Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 9, 2013, Pages 2134-2139

  Holmes, Natasha E ^a,b   Ballard, Susan A ^a   Lam, Margaret M C ^b   Johnson, Paul D R ^a,b   Grayson, M Lindsay ^a,b,c   Stinear, Timothy P ^b,c   Howden, Benjamin P ^a,b,c  

^a AUSTIN HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Single nucleotide polymorphisms; vanRS; Whole genome sequencing

Indexed keywords

TEICOPLANIN;

ADULT; ANASTOMOSIS LEAKAGE; ARTICLE; BACTEREMIA; CLINICAL ARTICLE; DONOR; FEMALE; GENE SEQUENCE; GENETIC ANALYSIS; GRAFT RECIPIENT; HUMAN; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MALE; OUT OF HOSPITAL CARDIAC ARREST; PERITONITIS; URINE CULTURE; URINE RETENTION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

SINGLE NUCLEOTIDE POLYMORPHISMS; VANRS; WHOLE GENOME SEQUENCING;

ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECIUM; FEMALE; GENOME, BACTERIAL; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; TEICOPLANIN; TRANSPLANTATION; TREATMENT FAILURE; VANCOMYCIN;

EID: 84882613721     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt130     Document Type: Article

References (18)

1. Teixeira LM, Carvalho MDGS, Shewmaker PL et al. Enterococcus. In: Versalovic J, ed. Manual of Clinical Microbiology. Washington, DC: ASM Press, 2011; 350-64.
2. Johnson PD, Ballard SA, Grabsch EA et al. A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203. J Infect Dis 2010; 202: 1278-86.
3. Rothberg JM, Hinz W, Rearick TM et al. An integrated semiconductor device enabling non-optical genome sequencing. Nature 2011; 475: 348-52.
4. Rumble SM, Lacroute P, Dalca AV et al. SHRiMP: accurate mapping of short color-space reads. PLoS Comput Biol 2009; 5: e1000386.
5. Huson DH, Bryant D. Application of phylogenetic networks in evolutionary studies. Mol Biol Evol 2006; 23: 254-67.
6. Sanofi-Aventis. Product information: Targocid (Teicoplanin). http://www. sanofi.com.au/products/aus_pi_targocid.pdf (13 January 2012, date last accessed).
7. Herrero IA, Issa NC, Patel R. Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. N Engl J Med 2002; 346: 867-9.
8. Hayden MK, Trenholme GM, Schultz JE et al. In vivo development of teicoplanin resistance in a VanB Enterococcus faecium isolate. J Infect Dis 1993; 167: 1224-7.
9. Kawalec M, Gniadkowski M, Kedzierska J et al. Selection of a teicoplanin-resistant Enterococcus faecium mutant during an outbreak caused by vancomycin-resistant enterococci with the VanB phenotype. J Clin Microbiol 2001; 39: 4274-82.
10. Lefort A, Arthur M, Depardieu F et al. Expression of glycopeptide-resistance gene in response to vancomycin and teicoplanin in the cardiac vegetations of rabbits infected with VanB-type Enterococcus faecalis. J Infect Dis 2004; 189: 90-7.
11. Aslangul E, Baptista M, Fantin B et al. Selection of glycopeptide-resistant mutants of VanB-type Enterococcus faecalis BM4281 in vitro and in experimental endocarditis. J Infect Dis 1997; 175: 598-605.
12. Baptista M, Rodrigues P, Depardieu F et al. Single-cell analysis of glycopeptide resistance gene expression in teicoplanin-resistant mutants of a VanB-type Enterococcus faecalis. Mol Microbiol 1999; 32: 17-28.
13. Arthur M, Quintiliani R. Regulation of VanA- and VanB-type glycopeptide resistance in enterococci. Antimicrob Agents Chemother 2001; 45: 375-81.
14. Baptista M, Depardieu F, Reynolds P et al. Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci. Mol Microbiol 1997; 25: 93-105.
15. Sifri CD, Ison MG. Highly resistant bacteria and donor-derived infections: treading in uncharted territory. Transpl Infect Dis 2012; 14: 223-8.
16. Fishman JA, Greenwald MA, Grossi PA. Transmission of infection with human allografts: essential considerations in donor screening. Clin Infect Dis 2012; 55: 720-7.
17. Blumberg E, Green M, Covington S et al. Donor Derived Bacterial Infections: Report From the Disease Transmission Advisory Committee (DTAC). http://idsa.confex.com/idsa/2010/webprogram/Paper3060.html (2 November 2012, date last accessed).
18. Depardieu F, Courvalin P, Msadek T. A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium. Mol Microbiol 2003; 50: 1069-83.