Structure diversification of vancomycin through peptide-catalyzed, site-selective lipidation: A catalysis-based approach to combat glycopeptide-resistant pathogens

Journal of Medicinal Chemistry

Volumn 58, Issue 5, 2015, Pages 2367-2377

  Yoganathan, Sabesan ^a   Miller, Scott J ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPEPTIDE; HYDROXYL GROUP; LINEZOLID; TEICOPLANIN; VANCOMYCIN; ANTIINFECTIVE AGENT; LIPID;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BIOLOGICAL ACTIVITY; CATALYSIS; CATALYST; HYDROGEN BOND; LIPID METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; PHENOTYPE; SITE SELECTIVE LIPIDATION; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; ENTEROCOCCUS; LIPOYLATION; MICROBIAL SENSITIVITY TEST; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENTEROCOCCUS; GLYCOPEPTIDES; LIPIDS; LIPOYLATION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN; VANCOMYCIN RESISTANCE;

EID: 84924674519     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501872s     Document Type: Article

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