Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex
    • Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B. 2010. Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. PLoS One 5:e10372. http://dx.doi.org/10.1371/journal.pone.0010372.
    • (2010) PLoS One , vol.5
    • Aggarwal, S.1    Bradel-Tretheway, B.2    Takimoto, T.3    Dewhurst, S.4    Kim, B.5
  • 3
    • 77749322610 scopus 로고    scopus 로고
    • Towards an atomic resolution understanding of the influenza virus replication machinery
    • Ruigrok RW, Crépin T, Hart DJ, Cusack S. 2010. Towards an atomic resolution understanding of the influenza virus replication machinery. Curr Opin Struct Biol 20:104-113. http://dx.doi.org/10.1016/j.sbi.2009.12.007.
    • (2010) Curr Opin Struct Biol , vol.20 , pp. 104-113
    • Ruigrok, R.W.1    Crépin, T.2    Hart, D.J.3    Cusack, S.4
  • 5
    • 0037560121 scopus 로고    scopus 로고
    • High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza
    • Shiraishi K, Mitamura K, Sakai-Tagawa Y, Goto H, Sugaya N, Kawaoka Y. 2003. High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza. J Infect Dis 188:57-61. http://dx.doi.org/10.1086/375799.
    • (2003) J Infect Dis , vol.188 , pp. 57-61
    • Shiraishi, K.1    Mitamura, K.2    Sakai-Tagawa, Y.3    Goto, H.4    Sugaya, N.5    Kawaoka, Y.6
  • 6
    • 84867692130 scopus 로고    scopus 로고
    • Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission
    • Ghedin E, Holmes EC, DePasse JV, Pinilla LT, Fitch A, Hamelin M-E, Papenburg J, Boivin G. 2012. Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission. J Infect Dis 206:1504-1511. http://dx.doi.org/10.1093/infdis/jis571.
    • (2012) J Infect Dis , vol.206 , pp. 1504-1511
    • Ghedin, E.1    Holmes, E.C.2    DePasse, J.V.3    Pinilla, L.T.4    Fitch, A.5    Hamelin, M.-E.6    Papenburg, J.7    Boivin, G.8
  • 8
    • 70350599175 scopus 로고    scopus 로고
    • Quantifying the impact of immune escape on transmission dynamics of influenza
    • Park AW, Daly JM, Lewis NS, Smith DJ, Wood JLN, Grenfell BT. 2009. Quantifying the impact of immune escape on transmission dynamics of influenza. Science 326:726-728. http://dx.doi.org/10.1126/science.1175980.
    • (2009) Science , vol.326 , pp. 726-728
    • Park, A.W.1    Daly, J.M.2    Lewis, N.S.3    Smith, D.J.4    Wood, J.L.N.5    Grenfell, B.T.6
  • 10
    • 73649127602 scopus 로고    scopus 로고
    • The fitness effects of random mutations in single-stranded DNA and RNA bacteriophages
    • Domingo-Calap P, Cuevas JM, Sanjuán R. 2009. The fitness effects of random mutations in single-stranded DNA and RNA bacteriophages. PLoS Genet 5:e1000742. http://dx.doi.org/10.1371/journal.pgen.1000742.
    • (2009) PLoS Genet , vol.5
    • Domingo-Calap, P.1    Cuevas, J.M.2    Sanjuán, R.3
  • 11
    • 36348963100 scopus 로고    scopus 로고
    • Distribution of fitness and virulence effects caused by single-nucleotide substitutions in tobacco etch virus
    • Carrasco P, de la Iglesia F, Elena SF. 2007. Distribution of fitness and virulence effects caused by single-nucleotide substitutions in tobacco etch virus. J Virol 81:12979-12984. http://dx.doi.org/10.1128/JVI.00524-07.
    • (2007) J Virol , vol.81 , pp. 12979-12984
    • Carrasco, P.1    de la Iglesia, F.2    Elena, S.F.3
  • 12
    • 2942565781 scopus 로고    scopus 로고
    • The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus
    • Sanjuán R, Moya A, Elena SF. 2004. The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus. Proc Natl Acad Sci USA 101:8396-8401. http://dx.doi.org/10.1073/pnas.0400146101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8396-8401
    • Sanjuán, R.1    Moya, A.2    Elena, S.F.3
  • 13
    • 33847247125 scopus 로고    scopus 로고
    • Theory of lethal mutagenesis for viruses
    • Bull JJ, Sanjuan R, Wilke CO. 2007. Theory of lethal mutagenesis for viruses. J Virol 81:2930-2939. http://dx.doi.org/10.1128/JVI.01624-06.
