Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis

Chemistry and Biology

Volumn 8, Issue 11, 2001, Pages 1095-1106

  Sinha Roy, Ranabir ^a   Yang, Ping ^a   Kodali, Srinivas ^a   Xiong, Yusheng ^a   Kim, Ronald M ^a   Griffin, Patrick R ^a   Onishi, H Russell ^a   Kohler, Joyce ^a   Silver, Lynn L ^a   Chapman, Kevin ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Affinity chromatography; Glycopeptide; Peptidoglycan; Transglycosylase; Vancomycin

Indexed keywords

BACTERIAL PROTEIN; PEPTIDOGLYCAN; PEPTIDYLTRANSFERASE; POLYPEPTIDE ANTIBIOTIC AGENT; VANCOMYCIN;

AFFINITY CHROMATOGRAPHY; ARTICLE; BIOSYNTHESIS; CELL WALL; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GLYCOSYLATION; METABOLISM; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, GLYCOPEPTIDE; BACTERIAL PROTEINS; CELL WALL; CHROMATOGRAPHY, AFFINITY; ESCHERICHIA COLI; GLYCOSYLATION; PEPTIDOGLYCAN; PEPTIDYLTRANSFERASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN;

EID: 0035198239     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00075-8     Document Type: Article

References (48)

1. Multiple-antibiotic-resistant pathogenic bacteria
2. Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine
3. Structure, biochemistry, and mechanism of action of glycopeptide antibiotics
4. The glycopeptide story - How to kill the deadly superbugs
5. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium
6. Bacterial resistance to vancomycin: Five genes and one missing hydrogen bond tell the story
7. Genetics and mechanisms of glycopeptide resistance in enterococci
8. Glycopeptide resistance in staphylococcus aureus
9. A closer look at vancomycin, teicoplanin, and antimicrobial resistance
10. Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria
11. Inhibition of peptidoglycan biosynthesis in vancomycin-susceptible and -resistant bacteria by a semisynthetic glycopeptide antibiotic
12. Novel glycopeptide antibiotics: N-alkylated derivatives active against vancomycin-resistant enterococci
13. Semisynthetic glycopeptide antibiotics derived from LY264826 active against vancomycin-resistant enterococci
14. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding DAla-DAla
15. Semiquantitation of cooperativity in binding of vancomycin-group antibiotics to vancomycin-susceptible and-resistant organisms
16. Enthalpic (electrostatic) contribution to the chelate effect: A correlation between ligand binding constant and a specific bond strength in complexes of glycopeptide antibiotics with cell wall analogues
17. The roles of dimerization and membrane anchoring in activity of glycopeptide antibiotics against vancomycin-resistant bacteria
18. Binding of glycopeptide antibiotics to a model of vancomycin-resistant bacterium
19. The role of hydrophobic substituents in the biological activity of glycopeptide antibiotics
20. The preparation of iodinated vancomycin and its distribution in bacteria treated with the antibiotic
21. Salting-out in amphiphilic gels as a new approach to hydrophobic adsorption
22. Salt effects on hydrophobic interactions in precipitation and chromatography of proteins: An interpretation of the lyotrophic series
23. BOCILLIN FL, a sensitive and commercially available reagent for the detection of penicillin-binding proteins
24. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
25. Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: Enzymology, antibiotics, and antibiotic resistance
26. Structure elucidation of the teicoplanin antibiotics
27. Enzymatic deacylation of teicoplanin followed by reductive alkylation: Synthesis and antibacterial activity of new glycopeptides
28. Penicillin-binding proteins of gram-negative bacteria
29. Direct quantitation of the number of individual penicillin-binding proteins per cell in Escherichia coli
30. Characterization of three different lytic transglycosylases in Escherichia coli
31. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli
32. Glucose-permease of the bacterial phosphotransferase system. Gene cloning, overproduction, and amino acid sequence of enzyme IIGlc
33. Escherichia coli mutants lacking all possible combinations of eight penicillin binding proteins: Viability, characteristics, and implications for peptidoglycan synthesis
34. In vitro peptidoglycan polymerization catalyzed by penicillin binding protein 1b of Escherichia coli
35. Purified penicillin binding proteins 1Bs from Escherichia coli membrane showing activities of both peptidoglycan polymerase and peptidoglycan crosslinking enzyme
36. Identification of two penicillin-binding multienzyme complexes in Haemophilus influenzae
37. Growth of the stress-bearing and shape-maintaining murein sacculus of Escherichia coli
38. Chlorobiphenyl-desleucyl-vancomycin inhibits the transglycosylation process required for peptidoglycan synthesis in bacteria in the absence of dipeptide binding
39. A novel glycan polymerase that synthesizes uncross-linked peptidoglycan in Escherichia coli
40. The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesizing enzymes
41. Staphylococcus aureus and Micrococcus luteus peptidoglycan transglycosylases that are not penicillin-binding proteins
42. Monofunctional biosynthetic peptidoglycan transglycosylases
43. A putative monofunctional glycosyltransferase is expressed in Ralstonia eutropha
44. Peptidoglycan transpeptidase inhibition in Pseudomonas aeruginosa and Escherichia coli by penicillins and cephalosporins
45. Direct database searching with MALDI-PSD spectra of peptides