Multiple complexes of long aliphatic N -acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus

Journal of the American Chemical Society

Volumn 136, Issue 31, 2014, Pages 10989-10995

  Lyu, Syue Yi ^a,b   Liu, Yu Chen ^a   Chang, Chin Yuan ^a   Huang, Chuen Jiuan ^d   Chiu, Ya Huang ^c   Huang, Chun Man ^a,b   Hsu, Ning Shian ^a   Lin, Kuan Hung ^a   Wu, Chang Jer ^c   Tsai, Ming Daw ^d   Li, Tsung Lin ^a,e  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^d INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; ENZYMES; X RAY CRYSTALLOGRAPHY;

ACYLTRANSFERASES; BACTERIAL INFECTIONS; CONFORMATIONAL CHANGE; GLYCOPEPTIDE ANTIBIOTICS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; REACTION CONTROL; STRUCTURAL INFORMATION; VANCOMYCIN-RESISTANT ENTEROCOCCI;

ANTIBIOTICS;

A 40926; ACYL COENZYME A; ACYLTRANSFERASE; GLYCOPEPTIDE ANTIBIOTIC DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; TEICOPLANIN A2 2; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; GLYCOPEPTIDE;

ARTICLE; BIOLOGICAL ACTIVITY; CONFORMATIONAL TRANSITION; DRUG MECHANISM; NONHUMAN; STOICHIOMETRY; VANCOMYCIN RESISTANT ENTEROCOCCUS; X RAY CRYSTALLOGRAPHY; ACYLATION; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACYLATION; ACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BIOCATALYSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; GLYCOPEPTIDES; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN-RESISTANT ENTEROCOCCI;

EID: 84905695318     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja504125v     Document Type: Article

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