    • (2007) J Virol , vol.81 , pp. 2930-2939
    • Bull, J.J.1    Sanjuan, R.2    Wilke, C.O.3
  • 14
    • 77957658175 scopus 로고    scopus 로고
    • Quasispecies theory and the behavior of RNA viruses
    • Lauring AS, Andino R. 2010. Quasispecies theory and the behavior of RNA viruses. PLoS Pathog 6:e1001005. http://dx.doi.org/10.1371/journal.ppat.1001005.
    • (2010) PLoS Pathog , vol.6
    • Lauring, A.S.1    Andino, R.2
  • 15
    • 0035811016 scopus 로고    scopus 로고
    • RNA virus error catastrophe: direct molecular test by using ribavirin
    • Crotty S, Cameron CE, Andino R. 2001. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad SciUS A 98:6895-6900. http://dx.doi.org/10.1073/pnas.111085598.
    • (2001) Proc Natl Acad SciUS A , vol.98 , pp. 6895-6900
    • Crotty, S.1    Cameron, C.E.2    Andino, R.3
  • 16
    • 0037213579 scopus 로고    scopus 로고
    • Ribavirin causes error catastrophe during Hantaan virus replication
    • Severson WE, Schmaljohn CS, Javadian A, Jonsson CB. 2003. Ribavirin causes error catastrophe during Hantaan virus replication. J Virol 77:481-488. http://dx.doi.org/10.1128/JVI.77.1.481-488.2003.
    • (2003) J Virol , vol.77 , pp. 481-488
    • Severson, W.E.1    Schmaljohn, C.S.2    Javadian, A.3    Jonsson, C.B.4
  • 18
    • 0034864550 scopus 로고    scopus 로고
    • Ribavirin induces error-prone Replication of GB virus B in primary tamarin hepatocytes
    • Lanford RE, Chavez D, Guerra B, Lau JYN, Hong Z, Brasky KM, Beames B. 2001. Ribavirin induces error-prone Replication of GB virus B in primary tamarin hepatocytes. J Virol 75:8074-8081. http://dx.doi.org/10.1128/JVI.75.17.8074-8081.2001.
    • (2001) J Virol , vol.75 , pp. 8074-8081
    • Lanford, R.E.1    Chavez, D.2    Guerra, B.3    Lau, J.Y.N.4    Hong, Z.5    Brasky, K.M.6    Beames, B.7
  • 19
    • 20444366559 scopus 로고    scopus 로고
    • Error-prone replication of West Nile virus caused by ribavirin
    • Day C, Smee D, Julander J, Yamshchikov V, Sidwell R, Morrey J. 2005. Error-prone replication of West Nile virus caused by ribavirin. Antiviral Res 67:38-45. http://dx.doi.org/10.1016/j.antiviral.2005.04.002.
    • (2005) Antiviral Res , vol.67 , pp. 38-45
    • Day, C.1    Smee, D.2    Julander, J.3    Yamshchikov, V.4    Sidwell, R.5    Morrey, J.6
  • 20
    • 77956209034 scopus 로고    scopus 로고
    • Cell type mediated resistance of vesicular stomatitis virus and Sendai virus to ribavirin
    • Shah NR, Sunderland A, Grdzelishvili VZ. 2010. Cell type mediated resistance of vesicular stomatitis virus and Sendai virus to ribavirin. PLoS One 5:e11265. http://dx.doi.org/10.1371/journal.pone.0011265.
    • (2010) PLoS One , vol.5
    • Shah, N.R.1    Sunderland, A.2    Grdzelishvili, V.Z.3
  • 22
    • 79955900300 scopus 로고    scopus 로고
    • Ribavirin for chronic hepatitis C: and the mystery goes on
    • Brillanti S, Mazzella G, Roda E. 2011. Ribavirin for chronic hepatitis C: and the mystery goes on. Dig Liver Dis 43:425-430. http://dx.doi.org/10.1016/j.dld.2010.10.007.
    • (2011) Dig Liver Dis , vol.43 , pp. 425-430
    • Brillanti, S.1    Mazzella, G.2    Roda, E.3
  • 23
    • 70350291512 scopus 로고    scopus 로고
    • 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1
    • Dapp MJ, Clouser CL, Patterson S, Mansky LM. 2009. 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1. J Virol 83:11950-11958. http://dx.doi.org/10.1128/JVI.01406-09.
    • (2009) J Virol , vol.83 , pp. 11950-11958
    • Dapp, M.J.1    Clouser, C.L.2    Patterson, S.3    Mansky, L.M.4
  • 24
    • 0033850837 scopus 로고    scopus 로고
    • Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity
    • Sierra S, Davila M, Lowenstein PR, Domingo E. 2000. Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. J Virol 74:8316-8323. http://dx.doi.org/10.1128/JVI.74.18.8316-8323.2000.
    • (2000) J Virol , vol.74 , pp. 8316-8323
    • Sierra, S.1    Davila, M.2    Lowenstein, P.R.3    Domingo, E.4
  • 25
    • 0345578679 scopus 로고    scopus 로고
    • Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)
    • Ruiz-Jarabo CM, Ly C, Domingo E, de la Torre JC. 2003. Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology 308:37-47. http://dx.doi.org/10.1016/S0042-6822(02)00046-6.
    • (2003) Virology , vol.308 , pp. 37-47
    • Ruiz-Jarabo, C.M.1    Ly, C.2    Domingo, E.3    de la Torre, J.C.4
  • 26
    • 84883438898 scopus 로고    scopus 로고
    • Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics
    • Smith EC, Blanc H, Vignuzzi M, Denison MR. 2013. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. PLoS Pathog 9:e1003565. http://dx.doi.org/10.1371/journal.ppat.1003565.
    • (2013) PLoS Pathog , vol.9
    • Smith, E.C.1    Blanc, H.2    Vignuzzi, M.3    Denison, M.R.4
  • 27
    • 70350132524 scopus 로고    scopus 로고
    • Therapeutically targeting RNA viruses via lethal mutagenesis
    • Graci JD, Cameron CE. 2008. Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol 3:553-566. http://dx.doi.org/10.2217/17460794.3.6.553.
    • (2008) Future Virol , vol.3 , pp. 553-566
    • Graci, J.D.1    Cameron, C.E.2
  • 28
    • 0031001563 scopus 로고    scopus 로고
    • Mutagenicity of 5-aza-2=-deoxycytidine is mediated by the mammalian DNA methyltransferase
    • Jackson-Grusby L, Laird PW, Magge SN, Moeller BJ, Jaenisch R. 1997. Mutagenicity of 5-aza-2=-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc Natl Acad Sci USA 94:4681-4685. http://dx.doi.org/10.1073/pnas.94.9.4681.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4681-4685
    • Jackson-Grusby, L.1    Laird, P.W.2    Magge, S.N.3    Moeller, B.J.4    Jaenisch, R.5
  • 29
    • 0022373784 scopus 로고
    • Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture
    • Lee H-J, Pawlak K, Nguyen BT, Robins RK, Sadée W. 1985. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Cancer Res 45:5512-5520.
    • (1985) Cancer Res , vol.45 , pp. 5512-5520
    • Lee, H.-J.1    Pawlak, K.2    Nguyen, B.T.3    Robins, R.K.4    Sadée, W.5
  • 30
    • 13744258758 scopus 로고    scopus 로고
    • The Predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase
    • Leyssen P, Balzarini J, De Clercq E, Neyts J. 2005. The Predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol 79:1943-1947. http://dx.doi.org/10.1128/JVI.79.3.1943-1947.2005.
    • (2005) J Virol , vol.79 , pp. 1943-1947
    • Leyssen, P.1    Balzarini, J.2    De Clercq, E.3    Neyts, J.4
  • 32
    • 84893704436 scopus 로고    scopus 로고
    • Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition
    • Binh NT, Wakai C, Kawaguchi A, Nagata K. 2014. Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition. Biochem Biophys Res Commun 443:975-979. http://dx.doi.org/10.1016/j.bbrc.2013.12.071.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 975-979
    • Binh, N.T.1    Wakai, C.2    Kawaguchi, A.3    Nagata, K.4
  • 33
    • 2542461026 scopus 로고    scopus 로고
    • The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme
    • Bougie I, Bisaillon M. 2004. The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme. J Biol Chem 279:22124-22130. http://dx.doi.org/10.1074/jbc.M400908200.
    • (2004) J Biol Chem , vol.279 , pp. 22124-22130
    • Bougie, I.1    Bisaillon, M.2
  • 34
    • 71749106859 scopus 로고    scopus 로고
    • A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function
    • Ogbomo H, Michaelis M, Altenbrandt B, Doerr HW, Cinatl J. 2010. A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function. Biochem Pharmacol 79:188-197. http://dx.doi.org/10.1016/j.bcp.2009.07.026.
    • (2010) Biochem Pharmacol , vol.79 , pp. 188-197
    • Ogbomo, H.1    Michaelis, M.2    Altenbrandt, B.3    Doerr, H.W.4    Cinatl, J.5
  • 35
    • 34247255323 scopus 로고    scopus 로고
    • Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus
    • Rigopoulou E, Abbott W, Williams R, Naoumov N. 2007. Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus. Antiviral Res 75:36-42. http://dx.doi.org/10.1016/j.antiviral.2006.11.008.
    • (2007) Antiviral Res , vol.75 , pp. 36-42
    • Rigopoulou, E.1    Abbott, W.2    Williams, R.3    Naoumov, N.4
  • 36
    • 84927798710 scopus 로고    scopus 로고
    • The multifaceted functions of ribavirin: antiviral, immunomodulator, or both?
    • Mondelli MU. 2014. The multifaceted functions of ribavirin: antiviral, immunomodulator, or both?. Hepatology 60:1126-1129. http://dx.doi.org/10.1002/hep.27186.
    • (2014) Hepatology , vol.60 , pp. 1126-1129
    • Mondelli, M.U.1
  • 37
    • 1842555264 scopus 로고    scopus 로고
    • Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance?
    • Freistadt M. 2004. Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance?. Drug Resist Updat 7:19-24. http://dx.doi.org/10.1016/j.drup.2003.12.003.
    • (2004) Drug Resist Updat , vol.7 , pp. 19-24
    • Freistadt, M.1
  • 38
    • 0038809107 scopus 로고    scopus 로고
    • A single mutation in poliovirus RNAdependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
    • Pfeiffer JK, Kirkegaard K. 2003. A single mutation in poliovirus RNAdependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc Natl Acad Sci USA 100:7289-7294. http://dx.doi.org/10.1073/pnas.1232294100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7289-7294
    • Pfeiffer, J.K.1    Kirkegaard, K.2
  • 39
    • 84881162575 scopus 로고    scopus 로고
    • An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo
    • Zeng J, Wang H, Xie X, Yang D, Zhou G, Yu L. 2013. An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo. Antiviral Res 100:1-7. http://dx.doi.org/10.1016/j.antiviral.2013.07.008.
    • (2013) Antiviral Res , vol.100 , pp. 1-7
    • Zeng, J.1    Wang, H.2    Xie, X.3    Yang, D.4    Zhou, G.5    Yu, L.6
  • 40
    • 80053164707 scopus 로고    scopus 로고
    • Arbovirus high fidelity variant loses fitness in mosquitoes and mice
    • Coffey LL, Beeharry Y, Borderia AV, Blanc H, Vignuzzi M. 2011. Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proc Natl Acad Sci USA 108:16038-16043. http://dx.doi.org/10.1073/pnas.1111650108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16038-16043
    • Coffey, L.L.1    Beeharry, Y.2    Borderia, A.V.3    Blanc, H.4    Vignuzzi, M.5
  • 42
    • 34347327212 scopus 로고    scopus 로고
    • Selection for robustness in mutagenized RNA viruses
    • Sanjuán R, Cuevas JM, Furió V, Holmes EC, Moya A. 2007. Selection for robustness in mutagenized RNA viruses. PLoS Genet 3:e93. http://dx.doi.org/10.1371/journal.pgen.0030093.
    • (2007) PLoS Genet , vol.3
    • Sanjuán, R.1    Cuevas, J.M.2    Furió, V.3    Holmes, E.C.4    Moya, A.5
  • 43
    • 84857851921 scopus 로고    scopus 로고
    • Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis
    • Graci JD, Gnadig NF, Galarraga JE, Castro C, Vignuzzi M, Cameron CE. 2012. Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J Virol 86:2869-2873. http://dx.doi.org/10.1128/JVI.05712-11.
    • (2012) J Virol , vol.86 , pp. 2869-2873
    • Graci, J.D.1    Gnadig, N.F.2    Galarraga, J.E.3    Castro, C.4    Vignuzzi, M.5    Cameron, C.E.6
  • 44
    • 0021991997 scopus 로고
    • Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis
    • Wray S, Gilbert B, Noall M, Knight V. 1985. Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis. Antiviral Res 5:29-37.
    • (1985) Antiviral Res , vol.5 , pp. 29-37
    • Wray, S.1    Gilbert, B.2    Noall, M.3    Knight, V.4
  • 47
    • 84924773343 scopus 로고    scopus 로고
    • Favipiravir elicits antiviral mutagenesis during virus replication in vivo
    • Arias A, Thorne L, Goodfellow I. 2014. Favipiravir elicits antiviral mutagenesis during virus replication in vivo. eLife 3:e03679. http://dx.doi.org/10.7554/eLife.03679.
    • (2014) eLife , vol.3
    • Arias, A.1    Thorne, L.2    Goodfellow, I.3
  • 48
    • 0034705225 scopus 로고    scopus 로고
    • A DNA transfection system for generation of influenza A virus from eight plasmids
    • Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. 2000. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci USA 97:6108-6113. http://dx.doi.org/10.1073/pnas.100133697.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6108-6113
    • Hoffmann, E.1    Neumann, G.2    Kawaoka, Y.3    Hobom, G.4    Webster, R.G.5
  • 49
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63. http://dx.doi.org/10.1016/0022-1759(83)90303-4.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 50
    • 84880666503 scopus 로고    scopus 로고
    • Influenza: propagation, quantification, and storage
    • Balish AL, Katz JM, Klimov AI. 2013. Influenza: propagation, quantification, and storage. Curr Protoc Microbiol 15G.1. http://dx.doi.org/10.1002/9780471729259.mc15g01s29.
    • (2013) Curr Protoc Microbiol , vol.15 G , Issue.1
    • Balish, A.L.1    Katz, J.M.2    Klimov, A.I.3
  • 51
    • 33745158157 scopus 로고
    • A simple method of estimating fifty per cent endpoints
    • Reed LJ, Muench H. 1938. A simple method of estimating fifty per cent endpoints. Am J Epidemiol 27:493-497.
    • (1938) Am J Epidemiol , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 52
    • 70349272201 scopus 로고    scopus 로고
    • Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and swine origin human influenza A viruses
    • Zhou B, Donnelly ME, Scholes DT, St George K, Hatta M, Kawaoka Y, Wentworth DE. 2009. Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and swine origin human influenza A viruses. J Virol 83:10309-10313. http://dx.doi.org/10.1128/JVI.01109-09.
    • (2009) J Virol , vol.83 , pp. 10309-10313
    • Zhou, B.1    Donnelly, M.E.2    Scholes, D.T.3    St George, K.4    Hatta, M.5    Kawaoka, Y.6    Wentworth, D.E.7
  • 53
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • Langmead B, Trapnell C, Pop M, Salzberg SL, others. 2009. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10:R25. http://dx.doi.org/10.1186/gb-2009-10-3-r25.
    • (2009) Genome Biol , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 54
  • 55
    • 9244238208 scopus 로고    scopus 로고
    • Viral error catastrophe by mutagenic nucleosides
    • Anderson JP, Daifuku R, Loeb LA. 2004. Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol 58:183-205. http://dx.doi.org/10.1146/annurev.micro.58.030603.123649.
    • (2004) Annu Rev Microbiol , vol.58 , pp. 183-205
    • Anderson, J.P.1    Daifuku, R.2    Loeb, L.A.3
  • 56
    • 0344665713 scopus 로고    scopus 로고
    • Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines
    • Li M-H, Ito D, Sanada M, Odani T, Hatori M, Iwase M, Nagumo M. 2004. Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines. Oral Oncol 40:63-70. http://dx.doi.org/10.1016/S1368-8375(03)00136-2.
    • (2004) Oral Oncol , vol.40 , pp. 63-70
    • Li, M.-H.1    Ito, D.2    Sanada, M.3    Odani, T.4    Hatori, M.5    Iwase, M.6    Nagumo, M.7
  • 57
    • 84861893973 scopus 로고    scopus 로고
    • 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives
    • Krečmerová M, Otmar M. 2012. 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives. Future Med Chem 4:991-1005. http://dx.doi.org/10.4155/fmc.12.36.
    • (2012) Future Med Chem , vol.4 , pp. 991-1005
    • Krečmerová, M.1    Otmar, M.2
  • 60
    • 0027717956 scopus 로고
    • Characterization of human type I and type I1 IMP dehydrogenases
    • Carr S, Papp E, Wu J, Natsumeda Y. 1993. Characterization of human type I and type I1 IMP dehydrogenases. J Biol Chem 268:27286-27290.
    • (1993) J Biol Chem , vol.268 , pp. 27286-27290
    • Carr, S.1    Papp, E.2    Wu, J.3    Natsumeda, Y.4
  • 61
    • 0019248610 scopus 로고
    • Defective interfering influenza viruses
    • Nayak DP. 1980. Defective interfering influenza viruses. Annu Rev Microbiol 34:619-644. http://dx.doi.org/10.1146/annurev.mi.34.100180.003155.
    • (1980) Annu Rev Microbiol , vol.34 , pp. 619-644
    • Nayak, D.P.1
  • 62
    • 77958062791 scopus 로고    scopus 로고
    • Population dynamics of an RNA virus and its defective interfering particles in passage cultures
    • Thompson KA, Yin J. 2010. Population dynamics of an RNA virus and its defective interfering particles in passage cultures. Virol J 7:257. http://dx.doi.org/10.1186/1743-422X-7-257.
    • (2010) Virol J , vol.7 , pp. 257
    • Thompson, K.A.1    Yin, J.2
  • 64
    • 79952189030 scopus 로고    scopus 로고
    • Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA
    • Kawakami E, Watanabe T, Fujii K, Goto H, Watanabe S, Noda T, Kawaoka Y. 2011. Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA. J Virol Methods 173:1-6. http://dx.doi.org/10.1016/j.jviromet.2010.12.014.
    • (2011) J Virol Methods , vol.173 , pp. 1-6
    • Kawakami, E.1    Watanabe, T.2    Fujii, K.3    Goto, H.4    Watanabe, S.5    Noda, T.6    Kawaoka, Y.7
  • 65
    • 84869189162 scopus 로고    scopus 로고
    • Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virus
    • Lauring AS, Acevedo A, Cooper SB, Andino R. 2012. Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virus. Cell Host Microbe 12:623-632. http://dx.doi.org/10.1016/j.chom.2012.10.008.
    • (2012) Cell Host Microbe , vol.12 , pp. 623-632
    • Lauring, A.S.1    Acevedo, A.2    Cooper, S.B.3    Andino, R.4
  • 66
    • 0038133117 scopus 로고    scopus 로고
    • Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus
    • Plotkin JB, Dushoff J. 2003. Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus. Proc Natl Acad Sci USA 100:7152-7157. http://dx.doi.org/10.1073/pnas.1132114100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7152-7157
    • Plotkin, J.B.1    Dushoff, J.2
  • 67
    • 84855261948 scopus 로고    scopus 로고
    • Triple combination antiviral drug (TCAD) composed of amantadine, oseltamivir, and ribavirin impedes the selection of drug-resistant influenza A Virus
    • Hoopes JD, Driebe EM, Kelley E, Engelthaler DM, Keim PS, Perelson AS, Rong L, Went GT, Nguyen JT. 2011. Triple combination antiviral drug (TCAD) composed of amantadine, oseltamivir, and ribavirin impedes the selection of drug-resistant influenza A Virus. PLoS One 6:e29778. http://dx.doi.org/10.1371/journal.pone.0029778.
    • (2011) PLoS One , vol.6
    • Hoopes, J.D.1    Driebe, E.M.2    Kelley, E.3    Engelthaler, D.M.4    Keim, P.S.5    Perelson, A.S.6    Rong, L.7    Went, G.T.8    Nguyen, J.T.9


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